{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:57:37Z","timestamp":1791421057098,"version":"4.3.3"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2005,8,14]],"date-time":"2005-08-14T00:00:00Z","timestamp":1123977600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Neurosci"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1038\/nn1522","type":"journal-article","created":{"date-parts":[[2005,8,22]],"date-time":"2005-08-22T14:07:21Z","timestamp":1124719641000},"page":"1179-1187","source":"Crossref","is-referenced-by-count":391,"title":["Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors"],"prefix":"10.1038","volume":"8","author":[{"given":"Xiuxin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarik F","family":"Haydar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lique","family":"Bordey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,8,14]]},"reference":[{"key":"BFnn1522_CR1","doi-asserted-by":"publisher","first-page":"5046","DOI":"10.1523\/JNEUROSCI.17-13-05046.1997","volume":"17","author":"F Doetsch","year":"1997","unstructured":"Doetsch, F., Garcia-Verdugo, J.M. & Alvarez-Buylla, A. Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain. J. Neurosci. 17, 5046\u20135061 (1997).","journal-title":"J. Neurosci."},{"key":"BFnn1522_CR2","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1126\/science.271.5251.978","volume":"271","author":"C Lois","year":"1996","unstructured":"Lois, C., Garcia-Verdugo, J.M. & Alvarez-Buylla, A. Chain migration of neuronal precursors. Science 271, 978\u2013981 (1996).","journal-title":"Science"},{"key":"BFnn1522_CR3","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1006\/mcne.1996.0592","volume":"8","author":"MB Luskin","year":"1997","unstructured":"Luskin, M.B., Zigova, T., Soteres, B.J. & Stewart, R.R. Neuronal progenitor cells derived from the anterior subventricular zone of the neonatal rat forebrain continue to proliferate in vitro and express a neuronal phenotype. Mol. Cell. Neurosci. 8, 351\u2013366 (1997).","journal-title":"Mol. Cell. Neurosci."},{"key":"BFnn1522_CR4","doi-asserted-by":"publisher","first-page":"10411","DOI":"10.1523\/JNEUROSCI.23-32-10411.2003","volume":"23","author":"O Belluzzi","year":"2003","unstructured":"Belluzzi, O., Benedusi, M., Ackman, J. & LoTurco, J.J. Electrophysiological differentiation of new neurons in the olfactory bulb. J. Neurosci. 23, 10411\u201310418 (2003).","journal-title":"J. Neurosci."},{"key":"BFnn1522_CR5","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/nn1048","volume":"6","author":"A Carleton","year":"2003","unstructured":"Carleton, A., Petreanu, L.T., Lansford, R., Alvarez-Buylla, A. & Lledo, P.M. Becoming a new neuron in the adult olfactory bulb. Nat. Neurosci. 6, 507\u2013518 (2003).","journal-title":"Nat. Neurosci."},{"key":"BFnn1522_CR6","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/S0092-8674(00)80783-7","volume":"97","author":"F Doetsch","year":"1999","unstructured":"Doetsch, F., Caille, I., Lim, D.A., Garcia-Verdugo, J.M. & Alvarez-Buylla, A. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 97, 703\u2013716 (1999).","journal-title":"Cell"},{"key":"BFnn1522_CR7","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/S0896-6273(02)00835-8","volume":"35","author":"A Capela","year":"2002","unstructured":"Capela, A. & Temple, S. LeX\/ssea-1 is expressed by adult mouse CNS stem cells, identifying them as nonependymal. Neuron 35, 865\u2013875 (2002).","journal-title":"Neuron"},{"key":"BFnn1522_CR8","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1038\/nn1340","volume":"7","author":"AD Garcia","year":"2004","unstructured":"Garcia, A.D., Doan, N.B., Imura, T., Bush, T.G. & Sofroniew, M.V. GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain. Nat. Neurosci. 