{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:26:23Z","timestamp":1789007183831,"version":"build-2803163510"},"reference-count":81,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T00:00:00Z","timestamp":1502064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Neurosci"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1038\/nn.4616","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T15:03:36Z","timestamp":1502118216000},"page":"1247-1259","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["Antipsychotic-induced Hdac2 transcription via NF-\u03baB leads to synaptic and cognitive side effects"],"prefix":"10.1038","volume":"20","author":[{"given":"Daisuke","family":"Ibi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"de la Fuente Revenga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nebojsa","family":"Kezunovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Muguruza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin M","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supriya A","family":"Gaitonde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryum K","family":"Ijaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishaka","family":"Santosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey","family":"Kozlenkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrell","family":"Holloway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Seto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aintzane","family":"Garc\u00eda-Bea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsumasa","family":"Kurita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace E","family":"Mosley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J","family":"Christoffel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9941-012X","authenticated-orcid":false,"given":"Luis F","family":"Callado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Dracheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F","family":"L\u00f3pez-Gim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchao","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos R","family":"Escalante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Javier","family":"Meana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schahram","family":"Akbarian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George W","family":"Huntley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Gonz\u00e1lez-Maeso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,7]]},"reference":[{"key":"BFnn4616_CR1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0140-6736(09)60995-8","volume":"374","author":"J van Os","year":"2009","unstructured":"van Os, J. & Kapur, S. Schizophrenia. Lancet 374, 635\u2013645 (2009).","journal-title":"Lancet"},{"key":"BFnn4616_CR2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1177\/0957154X07070335","volume":"18","author":"J Crilly","year":"2007","unstructured":"Crilly, J. The history of clozapine and its emergence in the US market: a review and analysis. Hist. Psychiatry 18, 39\u201360 (2007).","journal-title":"Hist. Psychiatry"},{"key":"BFnn4616_CR3","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1146\/annurev-med-050911-161504","volume":"64","author":"HY Meltzer","year":"2013","unstructured":"Meltzer, H.Y. Update on typical and atypical antipsychotic drugs. Annu. Rev. Med. 64, 393\u2013406 (2013).","journal-title":"Annu. Rev. Med."},{"key":"BFnn4616_CR4","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1038\/mp.2012.47","volume":"17","author":"S Miyamoto","year":"2012","unstructured":"Miyamoto, S., Miyake, N., Jarskog, L.F., Fleischhacker, W.W. & Lieberman, J.A. Pharmacological treatment of schizophrenia: a critical review of the pharmacology and clinical effects of current and future therapeutic agents. Mol. Psychiatry 17, 1206\u20131227 (2012).","journal-title":"Mol. Psychiatry"},{"key":"BFnn4616_CR5","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.schres.2014.06.035","volume":"158","author":"AP Husa","year":"2014","unstructured":"Husa, A.P. et al. Lifetime use of antipsychotic medication and its relation to change of verbal learning and memory in midlife schizophrenia - an observational 9-year follow-up study. Schizophr. Res. 158, 134\u2013141 (2014).","journal-title":"Schizophr. Res."