{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:28:36Z","timestamp":1791646116444,"version":"4.3.4"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2001,12]]},"DOI":"10.1038\/nm1201-1291","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T04:34:56Z","timestamp":1027658096000},"page":"1291-1297","source":"Crossref","is-referenced-by-count":649,"title":["Possible new role for NF-\u03baB in the resolution of inflammation"],"prefix":"10.1038","volume":"7","author":[{"given":"Toby","family":"Lawrence","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek W.","family":"Gilroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Colville-Nash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek A.","family":"Willoughby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFnm12011291_CR1","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/9550","volume":"5","author":"DW Gilroy","year":"1999","unstructured":"Gilroy, D.W. et al. Inducible cyclooxygenase may have anti-inflammatory properties. Nature Med. 5, 698\u2013701 (1999).","journal-title":"Nature Med."},{"key":"BFnm12011291_CR2","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/89759","volume":"2","author":"BD Levy","year":"2001","unstructured":"Levy, B.D., Clish, C.B., Schmidt, B., Gronert, K. & Serhan, C.N. Lipid mediator class switching during acute inflammation: signals in resolution. Nature Immunol. 2, 612\u2013619 (2001).","journal-title":"Nature Immunol."},{"key":"BFnm12011291_CR3","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1002\/jlb.61.4.375","volume":"61","author":"J Savill","year":"1997","unstructured":"Savill, J. Apoptosis in resolution of inflammation. J. Leukoc. Biol. 61, 375\u2013380 (1997).","journal-title":"J. Leukoc. Biol."},{"key":"BFnm12011291_CR4","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1093\/oxfordjournals.bmb.a011638","volume":"53","author":"C Haslett","year":"1997","unstructured":"Haslett, C. Granulocyte apoptosis and inflammatory disease. Br. Med. Bull. 53, 669\u2013683 (1997).","journal-title":"Br. Med. Bull."},{"key":"BFnm12011291_CR5","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1146\/annurev.immunol.18.1.621","volume":"18","author":"M Karin","year":"2000","unstructured":"Karin, M. & Ben-Neriah, Y. Phosphorylation meets ubiquitination: the control of NF-\u03baB activity. Ann. Rev. Immunol. 18, 621\u2013663 (2000).","journal-title":"Ann. Rev. Immunol."},{"key":"BFnm12011291_CR6","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.1073\/pnas.91.6.2046","volume":"91","author":"JR Vane","year":"1994","unstructured":"Vane, J.R. et al. Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation. Proc. Natl. Acad. Sci. U.S.A. 91, 2046\u20132050 (1994).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"BFnm12011291_CR7","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/978-3-0348-8747-2_9","volume-title":"Inducible Enzymes in the Inflammatory Response","author":"A Tomlinson","year":"1999","unstructured":"Tomlinson, A. & Willoughby, D.A. Inducible enzymes in inflammation: advances, interactions and conflict. Inducible Enzymes in the Inflammatory Response (eds Tomlinson, A. & Willoughby, D.A.) 187\u2013207 (Birkh\u00e4user, Basel, Switzerland, 1999)."},{"key":"BFnm12011291_CR8","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1172\/JCI11830","volume":"107","author":"PP Tak","year":"2001","unstructured":"Tak, P.P. & Firestein, G.S. NF-\u03baB : a key role in inflammatory diseases. J. Clin. Invest. 107, 7\u201311 (2001).","journal-title":"J. Clin. Invest."