{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:33:19Z","timestamp":1760121199989},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[1995,9,1]],"date-time":"1995-09-01T00:00:00Z","timestamp":809913600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[1995,9]]},"DOI":"10.1038\/nm0995-927","type":"journal-article","created":{"date-parts":[[2004,8,19]],"date-time":"2004-08-19T01:19:27Z","timestamp":1092878367000},"page":"927-931","source":"Crossref","is-referenced-by-count":65,"title":["A picornaviral protein synthesized out of frame with the polyprotein plays a key role in a virus\u2013induced immune\u2013mediated demyelinating disease"],"prefix":"10.1038","volume":"1","author":[{"given":"Hsiao-Huei","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wing-Pui","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia L.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond P.","family":"Roos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BFnm0995927_CR1","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/978-1-4612-0407-7_7","volume-title":"Molecular Neurovirology","author":"RP Roos","year":"1992","unstructured":"Roos, R.P. & Casteel, N. Determinants of neurological disease induced by Theiler's murine encephalomyelitis virus. in Molecular Neurovirology (ed Roos, R.P.) 283\u2013318 (Humana Press, Totowa, New Jersey, 1992)."},{"key":"BFnm0995927_CR2","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1002\/j.1460-2075.1994.tb06431.x","volume":"13","author":"A Kaminski","year":"1994","unstructured":"Kaminski, A., Belsham, G.J. & Jackson, R.J. Translation of encephalomyocarditis virus RNA: Parameters influencing the selection of the internal initiation site. EMBO J. 13, 1673\u20131681 (1994).","journal-title":"EMBO J."},{"key":"BFnm0995927_CR3","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1146\/annurev.ge.27.120193.002033","volume":"27","author":"E Wimmer","year":"1993","unstructured":"Wimmer, E., Hellen, C.U.T. & Cao, X. Genetics of poliovirus. Annu. Rev. Genet. 27, 353\u2013436 (1993).","journal-title":"Annu. Rev. Genet."},{"key":"BFnm0995927_CR4","doi-asserted-by":"publisher","first-page":"3753","DOI":"10.1002\/j.1460-2075.1990.tb07588.x","volume":"9","author":"A Kaminski","year":"1990","unstructured":"Kaminski, A., Howell, M.T. & Jackson, R.J. Initiation of encephalomyocarditis virus RNA translation: The authentic initiation site is not selected by a scanning mechanism. EMBO J. 9, 3753\u20133759 (1990).","journal-title":"EMBO J."},{"key":"BFnm0995927_CR5","doi-asserted-by":"publisher","first-page":"3305","DOI":"10.1093\/nar\/15.8.3305","volume":"15","author":"DV Sangar","year":"1987","unstructured":"Sangar, D.V., Newton, S.E., Rowlands, D.J. & Clarke, B.E. All foot and mouth disease virus serotypes initiate protein synthesis at two separate AUGs. Nucleic Acids Res. 15, 3305\u20133315 (1987).","journal-title":"Nucleic Acids Res."},{"key":"BFnm0995927_CR6","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/0042-6822(92)90027-M","volume":"186","author":"M Tesar","year":"1992","unstructured":"Tesar, M., Harmon, S.A., Summers, D.F. & Ehrenfeld, E. Hepatitis A virus polyprotein synthesis initiates from two alternative AUG codons. Virology 186, 609\u2013618 (1992).","journal-title":"Virology"},{"key":"BFnm0995927_CR7","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1128\/JVI.65.6.3395-3399.1991","volume":"65","author":"W-P Kong","year":"1991","unstructured":"Kong, W.-P. & Roos, R.P. Alternative translation initiation site in the DA strain of Theiler's murine encephalomyelitis virus. J. Virol. 65, 3395\u20133399 (1991).","journal-title":"J. Virol."},{"key":"BFnm0995927_CR8","first-page":"3395","volume":"65","author":"ML Celma","year":"1975","unstructured":"Celma, M.L. & Ehrenfeld, E. Translation of poliovirus RNA in vitro: Detection of two different initiation sites. J. molec. Biol. 65, 3395\u20133399 (1975).","journal-title":"J. molec. Biol."},{"key":"BFnm0995927_CR9","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1128\/JVI.50.2.507-514.1984","volume":"50","author":"AJ Dorner","year":"1984","unstructured":"Dorner, A.J. et al. In vitro translation of poliovirus RNA: Utilization of internal initiation sites in reticulocyte lysate. J. Virol. 