},{"key":"BFnn4616_CR6","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1038\/npp.2015.3","volume":"40","author":"G Fervaha","year":"2015","unstructured":"Fervaha, G. et al. Antipsychotics and amotivation. Neuropsychopharmacology 40, 1539\u20131548 (2015).","journal-title":"Neuropsychopharmacology"},{"key":"BFnn4616_CR7","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1192\/bjp.162.1.43","volume":"162","author":"TE Goldberg","year":"1993","unstructured":"Goldberg, T.E. et al. The effect of clozapine on cognition and psychiatric symptoms in patients with schizophrenia. Br. J. Psychiatry 162, 43\u201348 (1993).","journal-title":"Br. J. Psychiatry"},{"key":"BFnn4616_CR8","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/acps.12374","volume":"131","author":"RE Nielsen","year":"2015","unstructured":"Nielsen, R.E. et al. Second-generation antipsychotic effect on cognition in patients with schizophrenia--a meta-analysis of randomized clinical trials. Acta Psychiatr. Scand. 131, 185\u2013196 (2015).","journal-title":"Acta Psychiatr. Scand."},{"key":"BFnn4616_CR9","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.schres.2004.06.015","volume":"73","author":"N Schr\u00f6der","year":"2005","unstructured":"Schr\u00f6der, N., de Lima, M.N., Quevedo, J., Dal Pizzol, F. & Roesler, R. Impairing effects of chronic haloperidol and clozapine treatment on recognition memory: possible relation to oxidative stress. Schizophr. Res. 73, 377\u2013378 (2005).","journal-title":"Schizophr. Res."},{"key":"BFnn4616_CR10","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S0278-5846(02)00221-X","volume":"26","author":"H Rosengarten","year":"2002","unstructured":"Rosengarten, H. & Quartermain, D. The effect of chronic treatment with typical and atypical antipsychotics on working memory and jaw movements in three- and eighteen-month-old rats. Prog. Neuropsychopharmacol. Biol. Psychiatry 26, 1047\u20131054 (2002).","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"BFnn4616_CR11","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.tins.2009.02.003","volume":"32","author":"C Kellendonk","year":"2009","unstructured":"Kellendonk, C., Simpson, E.H. & Kandel, E.R. Modeling cognitive endophenotypes of schizophrenia in mice. Trends Neurosci. 32, 347\u2013358 (2009).","journal-title":"Trends Neurosci."},{"key":"BFnn4616_CR12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrd3628","volume":"11","author":"MJ Millan","year":"2012","unstructured":"Millan, M.J. et al. Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy. Nat. Rev. Drug Discov. 11, 141\u2013168 (2012).","journal-title":"Nat. Rev. Drug Discov."},{"key":"BFnn4616_CR13","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev-pharmtox-011112-140216","volume":"53","author":"J Gr\u00e4ff","year":"2013","unstructured":"Gr\u00e4ff, J. & Tsai, L.H. The potential of HDAC inhibitors as cognitive enhancers. Annu. Rev. Pharmacol. Toxicol. 53, 311\u2013330 (2013).","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"BFnn4616_CR14","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.cell.2013.12.020","volume":"156","author":"J Gr\u00e4ff","year":"2014","unstructured":"Gr\u00e4ff, J. et al. Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories. Cell 156, 261\u2013276 (2014).","journal-title":"Cell"},{"key":"BFnn4616_CR15","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature07925","volume":"459","author":"JS Guan","year":"2009","unstructured":"Guan, J.S. et al. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 459, 55\u201360 (2009).","journal-title":"Nature"},{"key":"BFnn4616_CR16","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/nn.3181","volume":"15","author":"M Kurita","year":"2012","unstructured":"Kurita, M. et al. HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat. Neurosci. 15, 1245\u20131254 (2012).","journal-title":"Nat. Neurosci."},{"key":"BFnn4616_CR17","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1124\/mol.112.084582","volume":"83","author":"M Kurita","year":"2013","unstructured":"Kurita, M. et al. Repressive epigenetic changes at the mGlu2 promoter in frontal cortex of 5-HT2A knockout mice. Mol. Pharmacol. 83, 1166\u20131175 (2013).","journal-title":"Mol. Pharmacol."},{"key":"BFnn4616_CR18","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.neuron.2007.01.008","volume":"53","author":"J Gonz\u00e1lez-Maeso","year":"2007","unstructured":"Gonz\u00e1lez-Maeso, J. et al. Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. Neuron 53, 439\u2013452 (2007).","journal-title":"Neuron"},{"key":"BFnn4616_CR19","doi-asserted-by":"crossref","first-page":"ra5","DOI":"10.1126\/scisignal.aab0467","volume":"9","author":"JL Moreno","year":"2016","unstructured":"Moreno, J.L. et al. Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia. Sci. Signal. 9, ra5 (2016).","journal-title":"Sci. Signal."},{"key":"BFnn4616_CR20","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nature06612","volume":"452","author":"J Gonz\u00e1lez-Maeso","year":"2008","unstructured":"Gonz\u00e1lez-Maeso, J. et al. Identification of a serotonin\/glutamate receptor complex implicated in psychosis. Nature 452, 93\u201397 (2008).","journal-title":"Nature"},{"key":"BFnn4616_CR21","doi-asserted-by":"crossref","first-page":"44301","DOI":"10.1074\/jbc.M112.413161","volume":"287","author":"JL Moreno","year":"2012","unstructured":"Moreno, J.L. et al. Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A\u00b7mGlu2) receptor heteromerization and its psychoactive behavioral function. J. Biol. Chem. 287, 44301\u201344319 (2012).","journal-title":"J. Biol. Chem."},{"key":"BFnn4616_CR22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/archpsyc.57.1.65","volume":"57","author":"LA Glantz","year":"2000","unstructured":"Glantz, L.A. & Lewis, D.A. Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia. Arch. Gen. Psychiatry 57, 65\u201373 (2000).","journal-title":"Arch. Gen. Psychiatry"},{"key":"BFnn4616_CR23","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1176\/appi.ajp.161.4.742","volume":"161","author":"JE Black","year":"2004","unstructured":"Black, J.E. et al. Pathology of layer V pyramidal neurons in the prefrontal cortex of patients with schizophrenia. Am. J. Psychiatry 161, 742\u2013744 (2004).","journal-title":"Am. J. Psychiatry"},{"key":"BFnn4616_CR24","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/sj.mp.4001792","volume":"11","author":"JJ Hill","year":"2006","unstructured":"Hill, J.J., Hashimoto, T. & Lewis, D.A. Molecular mechanisms contributing to dendritic spine alterations in the prefrontal cortex of subjects with schizophrenia. Mol. Psychiatry 11, 557\u2013566 (2006).","journal-title":"Mol. Psychiatry"},{"key":"BFnn4616_CR25","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.tins.2011.10.004","volume":"35","author":"DA Lewis","year":"2012","unstructured":"Lewis, D.A., Curley, A.A., Glausier, J.R. & Volk, D.W. Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia. Trends Neurosci. 35, 57\u201367 (2012).","journal-title":"Trends Neurosci."},{"key":"BFnn4616_CR26","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1101\/gad.1563807","volume":"21","author":"RL Montgomery","year":"2007","unstructured":"Montgomery, R.L. et al. Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. Genes Dev. 21, 1790\u20131802 (2007).","journal-title":"Genes Dev."},{"key":"BFnn4616_CR27","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00213-012-2809-7","volume":"225","author":"JL Moreno","year":"2013","unstructured":"Moreno, J.L. et al. Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice. Psychopharmacology (Berl.) 225, 217\u2013226 (2013).","journal-title":"Psychopharmacology (Berl.)"