{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:26:18Z","timestamp":1791426378843,"version":"4.3.3"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2013,7,14]],"date-time":"2013-07-14T00:00:00Z","timestamp":1373760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2013,7,14]],"date-time":"2013-07-14T00:00:00Z","timestamp":1373760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Neurosci"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1038\/nn.3461","type":"journal-article","created":{"date-parts":[[2013,7,14]],"date-time":"2013-07-14T18:29:04Z","timestamp":1373826544000},"page":"1049-1059","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Bidirectional NMDA receptor plasticity controls CA3 output and heterosynaptic metaplasticity"],"prefix":"10.1038","volume":"16","author":[{"given":"David L","family":"Hunt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagore","family":"Puente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Grandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo E","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,14]]},"reference":[{"key":"BFnn3461_CR1","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1146\/annurev.ne.16.030193.001231","volume":"16","author":"NW Daw","year":"1993","unstructured":"Daw, N.W., Stein, P.S. & Fox, K. The role of NMDA receptors in information processing. Annu. Rev. Neurosci. 16, 207\u2013222 (1993).","journal-title":"Annu. Rev. Neurosci."},{"key":"BFnn3461_CR2","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.conb.2012.01.007","volume":"22","author":"DL Hunt","year":"2012","unstructured":"Hunt, D.L. & Castillo, P.E. Synaptic plasticity of NMDA receptors: mechanisms and functional implications. Curr. Opin. Neurobiol. 22, 496\u2013508 (2012).","journal-title":"Curr. Opin. Neurobiol."},{"key":"BFnn3461_CR3","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1124\/pr.109.002451","volume":"62","author":"SF Traynelis","year":"2010","unstructured":"Traynelis, S.F. et al. Glutamate receptor ion channels: structure, regulation, and function. Pharmacol. Rev. 62, 405\u2013496 (2010).","journal-title":"Pharmacol. Rev."},{"key":"BFnn3461_CR4","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/S0959-4388(00)00217-8","volume":"11","author":"J Schiller","year":"2001","unstructured":"Schiller, J. & Schiller, Y. NMDA receptor-mediated dendritic spikes and coincident signal amplification. Curr. Opin. Neurobiol. 11, 343\u2013348 (2001).","journal-title":"Curr. Opin. Neurobiol."},{"key":"BFnn3461_CR5","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/322265a0","volume":"322","author":"CE Herron","year":"1986","unstructured":"Herron, C.E., Lester, R.A., Coan, E.J. & Collingridge, G.L. Frequency-dependent involvement of NMDA receptors in the hippocampus: a novel synaptic mechanism. Nature 322, 265\u2013268 (1986).","journal-title":"Nature"},{"key":"BFnn3461_CR6","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.neuron.2007.11.024","volume":"57","author":"HB Kwon","year":"2008","unstructured":"Kwon, H.B. & Castillo, P.E. Long-term potentiation selectively expressed by NMDA receptors at hippocampal mossy fiber synapses. Neuron 57, 108\u2013120 (2008).","journal-title":"Neuron"},{"key":"BFnn3461_CR7","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.neuron.2007.11.023","volume":"57","author":"N Rebola","year":"2008","unstructured":"Rebola, N., Lujan, R., Cunha, R.A. & Mulle, C. Adenosine A2A receptors are essential for long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses. Neuron 57, 121\u2013134 (2008).","journal-title":"Neuron"},{"key":"BFnn3461_CR8","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1038\/nrn1786","volume":"6","author":"RA Nicoll","year":"2005","unstructured":"Nicoll, R.A. & Schmitz, D. Synaptic plasticity at hippocampal mossy fibre synapses. Nat. Rev. Neurosci. 6, 863\u2013876 (2005).","journal-title":"Nat. Rev. Neurosci."},{"key":"BFnn3461_CR9","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1113\/jphysiol.1993.sp019965","volume":"472","author":"P Jonas","year":"1993","unstructured":"Jonas, P., Major, G. & Sakmann, B. Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. J. Physiol. (Lond.) 472, 615\u2013663 (1993).","journal-title":"J. Physiol. (Lond.)"