{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:52:12Z","timestamp":1791273132996,"version":"4.1.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2012,8,26]],"date-time":"2012-08-26T00:00:00Z","timestamp":1345939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Neurosci"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1038\/nn.3199","type":"journal-article","created":{"date-parts":[[2012,8,26]],"date-time":"2012-08-26T18:46:43Z","timestamp":1346006803000},"page":"1422-1429","source":"Crossref","is-referenced-by-count":105,"title":["Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease"],"prefix":"10.1038","volume":"15","author":[{"given":"Nikita","family":"Rudinskiy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M","family":"Hawkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A","family":"Betensky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Eguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara L","family":"Spires-Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley T","family":"Hyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,8,26]]},"reference":[{"key":"BFnn3199_CR1","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/nn.2708","volume":"14","author":"JD Shepherd","year":"2011","unstructured":"Shepherd, J.D. & Bear, M.F. New views of Arc, a master regulator of synaptic plasticity. Nat. Neurosci. 14, 279\u2013284 (2011).","journal-title":"Nat. Neurosci."},{"key":"BFnn3199_CR2","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.tins.2011.08.007","volume":"34","author":"E Korb","year":"2011","unstructured":"Korb, E. & Finkbeiner, S. Arc in synaptic plasticity: from gene to behavior. Trends Neurosci. 34, 591\u2013598 (2011).","journal-title":"Trends Neurosci."},{"key":"BFnn3199_CR3","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1523\/JNEUROSCI.4342-04.2005","volume":"25","author":"V Ram\u00edrez-Amaya","year":"2005","unstructured":"Ram\u00edrez-Amaya, V. et al. Spatial exploration-induced Arc mRNA and protein expression: evidence for selective, network-specific reactivation. J. Neurosci. 25, 1761\u20131768 (2005).","journal-title":"J. Neurosci."},{"key":"BFnn3199_CR4","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/nn1410","volume":"8","author":"Y Tagawa","year":"2005","unstructured":"Tagawa, Y., Kanold, P.O., Majdan, M. & Shatz, C.J. Multiple periods of functional ocular dominance plasticity in mouse visual cortex. Nat. Neurosci. 8, 380\u2013388 (2005).","journal-title":"Nat. Neurosci."},{"key":"BFnn3199_CR5","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.cell.2006.06.038","volume":"126","author":"KH Wang","year":"2006","unstructured":"Wang, K.H. et al. In vivo two-photon imaging reveals a role of arc in enhancing orientation specificity in visual cortex. Cell 126, 389\u2013402 (2006).","journal-title":"Cell"},{"key":"BFnn3199_CR6","doi-asserted-by":"publisher","first-page":"10445","DOI":"10.1523\/JNEUROSCI.2883-07.2007","volume":"27","author":"E Messaoudi","year":"2007","unstructured":"Messaoudi, E. et al. Sustained Arc\/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus in vivo. J. Neurosci. 27, 10445\u201310455 (2007).","journal-title":"J. Neurosci."},{"key":"BFnn3199_CR7","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.neuron.2006.08.033","volume":"52","author":"S Chowdhury","year":"2006","unstructured":"Chowdhury, S. et al. Arc\/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking. Neuron 52, 445\u2013459 (2006).","journal-title":"Neuron"},{"key":"BFnn3199_CR8","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.neuron.2006.08.034","volume":"52","author":"JD Shepherd","year":"2006","unstructured":"Shepherd, J.D. et al. Arc\/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors. Neuron 52, 475\u2013484 (2006).","journal-title":"Neuron"},{"key":"BFnn3199_CR9","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.neuron.2006.08.024","volume":"52","author":"N