},{"key":"BFnn4616_CR28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1124\/jpet.111.183780","volume":"339","author":"PN Yadav","year":"2011","unstructured":"Yadav, P.N., Kroeze, W.K., Farrell, M.S. & Roth, B.L. Antagonist functional selectivity: 5-HT2A serotonin receptor antagonists differentially regulate 5-HT2A receptor protein level in vivo. J. Pharmacol. Exp. Ther. 339, 99\u2013105 (2011).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"BFnn4616_CR29","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1038\/npp.2012.81","volume":"37","author":"AA Williams","year":"2012","unstructured":"Williams, A.A. et al. Reduced levels of serotonin 2A receptors underlie resistance of Egr3-deficient mice to locomotor suppression by clozapine. Neuropsychopharmacology 37, 2285\u20132298 (2012).","journal-title":"Neuropsychopharmacology"},{"key":"BFnn4616_CR30","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1038\/npp.2012.139","volume":"37","author":"CE McOmish","year":"2012","unstructured":"McOmish, C.E., Lira, A., Hanks, J.B. & Gingrich, J.A. Clozapine-induced locomotor suppression is mediated by 5-HT2A receptors in the forebrain. Neuropsychopharmacology 37, 2747\u20132755 (2012).","journal-title":"Neuropsychopharmacology"},{"key":"BFnn4616_CR31","doi-asserted-by":"crossref","first-page":"8836","DOI":"10.1523\/JNEUROSCI.23-26-08836.2003","volume":"23","author":"J Gonz\u00e1lez-Maeso","year":"2003","unstructured":"Gonz\u00e1lez-Maeso, J. et al. Transcriptome fingerprints distinguish hallucinogenic and nonhallucinogenic 5-hydroxytryptamine 2A receptor agonist effects in mouse somatosensory cortex. J. Neurosci. 23, 8836\u20138843 (2003).","journal-title":"J. Neurosci."},{"key":"BFnn4616_CR32","doi-asserted-by":"crossref","first-page":"D91","DOI":"10.1093\/nar\/gkh012","volume":"32","author":"A Sandelin","year":"2004","unstructured":"Sandelin, A., Alkema, W., Engstr\u00f6m, P., Wasserman, W.W. & Lenhard, B. JASPAR: an open-access database for eukaryotic transcription factor binding profiles. Nucleic Acids Res. 32, D91\u2013D94 (2004).","journal-title":"Nucleic Acids Res."},{"key":"BFnn4616_CR33","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.tins.2011.03.001","volume":"34","author":"H Gutierrez","year":"2011","unstructured":"Gutierrez, H. & Davies, A.M. Regulation of neural process growth, elaboration and structural plasticity by NF-\u03baB. Trends Neurosci. 34, 316\u2013325 (2011).","journal-title":"Trends Neurosci."},{"issue":"Suppl 1","key":"BFnn4616_CR34","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.neuropharm.2008.06.059","volume":"56","author":"SJ Russo","year":"2009","unstructured":"Russo, S.J., Mazei-Robison, M.S., Ables, J.L. & Nestler, E.J. Neurotrophic factors and structural plasticity in addiction. Neuropharmacology 56 (Suppl 1): 73\u201382 (2009).","journal-title":"Neuropharmacology"},{"key":"BFnn4616_CR35","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1073\/pnas.0910658107","volume":"107","author":"JW Koo","year":"2010","unstructured":"Koo, J.W., Russo, S.J., Ferguson, D., Nestler, E.J. & Duman, R.S. Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior. Proc. Natl. Acad. Sci. USA 107, 2669\u20132674 (2010).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn4616_CR36","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nrn1346","volume":"5","author":"GM Thomas","year":"2004","unstructured":"Thomas, G.M. & Huganir, R.L. MAPK cascade signalling and synaptic plasticity. Nat. Rev. Neurosci. 5, 173\u2013183 (2004).","journal-title":"Nat. Rev. Neurosci."},{"key":"BFnn4616_CR37","doi-asserted-by":"crossref","first-page":"7065","DOI":"10.1128\/MCB.21.20.7065-7077.2001","volume":"21","author":"BP Ashburner","year":"2001","unstructured":"Ashburner, B.P., Westerheide, S.D. & Baldwin, A.S. Jr. The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression. Mol. Cell. Biol. 21, 7065\u20137077 (2001).","journal-title":"Mol. Cell. Biol."