},{"key":"BFnn3461_CR10","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/nn.2809","volume":"14","author":"N Rebola","year":"2011","unstructured":"Rebola, N., Carta, M., Lanore, F., Blanchet, C. & Mulle, C. NMDA receptor-dependent metaplasticity at hippocampal mossy fiber synapses. Nat. Neurosci. 14, 691\u2013693 (2011).","journal-title":"Nat. Neurosci."},{"key":"BFnn3461_CR11","doi-asserted-by":"publisher","first-page":"4475","DOI":"10.1113\/jphysiol.2010.198366","volume":"588","author":"S Astori","year":"2010","unstructured":"Astori, S., Pawlak, V. & Kohr, G. Spike-timing-dependent plasticity in hippocampal CA3 neurons. J. Physiol. (Lond.) 588, 4475\u20134488 (2010).","journal-title":"J. Physiol. (Lond.)"},{"key":"BFnn3461_CR12","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/nn887","volume":"5","author":"DA Henze","year":"2002","unstructured":"Henze, D.A., Wittner, L. & Buzsaki, G. Single granule cells reliably discharge targets in the hippocampal CA3 network in vivo. Nat. Neurosci. 5, 790\u2013795 (2002).","journal-title":"Nat. Neurosci."},{"key":"BFnn3461_CR13","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1098\/rstb.1971.0078","volume":"262","author":"D Marr","year":"1971","unstructured":"Marr, D. Simple memory: a theory for archicortex. Phil. Trans. R. Soc. Lond. B 262, 23\u201381 (1971).","journal-title":"Phil. Trans. R. Soc. Lond. B"},{"key":"BFnn3461_CR14","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1002\/hipo.450030209","volume":"3","author":"MW Jung","year":"1993","unstructured":"Jung, M.W. & McNaughton, B.L. Spatial selectivity of unit activity in the hippocampal granular layer. Hippocampus 3, 165\u2013182 (1993).","journal-title":"Hippocampus"},{"key":"BFnn3461_CR15","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1146\/annurev.neuro.31.060407.125639","volume":"31","author":"N Caporale","year":"2008","unstructured":"Caporale, N. & Dan, Y. Spike timing-dependent plasticity: a Hebbian learning rule. Annu. Rev. Neurosci. 31, 25\u201346 (2008).","journal-title":"Annu. Rev. Neurosci."},{"key":"BFnn3461_CR16","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1111\/j.1460-9568.1996.tb01611.x","volume":"8","author":"R Lujan","year":"1996","unstructured":"Lujan, R., Nusser, Z., Roberts, J.D., Shigemoto, R. & Somogyi, P. Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus. Eur. J. Neurosci. 8, 1488\u20131500 (1996).","journal-title":"Eur. J. Neurosci."},{"key":"BFnn3461_CR17","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1038\/nn1506","volume":"8","author":"W Morishita","year":"2005","unstructured":"Morishita, W., Marie, H. & Malenka, R.C. Distinct triggering and expression mechanisms underlie LTD of AMPA and NMDA synaptic responses. Nat. Neurosci. 8, 1043\u20131050 (2005).","journal-title":"Nat. Neurosci."},{"key":"BFnn3461_CR18","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/hipo.20654","volume":"20","author":"Y Peng","year":"2010","unstructured":"Peng, Y. et al. Distinct trafficking and expression mechanisms underlie LTP and LTD of NMDA receptor-mediated synaptic responses. Hippocampus 20, 646\u2013658 (2010).","journal-title":"Hippocampus"},{"key":"BFnn3461_CR19","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1152\/jn.90643.2008","volume":"101","author":"DR Ireland","year":"2009","unstructured":"Ireland, D.R. & Abraham, W.C. Mechanisms of group I mGluR-dependent long-term depression of NMDA receptor-mediated transmission at Schaffer collateral-CA1 synapses. J. Neurophysiol. 101, 1375\u20131385 (2009).","journal-title":"J. Neurophysiol."},{"key":"BFnn3461_CR20","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/nrn2356","volume":"9","author":"WC Abraham","year":"2008","unstructured":"Abraham, W.C. Metaplasticity: tuning synapses and networks for plasticity. Nat. Rev. Neurosci. 9, 387\u2013399 (2008).","journal-title":"Nat. Rev. Neurosci."},{"key":"BFnn3461_CR21","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/S0896-6273(03)00873-0","volume":"41","author":"K Kobayashi","year":"2004","unstructured":"Kobayashi, K. & Poo, M.M. Spike train timing-dependent associative modification of hippocampal CA3 recurrent synapses by mossy fibers. Neuron 41, 445\u2013454 (2004).","journal-title":"Neuron"},{"key":"BFnn3461_CR22","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0306-4522(01)00293-7","volume":"107","author":"A Kapur","year":"2001","unstructured":"Kapur, A., Yeckel, M. & Johnston, D. Hippocampal mossy fiber activity evokes Ca2+ release in CA3 pyramidal neurons via a metabotropic glutamate receptor pathway. Neuroscience 107, 59\u201369 (2001).","journal-title":"Neuroscience"},{"key":"BFnn3461_CR23","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/nrn3168","volume":"13","author":"WN Ross","year":"2012","unstructured":"Ross, W.N. Understanding calcium waves and sparks in central neurons. Nat. Rev. Neurosci. 