{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:44:04Z","timestamp":1791888244566,"version":"4.3.4"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2007,1,28]],"date-time":"2007-01-28T00:00:00Z","timestamp":1169942400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1038\/nm1534","type":"journal-article","created":{"date-parts":[[2007,1,28]],"date-time":"2007-01-28T18:35:43Z","timestamp":1170009343000},"page":"181-188","source":"Crossref","is-referenced-by-count":312,"title":["Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation"],"prefix":"10.1038","volume":"13","author":[{"given":"Ben-Bo","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen","family":"Clermont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Rook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie J","family":"Fonda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek J","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Wojtkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L","family":"Avery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul G","family":"Arrigg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven-Erik","family":"Bursell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lloyd Paul","family":"Aiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward P","family":"Feener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,1,28]]},"reference":[{"key":"BFnm1534_CR1","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1001\/archopht.122.4.552","volume":"122","author":"JH Kempen","year":"2004","unstructured":"Kempen, J.H. et al. The prevalence of diabetic retinopathy among adults in the United States. Arch. Ophthalmol. 122, 552\u2013563 (2004).","journal-title":"Arch. Ophthalmol."},{"key":"BFnm1534_CR2","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1038\/sj.eye.6701476","volume":"18","author":"R Williams","year":"2004","unstructured":"Williams, R. et al. Epidemiology of diabetic retinopathy and macular oedema: a systematic review. Eye 18, 963\u2013983 (2004).","journal-title":"Eye"},{"key":"BFnm1534_CR3","doi-asserted-by":"crossref","unstructured":"The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med. 329, 977\u2013986 (1993).","DOI":"10.1056\/NEJM199309303291401"},{"key":"BFnm1534_CR4","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1136\/bmj.321.7258.405","volume":"321","author":"IM Stratton","year":"2000","unstructured":"Stratton, I.M. et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. Br. Med. J. 321, 405\u2013412 (2000).","journal-title":"Br. Med. J."},{"key":"BFnm1534_CR5","doi-asserted-by":"crossref","unstructured":"UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. Br. Med. J. 317, 703\u2013713 (1998).","DOI":"10.1136\/bmj.317.7160.703"},{"key":"BFnm1534_CR6","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1016\/S0161-6420(98)91020-X","volume":"105","author":"R Klein","year":"1998","unstructured":"Klein, R., Klein, B.E., Moss, S.E. & Cruickshanks, K.J. The Wisconsin epidemiologic study of diabetic retinopathy: XVII. The 14-year incidence and progression of diabetic retinopathy and associated risk factors in type 1 diabetes. Ophthalmology 105, 1801\u20131815 (1998).","journal-title":"Ophthalmology"},{"key":"BFnm1534_CR7","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1056\/NEJM199908263410907","volume":"341","author":"FL Ferris III","year":"1999","unstructured":"Ferris, F.L., III, Davis, M.D. & Aiello, L.M. Treatment of diabetic retinopathy. N. Engl. J. Med. 341, 667\u2013678 (1999).","journal-title":"N. Engl. J. Med."},{"key":"BFnm1534_CR8","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1016\/S0161-6420(84)34102-1","volume":"91","author":"R Klein","year":"1984","unstructured":"Klein, R., Klein, B.E., Moss, S.E., Davis, M.D. & DeMets, D.L. The Wisconsin epidemiologic study of diabetic retinopathy. IV. Diabetic macular edema. Ophthalmology 91, 1464\u20131474 (1984).","journal-title":"Ophthalmology"},{"key":"BFnm1534_CR9","doi-asserted-by":"publisher","first-page":"2328","DOI":"10.2337\/diacare.25.12.2328","volume":"25","author":"ST Knudsen","year":"2002","unstructured":"Knudsen, S.T. et al. Macular edema reflects generalized vascular hyperpermeability in type 2 diabetic patients with retinopathy. Diabetes Care 25, 2328\u20132334 (2002).","journal-title":"Diabetes Care"},{"key":"BFnm1534_CR10","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1111\/j.1755-3768.1981.tb08735.x","volume":"59","author":"B Krogsaa","year":"1981","unstructured":"Krogsaa, B., Lund-Andersen, H., Mehlsen, J., Sestoft, L. & Larsen, J. The blood-retinal barrier permeability in diabetic patients. Acta Ophthalmol. (Copenh.) 