7, 1233\u20131241 (2004).","journal-title":"Nat. Neurosci."},{"key":"BFnn1522_CR9","doi-asserted-by":"publisher","first-page":"11619","DOI":"10.1073\/pnas.96.20.11619","volume":"96","author":"F Doetsch","year":"1999","unstructured":"Doetsch, F., Garcia-Verdugo, J.M. & Alvarez-Buylla, A. Regeneration of a germinal layer in the adult mammalian brain. Proc. Natl. Acad. Sci. USA 96, 11619\u201311624 (1999).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn1522_CR10","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1113\/jphysiol.2003.042572","volume":"550","author":"DD Wang","year":"2003","unstructured":"Wang, D.D., Krueger, D.D. & Bordey, A. GABA depolarizes neuronal progenitors of the postnatal subventricular zone via GABAA receptor activation. J. Physiol. (Lond.) 550, 785\u2013800 (2003).","journal-title":"J. Physiol. (Lond.)"},{"key":"BFnn1522_CR11","doi-asserted-by":"publisher","first-page":"7623","DOI":"10.1523\/JNEUROSCI.1999-04.2004","volume":"24","author":"AJ Bolteus","year":"2004","unstructured":"Bolteus, A.J. & Bordey, A. GABA release and uptake regulate neuronal precursor migration in the postnatal subventricular zone. J. Neurosci. 24, 7623\u20137631 (2004).","journal-title":"J. Neurosci."},{"key":"BFnn1522_CR12","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.1523\/JNEUROSCI.18-07-02560.1998","volume":"18","author":"SM Fueshko","year":"1998","unstructured":"Fueshko, S.M., Key, S. & Wray, S. GABA inhibits migration of luteinizing hormone-releasing hormone neurons in embryonic olfactory explants. J. Neurosci. 18, 2560\u20132569 (1998).","journal-title":"J. Neurosci."},{"key":"BFnn1522_CR13","doi-asserted-by":"publisher","first-page":"5764","DOI":"10.1523\/JNEUROSCI.20-15-05764.2000","volume":"20","author":"TF Haydar","year":"2000","unstructured":"Haydar, T.F., Wang, F., Schwartz, M.L. & Rakic, P. Differential modulation of proliferation in the neocortical ventricular and subventricular zones. J. Neurosci. 20, 5764\u20135774 (2000).","journal-title":"J. Neurosci."},{"key":"BFnn1522_CR14","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1016\/0896-6273(95)90008-X","volume":"15","author":"JJ LoTurco","year":"1995","unstructured":"LoTurco, J.J., Owens, D.F., Heath, M.J., Davis, M.B. & Kriegstein, A.R. GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis. Neuron 15, 1287\u20131298 (1995).","journal-title":"Neuron"},{"key":"BFnn1522_CR15","first-page":"305","volume":"5","author":"JL Barker","year":"1998","unstructured":"Barker, J.L. et al. GABAergic cells and signals in CNS development. Perspect. Dev. Neurobiol. 5, 305\u2013322 (1998).","journal-title":"Perspect. Dev. Neurobiol."},{"key":"BFnn1522_CR16","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1038\/nrn919","volume":"3","author":"DF Owens","year":"2002","unstructured":"Owens, D.F. & Kriegstein, A.R. Is there more to GABA than synaptic inhibition? Nat. Rev. Neurosci. 3, 715\u2013727 (2002).","journal-title":"Nat. Rev. Neurosci."},{"key":"BFnn1522_CR17","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s004410000343","volume":"305","author":"L Nguyen","year":"2001","unstructured":"Nguyen, L. et al. Neurotransmitters as early signals for central nervous system development. Cell Tissue Res. 305, 187\u2013202 (2001).","journal-title":"Cell Tissue Res."},{"key":"BFnn1522_CR18","doi-asserted-by":"publisher","first-page":"3278","DOI":"10.1523\/JNEUROSCI.23-08-03278.2003","volume":"23","author":"L Nguyen","year":"2003","unstructured":"Nguyen, L. et al. Autocrine\/paracrine activation of the GABA(A) receptor inhibits the proliferation of neurogenic polysialylated neural cell adhesion molecule-positive (PSA-NCAM+) precursor cells from postnatal striatum. J. Neurosci. 