13, 157\u2013168 (2012).","journal-title":"Nat. Rev. Neurosci."},{"key":"BFnn3461_CR24","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.neuron.2009.05.013","volume":"62","author":"T Nakashiba","year":"2009","unstructured":"Nakashiba, T., Buhl, D.L., McHugh, T.J. & Tonegawa, S. Hippocampal CA3 output is crucial for ripple-associated reactivation and consolidation of memory. Neuron 62, 781\u2013787 (2009).","journal-title":"Neuron"},{"key":"BFnn3461_CR25","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1126\/science.1071795","volume":"297","author":"K Nakazawa","year":"2002","unstructured":"Nakazawa, K. et al. Requirement for hippocampal CA3 NMDA receptors in associative memory recall. Science 297, 211\u2013218 (2002).","journal-title":"Science"},{"key":"BFnn3461_CR26","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/S0896-6273(03)00165-X","volume":"38","author":"K Nakazawa","year":"2003","unstructured":"Nakazawa, K. et al. Hippocampal CA3 NMDA receptors are crucial for memory acquisition of one-time experience. Neuron 38, 305\u2013315 (2003).","journal-title":"Neuron"},{"key":"BFnn3461_CR27","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.conb.2005.10.002","volume":"15","author":"S Leutgeb","year":"2005","unstructured":"Leutgeb, S., Leutgeb, J.K., Moser, M.B. & Moser, E.I. Place cells, spatial maps and the population code for memory. Curr. Opin. Neurobiol. 15, 738\u2013746 (2005).","journal-title":"Curr. Opin. Neurobiol."},{"key":"BFnn3461_CR28","doi-asserted-by":"publisher","first-page":"15628","DOI":"10.1523\/JNEUROSCI.3099-10.2010","volume":"30","author":"CL Torborg","year":"2010","unstructured":"Torborg, C.L., Nakashiba, T., Tonegawa, S. & McBain, C.J. Control of CA3 output by feedforward inhibition despite developmental changes in the excitation-inhibition balance. J. Neurosci. 30, 15628\u201315637 (2010).","journal-title":"J. Neurosci."},{"key":"BFnn3461_CR29","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nature02854","volume":"431","author":"M Mori","year":"2004","unstructured":"Mori, M., Abegg, M.H., Gahwiler, B.H. & Gerber, U. A frequency-dependent switch from inhibition to excitation in a hippocampal unitary circuit. Nature 431, 453\u2013456 (2004).","journal-title":"Nature"},{"key":"BFnn3461_CR30","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1038\/nrn2886","volume":"11","author":"A Kumar","year":"2010","unstructured":"Kumar, A., Rotter, S. & Aertsen, A. Spiking activity propagation in neuronal networks: reconciling different perspectives on neural coding. Nat. Rev. Neurosci. 11, 615\u2013627 (2010).","journal-title":"Nat. Rev. Neurosci."},{"key":"BFnn3461_CR31","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/S0166-2236(96)10070-9","volume":"20","author":"JE Lisman","year":"1997","unstructured":"Lisman, J.E. Bursts as a unit of neural information: making unreliable synapses reliable. Trends Neurosci. 20, 38\u201343 (1997).","journal-title":"Trends Neurosci."},{"key":"BFnn3461_CR32","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1016\/j.neuron.2009.05.011","volume":"62","author":"MT Harnett","year":"2009","unstructured":"Harnett, M.T., Bernier, B.E., Ahn, K.C. & Morikawa, H. Burst-timing\u2013dependent plasticity of NMDA receptor-mediated transmission in midbrain dopamine neurons. Neuron 62, 826\u2013838 (2009).","journal-title":"Neuron"},{"key":"BFnn3461_CR33","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/S0959-4388(02)00325-2","volume":"12","author":"PJ Sjostrom","year":"2002","unstructured":"Sjostrom, P.J. & Nelson, S.B. Spike timing, calcium signals and synaptic plasticity. Curr. Opin. Neurobiol. 12, 305\u2013314 (2002).","journal-title":"Curr. Opin. Neurobiol."},{"key":"BFnn3461_CR34","doi-asserted-by":"publisher","first-page":"9574","DOI":"10.1073\/pnas.86.23.9574","volume":"86","author":"J Lisman","year":"1989","unstructured":"Lisman, J. A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory. Proc. Natl. Acad. Sci. USA 86, 9574\u20139578 (1989).