{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:15:51Z","timestamp":1791112551353,"version":"4.1.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2002,2,4]],"date-time":"2002-02-04T00:00:00Z","timestamp":1012780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Neurosci"],"published-print":{"date-parts":[[2002,3]]},"DOI":"10.1038\/nn805","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:30:40Z","timestamp":1027672240000},"page":"210-217","source":"Crossref","is-referenced-by-count":165,"title":["Differential modulation of Cav2.1 channels by calmodulin and Ca2+-binding protein 1"],"prefix":"10.1038","volume":"5","author":[{"given":"Amy","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth E.","family":"Westenbroek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Haeseleer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Palczewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Scheuer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Catterall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2002,2,4]]},"reference":[{"key":"BFnn805_CR1","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1126\/science.2432656","volume":"235","author":"RJ Miller","year":"1987","unstructured":"Miller, R. J. Multiple calcium channels and neuronal function. Science 235, 46\u201352 (1987).","journal-title":"Science"},{"key":"BFnn805_CR2","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0143-4160(98)90055-0","volume":"24","author":"WA Catterall","year":"1998","unstructured":"Catterall, W. A. Structure and function of neuronal Ca2+ channels and their role in neurotransmitter release. Cell Calcium 24, 307\u2013323 (1998).","journal-title":"Cell Calcium"},{"key":"BFnn805_CR3","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/380255a0","volume":"380","author":"SR Ikeda","year":"1996","unstructured":"Ikeda, S. R. Voltage-dependent modulation of N-type calcium channels by G-protein \u03b2\u03b3 subunits. Nature 380, 255\u2013258 (1996).","journal-title":"Nature"},{"key":"BFnn805_CR4","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/380258a0","volume":"380","author":"S Herlitze","year":"1996","unstructured":"Herlitze, S. et al. Modulation of Ca2+ channels by G protein \u03b2\u03b3 subunits. Nature 380, 258\u2013262 (1996).","journal-title":"Nature"},{"key":"BFnn805_CR5","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/385446a0","volume":"385","author":"M De Waard","year":"1997","unstructured":"De Waard, M. et al. Direct binding of G-protein \u03b2\u03b3 complex to voltage-dependent calcium channels. Nature 385, 446\u2013450 (1997).","journal-title":"Nature"},{"key":"BFnn805_CR6","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/378623a0","volume":"378","author":"I Bezprozvanny","year":"1995","unstructured":"Bezprozvanny, I., Scheller, R. H. & Tsien, R. W. Functional impact of syntaxin on gating of N-type and Q-type calcium channels. Nature 378, 623\u2013626 (1995).","journal-title":"Nature"},{"key":"BFnn805_CR7","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1038\/14721","volume":"2","author":"H Zhong","year":"1999","unstructured":"Zhong, H., Yokoyama, C. T., Scheuer, T. & Catterall, W. A. Reciprocal regulation of P\/Q-type Ca2+ channels by SNAP-25, syntaxin and synaptotagmin. Nat. Neurosci. 2, 939\u2013941 (1999).","journal-title":"Nat. Neurosci."},{"key":"BFnn805_CR8","doi-asserted-by":"publisher","first-page":"4100","DOI":"10.1002\/j.1460-2075.1996.tb00785.x","volume":"15","author":"O Wiser","year":"1996","unstructured":"Wiser, O., Bennett, M. K. & Atlas, D. Functional interaction of syntaxin and SNAP-25 with voltage-sensitive L- and N-type Ca2+ channels. EMBO J. 15, 4100\u20134110 (1996).","journal-title":"EMBO J."