23, 3278\u20133294 (2003).","journal-title":"J. Neurosci."},{"key":"BFnn1522_CR19","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1016\/S0896-6273(02)01053-X","volume":"36","author":"M Demarque","year":"2002","unstructured":"Demarque, M. et al. Paracrine intercellular communication by a Ca2+- and SNARE-independent release of GABA and glutamate prior to synapse formation. Neuron 36, 1051\u20131061 (2002).","journal-title":"Neuron"},{"key":"BFnn1522_CR20","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/S0896-6273(04)00077-7","volume":"41","author":"C Verderio","year":"2004","unstructured":"Verderio, C. et al. SNAP-25 modulation of calcium dynamics underlies differences in GABAergic and glutamatergic responsiveness to depolarization. Neuron 41, 599\u2013610 (2004).","journal-title":"Neuron"},{"key":"BFnn1522_CR21","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1006\/dbio.1997.8601","volume":"187","author":"L Zhuo","year":"1997","unstructured":"Zhuo, L. et al. Live astrocytes visualized by green fluorescent protein in transgenic mice. Dev. Biol. 187, 36\u201342 (1997).","journal-title":"Dev. Biol."},{"key":"BFnn1522_CR22","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1002\/(SICI)1098-1136(200003)30:1<27::AID-GLIA4>3.0.CO;2-#","volume":"30","author":"A Bordey","year":"2000","unstructured":"Bordey, A. & Sontheimer, H. Ion channel expression by astrocytes in situ: comparison of different CNS regions. Glia 30, 27\u201338 (2000).","journal-title":"Glia"},{"key":"BFnn1522_CR23","doi-asserted-by":"publisher","first-page":"3161","DOI":"10.1523\/JNEUROSCI.22-08-03161.2002","volume":"22","author":"SC Noctor","year":"2002","unstructured":"Noctor, S.C. et al. Dividing precursor cells of the embryonic cortical ventricular zone have morphological and molecular characteristics of radial glia. J. Neurosci. 22, 3161\u20133173 (2002).","journal-title":"J. Neurosci."},{"key":"BFnn1522_CR24","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1152\/jn.01116.2002","volume":"90","author":"DD Wang","year":"2003","unstructured":"Wang, D.D., Krueger, D.D. & Bordey, A. Biophysical properties and ionic signature of neuronal progenitors of the postnatal subventricular zone in situ. J. Neurophysiol. 90, 2291\u20132302 (2003).","journal-title":"J. Neurophysiol."},{"key":"BFnn1522_CR25","doi-asserted-by":"publisher","first-page":"3310","DOI":"10.1523\/JNEUROSCI.05-12-03310.1985","volume":"5","author":"S Hockfield","year":"1985","unstructured":"Hockfield, S. & McKay, R.D. Identification of major cell classes in the developing mammalian nervous system. J. Neurosci. 5, 3310\u20133328 (1985).","journal-title":"J. Neurosci."},{"key":"BFnn1522_CR26","first-page":"1033","volume":"298","author":"EG Harks","year":"2001","unstructured":"Harks, E.G. et al. Fenamates: a novel class of reversible gap junction blockers. J. Pharmacol. Exp. Ther. 298, 1033\u20131041 (2001).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"BFnn1522_CR27","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1124\/jpet.104.070342","volume":"311","author":"AJ Smith","year":"2004","unstructured":"Smith, A.J., Oxley, B., Malpas, S., Pillai, G.V. & Simpson, P.B. Compounds exhibiting selective efficacy for different beta subunits of human recombinant gamma-aminobutyric acid A receptors. J. Pharmacol. Exp. Ther. 311, 601\u2013609 (2004).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"BFnn1522_CR28","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1146\/annurev.neuro.24.1.933","volume":"24","author":"TC Sudhof","year":"2001","unstructured":"Sudhof, T.C. alpha-Latrotoxin and its receptors: neurexins and CIRL\/latrophilins. Annu. Rev. Neurosci. 