{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:23:24Z","timestamp":1790432604229,"version":"4.1.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T00:00:00Z","timestamp":1439164800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Neurosci"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1038\/nn.4088","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T16:15:51Z","timestamp":1439223351000},"page":"1236-1246","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["EAG2 potassium channel with evolutionarily conserved function as a brain tumor target"],"prefix":"10.1038","volume":"18","author":[{"given":"Xi","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian M","family":"Dubuc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rintaro","family":"Hashizume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcri","family":"Reimand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanghe","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongfei A","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha J","family":"Stehbens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Younger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Barshow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Peacock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6557-895X","authenticated-orcid":false,"given":"Vijay","family":"Ramaswamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Garzia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9404-9993","authenticated-orcid":false,"given":"Marc","family":"Remke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig M","family":"Forester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles C","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C David","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A","family":"Shuman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0185-8861","authenticated-orcid":false,"given":"Gary D","family":"Bader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8216-9357","authenticated-orcid":false,"given":"Sabine","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuh Nung","family":"Jan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily Yeh","family":"Jan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,8,10]]},"reference":[{"key":"BFnn4088_CR1","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1200\/JCO.2005.04.4974","volume":"24","author":"MC Thompson","year":"2006","unstructured":"Thompson, M.C. et al. Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J. Clin. Oncol. 24, 1924\u20131931 (2006).","journal-title":"J. Clin. Oncol."},{"key":"BFnn4088_CR2","doi-asserted-by":"crossref","first-page":"e3088","DOI":"10.1371\/journal.pone.0003088","volume":"3","author":"M Kool","year":"2008","unstructured":"Kool, M. et al. Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PLoS ONE 3, e3088 (2008).","journal-title":"PLoS ONE"},{"key":"BFnn4088_CR3","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1200\/JCO.2010.28.5148","volume":"29","author":"YJ Cho","year":"2011","unstructured":"Cho, Y.J. et al. Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome. J. Clin. Oncol. 29, 1424\u20131430 (2011).","journal-title":"J. Clin. Oncol."},{"key":"BFnn4088_CR4","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1200\/JCO.2009.27.4324","volume":"29","author":"PA Northcott","year":"2011","unstructured":"Northcott, P.A. et al. Medulloblastoma comprises four distinct molecular variants. J. Clin. Oncol. 29, 1408\u20131414 (2011).","journal-title":"J. Clin. Oncol."},{"key":"BFnn4088_CR5","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1126\/science.277.5329.1109","volume":"277","author":"LV Goodrich","year":"1997","unstructured":"Goodrich, L.V., Milenkovic, L., Higgins, K.M. & Scott, M.P. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277, 1109\u20131113 (1997).","journal-title":"Science"},{"key":"BFnn4088_CR6","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ccr.2008.07.003","volume":"14","author":"ZJ Yang","year":"2008","unstructured":"Yang, Z.J. et al. Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell 14, 135\u2013145 (2008).","journal-title":"Cancer Cell"},{"key":"BFnn4088_CR7","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ccr.2008.07.005","volume":"14","author":"U Sch\u00fcller","year":"2008","unstructured":"Sch\u00fcller, U. et al. Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell 14, 123\u2013134 (2008).","journal-title":"Cancer Cell"},{"key":"BFnn4088_CR8","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1158\/0008-5472.CAN-07-5092","volume":"68","author":"BA Hatton","year":"2008","unstructured":"Hatton, B.A. et al. The Smo\/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread. Cancer Res. 68, 1768\u20131776 (2008).","journal-title":"Cancer Res."},{"key":"BFnn4088_CR9","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.1158\/0008-5472.CAN-05-0481","volume":"65","author":"J Romer","year":"2005","unstructured":"Romer, J. & Curran, T. Targeting medulloblastoma: small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics. Cancer Res. 65, 4975\u20134978 (2005).","journal-title":"Cancer Res."},{"key":"BFnn4088_CR10","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1056\/NEJMoa0902903","volume":"361","author":"CM Rudin","year":"2009","unstructured":"Rudin, C.M. et al. Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N. Engl. J. Med. 361, 1173\u20131178 (2009).","journal-title":"N. Engl. J. Med."},{"key":"BFnn4088_CR11","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1126\/science.1179386","volume":"326","author":"RL Yauch","year":"2009","unstructured":"Yauch, R.L. et al. Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma. Science 326, 572\u2013574 (2009).","journal-title":"Science"},{"key":"BFnn4088_CR12","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nature10825","volume":"482","author":"X Wu","year":"2012","unstructured":"Wu, X. et al. Clonal selection drives genetic divergence of metastatic medulloblastoma. Nature 482, 529\u2013533 (2012).","journal-title":"Nature"},{"key":"BFnn4088_CR13","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00232-005-0782-3","volume":"205","author":"R Sch\u00f6nherr","year":"2005","unstructured":"Sch\u00f6nherr, R. Clinical relevance of ion channels for diagnosis and therapy of cancer. J. Membr. Biol. 205, 175\u2013184 (2005).","journal-title":"J. Membr. Biol."},{"key":"BFnn4088_CR14","first-page":"285","volume":"19","author":"LA Pardo","year":"2004","unstructured":"Pardo, L.A. Voltage-gated potassium channels in cell proliferation. Physiology (Bethesda) 19, 285\u2013292 (2004).","journal-title":"Physiology (Bethesda)"},{"key":"BFnn4088_CR15","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/embor.2008.75","volume":"9","author":"SP Fraser","year":"2008","unstructured":"Fraser, S.P. & Pardo, L.A. Ion channels: functional expression and therapeutic potential in cancer. Colloquium on ion channels and cancer. EMBO Rep. 9, 512\u2013515 (2008).","journal-title":"EMBO Rep."},{"key":"BFnn4088_CR16","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.molmed.2010.01.005","volume":"16","author":"N Prevarskaya","year":"2010","unstructured":"Prevarskaya, N., Skryma, R. & Shuba, Y. Ion channels and the hallmarks of cancer. Trends Mol. Med. 16, 107\u2013121 (2010).","journal-title":"Trends Mol. Med."},{"key":"BFnn4088_CR17","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1083\/jcb.201404136","volume":"206","author":"X Huang","year":"2014","unstructured":"Huang, X. & Jan, L.Y. Targeting potassium channels in cancer. J. Cell Biol. 206, 151\u2013162 (2014).","journal-title":"J. Cell Biol."},{"key":"BFnn4088_CR18","doi-asserted-by":"crossref","first-page":"4297","DOI":"10.1242\/dev.080515","volume":"139","author":"CC Homem","year":"2012","unstructured":"Homem, C.C. & Knoblich, J.A. Drosophila neuroblasts: a model for stem cell biology. Development 139, 4297\u20134310 (2012).","journal-title":"Development"},{"key":"BFnn4088_CR19","doi-asserted-by":"crossref","first-page":"e46724","DOI":"10.1371\/journal.pone.0046724","volume":"7","author":"S Zhu","year":"2012","unstructured":"Zhu, S. et al. The bHLH repressor Deadpan regulates the self-renewal and specification of Drosophila larval neural stem cells independently of Notch. PLoS ONE 7, e46724 (2012).","journal-title":"PLoS ONE"},{"key":"BFnn4088_CR20","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.devcel.2008.03.004","volume":"14","author":"SK Bowman","year":"2008","unstructured":"Bowman, S.K. et al. The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila. Dev. Cell 14, 535\u2013546 (2008).","journal-title":"Dev. Cell"},{"key":"BFnn4088_CR21","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/ncb2306","volume":"13","author":"C Richter","year":"2011","unstructured":"Richter, C., Oktaba, K., Steinmann, J., Muller, J. & Knoblich, J.A. The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. Nat. Cell Biol. 13, 1029\u20131039 (2011).","journal-title":"Nat. Cell Biol."