{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:00:55Z","timestamp":1791302455224,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2007,1,14]],"date-time":"2007-01-14T00:00:00Z","timestamp":1168732800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Neurosci"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1038\/nn1841","type":"journal-article","created":{"date-parts":[[2007,1,14]],"date-time":"2007-01-14T13:03:28Z","timestamp":1168779808000},"page":"177-185","source":"Crossref","is-referenced-by-count":162,"title":["Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubules"],"prefix":"10.1038","volume":"10","author":[{"given":"Xinnan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W Robert","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilda T H","family":"Tsang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Reid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cahir J","family":"O'Kane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,1,14]]},"reference":[{"key":"BFnn1841_CR1","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1146\/annurev.biochem.75.103004.142637","volume":"75","author":"GB Stokin","year":"2006","unstructured":"Stokin, G.B. & Goldstein, L.S.B. Axonal transport and Alzheimer's disease. Annu. Rev. Biochem. 75, 607\u2013627 (2006).","journal-title":"Annu. Rev. Biochem."},{"key":"BFnn1841_CR2","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1136\/jmg.40.2.81","volume":"40","author":"E Reid","year":"2003","unstructured":"Reid, E. Science in motion: common molecular pathological themes emerge in the hereditary spastic paraplegias. J. Med. Genet. 40, 81\u201386 (2003).","journal-title":"J. Med. Genet."},{"key":"BFnn1841_CR3","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s11910-996-0011-1","volume":"6","author":"JK Fink","year":"2006","unstructured":"Fink, J.K. Hereditary spastic paraplegia. Curr. Neurol. Neurosci. Rep. 6, 65\u201376 (2006).","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"BFnn1841_CR4","doi-asserted-by":"publisher","first-page":"9123","DOI":"10.1074\/jbc.M009270200","volume":"276","author":"L Zeitlmann","year":"2001","unstructured":"Zeitlmann, L., Sirim, P., Kremmer, E. & Kolanus, W. Cloning of ACP33 as a novel intracellular ligand of CD4. J. Biol. Chem. 276, 9123\u20139132 (2001).","journal-title":"J. Biol. Chem."},{"key":"BFnn1841_CR5","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1086\/379522","volume":"73","author":"MA Simpson","year":"2003","unstructured":"Simpson, M.A. et al. Maspardin is mutated in mast syndrome, a complicated form of hereditary spastic paraplegia associated with dementia. Am. J. Hum. Genet. 73, 1147\u20131156 (2003).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnn1841_CR6","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1016\/j.bbrc.2005.06.201","volume":"334","author":"JC Bakowska","year":"2005","unstructured":"Bakowska, J.C., Jenkins, R., Pendleton, J. & Blackstone, C. The Troyer syndrome (SPG20) protein spartin interacts with Eps15. Biochem. Biophys. Res. Commun. 334, 1042\u20131048 (2005).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFnn1841_CR7","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1093\/hmg\/ddi003","volume":"14","author":"E Reid","year":"2005","unstructured":"Reid, E. et al. The hereditary spastic paraplegia protein spastin interacts with the ESCRT-III complex-associated endosomal protein CHMP1B. Hum. Mol. Genet. 14, 19\u201338 (2005).","journal-title":"Hum. Mol. Genet."},{"key":"BFnn1841_CR8","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1086\/504927","volume":"79","author":"AU Mannan","year":"2006","unstructured":"Mannan, A.U. et al. ZFYVE27 (SPG33), a novel spastin-binding protein, is mutated in hereditary spastic paraplegia. Am. J. Hum. Genet. 79, 351\u2013357 (2006).