24, 933\u2013962 (2001).","journal-title":"Annu. Rev. Neurosci."},{"key":"BFnn1522_CR29","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1098\/rstb.1999.0378","volume":"354","author":"S Hilfiker","year":"1999","unstructured":"Hilfiker, S. et al. Synapsins as regulators of neurotransmitter release. Phil. Trans. R. Soc. Lond. B 354, 269\u2013279 (1999).","journal-title":"Phil. Trans. R. Soc. Lond. B"},{"key":"BFnn1522_CR30","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/0197-0186(95)00158-1","volume":"29","author":"LA Borden","year":"1996","unstructured":"Borden, L.A. GABA transporter heterogeneity: pharmacology and cellular localization. Neurochem. Int. 29, 335\u2013356 (1996).","journal-title":"Neurochem. Int."},{"key":"BFnn1522_CR31","doi-asserted-by":"crossref","first-page":"17491","DOI":"10.1016\/S0021-9258(19)37067-X","volume":"267","author":"B Lopez-Corcuera","year":"1992","unstructured":"Lopez-Corcuera, B., Liu, Q.R., Mandiyan, S., Nelson, H. & Nelson, N. Expression of a mouse brain cDNA encoding novel gamma-aminobutyric acid transporter. J. Biol. Chem. 267, 17491\u201317493 (1992).","journal-title":"J. Biol. Chem."},{"key":"BFnn1522_CR32","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/(SICI)1097-4547(19970415)48:2<83::AID-JNR1>3.0.CO;2-8","volume":"48","author":"SW Levison","year":"1997","unstructured":"Levison, S.W. & Goldman, J.E. Multipotential and lineage restricted precursors coexist in the mammalian perinatal subventricular zone. J. Neurosci. Res. 48, 83\u201394 (1997).","journal-title":"J. Neurosci. Res."},{"key":"BFnn1522_CR33","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1242\/dev.119.3.611","volume":"119","author":"SW Levison","year":"1993","unstructured":"Levison, S.W., Chuang, C., Abramson, B.J. & Goldman, J.E. The migrational patterns and developmental fates of glial precursors in the rat subventricular zone are temporally regulated. Development 119, 611\u2013622 (1993).","journal-title":"Development"},{"key":"BFnn1522_CR34","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1111\/j.1460-9568.2004.03584.x","volume":"20","author":"S De Marchis","year":"2004","unstructured":"De Marchis, S. et al. GABAergic phenotypic differentiation of a subpopulation of subventricular derived migrating progenitors. Eur. J. Neurosci. 20, 1307\u20131317 (2004).","journal-title":"Eur. J. Neurosci."},{"key":"BFnn1522_CR35","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1002\/neu.10038","volume":"50","author":"RR Stewart","year":"2002","unstructured":"Stewart, R.R., Hoge, G.J., Zigova, T. & Luskin, M.B. Neural progenitor cells of the neonatal rat anterior subventricular zone express functional GABA(A) receptors. J. Neurobiol. 50, 305\u2013322 (2002).","journal-title":"J. Neurobiol."},{"key":"BFnn1522_CR36","doi-asserted-by":"publisher","first-page":"15735","DOI":"10.1073\/pnas.95.26.15735","volume":"95","author":"ML Cotrina","year":"1998","unstructured":"Cotrina, M.L. et al. Connexins regulate calcium signaling by controlling ATP release. Proc. Natl. Acad. Sci. USA 95, 15735\u201315740 (1998).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn1522_CR37","doi-asserted-by":"publisher","first-page":"3588","DOI":"10.1523\/JNEUROSCI.23-09-03588.2003","volume":"23","author":"ZC Ye","year":"2003","unstructured":"Ye, Z.C., Wyeth, M.S., Baltan-Tekkok, S. & Ransom, B.R. Functional hemichannels in astrocytes: a novel mechanism of glutamate release. J. Neurosci. 23, 3588\u20133596 (2003).","journal-title":"J. Neurosci."