50, 507\u2013514 (1984).","journal-title":"J. Virol."},{"key":"BFnm0995927_CR10","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/0042-6822(86)90323-5","volume":"148","author":"BA Phillips","year":"1986","unstructured":"Phillips, B.A. & Emmert, A. Modulation of the expression of poliovirus proteins in reticulocyte lysate. Virology 148, 255\u2013267 (1986).","journal-title":"Virology"},{"key":"BFnm0995927_CR11","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1159\/000163781","volume":"61","author":"R Nunez","year":"1993","unstructured":"Nunez, R. & Lynch, R.G. CD23 isoforms in murine T and B lymphocytes. Pathobiology 61, 128\u2013137 (1993).","journal-title":"Pathobiology"},{"key":"BFnm0995927_CR12","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/0167-5699(94)90270-4","volume":"15","author":"J Gordon","year":"1994","unstructured":"Gordon, J. B-cell signalling via the C-type lectins CD23 and CD72. Immim. Today 15, 411\u2013417 (1994).","journal-title":"Immim. Today"},{"key":"BFnm0995927_CR13","doi-asserted-by":"crossref","first-page":"6414","DOI":"10.1128\/JVI.65.12.6414-6424.1991","volume":"65","author":"JD Baines","year":"1991","unstructured":"Baines, J.D., Ward, P.L., Campadelli-Fiume, G. & Roizman, B. The UI20 gene of herpes simplex virus 1 encodes a function necessary for viral egress. J. Virol. 65, 6414\u20136424 (1991).","journal-title":"J. Virol."},{"key":"BFnm0995927_CR14","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1128\/JVI.9.1.143-159.1972","volume":"9","author":"PG Spear","year":"1972","unstructured":"Spear, P.G. & Roizman, B. Proteins specified by herpes simplex viruses. I. Identification of four glycoprotein precursors and their products in type I-in-fected cells. J. Virol. 9, 143\u2013159 (1972).","journal-title":"J. Virol."},{"key":"BFnm0995927_CR15","doi-asserted-by":"publisher","first-page":"4125","DOI":"10.1073\/pnas.87.11.4125","volume":"87","author":"J Fu","year":"1990","unstructured":"Fu, J. et al. Neurovirulence determinants of genetically engineered Theiler viruses. Proc. natn. Acad. Sci. U.S.A. 87, 4125\u20134129 (1990).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BFnm0995927_CR16","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1128\/JVI.66.4.1951-1958.1992","volume":"66","author":"AE Pritchard","year":"1992","unstructured":"Pritchard, A.E., Calenoff, M.A., Simpson, S., Jensen, K. & Lipton, H.L. A single base deletion in the 5\u2032 noncoding region of Theiler's virus attenuates neurovirulence. J. Virol. 66, 1951\u20131958 (1992).","journal-title":"J. Virol."},{"key":"BFnm0995927_CR17","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1128\/JVI.69.5.3171-3175.1995","volume":"69","author":"L Zhang","year":"1995","unstructured":"Zhang, L., Sato, S., Kim, J.I. & Roos, R.P. Theiler's virus as a vector for foreign gene delivery. J. Virol. 69, 3171\u20133175 (1995).","journal-title":"J. Virol."},{"key":"BFnm0995927_CR18","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1128\/JVI.65.4.1929-1937.1991","volume":"65","author":"A Zurbriggen","year":"1991","unstructured":"Zurbriggen, A., Thomas, C., Yamada, M., Roos, R.P. & Fujinami, R.S. Direct evidence of a role for amino acid 101 of VP-1 in central nervous system disease in Theiler's murine encephalomyelitis virus infection. J. Virol. 65, 1929\u20131937 (1991).","journal-title":"J. Virol."},{"key":"BFnm0995927_CR19","doi-asserted-by":"crossref","first-page":"4469","DOI":"10.1128\/JVI.63.10.4469-4473.1989","volume":"63","author":"RP Roos","year":"1989","unstructured":"Roos, R.P. et al. Theiler's murine encephalomyelitis virus neutralization escape mutants have a change in disease phenotype. J. Virol. 63, 4469\u20134473 (1989).","journal-title":"J. Virol."},{"key":"BFnm0995927_CR20","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1128\/JVI.68.5.3364-3368.1994","volume":"68","author":"N Jarousse","year":"1994","unstructured":"Jarousse, N. et al. A single amino acid change determines persistence of a chimeric Theiler's virus. J. Virol. 68, 3364\u20133368 (1994).","journal-title":"J. Virol."