},{"key":"BFnm12011291_CR9","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1172\/JCI11914","volume":"107","author":"Y Yamamoto","year":"2001","unstructured":"Yamamoto, Y. & Gaynor, R.B. Therapeutic potential of inhibition of the NF-\u03baB pathway in the treatment of inflammation and cancer. J. Clin. Invest. 107, 135\u2013142 (2001).","journal-title":"J. Clin. Invest."},{"key":"BFnm12011291_CR10","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/978-3-0348-8747-2_2","volume-title":"Inducible Enzymes in the Inflammatory Response","author":"AJ Hobbs","year":"1999","unstructured":"Hobbs, A.J. & Moncada, S. Inducible nitric oxide synthase and inflammation. Inducible Enzymes in the Inflammatory Response (eds Tomlinson, A. & Willoughby, D.A.) 31\u201355 (Birkh\u00e4user, Basel, Switzerland, 1999)."},{"key":"BFnm12011291_CR11","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.4049\/jimmunol.167.3.1592","volume":"167","author":"E Alcamo","year":"2001","unstructured":"Alcamo, E. et al. Targeted mutation of TNF-receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-\u03baB in leukocyte recruitment. J. Immunol. 167, 1592\u20131600 (2001).","journal-title":"J. Immunol."},{"key":"BFnm12011291_CR12","doi-asserted-by":"publisher","first-page":"7099","DOI":"10.1002\/j.1460-2075.1996.tb01101.x","volume":"15","author":"G Grigoriadis","year":"1996","unstructured":"Grigoriadis, G. et al. The Rel subunit of NF-\u03baB\u2013like transcription factor is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations. EMBO J. 15, 7099\u20137170 (1996).","journal-title":"EMBO J."},{"key":"BFnm12011291_CR13","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1084\/jem.187.7.973","volume":"187","author":"D Carrasco","year":"1998","unstructured":"Carrasco, D. et al. Multiple hemopoietic defects and lymphoid hyperplasia in mice lacking the transcriptional activation domain of the c-Rel protein. J. Exp. Med. 187, 973\u2013984 (1998).","journal-title":"J. Exp. Med."},{"key":"BFnm12011291_CR14","doi-asserted-by":"publisher","first-page":"11848","DOI":"10.1073\/pnas.96.21.11848","volume":"96","author":"M Grossmann","year":"1999","unstructured":"Grossmann, M. et al. The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects. Proc. Natl. Acad. Sci. USA 96, 11848\u201311853 (1999).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm12011291_CR15","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1172\/JCI3877","volume":"102","author":"J Bohuslav","year":"1998","unstructured":"Bohuslav, J. et al. Regulation of an essential innate immune response by the p50 subunit of NF-\u03baB. J. Clin. Invest. 102, 1645\u20131652 (1998).","journal-title":"J. Clin. Invest."},{"key":"BFnm12011291_CR16","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1084\/jem.187.7.985","volume":"187","author":"H Ishikawa","year":"1998","unstructured":"Ishikawa, H. et al. Chronic inflammation and susceptibility to bacterial infections in mice lacking the polypeptide (p)105 precursor ( NF-\u03baB1) but expressing p50. J. Exp. Med. 187, 985\u2013996 (1998).","journal-title":"J. Exp. Med."},{"key":"BFnm12011291_CR17","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1111\/j.1476-5381.1994.tb17048.x","volume":"113","author":"A Tomlinson","year":"1994","unstructured":"Tomlinson, A. et al. Cyclo-oxygenase and nitric oxide synthase isoforms in rat carrageenin-induced pleurisy. Brit. J. Pharm. 113, 693\u2013698 (1994).","journal-title":"Brit. J. Pharm."},{"key":"BFnm12011291_CR18","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1016\/S0021-9258(17)37600-7","volume":"269","author":"QW Xie","year":"1994","unstructured":"Xie, Q.W., Kashiwabara, Y. & Nathan, C. Role of transcription factor NF-\u03baB\/Rel in induction of nitric oxide synthase. J. Biol. Chem. 269, 4705\u20138 (1994).","journal-title":"J. Biol. Chem."