{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:55:38Z","timestamp":1791107738159,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2002,7,15]],"date-time":"2002-07-15T00:00:00Z","timestamp":1026691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2002,7,15]],"date-time":"2002-07-15T00:00:00Z","timestamp":1026691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2002,8,1]]},"DOI":"10.1038\/nm741","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T21:36:31Z","timestamp":1027892191000},"page":"825-830","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":300,"title":["Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist"],"prefix":"10.1038","volume":"8","author":[{"given":"Beth","family":"Borowsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret M.","family":"Durkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Ogozalek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad R.","family":"Marzabadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"DeLeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Heurich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey","family":"Lichtblau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoya","family":"Shaposhnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Daniewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P.","family":"Blackburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa A.","family":"Branchek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Gerald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre J.","family":"Vaysse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Forray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2002,7,15]]},"reference":[{"key":"BFnm741_CR1","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1002\/cne.903190204","volume":"319","author":"JC Bittencourt","year":"1992","unstructured":"Bittencourt, J.C. et al. The melanin concentrating hormone system of the rat brain: an immuno-histochemical characterization. J. Comp. Neurol. 319, 218\u2013245 (1992).","journal-title":"J. Comp. Neurol."},{"key":"BFnm741_CR2","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/380243a0","volume":"380","author":"D Qu","year":"1996","unstructured":"Qu, D. et al. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 380, 243\u2013247 (1996).","journal-title":"Nature"},{"key":"BFnm741_CR3","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1038\/25341","volume":"396","author":"M Shimada","year":"1998","unstructured":"Shimada, M., Tritos, N.A., Lowell, B.B., Flier, J.S. & Maratos-Flier, E. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature 396, 670\u2013674 (1998).","journal-title":"Nature"},{"key":"BFnm741_CR4","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1172\/JCI10660","volume":"107","author":"DS Ludwig","year":"2001","unstructured":"Ludwig, D.S. et al. Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. J. Clin. Invest. 107, 379\u2013386 (2001).","journal-title":"J. Clin. Invest."},{"key":"BFnm741_CR5","doi-asserted-by":"publisher","first-page":"2056","DOI":"10.1210\/endo-125-4-2056","volume":"125","author":"JL Nahon","year":"1989","unstructured":"Nahon, J.L., Presse, F., Bittencourt, J.C., Sawchenko, P.E. & Vale, W. The rat melanin-concentrating hormone messenger ribonucleic acid encodes multiple putative neuropeptides coexpressed in the dorsolateral hypothalamus. Endocrinol. 125, 2056\u201365 (1989).","journal-title":"Endocrinol."},{"key":"BFnm741_CR6","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/22321","volume":"400","author":"Y Sato","year":"1999","unstructured":"Sato, Y. et al. Molecular characterization of the melanin-concentrating-hormone receptor. Nature 400, 265\u2013269 (1999).","journal-title":"Nature"},{"key":"BFnm741_CR7","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/22313","volume":"400","author":"J Chambers","year":"1999","unstructured":"Chambers, J. et al. Melanin-concentrating hormone is the cognate ligand for the orphan G protein-coupled receptor SLC-1. Nature 400, 261\u2013265 (1999).","journal-title":"Nature"},{"key":"BFnm741_CR8","doi-asserted-by":"publisher","first-page":"20125","DOI":"10.1074\/jbc.M102068200","volume":"276","author":"J Hill","year":"2001","unstructured":"Hill, J. et al. Molecular cloning and functional characterization of MCH2, a novel human MCH receptor. J. Biol. Chem. 276, 20125\u201320129 (2001).","journal-title":"J. Biol. Chem."},{"key":"BFnm741_CR9","doi-asserted-by":"publisher","first-page":"7564","DOI":"10.1073\/pnas.121170598","volume":"98","author":"AW Sailer","year":"2001","unstructured":"Sailer, A.W. et al. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc. Nat. Acad. Sci. USA 98, 7564\u20137569 (2001).","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"BFnm741_CR10","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1046\/j.1460-9568.2000.00008.x","volume":"12","author":"GJ Hervieu","year":"2000","unstructured":"Hervieu, G.J. et al. The distribution of the mRNA and protein products of the melanin-concentrating hormone (MCH) receptor gene, slc-1, in the central nervous system of the rat. Eur. J. Neurosci. 12, 1194\u20131216 (2000).","journal-title":"Eur. J. Neurosci."},{"key":"BFnm741_CR11","first-page":"327","volume":"229","author":"RD Porsolt","year":"1977","unstructured":"Porsolt, R.D., Bertin, A. & Jalfre, M. Behavioral despair in mice: A primary screening test for antidepressants. Arch Int Pharmacodyn Ther. 229, 327\u2013336 (1977).","journal-title":"Arch Int Pharmacodyn Ther."},{"key":"BFnm741_CR12","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s002130100694","volume":"155","author":"I Lucki","year":"2001","unstructured":"Lucki, I., Dalvi, A. & Mayorga, A.J. Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice. Psychopharmacology 155, 315\u2013322 (2001).","journal-title":"Psychopharmacology"},{"key":"BFnm741_CR13","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1476-5381.1978.tb07001.x","volume":"62","author":"SE File","year":"1987","unstructured":"File, S.E. & Hyde, J.R.G. Can social interaction be used to measure anxiety? Br. J. Pharmacol. 62, 19\u201324 (1987).","journal-title":"Br. J. Pharmacol."},{"key":"BFnm741_CR14","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1590\/S0100-879X1997000300002","volume":"30","author":"RJ Rodgers","year":"1977","unstructured":"Rodgers, R.J., Cao. B.J., Calvi, A. & Holmes, A. Animals models of anxiety: An ethological perspective. Braz. J. Med. Biol. Res. 30, 289\u2013304 (1977).","journal-title":"Braz. J. Med. Biol. Res."},{"key":"BFnm741_CR15","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/0091-3057(94)90422-7","volume":"49","author":"S Lightowler","year":"1994","unstructured":"Lightowler, S., Kennett, G.A., Williamson, I.J.R., Blackburn, T.P. & Tulloch, I.F. Anxiolytic-like effect of paroxetine in a rat social-interaction test. Pharmacol. Biochem. Behav. 49, 281\u2013285 (1994).","journal-title":"Pharmacol. Biochem. Behav."},{"key":"BFnm741_CR16","first-page":"918","volume-title":"Psychological Reports","author":"TF Pettijohn","year":"1979","unstructured":"Pettijohn, T.F. Effects of imipramine on infant guinea pig distress vocalization. Psychological Reports. 44, 918 (1979)."},{"key":"BFnm741_CR17","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/dev.420120109","volume":"12","author":"TF Pettijohn","year":"1979","unstructured":"Pettijohn, T.F. Attachment and separation distress in the infant guinea pig. Devel. Psychobiol. 12, 73\u201381 (1979).","journal-title":"Devel. Psychobiol."},{"key":"BFnm741_CR18","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1126\/science.281.5383.1640","volume":"281","author":"MS Kramer","year":"1998","unstructured":"Kramer, M.S. et al. Distinct Mechanism for Antidepressant Activity by blockade of central substance P receptors. Science 281, 1640\u20131645 (1998).","journal-title":"Science"},{"key":"BFnm741_CR19","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.2337\/diabetes.49.7.1073","volume":"49","author":"RL Bradley","year":"2000","unstructured":"Bradley, R.L., Kokkotou, E.G., Maratos-Flier, E. & Cheatham, B. Melanin-concentrating hormone regulates leptin synthesis and secretion in rat adipocytes. Diabetes. 49, 1073\u20131077 (2000).","journal-title":"Diabetes."},{"key":"BFnm741_CR20","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1210\/endo.142.2.7981","volume":"142","author":"EG Kokkotou","year":"2001","unstructured":"Kokkotou, E.G., Tritos, N.A., Mastaitis, J.W., Slieker, L., & Maratos-Flier, E. Melanin-concentrating hormone receptor is a target of leptin action in the mouse brain. Endocrinol. 142, 680\u2013686 (2001).","journal-title":"Endocrinol."},{"key":"BFnm741_CR21","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/0196-9781(95)02092-6","volume":"17","author":"MI Gonzalez","year":"1996","unstructured":"Gonzalez, M.I., Vaziri, S. & Wilson, C.A. Behavioral effects of a-MSH and MCH alter central administration in the female rat. Peptides 17, 171\u2013177 (1996).","journal-title":"Peptides"},{"key":"BFnm741_CR22","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/S0031-9384(99)00117-1","volume":"67","author":"ME Monz\u00f3n","year":"1999","unstructured":"Monz\u00f3n, M.E. & DeBarioglio, S.R. Response to novelty after i.c.v. injection of melanin-concentrating hormone (MCH) in rats. Physiol. Behav. 67, 813\u2013817 (1999).","journal-title":"Physiol. Behav."},{"key":"BFnm741_CR23","doi-asserted-by":"publisher","first-page":"26758","DOI":"10.1074\/jbc.270.45.26758","volume":"270","author":"C Gerald","year":"1995","unstructured":"Gerald, C. et al. Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y\/peptide YY Y2 receptor subtype. J. Biol. Chem. 270, 26758\u201326761 (1995).","journal-title":"J. Biol. Chem."},{"key":"BFnm741_CR24","doi-asserted-by":"publisher","first-page":"39324","DOI":"10.1074\/jbc.M004385200","volume":"275","author":"JA Bonini","year":"2000","unstructured":"Bonini, J.A. et al. Identification and characterization of two G protein-coupled receptors for neuropeptide FF. J. Biol. Chem. 275, 39324\u201339331 (2000).","journal-title":"J. Biol. Chem."},{"key":"BFnm741_CR25","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"G Paxinos","year":"1998","unstructured":"Paxinos, G. & Watson, C. in The Rat Brain in Stereotaxic Coordinates. (Academic, San Diego, California, 1998)."}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm741.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm741","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm741.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T22:32:10Z","timestamp":1684449130000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7,15]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2002,8,1]]}},"alternative-id":["BFnm741"],"URL":"https:\/\/doi.org\/10.1038\/nm741","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,7,15]]},"assertion":[{"value":"7 May 2002","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2002","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2002","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All authors at the time they contributed their work to the study were full-time employees of Synaptic Pharmaceutical Corporation.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}