{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:48:57Z","timestamp":1792464537777,"version":"4.5.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2003,11,16]],"date-time":"2003-11-16T00:00:00Z","timestamp":1068940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Neurosci"],"published-print":{"date-parts":[[2003,12]]},"DOI":"10.1038\/nn1155","type":"journal-article","created":{"date-parts":[[2003,11,17]],"date-time":"2003-11-17T20:40:52Z","timestamp":1069101652000},"page":"1255-1263","source":"Crossref","is-referenced-by-count":576,"title":["Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development"],"prefix":"10.1038","volume":"6","author":[{"given":"Akihiro","family":"Nishida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieko","family":"Koike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Tano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Aizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2003,11,16]]},"reference":[{"key":"BFnn1155_CR1","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/S0092-8674(00)80439-0","volume":"91","author":"T Furukawa","year":"1997","unstructured":"Furukawa, T., Morrow, E.M. & Cepko, C.L. Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation. Cell 91, 531\u2013541 (1997).","journal-title":"Cell"},{"key":"BFnn1155_CR2","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1016\/S0896-6273(00)80394-3","volume":"19","author":"S Chen","year":"1997","unstructured":"Chen, S. et al. Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes. Neuron 19, 1017\u20131030 (1997).","journal-title":"Neuron"},{"key":"BFnn1155_CR3","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/70591","volume":"23","author":"T Furukawa","year":"1999","unstructured":"Furukawa, T., Morrow, E.M., Li, T., Davis, F.C. & Cepko, C.L. Retinopathy and attenuated circadian entrainment in Crx-deficient mice. Nat. Genet. 23, 466\u2013470 (1999).","journal-title":"Nat. Genet."},{"key":"BFnn1155_CR4","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/S0092-8674(00)80440-7","volume":"91","author":"CL Freund","year":"1997","unstructured":"Freund, C.L. et al. Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor. Cell 91, 543\u2013553 (1997).","journal-title":"Cell"},{"key":"BFnn1155_CR5","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1016\/S0896-6273(00)80423-7","volume":"19","author":"PK Swain","year":"1997","unstructured":"Swain, P.K. et al. Mutations in the cone-rod homeobox gene are associated with the cone-rod dystrophy photoreceptor degeneration. Neuron 19, 1329\u20131336 (1997).","journal-title":"Neuron"},{"key":"BFnn1155_CR6","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1086\/302101","volume":"63","author":"MM Sohocki","year":"1998","unstructured":"Sohocki, M.M. et al. A range of clinical phenotypes associated with mutations in CRX, a photoreceptor transcription-factor gene. Am. J. Hum. Genet. 63, 1307\u20131315 (1998).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnn1155_CR7","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/ng0498-311","volume":"18","author":"CL Freund","year":"1998","unstructured":"Freund, C.L. et al. De novo mutations in the CRX homeobox gene associated with Leber congenital amaurosis. Nat. Genet. 18, 311\u2013312 (1998).","journal-title":"Nat. Genet."},{"key":"BFnn1155_CR8","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1038\/358687a0","volume":"358","author":"A Simeone","year":"1992","unstructured":"Simeone, A., Acampora, D., Gulisano, M., Stornaiuolo, A. & Boncinelli, E. Nested expression domains of four homeobox genes in developing rostral brain. Nature 358, 687\u2013690 (1992).","journal-title":"Nature"},{"key":"BFnn1155_CR9","doi-asserted-by":"publisher","first-page":"2735","DOI":"10.1002\/j.1460-2075.1993.tb05935.x","volume":"12","author":"A Simeone","year":"1993","unstructured":"Simeone, A. et al. A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo. EMBO J. 12, 2735\u20132747 (1993).","journal-title":"EMBO J."},{"key":"BFnn1155_CR10","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1006\/dbio.1996.0020","volume":"173","author":"ER Vandendries","year":"1996","unstructured":"Vandendries, E.R., Johnson, D. & Reinke, R. orthodenticle is required for photoreceptor cell development in the Drosophila eye. Dev. Biol. 173, 243\u2013255 (1996).","journal-title":"Dev. Biol."