Plath","year":"2006","unstructured":"Plath, N. et al. Arc\/Arg3.1 is essential for the consolidation of synaptic plasticity and memories. Neuron 52, 437\u2013444 (2006).","journal-title":"Neuron"},{"key":"BFnn3199_CR10","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1016\/j.neuroimage.2008.10.046","volume":"44","author":"M Eguchi","year":"2009","unstructured":"Eguchi, M. & Yamaguchi, S. In vivo and in vitro visualization of gene expression dynamics over extensive areas of the brain. Neuroimage 44, 1274\u20131283 (2009).","journal-title":"Neuroimage"},{"key":"BFnn3199_CR11","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/nn1372","volume":"8","author":"JP Cleary","year":"2005","unstructured":"Cleary, J.P. et al. Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nat. Neurosci. 8, 79\u201384 (2005).","journal-title":"Nat. Neurosci."},{"key":"BFnn3199_CR12","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1038\/nm1782","volume":"14","author":"GM Shankar","year":"2008","unstructured":"Shankar, G.M. et al. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat. Med. 14, 837\u2013842 (2008).","journal-title":"Nat. Med."},{"key":"BFnn3199_CR13","doi-asserted-by":"publisher","first-page":"4012","DOI":"10.1073\/pnas.0811698106","volume":"106","author":"RM Koffie","year":"2009","unstructured":"Koffie, R.M. et al. Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques. Proc. Natl. Acad. Sci. USA 106, 4012\u20134017 (2009).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn3199_CR14","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S1389-0344(01)00067-3","volume":"17","author":"JL Jankowsky","year":"2001","unstructured":"Jankowsky, J.L. et al. Coexpression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol. Eng. 17, 157\u2013165 (2001).","journal-title":"Biomol. Eng."},{"key":"BFnn3199_CR15","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/0006-8993(71)90193-4","volume":"31","author":"C Blakemore","year":"1971","unstructured":"Blakemore, C. & Cooper, G.F. Modification of the visual cortex by experience. Brain Res. 31, 366 (1971).","journal-title":"Brain Res."},{"key":"BFnn3199_CR16","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1038\/11192","volume":"2","author":"F Sengpiel","year":"1999","unstructured":"Sengpiel, F., Stawinski, P. & Bonhoeffer, T. Influence of experience on orientation maps in cat visual cortex. Nat. Neurosci. 2, 727\u2013732 (1999).","journal-title":"Nat. Neurosci."},{"key":"BFnn3199_CR17","doi-asserted-by":"publisher","first-page":"13990","DOI":"10.1073\/pnas.222433299","volume":"99","author":"B Urbanc","year":"2002","unstructured":"Urbanc, B. et al. Neurotoxic effects of thioflavin S\u2013positive amyloid deposits in transgenic mice and Alzheimer's disease. Proc. Natl. Acad. Sci. USA 99, 13990\u201313995 (2002).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn3199_CR18","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S0306-4522(01)00169-5","volume":"105","author":"TC Dickson","year":"2001","unstructured":"Dickson, T.C. & Vickers, J.C. The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer's disease. Neuroscience 105, 99\u2013107 (2001).","journal-title":"Neuroscience"},{"key":"BFnn3199_CR19","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1093\/jnen\/62.12.1220","volume":"62","author":"JL Jankowsky","year":"2003","unstructured":"Jankowsky, J.L., Xu, G., Fromholt, D., Gonzales, V. & Borchelt, D.R. Environmental enrichment exacerbates amyloid plaque formation in a transgenic mouse model of Alzheimer disease. J. Neuropathol. Exp. Neurol. 62, 1220\u20131227 (2003).","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"BFnn3199_CR20","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1038\/nature06616","volume":"451","author":"M Meyer-Luehmann","year":"2008","unstructured":"Meyer-Luehmann, M. et al. Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease. Nature 451, 720\u2013724 (2008).","journal-title":"Nature"},{"key":"BFnn3199_CR21","doi-asserted-by":"publisher","first-page":"7278","DOI":"10.1523\/JNEUROSCI.1879-05.2005","volume":"25","author":"TL Spires","year":"2005","unstructured":"Spires, T.L. et al. Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. J. Neurosci. 25, 7278\u20137287 (2005).","journal-title":"J. Neurosci."},{"key":"BFnn3199_CR22","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.nbd.2010.11.014","volume":"41","author":"A Rozkalne","year":"2011","unstructured":"Rozkalne, A., Hyman, B.T. & Spires-Jones, T.L. Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice. Neurobiol. Dis. 41, 650\u2013654 (2011).","journal-title":"Neurobiol. Dis."},{"key":"BFnn3199_CR23","doi-asserted-by":"publisher","first-page":"7073","DOI":"10.1523\/JNEUROSCI.1120-11.2011","volume":"31","author":"SA Maddox","year":"2011","unstructured":"Maddox, S.A. & Schafe, G.E. The activity-regulated cytoskeletal-associated protein (Arc\/Arg3.1) is required for reconsolidation of a Pavlovian fear memory. J. Neurosci. 31, 7073\u20137082 (2011).","journal-title":"J. Neurosci."},{"key":"BFnn3199_CR24","doi-asserted-by":"publisher","first-page":"3993","DOI":"10.1523\/JNEUROSCI.20-11-03993.2000","volume":"20","author":"JF Guzowski","year":"2000","unstructured":"Guzowski, J.F. et al. Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory. J. Neurosci. 20, 3993\u20134001 (2000).","journal-title":"J. Neurosci."},{"key":"BFnn3199_CR25","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.neuron.2006.09.031","volume":"52","author":"EM Rial Verde","year":"2006","unstructured":"Rial Verde, E.M., Lee-Osbourne, J., Worley, P.F., Malinow, R. & Cline, H.T. Increased expression of the immediate-early gene Arc\/Arg3.1 reduces AMPA receptor-mediated synaptic transmission. Neuron 52, 461\u2013474 (2006).","journal-title":"Neuron"},{"key":"BFnn3199_CR26","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/1750-1326-6-63","volume":"6","author":"RM Koffie","year":"2011","unstructured":"Koffie, R.M., Hyman, B.T. & Spires-Jones, T.L. Alzheimer's disease: synapses gone cold. Mol. Neurodegener. 6, 63 (2011).","journal-title":"Mol. Neurodegener."},{"key":"BFnn3199_CR27","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1126\/science.1162844","volume":"321","author":"MA Busche","year":"2008","unstructured":"Busche, M.A. et al. Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease. Science 321, 1686\u20131689 (2008).","journal-title":"Science"},{"key":"BFnn3199_CR28","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.neuron.2008.06.008","volume":"59","author":"KV Kuchibhotla","year":"2008","unstructured":"Kuchibhotla, K.V. et al. Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks. Neuron 59, 214\u2013225 (2008).","journal-title":"Neuron"},{"key":"BFnn3199_CR29","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.jneumeth.2009.07.015","volume":"184","author":"V Grinevich","year":"2009","unstructured":"Grinevich, V. et al. Fluorescent Arc\/Arg3.1 indicator mice: a versatile tool to study brain activity changes in vitro and in vivo. J. Neurosci. Methods 184, 25\u201336 (2009).","journal-title":"J. Neurosci. Methods"},{"key":"BFnn3199_CR30","doi-asserted-by":"publisher","first-page":"10191","DOI":"10.1523\/JNEUROSCI.3432-04.2004","volume":"24","author":"PN Lacor","year":"2004","unstructured":"Lacor, P.N. et al. Synaptic targeting by Alzheimer's-related amyloid beta oligomers. J. Neurosci. 24, 10191\u201310200 (2004).","journal-title":"J. Neurosci."},{"key":"BFnn3199_CR31","doi-asserted-by":"publisher","first-page":"3926","DOI":"10.1523\/JNEUROSCI.6142-10.2011","volume":"31","author":"C Perez-Cruz","year":"2011","unstructured":"Perez-Cruz, C. et al. Reduced spine density in specific regions of CA1 pyramidal neurons in two transgenic mouse models of Alzheimer's disease. J. Neurosci. 31, 3926\u20133934 (2011).","journal-title":"J. Neurosci."