},{"key":"BFnm0995927_CR21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1128\/JVI.66.1.217-225.1992","volume":"66","author":"M Rodriguez","year":"1992","unstructured":"Rodriguez, M. & Roos, R.P. Pathogenesis of early and late disease in mice infected with Theiler's virus, using intratypic recombinant GDVII\/DA viruses. J. Virol. 66, 217\u2013225 (1992).","journal-title":"J. Virol."},{"key":"BFnm0995927_CR22","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1099\/0022-1317-71-9-2123","volume":"71","author":"AK Patick","year":"1990","unstructured":"Patick, A.K., Oleszak, E.L., Leibowitz, J.L. & Rodriguez, M. Persistent infection of a glioma cell line generates a Theiler's virus variant which fails to induce de-myelinating disease in SJL\/J mice. J. gen. Virol. 71, 2123\u20132132 (1990).","journal-title":"J. gen. Virol."},{"key":"BFnm0995927_CR23","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.1099\/0022-1317-69-9-2413","volume":"69","author":"EL Oleszak","year":"1988","unstructured":"Oleszak, E.L., Leibowitz, J.L. & Rodriguez, M. Isolation and characterization of two plaque size variants of Theiler's murine encephalomyelitis virus (DA strain). J. gen. Virol. 69, 2413\u20132418 (1988).","journal-title":"J. gen. Virol."},{"key":"BFnm0995927_CR24","doi-asserted-by":"crossref","first-page":"920","DOI":"10.4049\/jimmunol.136.3.920","volume":"136","author":"RJ Clatch","year":"1986","unstructured":"Clatch, R.J., Lipton, H.L. & Miller, S.D. Characterization of Theiler's murine encephalomyelitis virus (TMEV)-specific delayed type hypersensitivity responses in TMEV-induced demyelinating disease: Correlation with clinical signs. J. Immun. 136, 920\u2013927 (1986).","journal-title":"J. Immun."},{"key":"BFnm0995927_CR25","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/0165-5728(88)90110-5","volume":"20","author":"RS Fujinami","year":"1988","unstructured":"Fujinami, R.S., Zurbriggen, A. & Powell, H.C. Monoclonal antibody defines a determinant between Theiler's virus and lipid-like structure. J. Neuroimmun. 20, 25\u201332 (1988).","journal-title":"J. Neuroimmun."},{"key":"BFnm0995927_CR26","doi-asserted-by":"crossref","first-page":"20668","DOI":"10.1016\/S0021-9258(17)32045-8","volume":"269","author":"H Imataka","year":"1994","unstructured":"Imataka, H. et al. Cell-specific translational control of transcription factor BTEB expression. J. biol. Chem. 269, 20668\u201320673 (1994).","journal-title":"J. biol. Chem."},{"key":"BFnm0995927_CR27","doi-asserted-by":"crossref","first-page":"21886","DOI":"10.1016\/S0021-9258(19)36695-5","volume":"267","author":"JR Hill","year":"1992","unstructured":"Hill, J.R. & Morris, D.R. Cell-specific translational regulation of S-adenosylme-thionine decarboxylase mRNA. Dependence on translation and coding capacity of the cis-acting upstream open reading frame. J. biol. Chem. 267, 21886\u201321893 (1992).","journal-title":"J. biol. Chem."},{"key":"BFnm0995927_CR28","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.1128\/JVI.63.12.5344-5353.1989","volume":"63","author":"RP Roos","year":"1989","unstructured":"Roos, R.P., Kong, W.-P. & Semler, B.L. Polyprotein processing of Theiler's murine encephalomyelitis virus. J. Virol. 63, 5344\u20135353 (1989).","journal-title":"J. Virol."},{"key":"BFnm0995927_CR29","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.1128\/JVI.63.12.5492-5496.1989","volume":"63","author":"RP Roos","year":"1989","unstructured":"Roos, R.P., Stein, S., Ohara, Y., Fu, J. & Semler, B.L. Infectious cDNA clones of the DA strain of Theiler's murine encephalomyelitis virus. J. Virol. 63, 5492\u20135496 (1989).","journal-title":"J. Virol."}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm0995-927","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm0995-927.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm0995-927.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T23:35:27Z","timestamp":1684452927000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm0995-927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,9]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1995,9]]}},"alternative-id":["BFnm0995927"],"URL":"https:\/\/doi.org\/10.1038\/nm0995-927","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,9]]}}}