},{"key":"BFnm12011291_CR19","doi-asserted-by":"publisher","first-page":"22215","DOI":"10.1074\/jbc.M101754200","volume":"276","author":"A Salmer\u00f3n","year":"2001","unstructured":"Salmer\u00f3n, A. et al. Direct phosphorylation of NF-\u03baB1 p105 by the I\u03baB kinase complex on serine 927 is essential for signal-induced p105 proteolysis. J. Biol. Chem. 276, 22215\u201322222 (2001).","journal-title":"J. Biol. Chem."},{"key":"BFnm12011291_CR20","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/47520","volume":"403","author":"A Rossi","year":"2000","unstructured":"Rossi, A. et al. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of I\u03baB kinase. Nature 403, 103\u2013108 (2000).","journal-title":"Nature"},{"key":"BFnm12011291_CR21","doi-asserted-by":"publisher","first-page":"4844","DOI":"10.1073\/pnas.97.9.4844","volume":"97","author":"DS Straus","year":"2000","unstructured":"Straus, D.S. et al. 15-deoxy-\u03b412,14-prostaglandin J2 inhibits multiple steps in the NF-\u03baB signaling pathway. Proc. Natl. Acad. Sci. U.S.A. 97, 4844\u20134849 (2000).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"BFnm12011291_CR22","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1128\/MCB.20.5.1692-1698.2000","volume":"20","author":"A Castrillo","year":"2000","unstructured":"Castrillo, A., Diaz-Guerra, M.J., Hortelano, S., Martin-Sanz, P. & Bosca, L. Inhibition of I\u03baB kinase and I\u03baB phosphorylation by 15-deoxy-\u03b4(12,14)-prostaglandin J(2) in activated murine macrophages. Mol. Cell. Biol. 20, 1692\u20131698 (2000).","journal-title":"Mol. Cell. Biol."},{"key":"BFnm12011291_CR23","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1126\/science.1062677","volume":"293","author":"U Senftleben","year":"2001","unstructured":"Senftleben, U. et al. Activation of a second, evolutionarily conserved, NF-\u03baB signaling pathway. Science 293, 1495\u20131499 (2001).","journal-title":"Science"},{"key":"BFnm12011291_CR24","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/0092-8674(93)90401-B","volume":"72","author":"V Bours","year":"1993","unstructured":"Bours, V. et al. The oncoprotein Bcl-3 directly transactivates through \u03baB motifs via association with DNA-binding p50B homodimers. Cell 72, 729\u2013739 (1993).","journal-title":"Cell"},{"key":"BFnm12011291_CR25","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1101\/gad.7.7b.1354","volume":"7","author":"T Fujita","year":"1993","unstructured":"Fujita, T., Nolan, G.P., Liou, H.C., Scott, M.L. & Baltimore, D. The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-\u03baB p50 homodimers. Genes Dev. 7, 1354\u20131363 (1993).","journal-title":"Genes Dev."},{"key":"BFnm12011291_CR26","doi-asserted-by":"publisher","first-page":"6798","DOI":"10.1046\/j.1432-1033.2000.01778.x","volume":"267","author":"B Thomas","year":"2000","unstructured":"Thomas, B. et al. Critical role of C\/EBP\u03b4 and C\/EBP\u03b2 factors in the stimulation of the cyclooxygenase-2 gene transcription by interleukin-1\u03b2 in articular chondrocytes. Eur. J. Biochem. 267, 6798\u20136809 (2000).","journal-title":"Eur. J. Biochem."},{"key":"BFnm12011291_CR27","doi-asserted-by":"publisher","first-page":"6259","DOI":"10.1074\/jbc.275.9.6259","volume":"275","author":"DJ Wadleigh","year":"2000","unstructured":"Wadleigh, D.J., Reddy, S.T., Kopp, E., Ghosh, S. & Herschman, H.R. Transcriptional activation of the cyclooxygenase-2 gene in endotoxin-treated RAW 264.7 macrophages. J. Biol. Chem. 275, 6259\u20136266 (2000).","journal-title":"J. Biol. Chem."