},{"key":"BFnn4616_CR38","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1084\/jem.20050466","volume":"203","author":"K Ito","year":"2006","unstructured":"Ito, K. et al. Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression. J. Exp. Med. 203, 7\u201313 (2006).","journal-title":"J. Exp. Med."},{"key":"BFnn4616_CR39","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nn.2780","volume":"14","author":"Y Chen","year":"2011","unstructured":"Chen, Y. et al. HDAC-mediated deacetylation of NF-\u03baB is critical for Schwann cell myelination. Nat. Neurosci. 14, 437\u2013441 (2011).","journal-title":"Nat. Neurosci."},{"key":"BFnn4616_CR40","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nature12143","volume":"497","author":"G Zhang","year":"2013","unstructured":"Zhang, G. et al. Hypothalamic programming of systemic ageing involving IKK-\u03b2, NF-\u03baB and GnRH. Nature 497, 211\u2013216 (2013).","journal-title":"Nature"},{"key":"BFnn4616_CR41","first-page":"199","volume":"2012","author":"AL Szymczak-Workman","year":"2012","unstructured":"Szymczak-Workman, A.L., Vignali, K.M. & Vignali, D.A. Design and construction of 2A peptide-linked multicistronic vectors. Cold Spring Harb. Protoc. 2012, 199\u2013204 (2012).","journal-title":"Cold Spring Harb. Protoc."},{"key":"BFnn4616_CR42","doi-asserted-by":"crossref","first-page":"25883","DOI":"10.1074\/jbc.M000296200","volume":"275","author":"QK Huynh","year":"2000","unstructured":"Huynh, Q.K. et al. Characterization of the recombinant IKK1\/IKK2 heterodimer. Mechanisms regulating kinase activity. J. Biol. Chem. 275, 25883\u201325891 (2000).","journal-title":"J. Biol. Chem."},{"key":"BFnn4616_CR43","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0896-6273(00)00008-8","volume":"27","author":"DE Feldman","year":"2000","unstructured":"Feldman, D.E. Timing-based LTP and LTD at vertical inputs to layer II\/III pyramidal cells in rat barrel cortex. Neuron 27, 45\u201356 (2000).","journal-title":"Neuron"},{"key":"BFnn4616_CR44","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1097\/00001756-199812010-00024","volume":"9","author":"FX Vollenweider","year":"1998","unstructured":"Vollenweider, F.X., Vollenweider-Scherpenhuyzen, M.F., B\u00e4bler, A., Vogel, H. & Hell, D. Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action. Neuroreport 9, 3897\u20133902 (1998).","journal-title":"Neuroreport"},{"key":"BFnn4616_CR45","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.biopsych.2014.11.015","volume":"78","author":"Y Schmid","year":"2015","unstructured":"Schmid, Y. et al. Acute effects of lysergic acid diethylamide in healthy subjects. Biol. Psychiatry 78, 544\u2013553 (2015).","journal-title":"Biol. Psychiatry"},{"key":"BFnn4616_CR46","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.coph.2004.08.008","volume":"5","author":"BJ Morris","year":"2005","unstructured":"Morris, B.J., Cochran, S.M. & Pratt, J.A. PCP: from pharmacology to modelling schizophrenia. Curr. Opin. Pharmacol. 5, 101\u2013106 (2005).","journal-title":"Curr. Opin. Pharmacol."},{"key":"BFnn4616_CR47","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.coph.2006.08.013","volume":"7","author":"LV Kristiansen","year":"2007","unstructured":"Kristiansen, L.V., Huerta, I., Beneyto, M. & Meador-Woodruff, J.H. NMDA receptors and schizophrenia. Curr. Opin. Pharmacol. 7, 48\u201355 (2007).","journal-title":"Curr. Opin. Pharmacol."},{"key":"BFnn4616_CR48","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1124\/pr.115.011478","volume":"68","author":"DE Nichols","year":"2016","unstructured":"Nichols, D.E. Psychedelics. Pharmacol. Rev. 68, 264\u2013355 (2016).","journal-title":"Pharmacol. Rev."},{"key":"BFnn4616_CR49","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.euroneuro.2012.10.006","volume":"23","author":"C Muguruza","year":"2013","unstructured":"Muguruza, C. et al. Dysregulated 5-HT(2A) receptor binding in postmortem frontal cortex of schizophrenic subjects. Eur. Neuropsychopharmacol. 