{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:14:40Z","timestamp":1780337680530,"version":"3.54.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2005,8,21]],"date-time":"2005-08-21T00:00:00Z","timestamp":1124582400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1038\/nm1290","type":"journal-article","created":{"date-parts":[[2005,8,22]],"date-time":"2005-08-22T13:50:51Z","timestamp":1124718651000},"page":"986-991","source":"Crossref","is-referenced-by-count":98,"title":["Vaccine-induced tumor-specific immunity despite severe B-cell depletion in mantle cell lymphoma"],"prefix":"10.1038","volume":"11","author":[{"given":"Sattva S","family":"Neelapu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry W","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol B","family":"Kobrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig W","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E","family":"Janik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kieron","family":"Dunleavy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therese","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Pennington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryalice","family":"Stetler-Stevenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine S","family":"Jaffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth M","family":"Steinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Gress","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran","family":"Hakim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wyndham H","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,8,21]]},"reference":[{"key":"BFnm1290_CR1","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/nm0598-627","volume":"4","author":"Z Qin","year":"1998","unstructured":"Qin, Z. et al. B cells inhibit induction of T-cell-dependent tumor immunity. Nat. Med. 4, 627\u2013630 (1998).","journal-title":"Nat. Med."},{"key":"BFnm1290_CR2","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.4049\/jimmunol.146.6.1750","volume":"146","author":"TF Gajewski","year":"1991","unstructured":"Gajewski, T.F., Pinnas, M., Wong, T. & Fitch, F.W. Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations. J. Immunol. 146, 1750\u20131758 (1991).","journal-title":"J. Immunol."},{"key":"BFnm1290_CR3","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1084\/jem.175.1.131","volume":"175","author":"EE Eynon","year":"1992","unstructured":"Eynon, E.E. & Parker, D.C. Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens. J. Exp. Med. 175, 131\u2013138 (1992).","journal-title":"J. Exp. Med."},{"key":"BFnm1290_CR4","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1084\/jem.188.11.1977","volume":"188","author":"SR Bennett","year":"1998","unstructured":"Bennett, S.R., Carbone, F.R., Toy, T., Miller, J.F. & Heath, W.R. B cells directly tolerize CD8(+) T cells. J. Exp. Med. 188, 1977\u20131983 (1998).","journal-title":"J. Exp. Med."},{"key":"BFnm1290_CR5","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.4049\/jimmunol.161.3.1439","volume":"161","author":"X Yang","year":"1998","unstructured":"Yang, X. & Brunham, R.C. Gene knockout B-cell-deficient mice demonstrate that B cells play an important role in the initiation of T-cell responses to Chlamydia trachomatis (mouse pneumonitis) lung infection. J. Immunol. 161, 1439\u20131446 (1998).","journal-title":"J. Immunol."},{"key":"BFnm1290_CR6","doi-asserted-by":"publisher","first-page":"5558","DOI":"10.4049\/jimmunol.165.10.5558","volume":"165","author":"PJ Linton","year":"2000","unstructured":"Linton, P.J., Harbertson, J. & Bradley, L.M. A critical role for B-cells in the development of memory CD4 cells. J. Immunol. 165, 5558\u20135565 (2000).","journal-title":"J. Immunol."},{"key":"BFnm1290_CR7","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.4049\/jimmunol.170.3.1443","volume":"170","author":"H Shen","year":"2003","unstructured":"Shen, H. et al. A specific role for B cells in the generation of CD8 T-cell memory by recombinant Listeria monocytogenes . J. Immunol. 170, 1443\u20131451 (2003).","journal-title":"J. Immunol."},{"key":"BFnm1290_CR8","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1056\/NEJM199210223271705","volume":"327","author":"LW Kwak","year":"1992","unstructured":"Kwak, L.W. et al. Induction of immune responses in patients with B-cell lymphoma against the surface immunoglobulin idiotype expressed by their tumors. N. Engl. J. Med. 327, 1209\u20131215 (1992).","journal-title":"N. Engl. J. Med."