},{"key":"BFnm12011291_CR28","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1161\/01.CIR.100.12.1330","volume":"100","author":"SF Liu","year":"1999","unstructured":"Liu, S.F., Ye, X. & Malik, A.B. Inhibition of NF-\u03baB activation by pyrrolidine dithiocarbamate prevents in vivo expression of proinflammatory genes. Circulation 100, 1330\u20131337 (1999).","journal-title":"Circulation"},{"key":"BFnm12011291_CR29","doi-asserted-by":"publisher","first-page":"21096","DOI":"10.1074\/jbc.272.34.21096","volume":"272","author":"JW Pierce","year":"1997","unstructured":"Pierce, J.W. et al. Novel inhibitors of cytokine-induced I\u03baB\u03b1 phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J. Biol. Chem. 272, 21096\u201321103 (1997).","journal-title":"J. Biol. Chem."},{"key":"BFnm12011291_CR30","doi-asserted-by":"publisher","first-page":"13859","DOI":"10.1073\/pnas.95.23.13859","volume":"95","author":"AV Miagkov","year":"1998","unstructured":"Miagkov, A.V. et al. NF-\u03baB activation provides the potential link between inflammation and hyperplasia in the arthritic joint. Proc. Natl. Acad. Sci. U.S.A. 95, 13859\u201313864 (1998).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"BFnm12011291_CR31","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1038\/sj.cdd.4400528","volume":"6","author":"B Lin","year":"1999","unstructured":"Lin, B. et al. NF-\u03baB functions as both a proapoptotic and antiapoptotic regulatory factor within a single cell type. Cell Death Differ. 6, 570\u2013582 (1999).","journal-title":"Cell Death Differ."},{"key":"BFnm12011291_CR32","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/385637a0","volume":"385","author":"C Yin","year":"1997","unstructured":"Yin, C., Knudson, M., Korsmeyer, S.J. & Van Dyke, T. Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature 385, 637\u2013640 (1997).","journal-title":"Nature"},{"key":"BFnm12011291_CR33","doi-asserted-by":"publisher","first-page":"9349","DOI":"10.1073\/pnas.94.17.9349","volume":"94","author":"J Lotem","year":"1997","unstructured":"Lotem, J. & Sachs, L. Cytokine suppression of protease activation in wild-type p53-dependent and p53-independent apoptosis. Proc. Natl. Acad. Sci. USA 94, 9349\u20139353 (1997).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm12011291_CR34","doi-asserted-by":"publisher","first-page":"13330","DOI":"10.1073\/pnas.96.23.13330","volume":"96","author":"B Dibbert","year":"1999","unstructured":"Dibbert, B. et al. Cytokine-mediated bax deficiency and consequent delayed neutrophil apoptosis: A general mechanism to accumulate effector cells in inflammation. Proc. Natl. Acad. Sci. USA 96, 13330\u201313335 (1999).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm12011291_CR35","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1182\/blood.V95.12.3823","volume":"95","author":"J Xaus","year":"2000","unstructured":"Xaus, J. et al.. LPS induces apoptosis in macrophages mostly through the autocrine production of TNF-\u03b1. Blood 95, 3823\u20133831 (2000).","journal-title":"Blood"},{"key":"BFnm12011291_CR36","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1084\/jem.189.11.1839","volume":"189","author":"Z-W Li","year":"1999","unstructured":"Li, Z-W. et al. The IKK\u03b2 subunit of I\u03baB kinase (IKK) is essential for nuclear factor \u03baB activation and prevention of apoptosis. J. Exp. Med. 189, 1839\u20131845 (1999).","journal-title":"J. Exp. Med."},{"key":"BFnm12011291_CR37","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/S0378-1119(99)00348-0","volume":"238","author":"E Igata","year":"1999","unstructured":"Igata, E. et al. Molecular cloning and functional analysis of the murine bax gene promoter. Gene 238, 407\u2013415 (1999).","journal-title":"Gene"},{"key":"BFnm12011291_CR38","doi-asserted-by":"crossref","first-page":"20067","DOI":"10.1016\/S0021-9258(17)32128-2","volume":"269","author":"H Wu","year":"1994","unstructured":"Wu, H. & Lozano, G. NF-\u03baB activation of p53. J. Biol. Chem. 269, 20067\u201320074 (1994).","journal-title":"J. Biol. Chem."