23, 852\u2013864 (2013).","journal-title":"Eur. Neuropsychopharmacol."},{"key":"BFnn4616_CR50","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrn1949","volume":"7","author":"E Marder","year":"2006","unstructured":"Marder, E. & Goaillard, J.M. Variability, compensation and homeostasis in neuron and network function. Nat. Rev. Neurosci. 7, 563\u2013574 (2006).","journal-title":"Nat. Rev. Neurosci."},{"key":"BFnn4616_CR51","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1124\/mol.108.048272","volume":"74","author":"JF Lopez-Gimenez","year":"2008","unstructured":"Lopez-Gimenez, J.F., Vilar\u00f3, M.T. & Milligan, G. Morphine desensitization, internalization, and down-regulation of the mu opioid receptor is facilitated by serotonin 5-hydroxytryptamine2A receptor coactivation. Mol. Pharmacol. 74, 1278\u20131291 (2008).","journal-title":"Mol. Pharmacol."},{"key":"BFnn4616_CR52","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0969-2126(02)00723-2","volume":"10","author":"CR Escalante","year":"2002","unstructured":"Escalante, C.R., Shen, L., Thanos, D. & Aggarwal, A.K. Structure of NF-kappaB p50\/p65 heterodimer bound to the PRDII DNA element from the interferon-beta promoter. Structure 10, 383\u2013391 (2002).","journal-title":"Structure"},{"key":"BFnn4616_CR53","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","volume":"66","author":"P Emsley","year":"2010","unstructured":"Emsley, P., Lohkamp, B., Scott, W.G. & Cowtan, K. Features and development of Coot. Acta Crystallogr. D Biol. Crystallogr. 66, 486\u2013501 (2010).","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"BFnn4616_CR54","doi-asserted-by":"crossref","first-page":"W425","DOI":"10.1093\/nar\/gkv493","volume":"43","author":"I Tuszynska","year":"2015","unstructured":"Tuszynska, I., Magnus, M., Jonak, K., Dawson, W. & Bujnicki, J.M. NPDock: a web server for protein-nucleic acid docking. Nucleic Acids Res. 43, W425-W430 (2015).","journal-title":"Nucleic Acids Res."},{"key":"BFnn4616_CR55","doi-asserted-by":"crossref","first-page":"6401","DOI":"10.1523\/JNEUROSCI.1001-12.2013","volume":"33","author":"MJ Morris","year":"2013","unstructured":"Morris, M.J., Mahgoub, M., Na, E.S., Pranav, H. & Monteggia, L.M. Loss of histone deacetylase 2 improves working memory and accelerates extinction learning. J. Neurosci. 33, 6401\u20136411 (2013).","journal-title":"J. Neurosci."},{"key":"BFnn4616_CR56","doi-asserted-by":"crossref","first-page":"9130","DOI":"10.1073\/pnas.1300454110","volume":"110","author":"JH Cabungcal","year":"2013","unstructured":"Cabungcal, J.H. et al. Perineuronal nets protect fast-spiking interneurons against oxidative stress. Proc. Natl. Acad. Sci. USA 110, 9130\u20139135 (2013).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn4616_CR57","unstructured":"Hof, P.R. et al. Comparative Cytoarchitectonic Atlas of the C57BL\/6 and 129\/Sv Mouse Brains (Elsevier, Amsterdam, 2000)."},{"key":"BFnn4616_CR58","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","volume":"29","author":"A Dobin","year":"2013","unstructured":"Dobin, A. et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29, 15\u201321 (2013).","journal-title":"Bioinformatics"},{"issue":"Suppl. 1","key":"BFnn4616_CR59","first-page":"1","volume":"7","author":"J Harrow","year":"2006","unstructured":"Harrow, J. et al. GENCODE: producing a reference annotation for ENCODE. Genome Biol. 7 (Suppl. 1), 1\u20139 (2006).","journal-title":"Genome Biol."},{"key":"BFnn4616_CR60","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","volume":"30","author":"Y Liao","year":"2014","unstructured":"Liao, Y., Smyth, G.K. & Shi, W. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics 30, 923\u2013930 (2014).","journal-title":"Bioinformatics"},{"key":"BFnn4616_CR61","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","volume":"5","author":"RC Gentleman","year":"2004","unstructured":"Gentleman, R.C. et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 5, R80 (2004).","journal-title":"Genome Biol."