{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:18:20Z","timestamp":1792523900397,"version":"4.5.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Neurosci"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1038\/nn.3512","type":"journal-article","created":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T13:29:34Z","timestamp":1378042174000},"page":"1453-1460","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":355,"title":["Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner"],"prefix":"10.1038","volume":"16","author":[{"given":"Varun K","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Scheunemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Eisenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mertel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Bhukel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom S","family":"Koemans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie M","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen S Y","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Schroeder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik G","family":"Stunnenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Sinner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Magnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R","family":"Pieber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubham","family":"Dipt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Fiala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Schenck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schwaerzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Madeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan J","family":"Sigrist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,9,1]]},"reference":[{"key":"BFnn3512_CR1","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/S0896-6273(03)00732-3","volume":"40","author":"T Tamura","year":"2003","unstructured":"Tamura, T. et al. Aging specifically impairs amnesiac-dependent memory in Drosophila. Neuron 40, 1003\u20131011 (2003).","journal-title":"Neuron"},{"key":"BFnn3512_CR2","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1038\/nn1863","volume":"10","author":"D Yamazaki","year":"2007","unstructured":"Yamazaki, D. et al. The Drosophila DCO mutation suppresses age-related memory impairment without affecting lifespan. Nat. Neurosci. 10, 478\u2013484 (2007).","journal-title":"Nat. Neurosci."},{"key":"BFnn3512_CR3","doi-asserted-by":"publisher","first-page":"6319","DOI":"10.1073\/pnas.1118126109","volume":"109","author":"A Tonoki","year":"2012","unstructured":"Tonoki, A. & Davis, R.L. Aging impairs intermediate-term behavioral memory by disrupting the dorsal paired medial neuron memory trace. Proc. Natl. Acad. Sci. USA 109, 6319\u20136324 (2012).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn3512_CR4","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1515\/REVNEURO.2005.16.2.137","volume":"16","author":"M Saitoe","year":"2005","unstructured":"Saitoe, M., Horiuchi, J., Tamura, T. & Ito, N. Drosophila as a novel animal model for studying the genetics of age-related memory impairment. Rev. Neurosci. 16, 137\u2013149 (2005).","journal-title":"Rev. Neurosci."},{"key":"BFnn3512_CR5","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/BF01350033","volume":"157","author":"T Tully","year":"1985","unstructured":"Tully, T. & Quinn, W.G. Classical conditioning and retention in normal and mutant Drosophila melanogaster. J. Comp. Physiol. A 157, 263\u2013277 (1985).","journal-title":"J. Comp. Physiol. A"},{"key":"BFnn3512_CR6","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/nature08983","volume":"464","author":"NA Bishop","year":"2010","unstructured":"Bishop, N.A., Lu, T. & Yankner, B.A. Neural mechanisms of ageing and cognitive decline. Nature 464, 529\u2013535 (2010).","journal-title":"Nature"},{"key":"BFnn3512_CR7","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1126\/science.1087782","volume":"301","author":"A Mel\u00e9ndez","year":"2003","unstructured":"Mel\u00e9ndez, A. et al. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 301, 1387\u20131391 (2003).","journal-title":"Science"},{"key":"BFnn3512_CR8","doi-asserted-by":"publisher","first-page":"e24","DOI":"10.1371\/journal.pgen.0040024","volume":"4","author":"M Hansen","year":"2008","unstructured":"Hansen, M. et al. A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet. 4, e24 (2008).","journal-title":"PLoS Genet."