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn3461_CR35","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1002\/jcp.10081","volume":"191","author":"O Valenti","year":"2002","unstructured":"Valenti, O., Conn, P.J. & Marino, M.J. Distinct physiological roles of the Gq-coupled metabotropic glutamate receptors Co-expressed in the same neuronal populations. J. Cell. Physiol. 191, 125\u2013137 (2002).","journal-title":"J. Cell. Physiol."},{"key":"BFnn3461_CR36","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1113\/jphysiol.2006.112896","volume":"575","author":"L Topolnik","year":"2006","unstructured":"Topolnik, L., Azzi, M., Morin, F., Kougioumoutzakis, A. & Lacaille, J.C. mGluR1\/5 subtype-specific calcium signalling and induction of long-term potentiation in rat hippocampal oriens\/alveus interneurones. J. Physiol. (Lond.) 575, 115\u2013131 (2006).","journal-title":"J. Physiol. (Lond.)"},{"key":"BFnn3461_CR37","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.coph.2006.08.008","volume":"7","author":"U Gerber","year":"2007","unstructured":"Gerber, U., Gee, C.E. & Benquet, P. Metabotropic glutamate receptors: intracellular signaling pathways. Curr. Opin. Pharmacol. 7, 56\u201361 (2007).","journal-title":"Curr. Opin. Pharmacol."},{"key":"BFnn3461_CR38","doi-asserted-by":"publisher","first-page":"16897","DOI":"10.1523\/JNEUROSCI.1264-11.2011","volume":"31","author":"SF Frausto","year":"2011","unstructured":"Frausto, S.F., Ito, K., Marszalec, W. & Swanson, G.T. A novel form of low-frequency hippocampal mossy fiber plasticity induced by bimodal mGlu1 receptor signaling. J. Neurosci. 31, 16897\u201316906 (2011).","journal-title":"J. Neurosci."},{"key":"BFnn3461_CR39","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/nn1387","volume":"8","author":"HX Wang","year":"2005","unstructured":"Wang, H.X., Gerkin, R.C., Nauen, D.W. & Bi, G.Q. Coactivation and timing-dependent integration of synaptic potentiation and depression. Nat. Neurosci. 8, 187\u2013193 (2005).","journal-title":"Nat. Neurosci."},{"key":"BFnn3461_CR40","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.neuron.2010.09.023","volume":"68","author":"G Buzsaki","year":"2010","unstructured":"Buzsaki, G. Neural syntax: cell assemblies, synapsembles, and readers. Neuron 68, 362\u2013385 (2010).","journal-title":"Neuron"},{"key":"BFnn3461_CR41","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1038\/11184","volume":"2","author":"JS Bains","year":"1999","unstructured":"Bains, J.S., Longacher, J.M. & Staley, K.J. Reciprocal interactions between CA3 network activity and strength of recurrent collateral synapses. Nat. Neurosci. 2, 720\u2013726 (1999).","journal-title":"Nat. Neurosci."},{"key":"BFnn3461_CR42","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.tins.2003.09.007","volume":"26","author":"JJ Lawrence","year":"2003","unstructured":"Lawrence, J.J. & McBain, C.J. Interneuron diversity series: containing the detonation\u2013feedforward inhibition in the CA3 hippocampus. Trends Neurosci. 26, 631\u2013640 (2003).","journal-title":"Trends Neurosci."},{"key":"BFnn3461_CR43","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1126\/science.1060342","volume":"293","author":"F Pouille","year":"2001","unstructured":"Pouille, F. & Scanziani, M. Enforcement of temporal fidelity in pyramidal cells by somatic feed-forward inhibition. Science 293, 1159\u20131163 (2001).","journal-title":"Science"},{"key":"BFnn3461_CR44","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1111\/j.1469-7793.1998.237bu.x","volume":"507","author":"D Debanne","year":"1998","unstructured":"Debanne, D., Gahwiler, B.H. & Thompson, S.M. Long-term synaptic plasticity between pairs of individual CA3 pyramidal cells in rat hippocampal slice cultures. J. Physiol. (Lond.) 507, 237\u2013247 (1998).","journal-title":"J. Physiol. (Lond.)"},{"key":"BFnn3461_CR45","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1038\/78829","volume":"3","author":"S Song","year":"2000","unstructured":"Song, S., Miller, K.D. & Abbott, L.F. Competitive Hebbian learning through spike-timing-dependent synaptic plasticity. Nat. Neurosci. 3, 919\u2013926 (2000).","journal-title":"Nat. Neurosci."