},{"key":"BFnn805_CR9","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/20194","volume":"339","author":"A Lee","year":"1999","unstructured":"Lee, A. et al. Ca2+\/calmodulin binds to and modulates P\/Q-type calcium channels. Nature 339, 155\u2013159 (1999).","journal-title":"Nature"},{"key":"BFnn805_CR10","doi-asserted-by":"publisher","first-page":"6830","DOI":"10.1523\/JNEUROSCI.20-18-06830.2000","volume":"20","author":"A Lee","year":"2000","unstructured":"Lee, A., Scheuer, T. & Catterall, W. A. Ca2+\/calmodulin-dependent facilitation and inactivation of P\/Q-type Ca2+ channels. J. Neurosci. 20, 6830\u20136838 (2000).","journal-title":"J. Neurosci."},{"key":"BFnn805_CR11","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.1073\/pnas.96.5.2435","volume":"96","author":"N Qin","year":"1999","unstructured":"Qin, N., Olcese, R., Bransby, M., Lin, T. & Birnbaumer, L. Ca2+-induced inhibition of the cardiac Ca2+ channel depends on calmodulin. Proc. Natl. Acad. Sci. USA 96, 2435\u20132438 (1999).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn805_CR12","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/S0896-6273(00)80709-6","volume":"22","author":"BZ Peterson","year":"1999","unstructured":"Peterson, B. Z., DeMaria, C. D. & Yue, D. T. Calmodulin is the Ca2+ sensor for Ca2+-dependent inactivation of L-type calcium channels. Neuron 22, 549\u2013558 (1999).","journal-title":"Neuron"},{"key":"BFnn805_CR13","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/20200","volume":"399","author":"RG Z\u00fchlke","year":"1999","unstructured":"Z\u00fchlke, R. G., Pitt, G. S., Deisseroth, K., Tsien, R. W. & Reuter, H. Calmodulin supports both inactivation and facilitation of L-type calcium channels. Nature 399, 159\u2013161 (1999).","journal-title":"Nature"},{"key":"BFnn805_CR14","doi-asserted-by":"publisher","first-page":"39786","DOI":"10.1074\/jbc.M007158200","volume":"275","author":"P Pate","year":"2000","unstructured":"Pate, P. et al. Determinants for calmodulin binding on voltage-dependent Ca2+ channels. J. Biol. Chem. 275, 39786\u201339792 (2000).","journal-title":"J. Biol. Chem."},{"key":"BFnn805_CR15","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1038\/35078091","volume":"411","author":"CD DeMaria","year":"2001","unstructured":"DeMaria, C. D., Soong, T., Alseikhan, B. A., Alvania, R. S. & Yue, D. T. Calmodulin bifurcates the local Ca2+ signal that modulates P\/Q-type Ca2+ channels. Nature 411, 484\u2013489 (2001).","journal-title":"Nature"},{"key":"BFnn805_CR16","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/S0896-6273(00)81017-X","volume":"20","author":"ID Forsythe","year":"1998","unstructured":"Forsythe, I. D., Tsujimoto, T., Barnes-Davies, M., Cuttle, M. F. & Takahashi, T. Inactivation of presynaptic calcium current contributes to synaptic depression at a fast central synapse. Neuron 20, 797\u2013807 (1998).","journal-title":"Neuron"},{"key":"BFnn805_CR17","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1111\/j.1469-7793.1998.723bd.x","volume":"512","author":"MF Cuttle","year":"1998","unstructured":"Cuttle, M. F., Tsujimoto, T., Forsythe, I. D. & Takahashi, T. Facilitation of the presynaptic calcium current at an auditory synapse in rat brainstem. J. Physiol. (Lond.) 512, 723\u2013729 (1998).","journal-title":"J. Physiol. (Lond.)"},{"key":"BFnn805_CR18","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/j.1469-7793.1998.149by.x","volume":"513","author":"JG Borst","year":"1998","unstructured":"Borst, J. G. & Sakmann, B. Facilitation of presynaptic calcium currents in the rat brainstem. J. Physiol. (Lond.) 513, 149\u2013155 (1998).","journal-title":"J. Physiol. (Lond.)"},{"key":"BFnn805_CR19","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/0166-2236(95)80030-6","volume":"18","author":"K Dunlap","year":"1995","unstructured":"Dunlap, K., Luebke, J. I. & Turner, T. J. Exocytotic Ca2+ channels in mammalian central neurons. Trends Neurosci. 18, 89\u201398 (1995).","journal-title":"Trends Neurosci."