},{"key":"BFnn1522_CR38","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1002\/cne.10417","volume":"454","author":"VA Pieribone","year":"2002","unstructured":"Pieribone, V.A. et al. Expression of synapsin III in nerve terminals and neurogenic regions of the adult brain. J. Comp. Neurol. 454, 105\u2013114 (2002).","journal-title":"J. Comp. Neurol."},{"key":"BFnn1522_CR39","doi-asserted-by":"publisher","first-page":"4667","DOI":"10.1073\/pnas.95.8.4667","volume":"95","author":"HT Kao","year":"1998","unstructured":"Kao, H.T. et al. A third member of the synapsin gene family. Proc. Natl. Acad. Sci. USA 95, 4667\u20134672 (1998).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn1522_CR40","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1093\/cercor\/13.6.580","volume":"13","author":"AD Tramontin","year":"2003","unstructured":"Tramontin, A.D., Garcia-Verdugo, J.M., Lim, D.A. & Alvarez-Buylla, A. Postnatal development of radial glia and the ventricular zone (VZ): a continuum of the neural stem cell compartment. Cereb. Cortex 13, 580\u2013587 (2003).","journal-title":"Cereb. Cortex"},{"key":"BFnn1522_CR41","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/0896-6273(93)90311-E","volume":"10","author":"SW Levison","year":"1993","unstructured":"Levison, S.W. & Goldman, J.E. Both oligodendrocytes and astrocytes develop from progenitors in the subventricular zone of postnatal rat forebrain. Neuron 10, 201\u2013212 (1993).","journal-title":"Neuron"},{"key":"BFnn1522_CR42","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1126\/science.8178174","volume":"264","author":"C Lois","year":"1994","unstructured":"Lois, C. & Alvarez-Buylla, A. Long-distance neuronal migration in the adult mammalian brain. Science 264, 1145\u20131148 (1994).","journal-title":"Science"},{"key":"BFnn1522_CR43","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1093\/chemse\/19.6.695","volume":"19","author":"MB Luskin","year":"1994","unstructured":"Luskin, M.B. & Boone, M.S. Rate and pattern of migration of lineally-related olfactory bulb interneurons generated postnatally in the subventricular zone of the rat. Chem. Senses 19, 695\u2013714 (1994).","journal-title":"Chem. Senses"},{"key":"BFnn1522_CR44","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1007\/BF00580998","volume":"414","author":"FA Edwards","year":"1989","unstructured":"Edwards, F.A., Konnerth, A., Sakmann, B. & Takahashi, T. A thin slice preparation for patch clamp recordings from neurones of the mammalian central nervous system. Pflugers Arch. 414, 600\u2013612 (1989).","journal-title":"Pflugers Arch."},{"key":"BFnn1522_CR45","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/S1385-299X(99)00033-1","volume":"4","author":"TF Haydar","year":"1999","unstructured":"Haydar, T.F., Bambrick, L.L., Krueger, B.K. & Rakic, P. Organotypic slice cultures for analysis of proliferation, cell death, and migration in the embryonic neocortex. Brain Res. Brain Res. Protoc. 4, 425\u2013437 (1999).","journal-title":"Brain Res. Brain Res. Protoc."}],"container-title":["Nature Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nn1522.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn1522","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn1522.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T23:55:30Z","timestamp":1684454130000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nn1522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,14]]},"references-count":45,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["BFnn1522"],"URL":"https:\/\/doi.org\/10.1038\/nn1522","relation":{},"ISSN":["1097-6256","1546-1726"],"issn-type":[{"value":"1097-6256","type":"print"},{"value":"1546-1726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8,14]]}}}