},{"key":"BFnn3199_CR32","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1523\/JNEUROSCI.4469-04.2005","volume":"25","author":"S Rosi","year":"2005","unstructured":"Rosi, S. et al. Neuroinflammation alters the hippocampal pattern of behaviorally induced Arc expression. J. Neurosci. 25, 723\u2013731 (2005).","journal-title":"J. Neurosci."},{"key":"BFnn3199_CR33","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.cell.2011.09.036","volume":"147","author":"J Wu","year":"2011","unstructured":"Wu, J. et al. Arc\/Arg3.1 regulates an endosomal pathway essential for activity-dependent beta-amyloid generation. Cell 147, 615\u2013628 (2011).","journal-title":"Cell"},{"key":"BFnn3199_CR34","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.neuron.2007.07.025","volume":"55","author":"JJ Palop","year":"2007","unstructured":"Palop, J.J. et al. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron 55, 697\u2013711 (2007).","journal-title":"Neuron"},{"key":"BFnn3199_CR35","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1002\/jnr.22057","volume":"87","author":"TJ Chen","year":"2009","unstructured":"Chen, T.J., Wang, D.C. & Chen, S.S. Amyloid-beta interrupts the PI3K-Akt-mTOR signaling pathway that could be involved in brain-derived neurotrophic factor\u2013induced Arc expression in rat cortical neurons. J. Neurosci. Res. 87, 2297\u20132307 (2009).","journal-title":"J. Neurosci. Res."},{"key":"BFnn3199_CR36","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1111\/j.1471-4159.2004.02185.x","volume":"88","author":"CA Dickey","year":"2004","unstructured":"Dickey, C.A. et al. Amyloid suppresses induction of genes critical for memory consolidation in APP + PS1 transgenic mice. J. Neurochem. 88, 434\u2013442 (2004).","journal-title":"J. Neurochem."},{"key":"BFnn3199_CR37","doi-asserted-by":"publisher","first-page":"5219","DOI":"10.1523\/JNEUROSCI.23-12-05219.2003","volume":"23","author":"CA Dickey","year":"2003","unstructured":"Dickey, C.A. et al. Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein + presenilin-1 transgenic mice. J. Neurosci. 23, 5219\u20135226 (2003).","journal-title":"J. Neurosci."},{"key":"BFnn3199_CR38","doi-asserted-by":"publisher","first-page":"518","DOI":"10.2174\/156720507783018190","volume":"4","author":"V Echeverria","year":"2007","unstructured":"Echeverria, V., Berman, D.E. & Arancio, O. Oligomers of beta-amyloid peptide inhibit BDNF-induced arc expression in cultured cortical Neurons. Curr. Alzheimer Res. 4, 518\u2013521 (2007).","journal-title":"Curr. Alzheimer Res."},{"key":"BFnn3199_CR39","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1097\/NEN.0b013e318220a658","volume":"70","author":"LM Fox","year":"2011","unstructured":"Fox, L.M. et al. Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model. J. Neuropathol. Exp. Neurol. 70, 588\u2013595 (2011).","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"BFnn3199_CR40","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1002\/1531-8249(200007)48:1<77::AID-ANA12>3.0.CO;2-A","volume":"48","author":"SD Ginsberg","year":"2000","unstructured":"Ginsberg, S.D., Hemby, S.E., Lee, V.M., Eberwine, J.H. & Trojanowski, J.Q. Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons. Ann. Neurol. 48, 77\u201387 (2000).","journal-title":"Ann. Neurol."},{"key":"BFnn3199_CR41","doi-asserted-by":"publisher","first-page":"9686","DOI":"10.1523\/JNEUROSCI.2829-05.2005","volume":"25","author":"JJ Palop","year":"2005","unstructured":"Palop, J.J. et al. Vulnerability of dentate granule cells to disruption of arc expression in human amyloid precursor protein transgenic mice. J. Neurosci. 25, 9686\u20139693 (2005).","journal-title":"J. Neurosci."},{"key":"BFnn3199_CR42","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.neulet.2005.12.057","volume":"398","author":"DC Wang","year":"2006","unstructured":"Wang, D.C., Chen, S.S., Lee, Y.C. & Chen, T.J. Amyloid-beta at sublethal level impairs BDNF-induced arc expression in cortical neurons. Neurosci. Lett. 398, 78\u201382 (2006).","journal-title":"Neurosci. Lett."