},{"key":"BFnn4088_CR22","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/ng.336","volume":"41","author":"PA Northcott","year":"2009","unstructured":"Northcott, P.A. et al. Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. Nat. Genet. 41, 465\u2013472 (2009).","journal-title":"Nat. Genet."},{"key":"BFnn4088_CR23","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/nrc3461","volume":"13","author":"C Gonzalez","year":"2013","unstructured":"Gonzalez, C. Drosophila melanogaster: a model and a tool to investigate malignancy and identify new therapeutics. Nat. Rev. Cancer 13, 172\u2013183 (2013).","journal-title":"Nat. Rev. Cancer"},{"key":"BFnn4088_CR24","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1101\/gad.193789.112","volume":"26","author":"X Huang","year":"2012","unstructured":"Huang, X. et al. Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Genes Dev. 26, 1780\u20131796 (2012).","journal-title":"Genes Dev."},{"key":"BFnn4088_CR25","doi-asserted-by":"crossref","first-page":"486169","DOI":"10.1155\/2012\/486169","volume":"2012","author":"N Saini","year":"2012","unstructured":"Saini, N. & Reichert, H. Neural stem cells in Drosophila: molecular genetic mechanisms underlying normal neural proliferation and abnormal brain tumor formation. Stem Cells Int. 2012, 486169 (2012).","journal-title":"Stem Cells Int."},{"key":"BFnn4088_CR26","doi-asserted-by":"crossref","first-page":"W307","DOI":"10.1093\/nar\/gkr378","volume":"39","author":"J Reimand","year":"2011","unstructured":"Reimand, J., Arak, T. & Vilo, J. g:Profiler\u2013a web server for functional interpretation of gene lists (2011 update). Nucleic Acids Res. 39, W307\u2013W315 (2011).","journal-title":"Nucleic Acids Res."},{"key":"BFnn4088_CR27","doi-asserted-by":"crossref","first-page":"e13984","DOI":"10.1371\/journal.pone.0013984","volume":"5","author":"D Merico","year":"2010","unstructured":"Merico, D., Isserlin, R., Stueker, O., Emili, A. & Bader, G.D. Enrichment map: a network-based method for gene-set enrichment visualization and interpretation. PLoS ONE 5, e13984 (2010).","journal-title":"PLoS ONE"},{"key":"BFnn4088_CR28","doi-asserted-by":"crossref","first-page":"11681","DOI":"10.1523\/JNEUROSCI.23-37-11681.2003","volume":"23","author":"A Bhattacharjee","year":"2003","unstructured":"Bhattacharjee, A. et al. Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP. J. Neurosci. 23, 11681\u201311691 (2003).","journal-title":"J. Neurosci."},{"key":"BFnn4088_CR29","doi-asserted-by":"crossref","first-page":"354262","DOI":"10.1155\/2013\/354262","volume":"2013","author":"LK Kaczmarek","year":"2013","unstructured":"Kaczmarek, L.K. Slack, Slick and sodium-activated potassium channels. ISRN Neurosci. 2013, 354262 (2013).","journal-title":"ISRN Neurosci."},{"key":"BFnn4088_CR30","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1523\/JNEUROSCI.5088-11.2012","volume":"32","author":"TA Hage","year":"2012","unstructured":"Hage, T.A. & Salkoff, L. Sodium-activated potassium channels are functionally coupled to persistent sodium currents. J. Neurosci. 32, 2714\u20132721 (2012).","journal-title":"J. Neurosci."},{"key":"BFnn4088_CR31","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1200\/JCO.2010.30.2299","volume":"28","author":"S Rutkowski","year":"2010","unstructured":"Rutkowski, S. et al. Survival and prognostic factors of early childhood medulloblastoma: an international meta-analysis. J. Clin. Oncol. 28, 4961\u20134968 (2010).","journal-title":"J. Clin. Oncol."},{"key":"BFnn4088_CR32","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1085\/jgp.200409041","volume":"124","author":"RE Garc\u00eda-Ferreiro","year":"2004","unstructured":"Garc\u00eda-Ferreiro, R.E. et al. Mechanism of block of hEag1 K+ channels by imipramine and astemizole. J. Gen. Physiol. 124, 301\u2013317 (2004).","journal-title":"J. Gen. Physiol."},{"key":"BFnn4088_CR33","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1469-7793.1998.003bi.x","volume":"511","author":"IM Herzberg","year":"1998","unstructured":"Herzberg, I.M., Trudeau, M.C. & Robertson, G.A. Transfer of rapid inactivation and sensitivity to the class III antiarrhythmic drug E-4031 from HERG to M-eag channels. J. Physiol. (Lond.) 511, 3\u201314 (1998).","journal-title":"J. Physiol. (Lond.)"