},{"key":"BFnn805_CR20","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1126\/science.7832825","volume":"264","author":"DB Wheeler","year":"1994","unstructured":"Wheeler, D. B., Randall, A. & Tsien, R. W. Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission. Science 264, 107\u2013111 (1994).","journal-title":"Science"},{"key":"BFnn805_CR21","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/S0166-2236(96)10059-X","volume":"19","author":"A Polans","year":"1996","unstructured":"Polans, A., Baehr, W. & Palczewski, K. Turned on by Ca2+! The physiology and pathology of Ca2+-binding proteins in the retina. Trends Neurosci. 19, 547\u2013554 (1996).","journal-title":"Trends Neurosci."},{"key":"BFnn805_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/bj3530001","volume":"353","author":"RD Burgoyne","year":"2001","unstructured":"Burgoyne, R. D. & Weiss, J. L. The neuronal calcium sensor family of Ca2+-binding proteins. Biochem. J. 353, 1\u201312 (2001).","journal-title":"Biochem. J."},{"key":"BFnn805_CR23","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1096\/fj.00-0072com","volume":"14","author":"M Sallese","year":"2000","unstructured":"Sallese, M. et al. The G-protein-coupled receptor kinase GRK4 mediates homologous desensitization of metabotropic glutamate receptor 1. FASEB J. 14, 2569\u20132580 (2000).","journal-title":"FASEB J."},{"key":"BFnn805_CR24","doi-asserted-by":"publisher","first-page":"9253","DOI":"10.1073\/pnas.93.17.9253","volume":"93","author":"NC Schaad","year":"1996","unstructured":"Schaad, N. C. et al. Direct modulation of calmodulin targets by the neuronal calcium sensor NCS-1. Proc. Natl. Acad. Sci. USA 93, 9253\u20139258 (1996).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn805_CR25","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1074\/jbc.275.2.1247","volume":"275","author":"F Haeseleer","year":"2000","unstructured":"Haeseleer, F. et al. Five members of a novel Ca2+-binding protein (CABP) subfamily with similarity to calmodulin. J. Biol. Chem. 275, 1247\u20131260 (2000).","journal-title":"J. Biol. Chem."},{"key":"BFnn805_CR26","doi-asserted-by":"publisher","first-page":"10576","DOI":"10.1073\/pnas.91.22.10576","volume":"91","author":"A Stea","year":"1994","unstructured":"Stea, A. et al. The localization and functional properties of a rat brain \u03b11A calcium channel reflect similarities to neuronal Q- and P-type channels. Proc. Natl. Acad. Sci. USA 91, 10576\u201310580 (1994).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn805_CR27","doi-asserted-by":"publisher","first-page":"21324","DOI":"10.1074\/jbc.273.33.21324","volume":"273","author":"CI Seidenbecher","year":"1998","unstructured":"Seidenbecher, C. I. et al. Caldendrin, a novel neuronal calcium-binding protein confined to the somato-dendritic compartment. J. Biol. Chem. 273, 21324\u201321331 (1998).","journal-title":"J. Biol. Chem."},{"key":"BFnn805_CR28","doi-asserted-by":"publisher","first-page":"6403","DOI":"10.1523\/JNEUROSCI.15-10-06403.1995","volume":"15","author":"RE Westenbroek","year":"1995","unstructured":"Westenbroek, R. E. et al. Immunochemical identification and subcellular distribution of the \u03b11A subunits of brain calcium channels. J. Neurosci. 15, 6403\u20136418 (1995).","journal-title":"J. Neurosci."},{"key":"BFnn805_CR29","first-page":"75","volume":"26","author":"SH Chao","year":"1984","unstructured":"Chao, S. H., Suzuki, Y., Zysk, J. R. & Cheung, W. Y. Activation of calmodulin by various metal cations as a function of ionic radius. Mol. Pharmacol. 26, 75\u201382 (1984).","journal-title":"Mol. Pharmacol."