},{"key":"BFnn1155_CR11","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1242\/dev.122.1.243","volume":"122","author":"SL Ang","year":"1996","unstructured":"Ang, S.L. et al. A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain. Development 122, 243\u2013252 (1996).","journal-title":"Development"},{"key":"BFnn1155_CR12","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1242\/dev.121.10.3279","volume":"121","author":"D Acampora","year":"1995","unstructured":"Acampora, D. et al. Forebrain and midbrain regions are deleted in Otx2\u2212\/\u2212 mutants due to a defective anterior neuroectoderm specification during gastrulation. Development 121, 3279\u20133290 (1995).","journal-title":"Development"},{"key":"BFnn1155_CR13","doi-asserted-by":"publisher","first-page":"2646","DOI":"10.1101\/gad.9.21.2646","volume":"9","author":"I Matsuo","year":"1995","unstructured":"Matsuo, I., Kuratani, S., Kimura, C., Takeda, N. & Aizawa, S. Mouse Otx2 functions in the formation and patterning of rostral head. Genes Dev. 9, 2646\u20132658 (1995).","journal-title":"Genes Dev."},{"key":"BFnn1155_CR14","doi-asserted-by":"publisher","first-page":"4243","DOI":"10.1523\/JNEUROSCI.17-11-04243.1997","volume":"17","author":"P Bovolenta","year":"1997","unstructured":"Bovolenta, P., Mallamaci, A., Briata, P., Corte, G. & Boncinelli, E. Implication of OTX2 in pigment epithelium determination and neural retina differentiation. J. Neurosci. 17, 4243\u20134252 (1997).","journal-title":"J. Neurosci."},{"key":"BFnn1155_CR15","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S0960-9822(98)70189-7","volume":"8","author":"F Nothias","year":"1998","unstructured":"Nothias, F., Fishell, G. & Ruiz i Altaba, A. Cooperation of intrinsic and extrinsic signals in the elaboration of regional identity in the posterior cerebral cortex. Curr. Biol. 8, 459\u2013462 (1998).","journal-title":"Curr. Biol."},{"key":"BFnn1155_CR16","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/S0169-328X(00)00060-7","volume":"78","author":"D Baas","year":"2000","unstructured":"Baas, D. et al. The subcellular localization of Otx2 is cell-type specific and developmentally regulated in the mouse retina. Brain Res. Mol. Brain Res. 78, 26\u201337 (2000).","journal-title":"Brain Res. Mol. Brain Res."},{"key":"BFnn1155_CR17","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1242\/dev.128.11.2019","volume":"128","author":"JR Martinez-Morales","year":"2001","unstructured":"Martinez-Morales, J.R., Signore, M., Acampora, D., Simeone, A. & Bovolenta, P. Otx genes are required for tissue specification in the developing eye. Development 128, 2019\u20132030 (2001).","journal-title":"Development"},{"key":"BFnn1155_CR18","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1242\/dev.00343","volume":"130","author":"AS Viczian","year":"2003","unstructured":"Viczian, A.S., Vignali, R., Zuber, M.E., Barsacchi, G. & Harris, W.A. XOtx5b and XOtx2 regulate photoreceptor and bipolar fates in the Xenopus retina. Development 130, 1281\u20131294 (2003).","journal-title":"Development"},{"key":"BFnn1155_CR19","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1523\/JNEUROSCI.22-05-01640.2002","volume":"22","author":"A Furukawa","year":"2002","unstructured":"Furukawa, A., Koike, C., Lippincott, P., Cepko, C.L. & Furukawa, T. The mouse Crx 5\u2032-upstream transgene sequence directs cell-specific and developmentally regulated expression in retinal photoreceptor cells. J. Neurosci. 22, 1640\u20131647 (2002).","journal-title":"J. Neurosci."},{"key":"BFnn1155_CR20","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1006\/bbrc.1997.7111","volume":"237","author":"K Sakai","year":"1997","unstructured":"Sakai, K. & Miyazaki, J. A transgenic mouse line that retains Cre recombinase activity in mature oocytes irrespective of the cre transgene transmission. Biochem. Biophys. Res. Commun. 237, 318\u2013324 (1997).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFnn1155_CR21","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1006\/dbio.2001.0531","volume":"242","author":"E Tian","year":"2002","unstructured":"Tian, E., Kimura, C., Takeda, N., Aizawa, S. & Matsuo, I. Otx2 is required to respond to signals from anterior neural ridge for forebrain specification. Dev Biol 242, 204\u2013223 (2002).","journal-title":"Dev Biol"},{"key":"BFnn1155_CR22","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1046\/j.1471-4159.2003.01583.x","volume":"84","author":"V Courtois","year":"2003","unstructured":"Courtois, V. et al. New Otx2 mRNA isoforms expressed in the mouse brain. J. Neurochem. 84, 840\u2013853 (2003).","journal-title":"J. Neurochem."