},{"key":"BFnn3512_CR9","doi-asserted-by":"publisher","first-page":"176","DOI":"10.4161\/auto.5269","volume":"4","author":"A Simonsen","year":"2008","unstructured":"Simonsen, A. et al. Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy 4, 176\u2013184 (2008).","journal-title":"Autophagy"},{"key":"BFnn3512_CR10","doi-asserted-by":"publisher","first-page":"3061","DOI":"10.1101\/gad.1600707","volume":"21","author":"G Juh\u00e1sz","year":"2007","unstructured":"Juh\u00e1sz, G., Erdi, B., Sass, M. & Neufeld, T.P. Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila. Genes Dev. 21, 3061\u20133066 (2007).","journal-title":"Genes Dev."},{"key":"BFnn3512_CR11","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/0531-5565(82)90042-0","volume":"17","author":"R Das","year":"1982","unstructured":"Das, R. & Kanungo, M.S. Activity and modulation of ornithine decarboxylase and concentrations of polyamines in various tissues of rats as a function of age. Exp. Gerontol. 17, 95\u2013103 (1982).","journal-title":"Exp. Gerontol."},{"key":"BFnn3512_CR12","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0304-3940(01)01776-1","volume":"304","author":"M Viv\u00f3","year":"2001","unstructured":"Viv\u00f3, M. et al. Polyamines in the basal ganglia of human brain. Influence of aging and degenerative movement disorders. Neurosci. Lett. 304, 107\u2013111 (2001).","journal-title":"Neurosci. Lett."},{"key":"BFnn3512_CR13","doi-asserted-by":"publisher","first-page":"716","DOI":"10.18632\/aging.100361","volume":"3","author":"N Minois","year":"2011","unstructured":"Minois, N., Carmona-Gutierrez, D. & Madeo, F. Polyamines in aging and disease. Aging (Albany, NY) 3, 716\u2013732 (2011).","journal-title":"Aging (Albany, NY)"},{"key":"BFnn3512_CR14","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1038\/ncb1975","volume":"11","author":"T Eisenberg","year":"2009","unstructured":"Eisenberg, T. et al. Induction of autophagy by spermidine promotes longevity. Nat. Cell Biol. 11, 1305\u20131314 (2009).","journal-title":"Nat. Cell Biol."},{"key":"BFnn3512_CR15","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/nrn1074","volume":"4","author":"M Heisenberg","year":"2003","unstructured":"Heisenberg, M. Mushroom body memoir: from maps to models. Nat. Rev. Neurosci. 4, 266\u2013275 (2003).","journal-title":"Nat. Rev. Neurosci."},{"key":"BFnn3512_CR16","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/262576a0","volume":"262","author":"WG Quinn","year":"1976","unstructured":"Quinn, W.G. & Dudai, Y. Memory phases in Drosophila. Nature 262, 576\u2013577 (1976).","journal-title":"Nature"},{"key":"BFnn3512_CR17","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/nn.2235","volume":"12","author":"X Liu","year":"2009","unstructured":"Liu, X. & Davis, R.L. The GABAergic anterior paired lateral neuron suppresses and is suppressed by olfactory learning. Nat. Neurosci. 12, 53\u201359 (2009).","journal-title":"Nat. Neurosci."},{"key":"BFnn3512_CR18","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1038\/nature04724","volume":"441","author":"T Hara","year":"2006","unstructured":"Hara, T. et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441, 885\u2013889 (2006).","journal-title":"Nature"},{"key":"BFnn3512_CR19","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1016\/j.cell.2007.10.035","volume":"131","author":"M Komatsu","year":"2007","unstructured":"Komatsu, M. et al. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 131, 1149\u20131163 (2007).","journal-title":"Cell"},{"key":"BFnn3512_CR20","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.cell.2011.07.030","volume":"146","author":"DC Rubinsztein","year":"2011","unstructured":"Rubinsztein, D.C., Marino, G. & Kroemer, G. Autophagy and aging. Cell 146, 682\u2013695 (2011).","journal-title":"Cell"},{"key":"BFnn3512_CR21","doi-asserted-by":"publisher","first-page":"151","DOI":"10.4161\/auto.5338","volume":"4","author":"DJ Klionsky","year":"2008","unstructured":"Klionsky, D.J. et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4, 151\u2013175 (2008).","journal-title":"Autophagy"},{"key":"BFnn3512_CR22","doi-asserted-by":"publisher","first-page":"572","DOI":"10.4161\/auto.7.6.14943","volume":"7","author":"BJ Bartlett","year":"2011","unstructured":"Bartlett, B.J. et al. p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects. Autophagy 7, 572\u2013583 (2011).","journal-title":"Autophagy"},{"key":"BFnn3512_CR23","doi-asserted-by":"publisher","first-page":"24131","DOI":"10.1074\/jbc.M702824200","volume":"282","author":"S Pankiv","year":"2007","unstructured":"Pankiv, S. et al. p62\/SQSTM1 binds directly to Atg8\/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J. Biol. Chem. 282, 24131\u201324145 (2007).","journal-title":"J. Biol. Chem."