},{"key":"BFnm1290_CR9","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1038\/13928","volume":"5","author":"M Bendandi","year":"1999","unstructured":"Bendandi, M. et al. Complete molecular remission induced by patient-specific vaccination plus granulocyte-monocyte colony-stimulating factor against lymphoma. Nat. Med. 5, 1171\u20131177 (1999).","journal-title":"Nat. Med."},{"key":"BFnm1290_CR10","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1182\/blood.V99.5.1517","volume":"99","author":"JM Timmerman","year":"2002","unstructured":"Timmerman, J.M. et al. Idiotype-pulsed dendritic cell vaccination for B-cell lymphoma: clinical and immune responses in 35 patients. Blood 99, 1517\u20131526 (2002).","journal-title":"Blood"},{"key":"BFnm1290_CR11","doi-asserted-by":"publisher","first-page":"10972","DOI":"10.1073\/pnas.93.20.10972","volume":"93","author":"LW Kwak","year":"1996","unstructured":"Kwak, L.W., Young, H.A., Pennington, R.W. & Weeks, S.D. Vaccination with syngeneic, lymphoma-derived immunoglobulin idiotype combined with granulocyte\/macrophage colony-stimulating factor primes mice for a protective T-cell response. Proc. Natl. Acad. Sci. USA 93, 10972\u201310977 (1996).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm1290_CR12","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1053\/sonc.2002.30151","volume":"29","author":"WH Wilson","year":"2002","unstructured":"Wilson, W.H. et al. The role of rituximab and chemotherapy in aggressive B-cell lymphoma: a preliminary report of dose-adjusted EPOCH-R. Semin. Oncol. 29, 41\u201347 (2002).","journal-title":"Semin. Oncol."},{"key":"BFnm1290_CR13","doi-asserted-by":"publisher","first-page":"4653","DOI":"10.1182\/blood-2002-11-3589","volume":"101","author":"RF Little","year":"2003","unstructured":"Little, R.F. et al. Highly effective treatment of acquired immunodeficiency syndrome-related lymphoma with dose-adjusted EPOCH: impact of antiretroviral therapy suspension and tumor biology. Blood 101, 4653\u20134659 (2003).","journal-title":"Blood"},{"key":"BFnm1290_CR14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1479-5876-2-9","volume":"2","author":"A Malyguine","year":"2004","unstructured":"Malyguine, A. et al. A modified human ELISPOT assay to detect specific responses to primary tumor cell targets. J. Transl. Med. 2, 9 (2004).","journal-title":"J. Transl. Med."},{"key":"BFnm1290_CR15","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/S0966-3274(03)00059-5","volume":"12","author":"C Schroder","year":"2003","unstructured":"Schroder, C. et al. Anti-CD20 treatment depletes B-cells in blood and lymphatic tissue of cynomolgus monkeys. Transpl. Immunol. 12, 19\u201328 (2003).","journal-title":"Transpl. Immunol."},{"key":"BFnm1290_CR16","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1078\/0171-2985-00200","volume":"206","author":"C Kneitz","year":"2002","unstructured":"Kneitz, C., Wilhelm, M. & Tony, H.P. Effective B-cell depletion with rituximab in the treatment of autoimmune diseases. Immunobiology 206, 519\u2013527 (2002).","journal-title":"Immunobiology"},{"key":"BFnm1290_CR17","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1182\/blood.V99.6.2131","volume":"99","author":"M Paroli","year":"2002","unstructured":"Paroli, M. et al. Long-lasting memory-resting and memory-effector CD4+ T-cells in human X-linked agammaglobulinemia. Blood 99, 2131\u20132137 (2002).","journal-title":"Blood"},{"key":"BFnm1290_CR18","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.4049\/jimmunol.166.4.2235","volume":"166","author":"C Kobrin","year":"2001","unstructured":"Kobrin, C., Bendandi, M. & Kwak, L. Novel secondary Ig VH gene rearrangement and in-frame Ig heavy chain complementarity-determining region III insertion\/deletion variants in de novo follicular lymphoma. J. Immunol. 166, 2235\u20132243 (2001).","journal-title":"J. Immunol."},{"key":"BFnm1290_CR19","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1038\/ni1102-999","volume":"3","author":"HT Khong","year":"2002","unstructured":"Khong, H.T. & Restifo, N.P. Natural selection of tumor variants in the generation of \u201ctumor escape\u201d phenotypes. Nat. Immunol. 3, 999\u20131005 (2002).","journal-title":"Nat. Immunol."},{"key":"BFnm1290_CR20","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.jamcollsurg.2004.01.025","volume":"198","author":"SA Rosenberg","year":"2004","unstructured":"Rosenberg, S.A. Development of effective immunotherapy for the treatment of patients with cancer. J. Am. Coll. Surg. 198, 685\u2013696 (2004).","journal-title":"J. Am. Coll. Surg."