{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:31:28Z","timestamp":1792477888147,"version":"4.5.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2004,11,21]],"date-time":"2004-11-21T00:00:00Z","timestamp":1100995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2004,12]]},"DOI":"10.1038\/nm1137","type":"journal-article","created":{"date-parts":[[2004,11,22]],"date-time":"2004-11-22T14:27:39Z","timestamp":1101133659000},"page":"1384-1389","source":"Crossref","is-referenced-by-count":582,"title":["Adiponectin-mediated modulation of hypertrophic signals in the heart"],"prefix":"10.1038","volume":"10","author":[{"given":"Rei","family":"Shibata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Ouchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Kihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Shiojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R","family":"Pimentel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Kumada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Schiekofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Ohashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Funahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson S","family":"Colucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,11,21]]},"reference":[{"key":"BFnm1137_CR1","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1161\/01.CIR.0000088846.10655.E0","volume":"108","author":"MP Reilly","year":"2003","unstructured":"Reilly, M.P. & Rader, D.J. The metabolic syndrome: more than the sum of its parts? Circulation 108, 1546\u20131551 (2003).","journal-title":"Circulation"},{"key":"BFnm1137_CR2","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1097\/00041433-200312000-00003","volume":"14","author":"N Ouchi","year":"2003","unstructured":"Ouchi, N., Kihara, S., Funahashi, T., Matsuzawa, Y. & Walsh, K. Obesity, adiponectin and vascular inflammatory disease. Curr. Opin. Lipidol. 14, 561\u2013566 (2003).","journal-title":"Curr. Opin. Lipidol."},{"key":"BFnm1137_CR3","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1067\/mhj.2001.115302","volume":"141","author":"A Ilercil","year":"2001","unstructured":"Ilercil, A. et al. Relationship of impaired glucose tolerance to left ventricular structure and function: The Strong Heart Study. Am. Heart J. 141, 992\u2013998 (2001).","journal-title":"Am. Heart J."},{"key":"BFnm1137_CR4","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1161\/01.CIR.0000045671.62860.98","volume":"107","author":"MK Rutter","year":"2003","unstructured":"Rutter, M.K. et al. Impact of glucose intolerance and insulin resistance on cardiac structure and function: sex-related differences in the Framingham Heart Study. Circulation 107, 448\u2013454 (2003).","journal-title":"Circulation"},{"key":"BFnm1137_CR5","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1159\/000064682","volume":"98","author":"CM Schannwell","year":"2002","unstructured":"Schannwell, C.M., Schneppenheim, M., Perings, S., Plehn, G. & Strauer, B.E. Left ventricular diastolic dysfunction as an early manifestation of diabetic cardiomyopathy. Cardiology 98, 33\u201339 (2002).","journal-title":"Cardiology"},{"key":"BFnm1137_CR6","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1172\/JCI10842","volume":"106","author":"BB Kahn","year":"2000","unstructured":"Kahn, B.B. & Flier, J.S. Obesity and insulin resistance. J. Clin. Invest. 106, 473\u2013481 (2000).","journal-title":"J. Clin. Invest."},{"key":"BFnm1137_CR7","doi-asserted-by":"publisher","first-page":"26746","DOI":"10.1074\/jbc.270.45.26746","volume":"270","author":"PE Scherer","year":"1995","unstructured":"Scherer, P.E., Williams, S., Fogliano, M., Baldini, G. & Lodish, H.F. A novel serum protein similar to C1q, produced exclusively in adipocytes. J. Biol. Chem. 270, 26746\u201326749 (1995).","journal-title":"J. Biol. Chem."},{"key":"BFnm1137_CR8","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/nm724","volume":"8","author":"N Maeda","year":"2002","unstructured":"Maeda, N. et al. Diet-induced insulin resistance in mice lacking adiponectin\/ACRP30. Nat. Med. 8, 731\u2013737 (2002).","journal-title":"Nat. Med."},{"key":"BFnm1137_CR9","doi-asserted-by":"publisher","first-page":"25863","DOI":"10.1074\/jbc.C200251200","volume":"277","author":"N Kubota","year":"2002","unstructured":"Kubota, N. et al. Disruption of adiponectin causes insulin resistance and neointimal formation. J. Biol. Chem. 277, 25863\u201325866 (2002).","journal-title":"J. Biol. Chem."},{"key":"BFnm1137_CR10","doi-asserted-by":"publisher","first-page":"28670","DOI":"10.1074\/jbc.M402558200","volume":"279","author":"R Shibata","year":"2004","unstructured":"Shibata, R. et al. Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling. J. Biol. Chem. 279, 28670\u201328674 (2004).","journal-title":"J. Biol. Chem."},{"key":"BFnm1137_CR11","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1006\/jmcc.2001.1348","volume":"33","author":"L Xiao","year":"2001","unstructured":"Xiao, L. et al. MEK1\/2\u2013ERK1\/2 mediates alpha1-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes. J. Mol. Cell. Cardiol. 33, 779\u2013787 (2001).","journal-title":"J. Mol. Cell. Cardiol."