},{"key":"BFnn3512_CR24","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/26506","volume":"395","author":"N Mizushima","year":"1998","unstructured":"Mizushima, N. et al. A protein conjugation system essential for autophagy. Nature 395, 395\u2013398 (1998).","journal-title":"Nature"},{"key":"BFnn3512_CR25","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.cell.2007.05.021","volume":"130","author":"H Nakatogawa","year":"2007","unstructured":"Nakatogawa, H., Ichimura, Y. & Ohsumi, Y. Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion. Cell 130, 165\u2013178 (2007).","journal-title":"Cell"},{"key":"BFnn3512_CR26","doi-asserted-by":"publisher","first-page":"3290","DOI":"10.1091\/mbc.e07-12-1292","volume":"19","author":"Z Xie","year":"2008","unstructured":"Xie, Z., Nair, U. & Klionsky, D.J. Atg8 controls phagophore expansion during autophagosome formation. Mol. Biol. Cell 19, 3290\u20133298 (2008).","journal-title":"Mol. Biol. Cell"},{"key":"BFnn3512_CR27","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1083\/jcb.201008167","volume":"192","author":"E Morselli","year":"2011","unstructured":"Morselli, E. et al. Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. J. Cell Biol. 192, 615\u2013629 (2011).","journal-title":"J. Cell Biol."},{"key":"BFnn3512_CR28","doi-asserted-by":"publisher","first-page":"e401","DOI":"10.1038\/cddis.2012.139","volume":"3","author":"N Minois","year":"2012","unstructured":"Minois, N. et al. Spermidine promotes stress resistance in Drosophila melanogaster through autophagy-dependent and -independent pathways. Cell Death Dis. 3, e401 (2012).","journal-title":"Cell Death Dis."},{"key":"BFnn3512_CR29","doi-asserted-by":"publisher","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","volume":"11","author":"S Anders","year":"2010","unstructured":"Anders, S. & Huber, W. Differential expression analysis for sequence count data. Genome Biol. 11, R106 (2010).","journal-title":"Genome Biol."},{"key":"BFnn3512_CR30","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"DW Huang","year":"2009","unstructured":"Huang, D.W., Sherman, B.T. & Lempicki, R.A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 4, 44\u201357 (2009).","journal-title":"Nat. Protoc."},{"key":"BFnn3512_CR31","doi-asserted-by":"publisher","first-page":"14529","DOI":"10.1074\/jbc.R500031200","volume":"281","author":"AE Pegg","year":"2006","unstructured":"Pegg, A.E. Regulation of ornithine decarboxylase. J. Biol. Chem. 281, 14529\u201314532 (2006).","journal-title":"J. Biol. Chem."},{"key":"BFnn3512_CR32","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1146\/annurev.neuro.28.061604.135651","volume":"28","author":"RL Davis","year":"2005","unstructured":"Davis, R.L. Olfactory memory formation in Drosophila: from molecular to systems neuroscience. Annu. Rev. Neurosci. 28, 275\u2013302 (2005).","journal-title":"Annu. Rev. Neurosci."},{"key":"BFnn3512_CR33","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1126\/science.1089035","volume":"302","author":"SE McGuire","year":"2003","unstructured":"McGuire, S.E., Le, P.T., Osborn, A.J., Matsumoto, K. & Davis, R.L. Spatiotemporal rescue of memory dysfunction in Drosophila. Science 302, 1765\u20131768 (2003).","journal-title":"Science"},{"key":"BFnn3512_CR34","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.neuroscience.2008.06.033","volume":"155","author":"P Liu","year":"2008","unstructured":"Liu, P., Gupta, N., Jing, Y. & Zhang, H. Age-related changes in polyamines in memory-associated brain structures in rats. Neuroscience 155, 789\u2013796 (2008).","journal-title":"Neuroscience"},{"key":"BFnn3512_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5607\/en.2012.21.1.1","volume":"21","author":"JA Lee","year":"2012","unstructured":"Lee, J.A. Neuronal autophagy: a housekeeper or a fighter in neuronal cell survival? Exp. Neurobiol. 21, 1\u20138 (2012).","journal-title":"Exp. Neurobiol."},{"key":"BFnn3512_CR36","doi-asserted-by":"publisher","first-page":"15024","DOI":"10.1073\/pnas.1206362109","volume":"109","author":"IF Wang","year":"2012","unstructured":"Wang, I.F. et al. Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43. Proc. Natl. Acad. Sci. USA 109, 15024\u201315029 (2012).