59, 689\u2013694 (1981).","journal-title":"Acta Ophthalmol. (Copenh.)"},{"key":"BFnm1534_CR11","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1136\/bjo.73.4.255","volume":"73","author":"WE Plehwe","year":"1989","unstructured":"Plehwe, W.E., Sleightholm, M.A. & Kohner, E.M. Does vitreous fluorophotometry reflect severity of early diabetic retinopathy? Br. J. Ophthalmol. 73, 255\u2013260 (1989).","journal-title":"Br. J. Ophthalmol."},{"key":"BFnm1534_CR12","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1177\/112067210201200606","volume":"12","author":"R Lattanzio","year":"2002","unstructured":"Lattanzio, R. et al. Macular thickness measured by optical coherence tomography (OCT) in diabetic patients. Eur. J. Ophthalmol. 12, 482\u2013487 (2002).","journal-title":"Eur. J. Ophthalmol."},{"key":"BFnm1534_CR13","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1056\/NEJM199412013312203","volume":"331","author":"LP Aiello","year":"1994","unstructured":"Aiello, L.P. et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N. Engl. J. Med. 331, 1480\u20131487 (1994).","journal-title":"N. Engl. J. Med."},{"key":"BFnm1534_CR14","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/S0002-9394(02)01568-4","volume":"134","author":"N Ogata","year":"2002","unstructured":"Ogata, N., Nishikawa, M., Nishimura, T., Mitsuma, Y. & Matsumura, M. Unbalanced vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in diabetic retinopathy. Am. J. Ophthalmol. 134, 348\u2013353 (2002).","journal-title":"Am. J. Ophthalmol."},{"key":"BFnm1534_CR15","doi-asserted-by":"publisher","first-page":"2805","DOI":"10.1056\/NEJMoa042760","volume":"351","author":"ES Gragoudas","year":"2004","unstructured":"Gragoudas, E.S., Adamis, A.P., Cunningham, E.T., Jr., Feinsod, M & Guyer, D.R. Pegaptanib for neovascular age-related macular degeneration. N. Engl. J. Med. 351, 2805\u20132816 (2004).","journal-title":"N. Engl. J. Med."},{"key":"BFnm1534_CR16","first-page":"3273","volume":"43","author":"SP Srinivas","year":"2002","unstructured":"Srinivas, S.P., Ong, A., Zhai, C.B. & Bonanno, J.A. Inhibition of carbonic anhydrase activity in cultured bovine corneal endothelial cells by dorzolamide. Invest. Ophthalmol. Vis. Sci. 43, 3273\u20133278 (2002).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"BFnm1534_CR17","first-page":"3401","volume":"35","author":"TJ Wolfensberger","year":"1994","unstructured":"Wolfensberger, T.J. et al. Membrane-bound carbonic anhydrase in human retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci. 35, 3401\u20133407 (1994).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"BFnm1534_CR18","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1023\/A:1016354517304","volume":"24","author":"C Giusti","year":"2001","unstructured":"Giusti, C., Forte, R., Vingolo, E.M. & Gargiulo, P. Is acetazolamide effective in the treatment of diabetic macular edema? A pilot study. Int. Ophthalmol. 24, 79\u201388 (2001).","journal-title":"Int. Ophthalmol."},{"key":"BFnm1534_CR19","doi-asserted-by":"publisher","first-page":"10836","DOI":"10.1073\/pnas.96.19.10836","volume":"96","author":"K Miyamoto","year":"1999","unstructured":"Miyamoto, K. et al. Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. Proc. Natl. Acad. Sci. USA 96, 10836\u201310841 (1999).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm1534_CR20","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1016\/j.ophtha.2005.05.023","volume":"112","author":"M Wojtkowski","year":"2005","unstructured":"Wojtkowski, M. et al. Three dimensional retinal imaging with high-speed, ultrahigh resolution, optical coherence tomography. Ophthalmology 112, 1734\u20131746 (2005).","journal-title":"Ophthalmology"},{"key":"BFnm1534_CR21","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1074\/mcp.M300127-MCP200","volume":"3","author":"NL Anderson","year":"2004","unstructured":"Anderson, N.L. et al. The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell. Proteomics 3, 311\u2013326 (2004).","journal-title":"Mol. Cell. Proteomics"},{"key":"BFnm1534_CR22","first-page":"419","volume":"27","author":"PJ Wistrand","year":"1986","unstructured":"Wistrand, P.J., Schenholm, M. & Lonnerholm, G. Carbonic anhydrase isoenzymes CA I and CA II in the human eye. Invest. Ophthalmol. Vis. Sci. 27, 419\u2013428 (1986).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"BFnm1534_CR23","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0161-5890(01)00040-2","volume":"38","author":"A Carugati","year":"2001","unstructured":"Carugati, A., Pappalardo, E., Zingale, L.C. & Cicardi, M. C1-inhibitor deficiency and angioedema. Mol. Immunol. 38, 161\u2013173 (2001).","journal-title":"Mol. Immunol."