},{"key":"BFnn3199_CR43","doi-asserted-by":"publisher","first-page":"271","DOI":"10.2353\/ajpath.2009.090044","volume":"175","author":"BM Wegenast-Braun","year":"2009","unstructured":"Wegenast-Braun, B.M. et al. Independent effects of intra- and extracellular Abeta on learning-related gene expression. Am. J. Pathol. 175, 271\u2013282 (2009).","journal-title":"Am. J. Pathol."},{"key":"BFnn3199_CR44","doi-asserted-by":"publisher","first-page":"9694","DOI":"10.1523\/JNEUROSCI.2980-05.2005","volume":"25","author":"J Chin","year":"2005","unstructured":"Chin, J. et al. Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease. J. Neurosci. 25, 9694\u20139703 (2005).","journal-title":"J. Neurosci."},{"key":"BFnn3199_CR45","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1111\/j.1476-5381.2011.01517.x","volume":"164","author":"M Cuadrado-Tejedor","year":"2011","unstructured":"Cuadrado-Tejedor, M. et al. Sildenafil restores cognitive function without affecting beta-amyloid burden in a mouse model of Alzheimer's disease. Br. J. Pharmacol. 164, 2029\u20132041 (2011).","journal-title":"Br. J. Pharmacol."},{"key":"BFnn3199_CR46","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1096\/fj.11-193193","volume":"26","author":"A Herring","year":"2012","unstructured":"Herring, A. et al. Exercise during pregnancy mitigates Alzheimer-like pathology in mouse offspring. FASEB J. 26, 117\u2013128 (2012).","journal-title":"FASEB J."},{"key":"BFnn3199_CR47","doi-asserted-by":"publisher","first-page":"3586","DOI":"10.1073\/pnas.92.8.3586","volume":"92","author":"BT Hyman","year":"1995","unstructured":"Hyman, B.T. et al. Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome). Proc. Natl. Acad. Sci. USA 92, 3586\u20133590 (1995).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn3199_CR48","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1038\/nn.2583","volume":"13","author":"JJ Palop","year":"2010","unstructured":"Palop, J.J. & Mucke, L. Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks. Nat. Neurosci. 13, 812\u2013818 (2010).","journal-title":"Nat. Neurosci."},{"key":"BFnn3199_CR49","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1093\/brain\/awr066","volume":"134","author":"A Drzezga","year":"2011","unstructured":"Drzezga, A. et al. Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden. Brain 134, 1635\u20131646 (2011).","journal-title":"Brain"},{"key":"BFnn3199_CR50","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.neuron.2009.07.003","volume":"63","author":"RA Sperling","year":"2009","unstructured":"Sperling, R.A. et al. Amyloid deposition is associated with impaired default network function in older persons without dementia. Neuron 63, 178\u2013188 (2009).","journal-title":"Neuron"},{"key":"BFnn3199_CR51","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1093\/bioinformatics\/btp184","volume":"25","author":"S Preibisch","year":"2009","unstructured":"Preibisch, S., Saalfeld, S. & Tomancak, P. Globally optimal stitching of tiled 3D microscopic image acquisitions. Bioinformatics 25, 1463\u20131465 (2009).","journal-title":"Bioinformatics"}],"container-title":["Nature Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nn.3199.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn.3199","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn.3199.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:11:57Z","timestamp":1684455117000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nn.3199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,26]]},"references-count":51,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["BFnn3199"],"URL":"https:\/\/doi.org\/10.1038\/nn.3199","relation":{},"ISSN":["1097-6256","1546-1726"],"issn-type":[{"value":"1097-6256","type":"print"},{"value":"1546-1726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,26]]}}}