},{"key":"BFnn4616_CR62","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love, M.I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15, 550 (2014).","journal-title":"Genome Biol."},{"key":"BFnn4616_CR63","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","volume":"38","author":"S Heinz","year":"2010","unstructured":"Heinz, S. et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol. Cell 38, 576\u2013589 (2010).","journal-title":"Mol. Cell"},{"key":"BFnn4616_CR64","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.neuron.2007.09.032","volume":"56","author":"W Renthal","year":"2007","unstructured":"Renthal, W. et al. Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron 56, 517\u2013529 (2007).","journal-title":"Neuron"},{"key":"BFnn4616_CR65","doi-asserted-by":"crossref","first-page":"11451","DOI":"10.1523\/JNEUROSCI.1758-09.2009","volume":"29","author":"HE Covington III","year":"2009","unstructured":"Covington, H.E. III et al. Antidepressant actions of histone deacetylase inhibitors. J. Neurosci. 29, 11451\u201311460 (2009).","journal-title":"J. Neurosci."},{"key":"BFnn4616_CR66","first-page":"147","volume":"114","author":"MH Baumann","year":"2011","unstructured":"Baumann, M.H., Williams, Z., Zolkowska, D. & Rothman, R.B. Serotonin (5-HT) precursor loading with 5-hydroxy-l-tryptophan (5-HTP) reduces locomotor activation produced by (+)-amphetamine in the rat. Drug Alcohol Depend. 114, 147\u2013152 (2011).","journal-title":"Drug Alcohol Depend."},{"key":"BFnn4616_CR67","unstructured":"American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: DSM-IV 4th edn. (Washington, DC, 1994)."},{"key":"BFnn4616_CR68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2006.09.025","volume":"1123","author":"AD Stan","year":"2006","unstructured":"Stan, A.D. et al. Human postmortem tissue: what quality markers matter? Brain Res. 1123, 1\u201311 (2006).","journal-title":"Brain Res."},{"key":"BFnn4616_CR69","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0169-328X(03)00337-1","volume":"118","author":"P Preece","year":"2003","unstructured":"Preece, P. & Cairns, N.J. Quantifying mRNA in postmortem human brain: influence of gender, age at death, postmortem interval, brain pH, agonal state and inter-lobe mRNA variance. Brain Res. Mol. Brain Res. 118, 60\u201371 (2003).","journal-title":"Brain Res. Mol. Brain Res."},{"key":"BFnn4616_CR70","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/hmg\/ddh065","volume":"13","author":"JZ Li","year":"2004","unstructured":"Li, J.Z. et al. Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions. Hum. Mol. Genet. 13, 609\u2013616 (2004).","journal-title":"Hum. Mol. Genet."},{"key":"BFnn4616_CR71","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1093\/nar\/gni054","volume":"33","author":"S Imbeaud","year":"2005","unstructured":"Imbeaud, S. et al. Towards standardization of RNA quality assessment using user-independent classifiers of microcapillary electrophoresis traces. Nucleic Acids Res. 33, e56 (2005).","journal-title":"Nucleic Acids Res."},{"key":"BFnn4616_CR72","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.euroneuro.2010.04.008","volume":"20","author":"JA Garc\u00eda-Sevilla","year":"2010","unstructured":"Garc\u00eda-Sevilla, J.A. et al. Reduced platelet G protein-coupled receptor kinase 2 in major depressive disorder: antidepressant treatment-induced upregulation of GRK2 protein discriminates between responder and non-responder patients. Eur. Neuropsychopharmacol. 20, 721\u2013730 (2010).","journal-title":"Eur. Neuropsychopharmacol."},{"key":"BFnn4616_CR73","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/nar\/gkt838","volume":"42","author":"A Kozlenkov","year":"2014","unstructured":"Kozlenkov, A. et al. Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites. Nucleic Acids Res. 42, 109\u2013127 (2014).","journal-title":"Nucleic Acids Res."