},{"key":"BFnm1534_CR24","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1172\/JCI200214211","volume":"109","author":"ED Han","year":"2002","unstructured":"Han, E.D., MacFarlane, R.C., Mulligan, A.N., Scafidi, J. & Davis, A.E., III. Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor. J. Clin. Invest. 109, 1057\u20131063 (2002).","journal-title":"J. Clin. Invest."},{"key":"BFnm1534_CR25","doi-asserted-by":"publisher","first-page":"17962","DOI":"10.1074\/jbc.M106101200","volume":"277","author":"Z Shariat-Madar","year":"2002","unstructured":"Shariat-Madar, Z., Mahdi, F. & Schmaier, A.H. Identification and characterization of prolylcarboxypeptidase as an endothelial cell prekallikrein activator. J. Biol. Chem. 277, 17962\u201317969 (2002).","journal-title":"J. Biol. Chem."},{"key":"BFnm1534_CR26","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1161\/01.HYP.0000054971.03046.9B","volume":"41","author":"S Houle","year":"2003","unstructured":"Houle, S., Molinaro, G., Adam, A. & Marceau, F. Tissue kallikrein actions at the rabbit natural or recombinant kinin B2 receptors. Hypertension 41, 611\u2013617 (2003).","journal-title":"Hypertension"},{"key":"BFnm1534_CR27","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1182\/blood.V70.4.1053.1053","volume":"70","author":"D Veloso","year":"1987","unstructured":"Veloso, D., Silver, L.D., Hahn, S. & Colman, R.W. A monoclonal anti-human plasma prekallikrein antibody that inhibits activation of prekallikrein by factor XIIa on a surface. Blood 70, 1053\u20131062 (1987).","journal-title":"Blood"},{"key":"BFnm1534_CR28","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1093\/hmg\/ddi023","volume":"14","author":"Z Yang","year":"2005","unstructured":"Yang, Z. et al. Mutant carbonic anhydrase 4 impairs pH regulation and causes retinal photoreceptor degeneration. Hum. Mol. Genet. 14, 255\u2013265 (2005).","journal-title":"Hum. Mol. Genet."},{"key":"BFnm1534_CR29","doi-asserted-by":"publisher","first-page":"2932","DOI":"10.1161\/hs1201.099820","volume":"32","author":"G Xi","year":"2001","unstructured":"Xi, G. et al. Mechanisms of edema formation after intracerebral hemorrhage: effects of extravasated red blood cells on blood flow and blood-brain barrier integrity. Stroke 32, 2932\u20132938 (2001).","journal-title":"Stroke"},{"key":"BFnm1534_CR30","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1056\/NEJM200105103441907","volume":"344","author":"AI Qureshi","year":"2001","unstructured":"Qureshi, A.I. et al. Spontaneous intracerebral hemorrhage. N. Engl. J. Med. 344, 1450\u20131460 (2001).","journal-title":"N. Engl. J. Med."},{"key":"BFnm1534_CR31","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1074\/mcp.M300038-MCP200","volume":"2","author":"K Yamane","year":"2003","unstructured":"Yamane, K. et al. Proteome analysis of human vitreous proteins. Mol. Cell. Proteomics 2, 1177\u20131187 (2003).","journal-title":"Mol. Cell. Proteomics"},{"key":"BFnm1534_CR32","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S1570-0232(02)00078-8","volume":"776","author":"T Nakanishi","year":"2002","unstructured":"Nakanishi, T., Koyama, R., Ikeda, T. & Shimizu, A. Catalogue of soluble proteins in the human vitreous humor: comparison between diabetic retinopathy and macular hole. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 776, 89\u2013100 (2002).","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"BFnm1534_CR33","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.exer.2005.01.020","volume":"81","author":"M Ouchi","year":"2005","unstructured":"Ouchi, M., West, K., Crabb, J.W., Kinoshita, S. & Kamei, M. Proteomic analysis of vitreous from diabetic macular edema. Exp. Eye Res. 81, 176\u2013182 (2005).","journal-title":"Exp. Eye Res."},{"key":"BFnm1534_CR34","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1034\/j.1600-0420.1999.770221.x","volume":"77","author":"M Henricsson","year":"1999","unstructured":"Henricsson, M., Sellman, A., Tyrberg, M. & Groop, L. Progression to proliferative retinopathy and macular oedema requiring treatment. Assessment of the alternative classification of the Wisconsin Study. Acta Ophthalmol. Scand. 77, 218\u2013223 (1999).","journal-title":"Acta Ophthalmol. Scand."},{"key":"BFnm1534_CR35","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.febslet.2004.10.043","volume":"577","author":"E Svastova","year":"2004","unstructured":"Svastova, E. et al. Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH. FEBS Lett. 577, 439\u2013445 (2004).","journal-title":"FEBS Lett."