},{"key":"BFnn4088_CR34","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/00131746-200105000-00007","volume":"7","author":"SH Preskorn","year":"2001","unstructured":"Preskorn, S.H. Antipsychotic drug development in the pre-human-genome era: a full circle. J. Psychiatr. Pract. 7, 209\u2013213 (2001).","journal-title":"J. Psychiatr. Pract."},{"key":"BFnn4088_CR35","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF00562905","volume":"11","author":"FA Vanderheeren","year":"1977","unstructured":"Vanderheeren, F.A. & Muusze, R.G. Plasma levels and half lives of thioridazine and some of its metabolites. I. High doses in young acute schizophrenics. Eur. J. Clin. Pharmacol. 11, 135\u2013140 (1977).","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"BFnn4088_CR36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0165-1781(88)90029-7","volume":"23","author":"CN Svendsen","year":"1988","unstructured":"Svendsen, C.N., Hrbek, C.C., Casendino, M., Nichols, R.D. & Bird, E.D. Concentration and distribution of thioridazine and metabolites in schizophrenic post-mortem brain tissue. Psychiatry Res. 23, 1\u201310 (1988).","journal-title":"Psychiatry Res."},{"key":"BFnn4088_CR37","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1242\/dmm.009985","volume":"6","author":"LF Willoughby","year":"2013","unstructured":"Willoughby, L.F. et al. An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery. Dis. Model. Mech. 6, 521\u2013529 (2013).","journal-title":"Dis. Model. Mech."},{"key":"BFnn4088_CR38","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.4161\/cc.6.13.4357","volume":"6","author":"CW Habela","year":"2007","unstructured":"Habela, C.W. & Sontheimer, H. Cytoplasmic volume condensation is an integral part of mitosis. Cell Cycle 6, 1613\u20131620 (2007).","journal-title":"Cell Cycle"},{"key":"BFnn4088_CR39","doi-asserted-by":"crossref","first-page":"e1477","DOI":"10.1371\/journal.pone.0001477","volume":"3","author":"E Boucrot","year":"2008","unstructured":"Boucrot, E. & Kirchhausen, T. Mammalian cells change volume during mitosis. PLoS ONE 3, e1477 (2008).","journal-title":"PLoS ONE"},{"key":"BFnn4088_CR40","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1152\/physrev.00018.2011","volume":"92","author":"A Schwab","year":"2012","unstructured":"Schwab, A., Fabian, A., Hanley, P.J. & Stock, C. Role of ion channels and transporters in cell migration. Physiol. Rev. 92, 1865\u20131913 (2012).","journal-title":"Physiol. Rev."},{"key":"BFnn4088_CR41","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000096322","volume":"152","author":"M Jakab","year":"2006","unstructured":"Jakab, M. & Ritter, M. Cell volume regulatory ion transport in the regulation of cell migration. Contrib. Nephrol. 152, 161\u2013180 (2006).","journal-title":"Contrib. Nephrol."},{"key":"BFnn4088_CR42","first-page":"212","volume":"23","author":"A Schwab","year":"2008","unstructured":"Schwab, A., Hanley, P., Fabian, A. & Stock, C. Potassium channels keep mobile cells on the go. Physiology (Bethesda) 23, 212\u2013220 (2008).","journal-title":"Physiology (Bethesda)"},{"key":"BFnn4088_CR43","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1007\/BF00386179","volume":"430","author":"A Schwab","year":"1995","unstructured":"Schwab, A. et al. Polarized ion transport during migration of transformed Madin-Darby canine kidney cells. Pflugers Arch. 430, 802\u2013807 (1995).","journal-title":"Pflugers Arch."},{"key":"BFnn4088_CR44","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s004249900176","volume":"439","author":"SW Schneider","year":"2000","unstructured":"Schneider, S.W. et al. Volume dynamics in migrating epithelial cells measured with atomic force microscopy. Pflugers Arch. 439, 297\u2013303 (2000).","journal-title":"Pflugers Arch."},{"key":"BFnn4088_CR45","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/jcp.20434","volume":"206","author":"A Schwab","year":"2006","unstructured":"Schwab, A. et al. Subcellular distribution of calcium-sensitive potassium channels (IK1) in migrating cells. J. Cell. Physiol. 206, 86\u201394 (2006).","journal-title":"J. Cell. Physiol."