},{"key":"BFnm1137_CR12","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1161\/01.CIR.103.10.1453","volume":"103","author":"G Esposito","year":"2001","unstructured":"Esposito, G. et al. Cardiac overexpression of a G(q) inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase activity in in vivo pressure overload. Circulation 103, 1453\u20131458 (2001).","journal-title":"Circulation"},{"key":"BFnm1137_CR13","doi-asserted-by":"publisher","first-page":"e27","DOI":"10.1161\/01.RES.0000119921.86460.37","volume":"94","author":"H Kobayashi","year":"2004","unstructured":"Kobayashi, H. et al. Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin. Circ. Res. 94, e27\u2013e31 (2004).","journal-title":"Circ. Res."},{"key":"BFnm1137_CR14","doi-asserted-by":"publisher","first-page":"16309","DOI":"10.1073\/pnas.222657499","volume":"99","author":"E Tomas","year":"2002","unstructured":"Tomas, E. et al. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc. Natl. Acad. Sci. USA 99, 16309\u201316313 (2002).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm1137_CR15","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1038\/nm788","volume":"8","author":"T Yamauchi","year":"2002","unstructured":"Yamauchi, T. et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat. Med. 8, 1288\u20131295 (2002).","journal-title":"Nat. Med."},{"key":"BFnm1137_CR16","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.2337\/diabetes.52.6.1355","volume":"52","author":"X Wu","year":"2003","unstructured":"Wu, X. et al. Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes. Diabetes 52, 1355\u20131363 (2003).","journal-title":"Diabetes"},{"key":"BFnm1137_CR17","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1074\/jbc.M310389200","volume":"279","author":"N Ouchi","year":"2004","unstructured":"Ouchi, N. et al. Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J. Biol. Chem. 279, 1304\u20131309 (2004).","journal-title":"J. Biol. Chem."},{"key":"BFnm1137_CR18","doi-asserted-by":"publisher","first-page":"32771","DOI":"10.1074\/jbc.M403528200","volume":"279","author":"AY Chan","year":"2004","unstructured":"Chan, A.Y., Soltys, C.L., Young, M.E., Proud, C.G. & Dyck, J.R. Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte. J. Biol. Chem. 279, 32771\u201332179 (2004).","journal-title":"J. Biol. Chem."},{"key":"BFnm1137_CR19","doi-asserted-by":"publisher","first-page":"31000","DOI":"10.1074\/jbc.M300643200","volume":"278","author":"D Nagata","year":"2003","unstructured":"Nagata, D., Mogi, M. & Walsh, K. AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress. J. Biol. Chem. 278, 31000\u201331006 (2003).","journal-title":"J. Biol. Chem."},{"key":"BFnm1137_CR20","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1016\/S1097-2765(01)00251-9","volume":"7","author":"J Mu","year":"2001","unstructured":"Mu, J., Brozinick, J.T., Jr, Valladares, O., Bucan, M. & Birnbaum, M.J. A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle. Mol. Cell 7, 1085\u20131094 (2001).","journal-title":"Mol. Cell"},{"key":"BFnm1137_CR21","doi-asserted-by":"publisher","first-page":"17513","DOI":"10.1074\/jbc.270.29.17513","volume":"270","author":"N Kudo","year":"1995","unstructured":"Kudo, N., Barr, A.J., Barr, R.L., Desai, S. & Lopaschuk, G.D. High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5\u2032-AMP-activated protein kinase inhibition of acetyl-CoA carboxylase. J. Biol. Chem. 270, 17513\u201317520 (1995).","journal-title":"J. Biol. Chem."},{"key":"BFnm1137_CR22","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1161\/hc4001.097183","volume":"104","author":"R Tian","year":"2001","unstructured":"Tian, R., Musi, N., D'Agostino, J., Hirshman, M.F. & Goodyear, L.J. Increased adenosine monophosphate-activated protein kinase activity in rat hearts with pressure-overload hypertrophy. Circulation 104, 1664\u20131669 (2001).","journal-title":"Circulation"},{"key":"BFnm1137_CR23","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1161\/hh1701.096615","volume":"89","author":"DR Pimentel","year":"2001","unstructured":"Pimentel, D.R. et al. Reactive oxygen species mediate amplitude-dependent hypertrophic and apoptotic responses to mechanical stretch in cardiac myocytes. Circ. Res. 89, 453\u2013460 (2001).","journal-title":"Circ. Res."},{"key":"BFnm1137_CR24","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1172\/JCI6713","volume":"104","author":"JH Rogers","year":"1999","unstructured":"Rogers, J.H. et al. RGS4 causes increased mortality and reduced cardiac hypertrophy in response to pressure overload. J. Clin. Invest. 104, 567\u2013576 (1999).","journal-title":"J. Clin. Invest."}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm1137.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm1137","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm1137.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T22:11:46Z","timestamp":1684447906000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm1137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,21]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["BFnm1137"],"URL":"https:\/\/doi.org\/10.1038\/nm1137","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11,21]]}}}