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn3512_CR37","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1091\/mbc.e08-12-1250","volume":"20","author":"YY Chang","year":"2009","unstructured":"Chang, Y.Y. & Neufeld, T.P. An Atg1\/Atg13 complex with multiple roles in TOR-mediated autophagy regulation. Mol. Biol. Cell 20, 2004\u20132014 (2009).","journal-title":"Mol. Biol. Cell"},{"key":"BFnn3512_CR38","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.cell.2010.10.007","volume":"143","author":"F Demontis","year":"2010","unstructured":"Demontis, F. & Perrimon, N. FOXO\/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. Cell 143, 813\u2013825 (2010).","journal-title":"Cell"},{"key":"BFnn3512_CR39","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/nature04723","volume":"441","author":"M Komatsu","year":"2006","unstructured":"Komatsu, M. et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441, 880\u2013884 (2006).","journal-title":"Nature"},{"key":"BFnn3512_CR40","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1111\/j.1474-9726.2010.00560.x","volume":"9","author":"JM Burger","year":"2010","unstructured":"Burger, J.M., Buechel, S.D. & Kawecki, T.J. Dietary restriction affects lifespan but not cognitive aging in Drosophila melanogaster. Aging Cell 9, 327\u2013335 (2010).","journal-title":"Aging Cell"},{"key":"BFnn3512_CR41","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1126\/science.1094932","volume":"304","author":"G Isabel","year":"2004","unstructured":"Isabel, G., Pascual, A. & Preat, T. Exclusive consolidated memory phases in Drosophila. Science 304, 1024\u20131027 (2004).","journal-title":"Science"},{"key":"BFnn3512_CR42","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/S0960-9822(03)00064-2","volume":"13","author":"J Dubnau","year":"2003","unstructured":"Dubnau, J. et al. The staufen\/pumilio pathway is involved in Drosophila long-term memory. Curr. Biol. 13, 286\u2013296 (2003).","journal-title":"Curr. Biol."},{"key":"BFnn3512_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/01677068509100140","volume":"2","author":"M Heisenberg","year":"1985","unstructured":"Heisenberg, M., Borst, A., Wagner, S. & Byers, D. Drosophila mushroom body mutants are deficient in olfactory learning. J. Neurogenet. 2, 1\u201330 (1985).","journal-title":"J. Neurogenet."},{"key":"BFnn3512_CR44","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/nature11345","volume":"489","author":"K Keleman","year":"2012","unstructured":"Keleman, K. et al. Dopamine neurons modulate pheromone responses in Drosophila courtship learning. Nature 489, 145\u2013149 (2012).","journal-title":"Nature"},{"key":"BFnn3512_CR45","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.cub.2005.02.059","volume":"15","author":"S Xia","year":"2005","unstructured":"Xia, S. et al. NMDA receptors mediate olfactory learning and memory in Drosophila. Curr. Biol. 15, 603\u2013615 (2005).","journal-title":"Curr. Biol."},{"key":"BFnn3512_CR46","doi-asserted-by":"publisher","first-page":"14281","DOI":"10.1523\/JNEUROSCI.0517-12.2012","volume":"32","author":"C Zhou","year":"2012","unstructured":"Zhou, C. et al. Molecular genetic analysis of sexual rejection: roles of octopamine and its receptor OAMB in Drosophila courtship conditioning. J. Neurosci. 32, 14281\u201314287 (2012).","journal-title":"J. Neurosci."},{"key":"BFnn3512_CR47","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/978-1-61779-034-8_28","volume":"720","author":"CE Schwartz","year":"2011","unstructured":"Schwartz, C.E., Wang, X., Stevenson, R.E. & Pegg, A.E. Spermine synthase deficiency resulting in X-linked intellectual disability (Snyder-Robinson syndrome). Methods Mol. Biol. 720, 437\u2013445 (2011).","journal-title":"Methods Mol. Biol."},{"key":"BFnn3512_CR48","doi-asserted-by":"publisher","first-page":"555","DOI":"10.2217\/clp.10.37","volume":"51","author":"DA Elliott","year":"2010","unstructured":"Elliott, D.A., Weickert, C.S. & Garner, B. Apolipoproteins in the brain: implications for neurological and psychiatric disorders. Clin. Lipidol. 51, 555\u2013573 (2010).","journal-title":"Clin. Lipidol."