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnn1841_CR9","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1093\/hmg\/ddg184","volume":"12","author":"A Otomo","year":"2003","unstructured":"Otomo, A. et al. ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics. Hum. Mol. Genet. 12, 1671\u20131687 (2003).","journal-title":"Hum. Mol. Genet."},{"key":"BFnn1841_CR10","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1086\/378817","volume":"73","author":"S Rainier","year":"2003","unstructured":"Rainier, S., Chai, J.H., Tokarz, D., Nicholls, R.D. & Fink, J.K. NIPA1 gene mutations cause autosomal dominant hereditary spastic paraplegia (SPG6). Am. J. Hum. Genet. 73, 967\u2013971 (2003).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnn1841_CR11","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1002\/humu.20126","volume":"25","author":"S Chen","year":"2005","unstructured":"Chen, S. et al. Distinct novel mutations affecting the same base in the NIPA1 gene cause autosomal dominant hereditary spastic paraplegia in two Chinese families. Hum. Mutat. 25, 135\u2013141 (2005).","journal-title":"Hum. Mutat."},{"key":"BFnn1841_CR12","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s10048-004-0209-9","volume":"6","author":"JA Reed","year":"2005","unstructured":"Reed, J.A. et al. A novel NIPA1 mutation associated with a pure form of autosomal dominant hereditary spastic paraplegia. Neurogenetics 6, 79\u201384 (2005).","journal-title":"Neurogenetics"},{"key":"BFnn1841_CR13","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1002\/mds.21005","volume":"21","author":"S Kaneko","year":"2006","unstructured":"Kaneko, S. et al. Novel SPG6 mutation p.A100T in a Japanese family with autosomal dominant form of hereditary spastic paraplegia. Mov. Disord. 21, 1531\u20131533 (2006).","journal-title":"Mov. Disord."},{"key":"BFnn1841_CR14","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1086\/378816","volume":"73","author":"JH Chai","year":"2003","unstructured":"Chai, J.H. et al. Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi\/Angelman Syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons. Am. J. Hum. Genet. 73, 898\u2013925 (2003).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnn1841_CR15","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1093\/hmg\/ddh263","volume":"13","author":"C Lef\u00e8vre","year":"2004","unstructured":"Lef\u00e8vre, C. et al. Mutations in ichthyin a new gene on chromosome 5q33 in a new form of autosomal recessive congenital ichthyosis. Hum. Mol. Genet. 13, 2473\u20132482 (2004).","journal-title":"Hum. Mol. Genet."},{"key":"BFnn1841_CR16","doi-asserted-by":"publisher","first-page":"81","DOI":"10.2165\/00128071-200304020-00002","volume":"4","author":"JJ DiGiovanna","year":"2003","unstructured":"DiGiovanna, J.J. & Robinson-Bostom, L. Ichthyosis: etiology, diagnosis, and management. Am. J. Clin. Dermatol. 4, 81\u201395 (2003).","journal-title":"Am. J. Clin. Dermatol."},{"key":"BFnn1841_CR17","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/S0896-6273(02)00589-5","volume":"33","author":"H Aberle","year":"2002","unstructured":"Aberle, H. et al. Wishful thinking encodes a BMP type II receptor that regulates synaptic growth in Drosophila. Neuron 33, 545\u2013558 (2002).","journal-title":"Neuron"},{"key":"BFnn1841_CR18","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0896-6273(02)00595-0","volume":"33","author":"G Marqu\u00e9s","year":"2002","unstructured":"Marqu\u00e9s, G. et al. The Drosophila BMP type II receptor Wishful Thinking regulates neuromuscular synapse morphology and function. Neuron 33, 529\u2013543 (2002).","journal-title":"Neuron"},{"key":"BFnn1841_CR19","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/S0896-6273(03)00426-4","volume":"39","author":"BD McCabe","year":"2003","unstructured":"McCabe, B.D. et al. The BMP homolog Gbb provides a retrograde signal that regulates synaptic growth at the Drosophila neuromuscular junction. Neuron 