},{"key":"BFnn4616_CR74","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/sj.mp.4001067","volume":"7","author":"J Gonz\u00e1lez-Maeso","year":"2002","unstructured":"Gonz\u00e1lez-Maeso, J., Rodr\u00edguez-Puertas, R., Meana, J.J., Garc\u00eda-Sevilla, J.A. & Guim\u00f3n, J. Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: selective supersensitivity of alpha(2A)-adrenoceptors. Mol. Psychiatry 7, 755\u2013767 (2002).","journal-title":"Mol. Psychiatry"},{"key":"BFnn4616_CR75","doi-asserted-by":"crossref","first-page":"e76310","DOI":"10.1371\/journal.pone.0076310","volume":"8","author":"DF Aschauer","year":"2013","unstructured":"Aschauer, D.F., Kreuz, S. & Rumpel, S. Analysis of transduction efficiency, tropism and axonal transport of AAV serotypes 1, 2, 5, 6, 8 and 9 in the mouse brain. PLoS One 8, e76310 (2013).","journal-title":"PLoS One"},{"key":"BFnn4616_CR76","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/cne.20377","volume":"482","author":"P Chan","year":"2005","unstructured":"Chan, P. et al. Epsilon-sarcoglycan immunoreactivity and mRNA expression in mouse brain. J. Comp. Neurol. 482, 50\u201373 (2005).","journal-title":"J. Comp. Neurol."},{"key":"BFnn4616_CR77","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/npp.2008.67","volume":"34","author":"RA Sweet","year":"2009","unstructured":"Sweet, R.A., Henteleff, R.A., Zhang, W., Sampson, A.R. & Lewis, D.A. Reduced dendritic spine density in auditory cortex of subjects with schizophrenia. Neuropsychopharmacology 34, 374\u2013389 (2009).","journal-title":"Neuropsychopharmacology"},{"key":"BFnn4616_CR78","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/schbul\/sbp133","volume":"36","author":"H Jaaro-Peled","year":"2010","unstructured":"Jaaro-Peled, H., Ayhan, Y., Pletnikov, M.V. & Sawa, A. Review of pathological hallmarks of schizophrenia: comparison of genetic models with patients and nongenetic models. Schizophr. Bull. 36, 301\u2013313 (2010).","journal-title":"Schizophr. Bull."},{"key":"BFnn4616_CR79","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.neubiorev.2004.06.006","volume":"28","author":"RN Hughes","year":"2004","unstructured":"Hughes, R.N. The value of spontaneous alternation behavior (SAB) as a test of retention in pharmacological investigations of memory. Neurosci. Biobehav. Rev. 28, 497\u2013505 (2004).","journal-title":"Neurosci. Biobehav. Rev."},{"key":"BFnn4616_CR80","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S0893-133X(01)00342-6","volume":"26","author":"J Gonz\u00e1lez-Maeso","year":"2002","unstructured":"Gonz\u00e1lez-Maeso, J. et al. Effects of age, postmortem delay and storage time on receptor-mediated activation of G-proteins in human brain. Neuropsychopharmacology 26, 468\u2013478 (2002).","journal-title":"Neuropsychopharmacology"},{"key":"BFnn4616_CR81","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1146\/annurev.ps.46.020195.003021","volume":"46","author":"JP Shaffer","year":"1995","unstructured":"Shaffer, J.P. Multiple hypothesis testing. Annu. Rev. Psychol. 46, 561\u2013584 (1995).","journal-title":"Annu. Rev. Psychol."}],"container-title":["Nature Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nn.4616.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn.4616","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/nn.4616","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/nn.4616.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:23:41Z","timestamp":1684455821000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nn.4616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,7]]},"references-count":81,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["BFnn4616"],"URL":"https:\/\/doi.org\/10.1038\/nn.4616","relation":{},"ISSN":["1097-6256","1546-1726"],"issn-type":[{"value":"1097-6256","type":"print"},{"value":"1546-1726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,7]]},"assertion":[{"value":"22 February 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}