},{"key":"BFnm1534_CR36","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1160\/TH06-03-0128","volume":"95","author":"T Iwaki","year":"2006","unstructured":"Iwaki, T. & Castellino, F.J. Plasma levels of bradykinin are suppressed in factor XII-deficient mice. Thromb. Haemost. 95, 1003\u20131010 (2006).","journal-title":"Thromb. Haemost."},{"key":"BFnm1534_CR37","doi-asserted-by":"publisher","first-page":"4554","DOI":"10.1182\/blood-2003-07-2510","volume":"103","author":"Z Shariat-Madar","year":"2004","unstructured":"Shariat-Madar, Z., Mahdi, F. & Schmaier, A.H. Recombinant prolylcarboxypeptidase activates plasma prekallikrein. Blood 103, 4554\u20134561 (2004).","journal-title":"Blood"},{"key":"BFnm1534_CR38","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S0065-2776(04)86005-X","volume":"86","author":"K Joseph","year":"2005","unstructured":"Joseph, K. & Kaplan, A.P. Formation of bradykinin: a major contributor to the innate inflammatory response. Adv. Immunol. 86, 159\u2013208 (2005).","journal-title":"Adv. Immunol."},{"key":"BFnm1534_CR39","doi-asserted-by":"publisher","first-page":"8030","DOI":"10.1073\/pnas.0503021102","volume":"102","author":"EA Nagelhus","year":"2005","unstructured":"Nagelhus, E.A. et al. Carbonic anhydrase XIV is enriched in specific membrane domains of retinal pigment epithelium, Muller cells, and astrocytes. Proc. Natl. Acad. Sci. USA 102, 8030\u20138035 (2005).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm1534_CR40","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1038\/eye.1993.159","volume":"7","author":"SM Rassam","year":"1993","unstructured":"Rassam, S.M., Patel, V. & Kohner, E.M. The effect of acetazolamide on the retinal circulation. Eye 7, 697\u2013702 (1993).","journal-title":"Eye"},{"key":"BFnm1534_CR41","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1172\/JCI111579","volume":"74","author":"S Vorstrup","year":"1984","unstructured":"Vorstrup, S., Henriksen, L. & Paulson, O.B. Effect of acetazolamide on cerebral blood flow and cerebral metabolic rate for oxygen. J. Clin. Invest. 74, 1634\u20131639 (1984).","journal-title":"J. Clin. Invest."},{"key":"BFnm1534_CR42","first-page":"2756","volume":"40","author":"E Stefansson","year":"1999","unstructured":"Stefansson, E. et al. Optic nerve oxygen tension in pigs and the effect of carbonic anhydrase inhibitors. Invest. Ophthalmol. Vis. Sci. 40, 2756\u20132761 (1999).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"BFnm1534_CR43","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1021\/jm030912m","volume":"47","author":"A Weber","year":"2004","unstructured":"Weber, A. et al. Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition. J. Med. Chem. 47, 550\u2013557 (2004).","journal-title":"J. Med. Chem."},{"key":"BFnm1534_CR44","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1016\/j.jaci.2005.05.019","volume":"116","author":"MB van Doorn","year":"2005","unstructured":"van Doorn, M.B. et al. A phase I study of recombinant human C1 inhibitor in asymptomatic patients with hereditary angioedema. J. Allergy Clin. Immunol. 116, 876\u2013883 (2005).","journal-title":"J. Allergy Clin. Immunol."},{"key":"BFnm1534_CR45","doi-asserted-by":"publisher","first-page":"13302","DOI":"10.1073\/pnas.0405449101","volume":"101","author":"M Kakoki","year":"2004","unstructured":"Kakoki, M., Takahashi, N., Jennette, J.C. & Smithies, O. Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor. Proc. Natl. Acad. Sci. USA 101, 13302\u201313305 (2004).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm1534_CR46","doi-asserted-by":"crossref","unstructured":"Early Treatment Diabetic Retinopathy Study Research Group. Grading diabetic retinopathy from stereoscopic color fundus photographs\u2013an extension of the modified Airlie House classification. ETDRS report number 10. Ophthalmology 98, 786\u2013806 (1991).","DOI":"10.1016\/S0161-6420(13)38012-9"},{"key":"BFnm1534_CR47","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.2337\/diab.46.9.1473","volume":"46","author":"LP Aiello","year":"1997","unstructured":"Aiello, L.P. et al. Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor. Diabetes 46, 1473\u20131480 (1997).","journal-title":"Diabetes"}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm1534.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm1534","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm1534.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T22:28:20Z","timestamp":1684448900000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm1534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,28]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["BFnm1534"],"URL":"https:\/\/doi.org\/10.1038\/nm1534","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,28]]}}}