39, 241\u2013254 (2003).","journal-title":"Neuron"},{"key":"BFnn1841_CR20","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/S0896-6273(04)00073-X","volume":"41","author":"BD McCabe","year":"2004","unstructured":"McCabe, B.D. et al. Highwire regulates presynaptic BMP signaling essential for synaptic growth. Neuron 41, 891\u2013905 (2004).","journal-title":"Neuron"},{"key":"BFnn1841_CR21","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.neuron.2005.08.010","volume":"47","author":"BA Eaton","year":"2005","unstructured":"Eaton, B.A. & Davis, G.W. LIM Kinase1 controls synaptic stability downstream of the type II BMP receptor. Neuron 47, 695\u2013708 (2005).","journal-title":"Neuron"},{"key":"BFnn1841_CR22","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0896-6273(02)01014-0","volume":"36","author":"ST Sweeney","year":"2002","unstructured":"Sweeney, S.T. & Davis, G.W. Unrestricted synaptic growth in spinster\u2014a late endosomal protein implicated in TGF-\u03b2-mediated synaptic growth regulation. Neuron 36, 403\u2013416 (2002).","journal-title":"Neuron"},{"key":"BFnn1841_CR23","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/S0896-6273(00)81166-6","volume":"26","author":"HI Wan","year":"2000","unstructured":"Wan, H.I. et al. Highwire regulates synaptic growth in Drosophila. Neuron 26, 313\u2013329 (2000).","journal-title":"Neuron"},{"key":"BFnn1841_CR24","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.neuron.2006.05.026","volume":"51","author":"CA Collins","year":"2006","unstructured":"Collins, C.A., Wairkar, Y.P., Johnson, S.L. & DiAntonio, A. Highwire restrains synaptic growth by attenuating a MAP kinase signal. Neuron 51, 57\u201369 (2006).","journal-title":"Neuron"},{"key":"BFnn1841_CR25","doi-asserted-by":"publisher","first-page":"e429","DOI":"10.1371\/journal.pbio.0020429","volume":"2","author":"NT Sherwood","year":"2004","unstructured":"Sherwood, N.T., Sun, Q., Xue, M., Zhang, B. & Zinn, K. Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function. PLoS Biol. 2, e429 (2004).","journal-title":"PLoS Biol."},{"key":"BFnn1841_CR26","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1016\/j.cub.2004.06.058","volume":"14","author":"N Trotta","year":"2004","unstructured":"Trotta, N., Orso, G., Rossetto, M.G., Daga, A. & Broadie, K. The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function. Curr. Biol. 14, 1135\u20131147 (2004).","journal-title":"Curr. Biol."},{"key":"BFnn1841_CR27","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1242\/jcs.92.1.57","volume":"92","author":"DR Webster","year":"1989","unstructured":"Webster, D.R. & Borisy, G.G. Microtubules are acetylated in domains that turn over slowly. J. Cell Sci. 92, 57\u201365 (1989).","journal-title":"J. Cell Sci."},{"key":"BFnn1841_CR28","doi-asserted-by":"publisher","first-page":"3726","DOI":"10.1128\/MCB.25.9.3726-3736.2005","volume":"25","author":"RK Vadlamudi","year":"2005","unstructured":"Vadlamudi, R.K. et al. p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B. Mol. Cell. Biol. 25, 3726\u20133736 (2005).","journal-title":"Mol. Cell. Biol."},{"key":"BFnn1841_CR29","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/S0896-6273(00)81170-8","volume":"26","author":"J Roos","year":"2000","unstructured":"Roos, J., Hummel, T., Ng, N., Klambt, C. & Davis, G.W. Drosophila Futsch regulates synaptic microtubule organization and is necessary for synaptic growth. Neuron 26, 371\u2013382 (2000).","journal-title":"Neuron"},{"key":"BFnn1841_CR30","doi-asserted-by":"crossref","first-page":"3373","DOI":"10.1242\/jcs.112.19.3373","volume":"112","author":"RG Goold","year":"1999","unstructured":"Goold, R.G., Owen, R. & Gordon-Weeks, P.R. Glycogen synthase kinase 3\u03b2 phosphorylation of microtubule-associated protein 1B regulates the stability of microtubules in growth cones. J. Cell Sci. 112, 3373\u20133384 (1999).","journal-title":"J. Cell Sci."