},{"key":"BFnn4088_CR46","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.1158\/0008-5472.CAN-09-0342","volume":"69","author":"RJ Ward","year":"2009","unstructured":"Ward, R.J. et al. Multipotent CD15+ cancer stem cells in patched-1-deficient mouse medulloblastoma. Cancer Res. 69, 4682\u20134690 (2009).","journal-title":"Cancer Res."},{"key":"BFnn4088_CR47","doi-asserted-by":"crossref","unstructured":"Huang, X., Ketova, T., Litingtung, Y. & Chiang, C. Isolation, enrichment, and maintenance of medulloblastoma stem cells. J. Vis. Exp. published online, 2086 (1 September 2010).","DOI":"10.3791\/2086"},{"key":"BFnn4088_CR48","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1126\/science.1073733","volume":"297","author":"DM Berman","year":"2002","unstructured":"Berman, D.M. et al. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 297, 1559\u20131561 (2002).","journal-title":"Science"},{"key":"BFnn4088_CR49","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1158\/2159-8290.CD-11-0199","volume":"2","author":"D Corno","year":"2012","unstructured":"Corno, D. et al. Gene signatures associated with mouse postnatal hindbrain neural stem cells and medulloblastoma cancer stem cells identify novel molecular mediators and predict human medulloblastoma molecular classification. Cancer Discov. 2, 554\u2013568 (2012).","journal-title":"Cancer Discov."},{"key":"BFnn4088_CR50","unstructured":"Lee, H.Y., Greene, L.A., Mason, C.A. & Manzini, M.C. Isolation and culture of post-natal mouse cerebellar granule neuron progenitor cells and neurons. J. Vis. Exp. published online, doi:10.3791\/99010.3791\/990 (16 January 2009)."},{"key":"BFnn4088_CR51","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/(SICI)1526-968X(200001)26:1<77::AID-GENE10>3.0.CO;2-R","volume":"26","author":"K Wallace","year":"2000","unstructured":"Wallace, K., Liu, T.H. & Vaessin, H. The pan-neural bHLH proteins DEADPAN and ASENSE regulate mitotic activity and cdk inhibitor dacapo expression in the Drosophila larval optic lobes. Genesis 26, 77\u201385 (2000).","journal-title":"Genesis"},{"key":"BFnn4088_CR52","doi-asserted-by":"crossref","first-page":"24022","DOI":"10.1074\/jbc.M201949200","volume":"277","author":"Z Wang","year":"2002","unstructured":"Wang, Z., Wilson, G.F. & Griffith, L.C. Calcium\/calmodulin-dependent protein kinase II phosphorylates and regulates the Drosophila eag potassium channel. J. Biol. Chem. 277, 24022\u201324029 (2002).","journal-title":"J. Biol. Chem."},{"key":"BFnn4088_CR53","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.cub.2004.03.037","volume":"14","author":"SJ Broughton","year":"2004","unstructured":"Broughton, S.J., Kitamoto, T. & Greenspan, R.J. Excitatory and inhibitory switches for courtship in the brain of Drosophila melanogaster. Curr. Biol. 14, 538\u2013547 (2004).","journal-title":"Curr. Biol."},{"key":"BFnn4088_CR54","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1523\/JNEUROSCI.3316-05.2006","volume":"26","author":"M Vahasoyrinki","year":"2006","unstructured":"Vahasoyrinki, M., Niven, J.E., Hardie, R.C., Weckstrom, M. & Juusola, M. Robustness of neural coding in Drosophila photoreceptors in the absence of slow delayed rectifier K+ channels. J. Neurosci. 26, 2652\u20132660 (2006).","journal-title":"J. Neurosci."},{"key":"BFnn4088_CR55","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1126\/science.1195481","volume":"330","author":"A Janic","year":"2010","unstructured":"Janic, A., Mendizabal, L., Llamazares, S., Rossell, D. & Gonzalez, C. Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila. Science 330, 1824\u20131827 (2010).","journal-title":"Science"}],"container-title":["Nature Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nn.4088.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn.4088","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn.4088.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:19:38Z","timestamp":1684455578000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nn.4088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,10]]},"references-count":55,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["BFnn4088"],"URL":"https:\/\/doi.org\/10.1038\/nn.4088","relation":{},"ISSN":["1097-6256","1546-1726"],"issn-type":[{"value":"1097-6256","type":"print"},{"value":"1546-1726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,10]]},"assertion":[{"value":"25 June 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}