{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:37:54Z","timestamp":1791077874349,"version":"4.1.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2009,11,22]],"date-time":"2009-11-22T00:00:00Z","timestamp":1258848000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Neurosci"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1038\/nn.2438","type":"journal-article","created":{"date-parts":[[2009,11,22]],"date-time":"2009-11-22T13:28:18Z","timestamp":1258896498000},"page":"1506-1513","source":"Crossref","is-referenced-by-count":84,"title":["Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system"],"prefix":"10.1038","volume":"12","author":[{"given":"Mikiko","family":"Ohno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Hiraoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuhiko","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Tomimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keizo","family":"Takao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Miyakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kiyonari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Kita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichiro","family":"Nishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,11,22]]},"reference":[{"key":"BFnn2438_CR1","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1146\/annurev.neuro.30.051606.094309","volume":"31","author":"KA Nave","year":"2008","unstructured":"Nave, K.A. & Trapp, B.D. Axon-glial signaling and the glial support of axon function. Annu. Rev. Neurosci. 31, 535\u2013561 (2008).","journal-title":"Annu. Rev. Neurosci."},{"key":"BFnn2438_CR2","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.conb.2007.08.003","volume":"17","author":"M Simons","year":"2007","unstructured":"Simons, M. & Trotter, J. Wrapping it up: the cell biology of myelination. Curr. Opin. Neurobiol. 17, 533\u2013540 (2007).","journal-title":"Curr. Opin. Neurobiol."},{"key":"BFnn2438_CR3","doi-asserted-by":"publisher","first-page":"R29","DOI":"10.1016\/j.cub.2006.11.042","volume":"17","author":"DK Hartline","year":"2007","unstructured":"Hartline, D.K. & Colman, D.R. Rapid conduction and the evolution of giant axons and myelinated fibers. Curr. Biol. 17, R29\u2013R35 (2007).","journal-title":"Curr. Biol."},{"key":"BFnn2438_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1471-4159.2008.05570.x","volume":"107","author":"DM McTigue","year":"2008","unstructured":"McTigue, D.M. & Tripathi, R.B. The life, death, and replacement of oligodendrocytes in the adult CNS. J. Neurochem. 107, 1\u201319 (2008).","journal-title":"J. Neurochem."},{"key":"BFnn2438_CR5","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1126\/science.280.5369.1610","volume":"280","author":"I Griffiths","year":"1998","unstructured":"Griffiths, I. et al. Axonal swellings and degeneration in mice lacking the major proteolipid of myelin. Science 280, 1610\u20131613 (1998).","journal-title":"Science"},{"key":"BFnn2438_CR6","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/ng1095","volume":"33","author":"C Lappe-Siefke","year":"2003","unstructured":"Lappe-Siefke, C. et al. Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination. Nat. Genet. 33, 366\u2013374 (2003).","journal-title":"Nat. Genet."},{"key":"BFnn2438_CR7","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1126\/science.1095862","volume":"304","author":"GV Michailov","year":"2004","unstructured":"Michailov, G.V. et al. Axonal neuregulin-1 regulates myelin sheath thickness. Science 304, 700\u2013703 (2004).","journal-title":"Science"},{"key":"BFnn2438_CR8","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.conb.2006.08.008","volume":"16","author":"KA Nave","year":"2006","unstructured":"Nave, K.A. & Salzer, J.L. Axonal regulation of myelination by neuregulin 1. Curr. Opin. Neurobiol. 16, 492\u2013500 (2006).","journal-title":"Curr. Opin. Neurobiol."},{"key":"BFnn2438_CR9","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/nrn2392","volume":"9","author":"L Mei","year":"2008","unstructured":"Mei, L. & Xiong, W.C. Neuregulin 1 in neural development, synaptic plasticity and schizophrenia. Nat. Rev. Neurosci. 9, 437\u2013452 (2008).","journal-title":"Nat. Rev. Neurosci."},{"key":"BFnn2438_CR10","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/S0014-4827(02)00102-7","volume":"284","author":"DL Falls","year":"2003","unstructured":"Falls, D.L. Neuregulins: functions, forms and signaling strategies. Exp. Cell Res. 284, 14\u201330 (2003).","journal-title":"Exp. Cell Res."},{"key":"BFnn2438_CR11","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1006\/mcne.2000.0896","volume":"16","author":"JC Montero","year":"2000","unstructured":"Montero, J.C., Yuste, L., Diaz-Rodriguez, E., Esparis-Ogando, A. & Pandiella, A. Differential shedding of transmembrane neuregulin isoforms by the tumor necrosis factor alpha\u2013converting enzyme. Mol. Cell. Neurosci. 16, 631\u2013648 (2000).","journal-title":"Mol. Cell. Neurosci."