},{"key":"BFnn1841_CR31","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1242\/dev.02214","volume":"133","author":"MB O'Connor","year":"2006","unstructured":"O'Connor, M.B., Umulis, D., Othmer, H. & Blair, S.S. Shaping BMP morphogen gradients in the Drosophila embryo and pupal wings. Development 133, 183\u2013193 (2006).","journal-title":"Development"},{"key":"BFnn1841_CR32","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.ydbio.2005.01.018","volume":"280","author":"A Ralston","year":"2005","unstructured":"Ralston, A. & Blair, S.S. Long-range Dpp signaling is regulated to restrict BMP signaling to a crossvein competent zone. Dev. Biol. 280, 187\u2013200 (2005).","journal-title":"Dev. Biol."},{"key":"BFnn1841_CR33","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/j.cub.2006.02.061","volume":"16","author":"V Dudu","year":"2006","unstructured":"Dudu, V. et al. Postsynaptic Mad signaling at the Drosophila neuromuscular junction. Curr. Biol. 16, 625\u2013635 (2006).","journal-title":"Curr. Biol."},{"key":"BFnn1841_CR34","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1038\/sj.embor.7400019","volume":"4","author":"G J\u00e9kely","year":"2003","unstructured":"J\u00e9kely, G. & R\u00f8rth, P. Hrs mediates downregulation of multiple signalling receptors in Drosophila. EMBO Rep. 4, 1163\u20131168 (2003).","journal-title":"EMBO Rep."},{"key":"BFnn1841_CR35","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.devcel.2005.09.020","volume":"9","author":"BJ Thompson","year":"2005","unstructured":"Thompson, B.J. et al. Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila. Dev. Cell 9, 711\u2013720 (2005).","journal-title":"Dev. Cell"},{"key":"BFnn1841_CR36","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1038\/ncb1324","volume":"7","author":"H Lu","year":"2005","unstructured":"Lu, H. & Bilder, D. Endocytic control of epithelial polarity and proliferation in Drosophila. Nat. Cell Biol. 7, 1232\u20131242 (2005).","journal-title":"Nat. Cell Biol."},{"key":"BFnn1841_CR37","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/S0896-6273(02)00721-3","volume":"34","author":"BA Eaton","year":"2002","unstructured":"Eaton, B.A., Fetter, R.D. & Davis, G.W. Dynactin is necessary for synapse stabilization. Neuron 34, 729\u2013741 (2002).","journal-title":"Neuron"},{"key":"BFnn1841_CR38","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1126\/science.1104751","volume":"307","author":"MC Gibson","year":"2005","unstructured":"Gibson, M.C. & Perrimon, N. Extrusion and death of DPP\/BMP-compromised epithelial cells in the developing Drosophila wing. Science 307, 1785\u20131789 (2005).","journal-title":"Science"},{"key":"BFnn1841_CR39","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1038\/sj.emboj.7600183","volume":"23","author":"AG Li","year":"2004","unstructured":"Li, A.G., Wang, D., Feng, X.-H. & Wang,, X.-J. Latent TGF\u03b21 overexpression in keratinocytes results in a severe psoriasis-like skin disorder. EMBO J. 23, 1770\u20131781 (2004).","journal-title":"EMBO J."},{"key":"BFnn1841_CR40","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/S0925-4773(00)00248-3","volume":"91","author":"D Casso","year":"2000","unstructured":"Casso, D., Ramirez-Weber, F.A. & Kornberg, T.B. GFP-tagged balancer chromosomes for Drosophila melanogaster. Mech. Dev. 91, 451\u2013454 (2000).","journal-title":"Mech. Dev."},{"key":"BFnn1841_CR41","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.118.2.401","volume":"118","author":"AH Brand","year":"1993","unstructured":"Brand, A.H. & Perrimon, N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401\u2013415 (1993).","journal-title":"Development"},{"key":"BFnn1841_CR42","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1101\/gad.13.1.98","volume":"13","author":"T Brummel","year":"1999","unstructured":"Brummel, T. et al. The Drosophila Activin receptor Baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development. Genes Dev. 13, 98\u2013111 (1999).","journal-title":"Genes Dev."