{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:08:21Z","timestamp":1791893301412,"version":"4.3.4"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2010,1,10]],"date-time":"2010-01-10T00:00:00Z","timestamp":1263081600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Neurosci"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1038\/nn.2477","type":"journal-article","created":{"date-parts":[[2010,1,10]],"date-time":"2010-01-10T18:35:32Z","timestamp":1263148532000},"page":"163-172","source":"Crossref","is-referenced-by-count":224,"title":["Tsc2-Rheb signaling regulates EphA-mediated axon guidance"],"prefix":"10.1038","volume":"13","author":[{"given":"Duyu","family":"Nie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Di Nardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette M","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasani","family":"Baharanyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Kramvis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ThanhThao","family":"Huynh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Dabora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Codeluppi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Paolo","family":"Pandolfi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena B","family":"Pasquale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,1,10]]},"reference":[{"key":"BFnn2477_CR1","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1056\/NEJMra055323","volume":"355","author":"PB Crino","year":"2006","unstructured":"Crino, P.B., Nathanson, K.L. & Henske, E.P. The tuberous sclerosis complex. N. Engl. J. Med. 355, 1345\u20131356 (2006).","journal-title":"N. Engl. J. Med."},{"key":"BFnn2477_CR2","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.1528-1167.2007.01270.x","volume":"49","author":"M Wong","year":"2008","unstructured":"Wong, M. Mechanisms of epileptogenesis in tuberous sclerosis complex and related malformations of cortical development with abnormal glioneuronal proliferation. Epilepsia 49, 8\u201321 (2008).","journal-title":"Epilepsia"},{"key":"BFnn2477_CR3","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S1097-2765(02)00568-3","volume":"10","author":"BD Manning","year":"2002","unstructured":"Manning, B.D., Tee, A.R., Logsdon, M.N., Blenis, J. & Cantley, L.C. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase\/akt pathway. Mol. Cell 10, 151\u2013162 (2002).","journal-title":"Mol. Cell"},{"key":"BFnn2477_CR4","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/ncb839","volume":"4","author":"K Inoki","year":"2002","unstructured":"Inoki, K., Li, Y., Zhu, T., Wu, J. & Guan, K.L. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling. Nat. Cell Biol. 4, 648\u2013657 (2002).","journal-title":"Nat. Cell Biol."},{"key":"BFnn2477_CR5","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.conb.2006.01.010","volume":"16","author":"JG Flanagan","year":"2006","unstructured":"Flanagan, J.G. Neural map specification by gradients. Curr. Opin. Neurobiol. 16, 59\u201366 (2006).","journal-title":"Curr. Opin. Neurobiol."},{"key":"BFnn2477_CR6","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1016\/S0896-6273(00)80650-9","volume":"21","author":"DA Feldheim","year":"1998","unstructured":"Feldheim, D.A. et al. Topographic guidance labels in a sensory projection to the forebrain. Neuron 21, 1303\u20131313 (1998).","journal-title":"Neuron"},{"key":"BFnn2477_CR7","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1038\/nn1508","volume":"8","author":"C Pfeiffenberger","year":"2005","unstructured":"Pfeiffenberger, C. et al. Ephrin-As and neural activity are required for eye-specific patterning during retinogeniculate mapping. Nat. Neurosci. 8, 1022\u20131027 (2005).","journal-title":"Nat. Neurosci."