},{"key":"BFnn3512_CR49","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1126\/science.1186088","volume":"328","author":"S Peleg","year":"2010","unstructured":"Peleg, S. et al. Altered histone acetylation is associated with age-dependent memory impairment in mice. Science 328, 753\u2013756 (2010).","journal-title":"Science"},{"key":"BFnn3512_CR50","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1038\/nature05772","volume":"447","author":"A Fischer","year":"2007","unstructured":"Fischer, A., Sananbenesi, F., Wang, X., Dobbin, M. & Tsai, L.H. Recovery of learning and memory is associated with chromatin remodeling. Nature 447, 178\u2013182 (2007).","journal-title":"Nature"},{"key":"BFnn3512_CR51","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1534\/genetics.106.056945","volume":"173","author":"JR Bateman","year":"2006","unstructured":"Bateman, J.R., Lee, A.M. & Wu, C.T. Site-specific transformation of Drosophila via phiC31 integrase-mediated cassette exchange. Genetics 173, 769\u2013777 (2006).","journal-title":"Genetics"},{"key":"BFnn3512_CR52","first-page":"1775","volume":"166","author":"AC Groth","year":"2004","unstructured":"Groth, A.C., Fish, M., Nusse, R. & Calos, M.P. Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31. Genetics 166, 1775\u20131782 (2004).","journal-title":"Genetics"},{"key":"BFnn3512_CR53","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/BF00226036","volume":"13","author":"R Minocha","year":"1994","unstructured":"Minocha, R., Shortle, W.C., Long, S.L. & Minocha, S.C. A rapid and reliable procedure for extraction of cellular polyamines and inorganic ions from plant tissues. J. Plant Growth Regul. 13, 187\u2013193 (1994).","journal-title":"J. Plant Growth Regul."},{"key":"BFnn3512_CR54","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/bmc.898","volume":"22","author":"JA Byun","year":"2008","unstructured":"Byun, J.A. et al. Analysis of polyamines as carbamoyl derivatives in urine and serum by liquid chromatography-tandem mass spectrometry. Biomed. Chromatogr. 22, 73\u201380 (2008).","journal-title":"Biomed. Chromatogr."},{"key":"BFnn3512_CR55","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1083\/jcb.200711108","volume":"180","author":"IP Nezis","year":"2008","unstructured":"Nezis, I.P. et al. Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain. J. Cell Biol. 180, 1065\u20131071 (2008).","journal-title":"J. Cell Biol."},{"key":"BFnn3512_CR56","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1038\/nmeth.1398","volume":"6","author":"L Tian","year":"2009","unstructured":"Tian, L. et al. Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators. Nat. Methods 6, 875\u2013881 (2009).","journal-title":"Nat. Methods"},{"key":"BFnn3512_CR57","doi-asserted-by":"publisher","first-page":"5443","DOI":"10.1523\/JNEUROSCI.16-17-05443.1996","volume":"16","author":"PS Estes","year":"1996","unstructured":"Estes, P.S. et al. Traffic of dynamin within individual Drosophila synaptic boutons relative to compartment-specific markers. J. Neurosci. 16, 5443\u20135456 (1996).","journal-title":"J. Neurosci."},{"key":"BFnn3512_CR58","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1186\/1471-2164-9-488","volume":"9","author":"T Hulsen","year":"2008","unstructured":"Hulsen, T., de Vlieg, J. & Alkema, W. BioVenn: a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams. BMC Genomics 9, 488 (2008).","journal-title":"BMC Genomics"},{"key":"BFnn3512_CR59","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/35006074","volume":"404","author":"MB Feany","year":"2000","unstructured":"Feany, M.B. & Bender, W.W. A Drosophila model of Parkinson's disease. Nature 404, 394\u2013398 (2000).","journal-title":"Nature"},{"key":"BFnn3512_CR60","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.cell.2012.12.023","volume":"152","author":"K Zarnack","year":"2013","unstructured":"Zarnack, K. et al. Direct competition between hnRNP C and U2AF65 protects the transcriptome from the exonization of Alu elements. Cell 152, 453\u2013466 (2013).","journal-title":"Cell"}],"container-title":["Nature Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/nn.3512.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nn.3512","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nn.3512.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T08:30:58Z","timestamp":1650357058000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nn.3512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,1]]},"references-count":60,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["BFnn3512"],"URL":"https:\/\/doi.org\/10.1038\/nn.3512","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718095446.793483079","asserted-by":"object"}]},"ISSN":["1097-6256","1546-1726"],"issn-type":[{"value":"1097-6256","type":"print"},{"value":"1546-1726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,1]]},"assertion":[{"value":"19 June 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}