},{"key":"BFnn1841_CR43","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1242\/dev.118.4.1077","volume":"118","author":"JT Littleton","year":"1993","unstructured":"Littleton, J.T., Bellen, H.J. & Perin, M.S. Expression of synaptotagmin in Drosophila reveals transport and localization of synaptic vesicles to the synapse. Development 118, 1077\u20131088 (1993).","journal-title":"Development"},{"key":"BFnn1841_CR44","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0014-5793(98)00954-5","volume":"434","author":"U Persson","year":"1998","unstructured":"Persson, U. et al. The L45 loop in type I receptors for TGF-\u03b2 family members is a critical determinant in specifying Smad isoform activation. FEBS Lett. 434, 83\u201387 (1998).","journal-title":"FEBS Lett."},{"key":"BFnn1841_CR45","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/BF00215114","volume":"175","author":"BA Stewart","year":"1994","unstructured":"Stewart, B.A., Atwood, H.L., Renger, J.J., Wang, J. & Wu, C.-F. Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions. J. Comp. Physiol. [A] 175, 179\u2013191 (1994).","journal-title":"J. Comp. Physiol. [A]"},{"key":"BFnn1841_CR46","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1083\/jcb.200211087","volume":"161","author":"T Wucherpfennig","year":"2003","unstructured":"Wucherpfennig, T., Wilsch-Brauninger, M. & Gonzalez-Gaitan,, M. Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter release. J. Cell Biol. 161, 609\u2013624 (2003).","journal-title":"J. Cell Biol."},{"key":"BFnn1841_CR47","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1083\/jcb.133.6.1205","volume":"133","author":"H Kr\u00e4mer","year":"1996","unstructured":"Kr\u00e4mer, H. & Phistry, M. Mutations in the Drosophila hook gene inhibit endocytosis of the boss transmembrane ligand into multivesicular bodies. J. Cell Biol. 133, 1205\u20131215 (1996).","journal-title":"J. Cell Biol."},{"key":"BFnn1841_CR48","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/S0896-6273(01)00485-8","volume":"32","author":"D Parnas","year":"2001","unstructured":"Parnas, D., Haghighi, A.P., Fetter, R.D., Kim, S.W. & Goodman, C.S. Regulation of postsynaptic structure and protein localization by the Rho-type guanine nucleotide exchange factor dPix. Neuron 32, 415\u2013424 (2001).","journal-title":"Neuron"},{"key":"BFnn1841_CR49","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3109\/01677069009084150","volume":"7","author":"KE Zinsmaier","year":"1990","unstructured":"Zinsmaier, K.E. et al. A cysteine-string protein is expressed in retina and brain of Drosophila. J. Neurogenet. 7, 15\u201329 (1990).","journal-title":"J. Neurogenet."},{"key":"BFnn1841_CR50","doi-asserted-by":"publisher","first-page":"3497","DOI":"10.1093\/nar\/gkg500","volume":"31","author":"R Chenna","year":"2003","unstructured":"Chenna, R. et al. Multiple sequence alignment with the Clustal series of programs. Nucleic Acids Res. 31, 3497\u20133500 (2003).","journal-title":"Nucleic Acids Res."}],"container-title":["Nature Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nn1841.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn1841","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn1841.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T19:59:06Z","timestamp":1684439946000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nn1841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,14]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["BFnn1841"],"URL":"https:\/\/doi.org\/10.1038\/nn1841","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1065931.518886","asserted-by":"object"}]},"ISSN":["1097-6256","1546-1726"],"issn-type":[{"value":"1097-6256","type":"print"},{"value":"1546-1726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,14]]}}}