{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:26:33Z","timestamp":1770999993379,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[1995,11,1]],"date-time":"1995-11-01T00:00:00Z","timestamp":815184000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[1995,11]]},"DOI":"10.1038\/nm1195-1184","type":"journal-article","created":{"date-parts":[[2004,8,19]],"date-time":"2004-08-19T01:03:14Z","timestamp":1092877394000},"page":"1184-1188","source":"Crossref","is-referenced-by-count":127,"title":["Induction of dopaminergic neuron phenotype in the midbrain by Sonic hedgehog protein"],"prefix":"10.1038","volume":"1","author":[{"given":"Monica Z.","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Bumcrot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valaria","family":"Marigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew P.","family":"Mcmahon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tod","family":"Woolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[1995,11,1]]},"reference":[{"key":"BFnm11951184_CR1","first-page":"103","volume-title":"Functional Neural Transplantation","author":"O Lindvall","year":"1994","unstructured":"Lindvall, O. Neural transplantation In Parkinson's disease. in Functional Neural Transplantation (eds Dunnett, S.B. & Bj\u00f6rklund, A.) 103\u2013137 (Raven, New York, 1994)."},{"key":"BFnm11951184_CR2","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1056\/NEJM199211263272202","volume":"327","author":"CR Freed","year":"1992","unstructured":"Freed, C.R. et al. Survival of implanted fetal dopamine cells and neurologic improvement 12 to 46 months after transplantation for Parkinson's disease. New Engl. J. Med. 327, 1549\u20131555 (1992).","journal-title":"New Engl. J. Med."},{"key":"BFnm11951184_CR3","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1056\/NEJM199504273321702","volume":"332","author":"JH Kordower","year":"1995","unstructured":"Kordower, J.H. et al. Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. New Engl. J. Med. 332, 1118\u20131124 (1995).","journal-title":"New Engl. J. Med."},{"key":"BFnm11951184_CR4","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/0092-8674(95)90454-9","volume":"80","author":"M Hynes","year":"1995","unstructured":"Hynes, M., Poulsen, K., Tessier-Lavigne, M. & Rosenthal, A. Control of neuronal diversity by the floor plate: Contact-mediated induction of midbrain dopaminergic neurons. Cell 80, 95\u2013101 (1995).","journal-title":"Cell"},{"key":"BFnm11951184_CR5","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1038\/287795a0","volume":"287","author":"C N\u00fcsslein-Volhard","year":"1980","unstructured":"N\u00fcsslein-Volhard, C. & Wieschaus, E. Mutations affecting segment number and polarity in Drosophila. Nature 287, 795\u2013801 (1980).","journal-title":"Nature"},{"key":"BFnm11951184_CR6","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/0092-8674(92)90264-D","volume":"71","author":"JJ Lee","year":"1992","unstructured":"Lee, J.J., von Kessler, D.P., Parks, S. & Beachy, P.A. Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog. Cell 71, 33\u201350 (1992).","journal-title":"Cell"},{"key":"BFnm11951184_CR7","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1126\/science.1636091","volume":"257","author":"T Donlach","year":"1992","unstructured":"Donlach, T., Phillips, C.R. & Gerhart, J.C. Planar induction of anteroposterior pattern in the developing central nervous system of Xenopus laevis. Science 257, 542\u2013545 (1992).","journal-title":"Science"},{"key":"BFnm11951184_CR8","doi-asserted-by":"crossref","unstructured":"Forbes, A.J., Nakano, Y., Taylor, A.M. & Ingham, P.W. Genetic analysis of hedgehog signaling in the Drosophila embryo. Development (suppl.) 115\u2013124 (1993).","DOI":"10.1242\/dev.119.Supplement.115"},{"key":"BFnm11951184_CR9","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/0092-8674(94)90289-5","volume":"78","author":"PA Lawrence","year":"1994","unstructured":"Lawrence, P.A. & Morata, G. Homeobox genes: Their function in Drosophila segmentation and pattern formation. Cell 78, 181\u2013189 (1994).","journal-title":"Cell"},{"key":"BFnm11951184_CR10","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1016\/0092-8674(93)90626-2","volume":"75","author":"R Riddle","year":"1993","unstructured":"Riddle, R., Johnson, R.L., Laufer, E. & Tabin, C. Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401\u20131416 (1993).","journal-title":"Cell"},{"key":"BFnm11951184_CR11","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1016\/0092-8674(93)90628-4","volume":"75","author":"S Krauss","year":"1993","unstructured":"Krauss, S., Concordet, J.P. & Ingham, P.W. A functionally conserved homologue of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebra fish embryos. Cell 75, 1431\u20131444 (1993).","journal-title":"Cell"},{"key":"BFnm11951184_CR12","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1016\/0092-8674(93)90627-3","volume":"75","author":"Y Echelard","year":"1993","unstructured":"Echelard, Y. et al. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417\u20131430 (1993).","journal-title":"Cell"},{"key":"BFnm11951184_CR13","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1242\/dev.120.11.3339","volume":"120","author":"DT Chang","year":"1994","unstructured":"Chang, D.T. et al. Products, genetic linkage and limb patterning activity of a murine hedgehog gene. Development 120, 3339\u20133353 (1994).","journal-title":"Development"},{"key":"BFnm11951184_CR14","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/0092-8674(94)90514-2","volume":"75","author":"H Roelink","year":"1994","unstructured":"Roelink, H. et al. Floor plate and motor neuron induction by whh-1, a vertebrate homologue of hedgehog expressed by the notochord. Cell 75, 761\u2013775 (1994).","journal-title":"Cell"},{"key":"BFnm11951184_CR15","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1126\/science.7985023","volume":"266","author":"JJ Lee","year":"1994","unstructured":"Lee, J.J. et al. Autoproteolysis in hedgehog protein biogenesis. Science 266, 1528\u20131537 (1994).","journal-title":"Science"},{"key":"BFnm11951184_CR16","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/374363a0","volume":"374","author":"JA Porter","year":"1995","unstructured":"Porter, J.A. et al. The product of hedgehog autoproteolytic cleavage active in local and long-range signaling. Nature 374, 363\u2013366 (1995).","journal-title":"Nature"},{"key":"BFnm11951184_CR17","doi-asserted-by":"publisher","first-page":"2294","DOI":"10.1128\/MCB.15.4.2294","volume":"15","author":"DA Bumcrot","year":"1995","unstructured":"Bumcrot, D.A., Takada, R. & McMahon, A.P. Proteolytic processing yields two secreted forms of Sonic hedgehog. Molec. cell. Biol. 15, 2294\u20132303 (1995).","journal-title":"Molec. cell. Biol."},{"key":"BFnm11951184_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0092-8674(95)90536-7","volume":"81","author":"J Ericson","year":"1995","unstructured":"Ericson, J. et al. Sonic hedgehog induces the differentiation of ventral forebrain neurons: A common signal for ventral patterning within the neural tube. Cell 81, 1\u201320 (1995).","journal-title":"Cell"},{"key":"BFnm11951184_CR19","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/S0960-9822(95)00130-8","volume":"5","author":"Y Tanabe","year":"1995","unstructured":"Tanabe, Y., Roelink, H. & Jessell, T.M. Motor neuron induction by Sonic hedgehog is independent of floor plate differentiation. Curr. Biol. 5, 651\u2013658 (1995).","journal-title":"Curr. Biol."},{"key":"BFnm11951184_CR20","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/0092-8674(95)90397-6","volume":"81","author":"H Roelink","year":"1995","unstructured":"Roelink, H. et al. Floor plate and motor neuron induction by different concentration of the amino-terminal cleavage product of Sonic hedgehog autoproteolysis. Cell 81, 445\u2013455 (1995).","journal-title":"Cell"},{"key":"BFnm11951184_CR21","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1038\/375322a0","volume":"375","author":"E Marti","year":"1995","unstructured":"Marti, E., Bumcrot, D.A., Takada, R. & McMahon, A.P. Requirement of 19K Sonic hedgehog for induction of distinct ventral cell types in CNS explants. Nature 375, 322\u2013325 (1995).","journal-title":"Nature"},{"key":"BFnm11951184_CR22","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/0092-8674(93)90248-O","volume":"73","author":"T Yamada","year":"1993","unstructured":"Yamada, T., Pfaff, S.L., Edlund, T. & Jessell, T.M. Control of cell pattern in the neural tube: Motor neuron induction by diffusible factors from notochord and floor plate. Cell 73, 673\u2013686 (1993).","journal-title":"Cell"},{"key":"BFnm11951184_CR23","unstructured":"Methods and Applications, Book 3. p. 39. (Clontech Laboratories, 4030 Fabian Way, Palo Alto, California 94303-4607)."},{"key":"BFnm11951184_CR24","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/0092-8674(91)90247-V","volume":"64","author":"T Yamada","year":"1991","unstructured":"Yamada, T., Placzek, M., Tanaka, H., Dodd, J. & Jessell, T.M. Control of cell pattern in the developing nervous system: Polarizing activity of the floor plate and notochord. Cell 64, 635\u2013647 (1991).","journal-title":"Cell"},{"key":"BFnm11951184_CR25","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1242\/dev.119.4.1301","volume":"119","author":"S-L Ang","year":"1993","unstructured":"Ang, S.-L. et al. The formation and maintenance of the definitive endoderm lineage in the mouse: Involvement of HNF3\/forkhead proteins. Development 119, 1301\u20131315 (1993).","journal-title":"Development"},{"key":"BFnm11951184_CR26","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1006\/geno.1995.1104","volume":"28","author":"V Marigo","year":"1995","unstructured":"Marigo, V. et al. Cloning, expression, and chromosomal location of SHH and IHH: Two human homologues of the Drosophila sement polarity gene hedgehog. Genomics 28, 44\u201351 (1995).","journal-title":"Genomics"},{"key":"BFnm11951184_CR27","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/0012-1606(87)90118-7","volume":"120","author":"F Couly","year":"1987","unstructured":"Couly, F. & Le Douarin, M. Mapping of the early neural primordium in quailchick chimeras. II. The prosencephalic neural plate and neural folds: Implications for the genesis of cephalic human congenital abnormalities. Dev. Biol. 120, 198\u2013214 (1987).","journal-title":"Dev. Biol."},{"key":"BFnm11951184_CR28","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1002\/jmor.1050880104","volume":"88","author":"H Hamburger","year":"1951","unstructured":"Hamburger, H. & Hamilton, H. A series of normal stages in the development of the chick embryo. J. Morphol. 88, 49\u201392 (1951).","journal-title":"J. Morphol."},{"key":"BFnm11951184_CR29","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1126\/science.11032544","volume":"247","author":"E Mitrani","year":"1990","unstructured":"Mitrani, E. & Shimoni, Y. Induction by soluble factors of organized axial structures in chick epiblasts. Science 247, 1092\u20131094 (1990).","journal-title":"Science"}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm1195-1184","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm1195-1184.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm1195-1184.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T22:12:48Z","timestamp":1684447968000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm1195-1184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,11]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1995,11]]}},"alternative-id":["BFnm11951184"],"URL":"https:\/\/doi.org\/10.1038\/nm1195-1184","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,11]]}}}