},{"key":"BFnm12011291_CR39","doi-asserted-by":"publisher","first-page":"4489","DOI":"10.1128\/MCB.15.8.4489","volume":"15","author":"X Sun","year":"1995","unstructured":"Sun, X., Shimizu, H. & Yamamoto, K-I. Identification of a novel p53 promoter element involved in genotoxic stress\u2013inducible p53 expression. Mol. Cell Biol. 15, 4489\u20134496 (1995).","journal-title":"Mol. Cell Biol."},{"key":"BFnm12011291_CR40","doi-asserted-by":"publisher","first-page":"2728","DOI":"10.1038\/sj.onc.1202626","volume":"18","author":"H-C Kirch","year":"1999","unstructured":"Kirch, H.-C., Flaswinkel, S., Rumpf, H., Brockmann, D. & Esche, H. Expression of human p53 requires synergistic activation of transcription from the p53 promoter by AP-1, NF-\u03baB and Myc\/Max. Oncogene 18, 2728\u20132738 (1999).","journal-title":"Oncogene"},{"key":"BFnm12011291_CR41","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1172\/JCI1112","volume":"101","author":"VA Fadok","year":"1998","unstructured":"Fadok, V.A. et al. Macrophages that have injested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine\/paracrine mechanisms involving TGF-\u03b2, PGE2 and PAF. J. Clin. Invest. 101, 890\u2013898 (1998).","journal-title":"J. Clin. Invest."},{"key":"BFnm12011291_CR42","doi-asserted-by":"crossref","first-page":"6164","DOI":"10.4049\/jimmunol.163.11.6164","volume":"163","author":"PP McDonald","year":"1999","unstructured":"McDonald, P.P., Fadok, V.A., Bratton, D. & Henson, P.M. Transcriptional and translational regulation of inflammatory mediator production by endogenous TGF-\u03b2 in macrophages that have injested apoptotic cells. J. Immunol. 163, 6164\u20136172 (1999).","journal-title":"J. Immunol."},{"key":"BFnm12011291_CR43","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/35011084","volume":"405","author":"VA Fadok","year":"2000","unstructured":"Fadok, V.A. et al. A receptor for phophatidylserine-specific clearance of apoptotic cells. Nature 405, 85\u201390 (2000).","journal-title":"Nature"},{"key":"BFnm12011291_CR44","doi-asserted-by":"publisher","first-page":"6525","DOI":"10.4049\/jimmunol.165.11.6525","volume":"165","author":"S Hortelano","year":"2000","unstructured":"Hortelano, S., Castrillo, A., Alvarez, A.M. & Bosc\u00e1, L. Contribution of cyclopentenone prostaglandins to the resolution of inflammation through the potentiation of apoptosis in activated macrophages. J. Immunol. 165, 6525\u20136531 (2000).","journal-title":"J. Immunol."},{"key":"BFnm12011291_CR45","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1172\/JCI9652","volume":"106","author":"Y Kawahito","year":"2000","unstructured":"Kawahito, Y. et al. 15-deoxy-\u039412,14-PGJ2 induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats. J. Clin. Invest. 106, 189\u2013197 (2000).","journal-title":"J. Clin. Invest."}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm1201-1291.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm1201-1291","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm1201-1291.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:16:34Z","timestamp":1684433794000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm1201-1291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12]]},"references-count":45,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["BFnm12011291"],"URL":"https:\/\/doi.org\/10.1038\/nm1201-1291","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,12]]}}}