},{"key":"BFnn2477_CR8","doi-asserted-by":"publisher","first-page":"12873","DOI":"10.1523\/JNEUROSCI.3595-06.2006","volume":"26","author":"C Pfeiffenberger","year":"2006","unstructured":"Pfeiffenberger, C., Yamada, J. & Feldheim, D.A. Ephrin-As and patterned retinal activity act together in the development of topographic maps in the primary visual system. J. Neurosci. 26, 12873\u201312884 (2006).","journal-title":"J. Neurosci."},{"key":"BFnn2477_CR9","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.pneurobio.2005.09.002","volume":"76","author":"CL Torborg","year":"2005","unstructured":"Torborg, C.L. & Feller, M.B. Spontaneous patterned retinal activity and the refinement of retinal projections. Prog. Neurobiol. 76, 213\u2013235 (2005).","journal-title":"Prog. Neurobiol."},{"key":"BFnn2477_CR10","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.cell.2008.03.011","volume":"133","author":"EB Pasquale","year":"2008","unstructured":"Pasquale, E.B. Eph-ephrin bidirectional signaling in physiology and disease. Cell 133, 38\u201352 (2008).","journal-title":"Cell"},{"key":"BFnn2477_CR11","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.conb.2008.05.004","volume":"18","author":"AC Lin","year":"2008","unstructured":"Lin, A.C. & Holt, C.E. Function and regulation of local axonal translation. Curr. Opin. Neurobiol. 18, 60\u201368 (2008).","journal-title":"Curr. Opin. Neurobiol."},{"key":"BFnn2477_CR12","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S0092-8674(02)00813-9","volume":"110","author":"PA Brittis","year":"2002","unstructured":"Brittis, P.A., Lu, Q. & Flanagan, J.G. Axonal protein synthesis provides a mechanism for localized regulation at an intermediate target. Cell 110, 223\u2013235 (2002).","journal-title":"Cell"},{"key":"BFnn2477_CR13","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1038\/nn1775","volume":"9","author":"KM Leung","year":"2006","unstructured":"Leung, K.M. et al. Asymmetrical beta-actin mRNA translation in growth cones mediates attractive turning to netrin-1. Nat. Neurosci. 9, 1247\u20131256 (2006).","journal-title":"Nat. Neurosci."},{"key":"BFnn2477_CR14","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1038\/nature03885","volume":"436","author":"KY Wu","year":"2005","unstructured":"Wu, K.Y. et al. Local translation of RhoA regulates growth cone collapse. Nature 436, 1020\u20131024 (2005).","journal-title":"Nature"},{"key":"BFnn2477_CR15","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1038\/nn1773","volume":"9","author":"J Yao","year":"2006","unstructured":"Yao, J., Sasaki, Y., Wen, Z., Bassell, G.J. & Zheng, J.Q. An essential role for beta-actin mRNA localization and translation in Ca2+-dependent growth cone guidance. Nat. Neurosci. 9, 1265\u20131273 (2006).","journal-title":"Nat. Neurosci."},{"key":"BFnn2477_CR16","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/S0896-6273(01)00551-7","volume":"32","author":"DS Campbell","year":"2001","unstructured":"Campbell, D.S. & Holt, C.E. Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation. Neuron 32, 1013\u20131026 (2001).","journal-title":"Neuron"},{"key":"BFnn2477_CR17","doi-asserted-by":"publisher","first-page":"2485","DOI":"10.1101\/gad.1685008","volume":"22","author":"YJ Choi","year":"2008","unstructured":"Choi, Y.J. et al. Tuberous sclerosis complex proteins control axon formation. Genes Dev. 22, 2485\u20132495 (2008).","journal-title":"Genes Dev."},{"key":"BFnn2477_CR18","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1172\/JCI7319","volume":"104","author":"H Onda","year":"1999","unstructured":"Onda, H., Lueck, A., Marks, P.W., Warren, H.B. & Kwiatkowski, D.J. Tsc2+\/\u2212 mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background. J. Clin. Invest. 104, 687\u2013695 (1999).","journal-title":"J. Clin. Invest."