},{"key":"BFnn2438_CR12","doi-asserted-by":"publisher","first-page":"9352","DOI":"10.1074\/jbc.M007913200","volume":"276","author":"K Shirakabe","year":"2001","unstructured":"Shirakabe, K., Wakatsuki, S., Kurisaki, T. & Fujisawa-Sehara, A. Roles of Meltrin beta\/ADAM19 in the processing of neuregulin. J. Biol. Chem. 276, 9352\u20139358 (2001).","journal-title":"J. Biol. Chem."},{"key":"BFnn2438_CR13","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1126\/science.1132341","volume":"314","author":"M Willem","year":"2006","unstructured":"Willem, M. et al. Control of peripheral nerve myelination by the beta-secretase BACE1. Science 314, 664\u2013666 (2006).","journal-title":"Science"},{"key":"BFnn2438_CR14","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1038\/nn1797","volume":"9","author":"X Hu","year":"2006","unstructured":"Hu, X. et al. Bace1 modulates myelination in the central and peripheral nervous system. Nat. Neurosci. 9, 1520\u20131525 (2006).","journal-title":"Nat. Neurosci."},{"key":"BFnn2438_CR15","doi-asserted-by":"publisher","first-page":"2970","DOI":"10.1096\/fj.08-106666","volume":"22","author":"X Hu","year":"2008","unstructured":"Hu, X. et al. Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves. FASEB J. 22, 2970\u20132980 (2008).","journal-title":"FASEB J."},{"key":"BFnn2438_CR16","doi-asserted-by":"publisher","first-page":"6078","DOI":"10.1073\/pnas.91.13.6078","volume":"91","author":"AR Pierotti","year":"1994","unstructured":"Pierotti, A.R. et al. N-arginine dibasic convertase, a metalloendopeptidase as a prototype of a class of processing enzymes. Proc. Natl. Acad. Sci. USA 91, 6078\u20136082 (1994).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn2438_CR17","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/0300-9084(94)90151-1","volume":"76","author":"V Chesneau","year":"1994","unstructured":"Chesneau, V. et al. N-arginine dibasic convertase (NRD convertase): a newcomer to the family of processing endopeptidases. An overview. Biochimie 76, 234\u2013240 (1994).","journal-title":"Biochimie"},{"key":"BFnn2438_CR18","doi-asserted-by":"publisher","first-page":"3342","DOI":"10.1093\/emboj\/20.13.3342","volume":"20","author":"E Nishi","year":"2001","unstructured":"Nishi, E., Prat, A., Hospital, V., Elenius, K. & Klagsbrun, M. N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration. EMBO J. 20, 3342\u20133350 (2001).","journal-title":"EMBO J."},{"key":"BFnn2438_CR19","doi-asserted-by":"publisher","first-page":"31164","DOI":"10.1074\/jbc.M601316200","volume":"281","author":"E Nishi","year":"2006","unstructured":"Nishi, E., Hiraoka, Y., Yoshida, K., Okawa, K. & Kita, T. Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor\u2013like growth factor through activation of tumor necrosis factor alpha\u2013converting enzyme. J. Biol. Chem. 281, 31164\u201331172 (2006).","journal-title":"J. Biol. Chem."},{"key":"BFnn2438_CR20","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1111\/j.1471-4159.2007.04685.x","volume":"102","author":"Y Hiraoka","year":"2007","unstructured":"Hiraoka, Y. et al. Enhancement of alpha-secretase cleavage of amyloid precursor protein by a metalloendopeptidase nardilysin. J. Neurochem. 102, 1595\u20131605 (2007).","journal-title":"J. Neurochem."},{"key":"BFnn2438_CR21","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.bbrc.2008.03.050","volume":"370","author":"Y Hiraoka","year":"2008","unstructured":"Hiraoka, Y. et al. Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases. Biochem. Biophys. Res. Commun. 370, 154\u2013158 (2008).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFnn2438_CR22","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1016\/j.neuroscience.2007.02.057","volume":"146","author":"HG Bernstein","year":"2007","unstructured":"Bernstein, H.G. et al. Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons. Neuroscience 146, 1513\u20131523 (2007).","journal-title":"Neuroscience"},{"key":"BFnn2438_CR23","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S0092-8674(02)00678-5","volume":"109","author":"QR Lu","year":"2002","unstructured":"Lu, Q.R. et al. Common developmental requirement for Olig function indicates a motor neuron\/oligodendrocyte connection. Cell 109, 75\u201386 (2002).","journal-title":"Cell"},{"key":"BFnn2438_CR24","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/0014-4886(86)90125-1","volume":"92","author":"RD Fields","year":"1986","unstructured":"Fields, R.D. & Ellisman, M.H. Axons regenerated through silicone tube splices. II. Functional morphology. Exp. Neurol. 92, 61\u201374 (1986).","journal-title":"Exp. Neurol."},{"key":"BFnn2438_CR25","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.neuron.2005.08.017","volume":"47","author":"C Taveggia","year":"2005","unstructured":"Taveggia, C. et al. Neuregulin-1 type III determines the ensheathment fate of axons. Neuron 47, 681\u2013694 (2005).","journal-title":"Neuron"},{"key":"BFnn2438_CR26","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/0092-8674(95)90009-8","volume":"81","author":"M Mayford","year":"1995","unstructured":"Mayford, M., Wang, J., Kandel, E.R. & O'Dell, T.J. CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP. Cell 81, 891\u2013904 (1995).","journal-title":"Cell"},{"key":"BFnn2438_CR27","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<133::AID-GENE10>3.0.CO;2-V","volume":"26","author":"I Dragatsis","year":"2000","unstructured":"Dragatsis, I. & Zeitlin, S. CaMKIIalpha-Cre transgene expression and recombination patterns in the mouse brain. Genesis 26, 133\u2013135 (2000).","journal-title":"Genesis"},{"key":"BFnn2438_CR28","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1756-6606-1-6","volume":"1","author":"N Yamasaki","year":"2008","unstructured":"Yamasaki, N. et al. Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders. Mol Brain 1, 6 (2008).","journal-title":"Mol Brain"},{"key":"BFnn2438_CR29","doi-asserted-by":"publisher","first-page":"3248","DOI":"10.1523\/JNEUROSCI.19-08-03248.1999","volume":"19","author":"RJ Carter","year":"1999","unstructured":"Carter, R.J. et al. Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation. J. Neurosci. 19, 3248\u20133257 (1999).","journal-title":"J. Neurosci."},{"key":"BFnn2438_CR30","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1756-6606-1-11","volume":"1","author":"K Takao","year":"2008","unstructured":"Takao, K. et al. Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia. Mol Brain 1, 11 (2008).","journal-title":"Mol Brain"},{"key":"BFnn2438_CR31","doi-asserted-by":"publisher","first-page":"29615","DOI":"10.1074\/jbc.R800019200","volume":"283","author":"G Thinakaran","year":"2008","unstructured":"Thinakaran, G. & Koo, E.H. Amyloid precursor protein trafficking, processing and function. J. Biol. Chem. 283, 29615\u201329619 (2008).","journal-title":"J. Biol. Chem."},{"key":"BFnn2438_CR32","doi-asserted-by":"publisher","first-page":"4740","DOI":"10.1523\/JNEUROSCI.21-13-04740.2001","volume":"21","author":"V Calaora","year":"2001","unstructured":"Calaora, V. et al. Neuregulin signaling regulates neural precursor growth and the generation of oligodendrocytes in vitro. J. Neurosci. 21, 4740\u20134751 (2001).","journal-title":"J. Neurosci."},{"key":"BFnn2438_CR33","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1074\/jbc.M803191200","volume":"284","author":"S Wakatsuki","year":"2009","unstructured":"Wakatsuki, S., Yumoto, N., Komatsu, K., Araki, T. & Sehara-Fujisawa, A. Roles of meltrin-beta\/ADAM19 in progression of Schwann cell differentiation and myelination during sciatic nerve regeneration. J. Biol. Chem. 284, 2957\u20132966 (2009).","journal-title":"J. Biol. Chem."},{"key":"BFnn2438_CR34","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1002\/glia.20612","volume":"56","author":"C Taveggia","year":"2008","unstructured":"Taveggia, C. et al. Type III neuregulin-1 promotes oligodendrocyte myelination. Glia 56, 284\u2013293 (2008).","journal-title":"Glia"},{"key":"BFnn2438_CR35","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.neuron.2008.06.028","volume":"59","author":"BG Brinkmann","year":"2008","unstructured":"Brinkmann, B.G. et al. Neuregulin-1\/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system. Neuron 59, 581\u2013595 (2008).","journal-title":"Neuron"},{"key":"BFnn2438_CR36","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1146\/annurev.neuro.30.051606.094313","volume":"31","author":"BD Trapp","year":"2008","unstructured":"Trapp, B.D. & Nave, K.A. Multiple sclerosis: an immune or neurodegenerative disorder? Annu. Rev. Neurosci. 31, 247\u2013269 (2008).","journal-title":"Annu. Rev. Neurosci."},{"key":"BFnn2438_CR37","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1006\/abio.1993.1458","volume":"214","author":"T Yagi","year":"1993","unstructured":"Yagi, T. et al. A novel ES cell line, TT2, with high germline-differentiating potency. Anal. Biochem. 214, 70\u201376 (1993).","journal-title":"Anal. Biochem."},{"key":"BFnn2438_CR38","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1083\/jcb.17.2.299","volume":"17","author":"GJ Todaro","year":"1963","unstructured":"Todaro, G.J. & Green, H. Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J. Cell Biol. 17, 299\u2013313 (1963).","journal-title":"J. Cell Biol."},{"key":"BFnn2438_CR39","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1042\/bj20020822","volume":"367","author":"V Hospital","year":"2002","unstructured":"Hospital, V. et al. The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor\u2013like growth factor (HB-EGF). Biochem. J. 367, 229\u2013238 (2002).","journal-title":"Biochem. J."}],"container-title":["Nature Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nn.2438.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn.2438","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn.2438.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T20:04:50Z","timestamp":1684440290000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nn.2438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,22]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["BFnn2438"],"URL":"https:\/\/doi.org\/10.1038\/nn.2438","relation":{},"ISSN":["1097-6256","1546-1726"],"issn-type":[{"value":"1097-6256","type":"print"},{"value":"1546-1726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,22]]}}}