},{"key":"BFnm1290_CR21","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1182\/blood-2004-01-0182","volume":"104","author":"S Vigouroux","year":"2004","unstructured":"Vigouroux, S., Yvon, E., Biagi, E. & Brenner, M.K. Antigen-induced regulatory T cells. Blood 104, 26\u201333 (2004).","journal-title":"Blood"},{"key":"BFnm1290_CR22","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/S1470-2045(04)01490-1","volume":"5","author":"BT Hennessy","year":"2004","unstructured":"Hennessy, B.T., Hanrahan, E.O. & Daly, P.A. Non-Hodgkin lymphoma: an update. Lancet Oncol. 5, 341\u2013353 (2004).","journal-title":"Lancet Oncol."},{"key":"BFnm1290_CR23","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1200\/JCO.1999.17.4.1244","volume":"17","author":"BD Cheson","year":"1999","unstructured":"Cheson, B.D. et al. Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas. NCI Sponsored International Working Group. J. Clin. Oncol. 17, 1244 (1999). (Erratum in J. Clin. Oncol. 18, 2351 (1999).)","journal-title":"J. Clin. Oncol."},{"key":"BFnm1290_CR24","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/0022-1759(86)90032-3","volume":"89","author":"WL Carroll","year":"1986","unstructured":"Carroll, W.L., Thielemans, K., Dilley, J. & Levy, R. Mouse x human heterohybridomas as fusion partners with human B-cell tumors. J. Immunol. Methods 89, 61\u201372 (1986).","journal-title":"J. Immunol. Methods"},{"key":"BFnm1290_CR25","doi-asserted-by":"publisher","first-page":"8309","DOI":"10.1158\/1078-0432.CCR-04-1071","volume":"10","author":"SS Neelapu","year":"2004","unstructured":"Neelapu, S.S. et al. Human autologous tumor-specific T-cell responses induced by liposomal delivery of a lymphoma antigen. Clin. Cancer Res. 10, 8309\u20138317 (2004).","journal-title":"Clin. Cancer Res."},{"key":"BFnm1290_CR26","doi-asserted-by":"publisher","first-page":"8200","DOI":"10.1073\/pnas.92.18.8200","volume":"92","author":"JL Schultze","year":"1995","unstructured":"Schultze, J.L. et al. Follicular lymphomas can be induced to present alloantigen efficiently: a conceptual model to improve their tumor immunogenicity. Proc. Natl. Acad. Sci. USA 92, 8200\u20138204 (1995).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm1290_CR27","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1182\/blood.V96.6.2219","volume":"96","author":"NS Andersen","year":"2000","unstructured":"Andersen, N.S. et al. Soluble CD40 ligand induces selective proliferation of lymphoma cells in primary mantle cell lymphoma cell cultures. Blood 96, 2219\u20132225 (2000).","journal-title":"Blood"},{"issue":"Suppl. 2","key":"BFnm1290_CR28","doi-asserted-by":"publisher","first-page":"R14","DOI":"10.1007\/BF01470994","volume":"127","author":"SS Neelapu","year":"2001","unstructured":"Neelapu, S.S., Baskar, S. & Kwak, L.W. Detection of keyhole limpet hemocyanin (KLH)-specific immune responses by intracellular cytokine assay in patients vaccinated with idiotype-KLH vaccine. J. Cancer Res. Clin. Oncol. 127 Suppl. 2, R14\u201319 (2001).","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"BFnm1290_CR29","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0022-1759(97)00047-1","volume":"204","author":"AE Mattis","year":"1997","unstructured":"Mattis, A.E., Bernhardt, G., Lipp, M. & Forster, R. Analyzing cytotoxic T lymphocyte activity: a simple and reliable flow cytometry-based assay. J. Immunol. Methods 204, 135\u2013142 (1997).","journal-title":"J. Immunol. Methods"},{"key":"BFnm1290_CR30","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1016\/S0140-6736(95)90757-2","volume":"345","author":"LW Kwak","year":"1995","unstructured":"Kwak, L.W. et al. Transfer of myeloma idiotype-specific immunity from an actively immunized marrow donor. Lancet 345, 1016\u20131020 (1995).","journal-title":"Lancet"}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm1290.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm1290","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm1290.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T22:22:13Z","timestamp":1684448533000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm1290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,21]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["BFnm1290"],"URL":"https:\/\/doi.org\/10.1038\/nm1290","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8,21]]}}}