},{"key":"BFnn2477_CR19","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jneumeth.2003.11.019","volume":"135","author":"CL Torborg","year":"2004","unstructured":"Torborg, C.L. & Feller, M.B. Unbiased analysis of bulk axonal segregation patterns. J. Neurosci. Methods 135, 17\u201326 (2004).","journal-title":"J. Neurosci. Methods"},{"key":"BFnn2477_CR20","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1016\/j.cell.2007.10.036","volume":"131","author":"B Stevens","year":"2007","unstructured":"Stevens, B. et al. The classical complement cascade mediates CNS synapse elimination. Cell 131, 1164\u20131178 (2007).","journal-title":"Cell"},{"key":"BFnn2477_CR21","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1002\/cne.20602","volume":"488","author":"CA Ellsworth","year":"2005","unstructured":"Ellsworth, C.A., Lyckman, A.W., Feldheim, D.A., Flanagan, J.G. & Sur, M. Ephrin-A2 and -A5 influence patterning of normal and novel retinal projections to the thalamus: conserved mapping mechanisms in visual and auditory thalamic targets. J. Comp. Neurol. 488, 140\u2013151 (2005).","journal-title":"J. Comp. Neurol."},{"key":"BFnn2477_CR22","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1038\/nn1505","volume":"8","author":"AD Huberman","year":"2005","unstructured":"Huberman, A.D., Murray, K.D., Warland, D.K., Feldheim, D.A. & Chapman, B. Ephrin-As mediate targeting of eye-specific projections to the lateral geniculate nucleus. Nat. Neurosci. 8, 1013\u20131021 (2005).","journal-title":"Nat. Neurosci."},{"key":"BFnn2477_CR23","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.neuron.2005.01.030","volume":"46","author":"M Sahin","year":"2005","unstructured":"Sahin, M. et al. Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse. Neuron 46, 191\u2013204 (2005).","journal-title":"Neuron"},{"key":"BFnn2477_CR24","doi-asserted-by":"publisher","first-page":"5926","DOI":"10.1523\/JNEUROSCI.0778-09.2009","volume":"29","author":"A Di Nardo","year":"2009","unstructured":"Di Nardo, A. et al. Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner. J. Neurosci. 29, 5926\u20135937 (2009).","journal-title":"J. Neurosci."},{"key":"BFnn2477_CR25","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/35074604","volume":"3","author":"H Miao","year":"2001","unstructured":"Miao, H. et al. Activation of EphA receptor tyrosine kinase inhibits the Ras\/MAPK pathway. Nat. Cell Biol. 3, 527\u2013530 (2001).","journal-title":"Nat. Cell Biol."},{"key":"BFnn2477_CR26","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1083\/jcb.200703209","volume":"178","author":"DE Willis","year":"2007","unstructured":"Willis, D.E. et al. Extracellular stimuli specifically regulate localized levels of individual neuronal mRNAs. J. Cell Biol. 178, 965\u2013980 (2007).","journal-title":"J. Cell Biol."},{"key":"BFnn2477_CR27","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/S0896-6273(01)00295-1","volume":"30","author":"G Aakalu","year":"2001","unstructured":"Aakalu, G., Smith, W.B., Nguyen, N., Jiang, C. & Schuman, E.M. Dynamic visualization of local protein synthesis in hippocampal neurons. Neuron 30, 489\u2013502 (2001).","journal-title":"Neuron"},{"key":"BFnn2477_CR28","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.neuron.2008.05.029","volume":"59","author":"D Yudin","year":"2008","unstructured":"Yudin, D. et al. Localized regulation of axonal RanGTPase controls retrograde injury signaling in peripheral nerve. Neuron 59, 241\u2013252 (2008).","journal-title":"Neuron"},{"key":"BFnn2477_CR29","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1523\/JNEUROSCI.3845-08.2009","volume":"29","author":"FK Roche","year":"2009","unstructured":"Roche, F.K., Marsick, B.M. & Letourneau, P.C. Protein synthesis in distal axons is not required for growth cone responses to guidance cues. J. Neurosci. 29, 638\u2013652 (2009).","journal-title":"J. Neurosci."},{"key":"BFnn2477_CR30","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.cell.2005.02.031","volume":"121","author":"L Ma","year":"2005","unstructured":"Ma, L., Chen, Z., Erdjument-Bromage, H., Tempst, P. & Pandolfi, P.P. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 121, 179\u2013193 (2005).","journal-title":"Cell"},{"key":"BFnn2477_CR31","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/nature08362","volume":"461","author":"M Torii","year":"2009","unstructured":"Torii, M., Hashimoto-Torii, K., Levitt, P. & Rakic, P. Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signaling. Nature 461, 524\u2013528 (2009).","journal-title":"Nature"},{"key":"BFnn2477_CR32","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1038\/nn.2394","volume":"12","author":"A Filosa","year":"2009","unstructured":"Filosa, A. et al. Neuron-glia communication via EphA4\/ephrin-A3 modulates LTP through glial glutamate transport. Nat. Neurosci. 12, 1285\u20131292 (2009).","journal-title":"Nat. Neurosci."},{"key":"BFnn2477_CR33","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/nm1788","volume":"14","author":"D Ehninger","year":"2008","unstructured":"Ehninger, D. et al. Reversal of learning deficits in a Tsc2+\/\u2212 mouse model of tuberous sclerosis. Nat. Med. 14, 843\u2013848 (2008).","journal-title":"Nat. Med."},{"key":"BFnn2477_CR34","doi-asserted-by":"publisher","first-page":"10694","DOI":"10.1073\/pnas.0504021102","volume":"102","author":"MD Benson","year":"2005","unstructured":"Benson, M.D. et al. Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth. Proc. Natl. Acad. Sci. USA 102, 10694\u201310699 (2005).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn2477_CR35","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1126\/science.1161566","volume":"322","author":"KK Park","year":"2008","unstructured":"Park, K.K. et al. Promoting axon regeneration in the adult CNS by modulation of the PTEN\/mTOR pathway. Science 322, 963\u2013966 (2008).","journal-title":"Science"},{"key":"BFnn2477_CR36","doi-asserted-by":"publisher","first-page":"6811","DOI":"10.1073\/pnas.0602282103","volume":"103","author":"Q Yang","year":"2006","unstructured":"Yang, Q., Inoki, K., Kim, E. & Guan, K.L. TSC1\/TSC2 and Rheb have different effects on TORC1 and TORC2 activity. Proc. Natl. Acad. Sci. USA 103, 6811\u20136816 (2006).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn2477_CR37","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.neuron.2005.12.008","volume":"49","author":"M Piper","year":"2006","unstructured":"Piper, M. et al. Signaling mechanisms underlying Slit2-induced collapse of Xenopus retinal growth cones. Neuron 49, 215\u2013228 (2006).","journal-title":"Neuron"},{"key":"BFnn2477_CR38","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.mcn.2008.09.008","volume":"40","author":"TT Merianda","year":"2009","unstructured":"Merianda, T.T. et al. A functional equivalent of endoplasmic reticulum and Golgi in axons for secretion of locally synthesized proteins. Mol. Cell. Neurosci. 40, 128\u2013142 (2009).","journal-title":"Mol. Cell. Neurosci."},{"key":"BFnn2477_CR39","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1093\/brain\/awf124","volume":"125","author":"PF Bolton","year":"2002","unstructured":"Bolton, P.F., Park, R.J., Higgins, J.N., Griffiths, P.D. & Pickles, A. Neuro-epileptic determinants of autism spectrum disorders in tuberous sclerosis complex. Brain 125, 1247\u20131255 (2002).","journal-title":"Brain"},{"key":"BFnn2477_CR40","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1023\/A:1005679108529","volume":"30","author":"AM Weber","year":"2000","unstructured":"Weber, A.M., Egelhoff, J.C., McKellop, J.M. & Franz, D.N. Autism and the cerebellum: evidence from tuberous sclerosis. J. Autism Dev. Disord. 30, 511\u2013517 (2000).","journal-title":"J. Autism Dev. Disord."},{"key":"BFnn2477_CR41","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1177\/08830738060210020901","volume":"21","author":"V Wong","year":"2006","unstructured":"Wong, V. & Khong, P.L. Tuberous sclerosis complex: correlation of magnetic resonance imaging (MRI) findings with comorbidities. J. Child Neurol. 