},{"key":"BFnn1155_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/1096-9861(20000814)424:1<1::AID-CNE1>3.0.CO;2-V","volume":"424","author":"S Haverkamp","year":"2000","unstructured":"Haverkamp, S. & Wassle, H. Immunocytochemical analysis of the mouse retina. J. Comp. Neurol. 424, 1\u201323 (2000).","journal-title":"J. Comp. Neurol."},{"key":"BFnn1155_CR24","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1002\/1096-9861(20010122)429:4<601::AID-CNE7>3.0.CO;2-V","volume":"429","author":"MA Dyer","year":"2001","unstructured":"Dyer, M.A. & Cepko, C.L. The p57Kip2 cyclin kinase inhibitor is expressed by a restricted set of amacrine cells in the rodent retina. J. Comp. Neurol. 429, 601\u2013614 (2001).","journal-title":"J. Comp. Neurol."},{"key":"BFnn1155_CR25","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/328131a0","volume":"328","author":"DL Turner","year":"1987","unstructured":"Turner, D.L. & Cepko, C.L. A common progenitor for neurons and glia persists in rat retina late in development. Nature 328, 131\u2013136 (1987).","journal-title":"Nature"},{"key":"BFnn1155_CR26","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0092-8674(01)00295-1","volume":"105","author":"T Marquardt","year":"2001","unstructured":"Marquardt, T. et al. Pax6 is required for the multipotent state of retinal progenitor cells. Cell 105, 43\u201355 (2001).","journal-title":"Cell"},{"key":"BFnn1155_CR27","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1101\/gad.855301","volume":"15","author":"SW Wang","year":"2000","unstructured":"Wang, S.W. et al. Requirement for math5 in the development of retinal ganglion cells. Genes Dev. 15, 24\u201329 (2000).","journal-title":"Genes Dev."},{"key":"BFnn1155_CR28","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1242\/dev.128.13.2497","volume":"128","author":"NL Brown","year":"2001","unstructured":"Brown, N.L., Patel, S., Brzezinski, J. & Glaser, T. Math5 is required for retinal ganglion cell and optic nerve formation. Development 128, 2497\u20132508 (2001).","journal-title":"Development"},{"key":"BFnn1155_CR29","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/S0896-6273(00)80391-8","volume":"19","author":"S Kanekar","year":"1997","unstructured":"Kanekar, S. et al. Xath5 participates in a network of bHLH genes in the developing Xenopus retina. Neuron 19, 981\u2013994 (1997).","journal-title":"Neuron"},{"key":"BFnn1155_CR30","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1073\/pnas.98.4.1649","volume":"98","author":"W Liu","year":"2001","unstructured":"Liu, W., Mo, Z. & Xiang, M. The Ath5 proneural genes function upstream of Brn3 POU domain transcription factor genes to promote retinal ganglion cell development. Proc. Natl. Acad. Sci. USA 98, 1649\u20131654 (2001).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn1155_CR31","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/ng1144","volume":"34","author":"MA Dyer","year":"2003","unstructured":"Dyer, M.A., Livesey, F.J., Cepko, C.L. & Oliver, G. Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina. Nat. Genet. 34, 53\u201358 (2003).","journal-title":"Nat. Genet."},{"key":"BFnn1155_CR32","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1038\/ng774","volume":"29","author":"AJ Mears","year":"2001","unstructured":"Mears, A.J. et al. Nrl is required for rod photoreceptor development. Nat. Genet. 29, 447\u2013452 (2001).","journal-title":"Nat. Genet."},{"key":"BFnn1155_CR33","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1002\/(SICI)1097-4695(19980915)36:4<485::AID-NEU3>3.0.CO;2-S","volume":"36","author":"RT Yan","year":"1998","unstructured":"Yan, R.T. & Wang, S.Z. neuroD induces photoreceptor cell overproduction in vivo and de novo generation in vitro. J. Neurobiol. 36, 485\u2013496 (1998).","journal-title":"J. Neurobiol."},{"key":"BFnn1155_CR34","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1242\/dev.126.1.23","volume":"126","author":"EM Morrow","year":"1999","unstructured":"Morrow, E.M., Furukawa, T., Lee, J.E. & Cepko, C.L. NeuroD regulates multiple functions in the developing neural retina in rodent. Development 126, 23\u201336 (1999).","journal-title":"Development"},{"key":"BFnn1155_CR35","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1242\/dev.128.8.1313","volume":"128","author":"J Hatakeyama","year":"2001","unstructured":"Hatakeyama, J., Tomita, K., Inoue, T. & Kageyama, R. Roles of homeobox and bHLH genes in specification of a retinal cell type. Development 128, 1313\u20131322 (2001).","journal-title":"Development"},{"key":"BFnn1155_CR36","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1242\/dev.129.4.831","volume":"129","author":"T Inoue","year":"2002","unstructured":"Inoue, T. et al. Math3 and NeuroD regulate amacrine cell fate specification in the retina. Development 129, 831\u2013842 (2002).","journal-title":"Development"},{"key":"BFnn1155_CR37","doi-asserted-by":"publisher","first-page":"5460","DOI":"10.1093\/emboj\/19.20.5460","volume":"19","author":"K Tomita","year":"2000","unstructured":"Tomita, K., Moriyoshi, K., Nakanishi, S., Guillemot, F. & Kageyama, R. Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system. EMBO J. 19, 5460\u20135472 (2000).","journal-title":"EMBO J."},{"key":"BFnn1155_CR38","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1242\/dev.124.5.1055","volume":"124","author":"ZD Ezzeddine","year":"1997","unstructured":"Ezzeddine, Z.D., Yang, X., DeChiara, T., Yancopoulos, G. & Cepko, C.L. Postmitotic cells fated to become rod photoreceptors can be respecified by CNTF treatment of the retina. Development 124, 1055\u20131067 (1997).","journal-title":"Development"},{"key":"BFnn1155_CR39","doi-asserted-by":"publisher","first-page":"8074","DOI":"10.1523\/JNEUROSCI.17-21-08074.1997","volume":"17","author":"S Blackshaw","year":"1997","unstructured":"Blackshaw, S. & Snyder, S.H. Developmental expression pattern of phototransduction components in mammalian pineal implies a light-sensing function. J. Neurosci. 17, 8074\u20138082 (1997).","journal-title":"J. Neurosci."},{"key":"BFnn1155_CR40","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0925-4773(98)00162-2","volume":"82","author":"N Bobola","year":"1999","unstructured":"Bobola, N. et al. OTX2 homeodomain protein binds a DNA element necessary for interphotoreceptor retinoid binding protein gene expression. Mech. Dev. 82, 165\u2013169 (1999).","journal-title":"Mech. Dev."},{"key":"BFnn1155_CR41","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/ng793","volume":"30","author":"JT Gamse","year":"2002","unstructured":"Gamse, J.T. et al. Otx5 regulates genes that show circadian expression in the zebrafish pineal complex. Nat. Genet. 30, 117\u2013121 (2002).","journal-title":"Nat. Genet."},{"key":"BFnn1155_CR42","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1093\/molbev\/msg085","volume":"20","author":"JL Plouhinec","year":"2003","unstructured":"Plouhinec, J.L. et al. The Mammalian crx genes are highly divergent representatives of the otx5 gene family, a gnathostome orthology class of orthodenticle-related homeogenes involved in the differentiation of retinal photoreceptors and circadian entrainment. Mol. Biol. Evol. 20, 513\u2013521 (2003).","journal-title":"Mol. Biol. Evol."},{"key":"BFnn1155_CR43","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/0092-8674(93)90644-6","volume":"73","author":"H Gu","year":"1993","unstructured":"Gu, H., Zou, Y.R. & Rajewsky, K. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell 73, 1155\u20131164 (1993).","journal-title":"Cell"},{"key":"BFnn1155_CR44","first-page":"419","volume":"29","author":"DW Laird","year":"1988","unstructured":"Laird, D.W. & Molday, R.S. Evidence against the role of rhodopsin in rod outer segment binding to RPE cells. Invest. Ophthalmol. Vis. Sci. 29, 419\u2013428 (1988).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"BFnn1155_CR45","doi-asserted-by":"publisher","first-page":"3088","DOI":"10.1073\/pnas.94.7.3088","volume":"94","author":"T Furukawa","year":"1997","unstructured":"Furukawa, T., Kozak, C.A. & Cepko, C.L. rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina. Proc. Natl. Acad. Sci. USA 94, 3088\u20133093 (1997).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn1155_CR46","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1242\/dev.113.4.1435","volume":"113","author":"C Walther","year":"1991","unstructured":"Walther, C. & Gruss, P. Pax-6, a murine paired box gene, is expressed in the developing CNS. Development 113, 1435\u20131449 (1991).","journal-title":"Development"}],"container-title":["Nature Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nn1155.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn1155","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn1155.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T19:50:37Z","timestamp":1684439437000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nn1155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11,16]]},"references-count":46,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["BFnn1155"],"URL":"https:\/\/doi.org\/10.1038\/nn1155","relation":{},"ISSN":["1097-6256","1546-1726"],"issn-type":[{"value":"1097-6256","type":"print"},{"value":"1546-1726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,11,16]]}}}