},{"key":"BFnn3461_CR46","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1113\/jphysiol.2002.033803","volume":"546","author":"M Tsukamoto","year":"2003","unstructured":"Tsukamoto, M. et al. Mossy fibre synaptic NMDA receptors trigger non-Hebbian long-term potentiation at entorhino-CA3 synapses in the rat. J. Physiol. (Lond.) 546, 665\u2013675 (2003).","journal-title":"J. Physiol. (Lond.)"},{"key":"BFnn3461_CR47","doi-asserted-by":"publisher","first-page":"2584","DOI":"10.1152\/jn.00011.2008","volume":"99","author":"G Major","year":"2008","unstructured":"Major, G., Polsky, A., Denk, W., Schiller, J. & Tank, D.W. Spatiotemporally graded NMDA spike\/plateau potentials in basal dendrites of neocortical pyramidal neurons. J. Neurophysiol. 99, 2584\u20132601 (2008).","journal-title":"J. Neurophysiol."},{"key":"BFnn3461_CR48","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/j.neuron.2011.02.006","volume":"69","author":"T Branco","year":"2011","unstructured":"Branco, T. & Hausser, M. Synaptic integration gradients in single cortical pyramidal cell dendrites. Neuron 69, 885\u2013892 (2011).","journal-title":"Neuron"},{"key":"BFnn3461_CR49","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/35046067","volume":"408","author":"M Nishiyama","year":"2000","unstructured":"Nishiyama, M., Hong, K., Mikoshiba, K., Poo, M.M. & Kato, K. Calcium stores regulate the polarity and input specificity of synaptic modification. Nature 408, 584\u2013588 (2000).","journal-title":"Nature"},{"key":"BFnn3461_CR50","doi-asserted-by":"publisher","first-page":"6785","DOI":"10.1523\/JNEUROSCI.0634-12.2012","volume":"32","author":"SR Hulme","year":"2012","unstructured":"Hulme, S.R., Jones, O.D., Ireland, D.R. & Abraham, W.C. Calcium-Dependent But Action Potential-Independent BCM-Like Metaplasticity in the Hippocampus. J. Neurosci. 32, 6785\u20136794 (2012).","journal-title":"J. Neurosci."},{"key":"BFnn3461_CR51","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1002\/(SICI)1096-9861(19980112)390:2<225::AID-CNE5>3.0.CO;2-3","volume":"390","author":"JM Mateos","year":"1998","unstructured":"Mateos, J.M. et al. Immunocytochemical localization of the mGluR1b metabotropic glutamate receptor in the rat hypothalamus. J. Comp. Neurol. 390, 225\u2013233 (1998).","journal-title":"J. Comp. Neurol."},{"key":"BFnn3461_CR52","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1002\/(SICI)1096-9861(19981026)400:3<391::AID-CNE8>3.0.CO;2-3","volume":"400","author":"F Ferraguti","year":"1998","unstructured":"Ferraguti, F. et al. Immunohistochemical localization of the mGluR1beta metabotropic glutamate receptor in the adult rodent forebrain: evidence for a differential distribution of mGluR1 splice variants. J. Comp. Neurol. 400, 391\u2013407 (1998).","journal-title":"J. Comp. Neurol."},{"key":"BFnn3461_CR53","doi-asserted-by":"publisher","first-page":"3663","DOI":"10.1523\/JNEUROSCI.0448-07.2007","volume":"27","author":"M Uchigashima","year":"2007","unstructured":"Uchigashima, M. et al. Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum. J. Neurosci. 27, 3663\u20133676 (2007).","journal-title":"J. Neurosci."},{"key":"BFnn3461_CR54","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1046\/j.1460-9568.2000.00959.x","volume":"12","author":"J Tanaka","year":"2000","unstructured":"Tanaka, J. et al. Gq protein alpha subunits Galphaq and Galpha11 are localized at postsynaptic extra-junctional membrane of cerebellar Purkinje cells and hippocampal pyramidal cells. Eur. J. Neurosci. 12, 781\u2013792 (2000).","journal-title":"Eur. J. Neurosci."}],"container-title":["Nature Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/nn.3461.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nn.3461","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nn.3461.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T15:38:46Z","timestamp":1715701126000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nn.3461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,14]]},"references-count":54,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["BFnn3461"],"URL":"https:\/\/doi.org\/10.1038\/nn.3461","relation":{},"ISSN":["1097-6256","1546-1726"],"issn-type":[{"value":"1097-6256","type":"print"},{"value":"1546-1726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,14]]},"assertion":[{"value":"23 December 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}