21, 99\u2013105 (2006).","journal-title":"J. Child Neurol."},{"key":"BFnn2477_CR42","unstructured":"Volpe, J.J. Neuronal proliferation, migration, organization and myelination. in Neurology of the Newborn (ed. Volpe, J.J.) 45\u201399 (W.B. Saunders, Philadelphia, 2001)."},{"key":"BFnn2477_CR43","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1002\/ana.410260303","volume":"26","author":"T Sutula","year":"1989","unstructured":"Sutula, T., Cascino, G., Cavazos, J., Parada, I. & Ramirez, L. Mossy fiber synaptic reorganization in the epileptic human temporal lobe. Ann. Neurol. 26, 321\u2013330 (1989).","journal-title":"Ann. Neurol."},{"key":"BFnn2477_CR44","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1212\/WNL.57.2.245","volume":"57","author":"E Courchesne","year":"2001","unstructured":"Courchesne, E. et al. Unusual brain growth patterns in early life in patients with autistic disorder: an MRI study. Neurology 57, 245\u2013254 (2001).","journal-title":"Neurology"},{"key":"BFnn2477_CR45","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.biopsych.2003.10.022","volume":"55","author":"N Barnea-Goraly","year":"2004","unstructured":"Barnea-Goraly, N. et al. White matter structure in autism: preliminary evidence from diffusion tensor imaging. Biol. Psychiatry 55, 323\u2013326 (2004).","journal-title":"Biol. Psychiatry"},{"key":"BFnn2477_CR46","first-page":"400","volume":"59","author":"EP Henske","year":"1996","unstructured":"Henske, E.P. et al. Allelic loss is frequent in tuberous sclerosis kidney lesions but rare in brain lesions. Am. J. Hum. Genet. 59, 400\u2013406 (1996).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnn2477_CR47","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1038\/nn1566","volume":"8","author":"SF Tavazoie","year":"2005","unstructured":"Tavazoie, S.F., Alvarez, V.A., Ridenour, D.A., Kwiatkowski, D.J. & Sabatini, B.L. Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nat. Neurosci. 8, 1727\u20131734 (2005).","journal-title":"Nat. Neurosci."},{"key":"BFnn2477_CR48","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1002\/ana.21317","volume":"62","author":"SM Goorden","year":"2007","unstructured":"Goorden, S.M., van Woerden, G.M., van der Weerd, L., Cheadle, J.P. & Elgersma, Y. Cognitive deficits in Tsc1+\/\u2212 mice in the absence of cerebral lesions and seizures. Ann. Neurol. 62, 648\u2013655 (2007).","journal-title":"Ann. Neurol."},{"key":"BFnn2477_CR49","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S0092-8674(01)00314-2","volume":"105","author":"SM Shamah","year":"2001","unstructured":"Shamah, S.M. et al. EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin. Cell 105, 233\u2013244 (2001).","journal-title":"Cell"},{"key":"BFnn2477_CR50","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1002\/dvg.20271","volume":"45","author":"O Hernandez","year":"2007","unstructured":"Hernandez, O., Way, S., McKenna, J. III & Gambello, M.J. Generation of a conditional disruption of the Tsc2 gene. Genesis 45, 101\u2013106 (2007).","journal-title":"Genesis"}],"container-title":["Nature Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nn.2477.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn.2477","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn.2477.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:05:11Z","timestamp":1684454711000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nn.2477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,10]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["BFnn2477"],"URL":"https:\/\/doi.org\/10.1038\/nn.2477","relation":{},"ISSN":["1097-6256","1546-1726"],"issn-type":[{"value":"1097-6256","type":"print"},{"value":"1546-1726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,10]]}}}