},{"key":"BFnn805_CR30","doi-asserted-by":"publisher","first-page":"7807","DOI":"10.1021\/bi0005660","volume":"39","author":"GG Rodney","year":"2000","unstructured":"Rodney, G. G., Williams, B. Y., Strasburg, G. M., Beckingham, K. & Hamilton, S. L. Regulation of RYR1 activity by Ca2+ and calmodulin. Biochemistry 39, 7807\u20137812 (2000).","journal-title":"Biochemistry"},{"key":"BFnn805_CR31","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/0006-291X(80)91293-0","volume":"94","author":"T Yamaki","year":"1980","unstructured":"Yamaki, T. & Hidaka, H. Ca2+-independent stimulation of cyclic GMP-dependent protein kinase by calmodulin. Biochem. Biophys. Res. Commun. 94, 727\u2013733 (1980).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFnn805_CR32","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.1021\/bi00540a028","volume":"21","author":"DV Greenlee","year":"1982","unstructured":"Greenlee, D. V., Andreasen, T. J. & Storm, D. R. Calcium-independent stimulation of Bordetella pertussis adenylate cyclase. Biochemistry 21, 2759\u20132764 (1982).","journal-title":"Biochemistry"},{"key":"BFnn805_CR33","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1021\/bi972306x","volume":"37","author":"M Rudnicka-Nawrot","year":"1998","unstructured":"Rudnicka-Nawrot, M. et al. Changes in biological activity and folding of guanylate cyclase-activating protein 1 as a function of calcium. Biochemistry 37, 248\u2013257 (1998).","journal-title":"Biochemistry"},{"key":"BFnn805_CR34","doi-asserted-by":"publisher","first-page":"6526","DOI":"10.1074\/jbc.274.10.6526","volume":"274","author":"F Haeseleer","year":"1999","unstructured":"Haeseleer, F. et al. Molecular characterization of a third member of the guanylyl cyclase-activating protein subfamily. J. Biol. Chem. 274, 6526\u20136535 (1999).","journal-title":"J. Biol. Chem."},{"key":"BFnn805_CR35","doi-asserted-by":"publisher","first-page":"22768","DOI":"10.1074\/jbc.273.35.22768","volume":"273","author":"BW McFerran","year":"1998","unstructured":"McFerran, B. W., Graham, M. E. & Burgoyne, R. D. Neuronal Ca2+ sensor 1, the mammalian homologue of frequenin, is expressed in chromaffin and PC12 cells and regulates neurosecretion from dense-core granules. J. Biol. Chem. 273, 22768\u201322772 (1998).","journal-title":"J. Biol. Chem."},{"key":"BFnn805_CR36","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1111\/j.1469-7793.2001.0649e.x","volume":"532","author":"XL Chen","year":"2001","unstructured":"Chen, X. L. et al. Overexpression of rat neuronal calcium sensor-1 in rodent NG108-15 cells enhances synapse formation and transmission. J. Physiol. (Lond.) 532, 649\u2013659 (2001).","journal-title":"J. Physiol. (Lond.)"},{"key":"BFnn805_CR37","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/S0896-6273(01)00276-8","volume":"30","author":"M Gomez","year":"2001","unstructured":"Gomez, M. et al. Ca2+ signaling via the neuronal calcium sensor-1 regulates associative learning and memory in C. elegans. Neuron 30, 241\u2013248 (2001).","journal-title":"Neuron"},{"key":"BFnn805_CR38","doi-asserted-by":"publisher","first-page":"40082","DOI":"10.1074\/jbc.M008603200","volume":"275","author":"JL Weiss","year":"2000","unstructured":"Weiss, J. L., Archer, D. A. & Burgoyne, R. D. Neuronal Ca2+ sensor-1\/frequenin functions in an autocrine pathway regulating Ca2+ channels in bovine adrenal chromaffin cells. J. Biol. Chem. 275, 40082\u201340087 (2000).","journal-title":"J. Biol. Chem."},{"key":"BFnn805_CR39","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1083\/jcb.134.2.511","volume":"134","author":"T Sakurai","year":"1996","unstructured":"Sakurai, T., Westenbroek, R. E., Rettig, J., Hell, J. & Catterall, W. A. Biochemical properties and subcellular distribution of the BI and rbA isoforms of \u03b11A subunits of brain calcium channels. J. Cell Biol. 134, 511\u2013528 (1996).","journal-title":"J. Cell Biol."}],"container-title":["Nature Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nn805.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn805","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn805.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:02:38Z","timestamp":1684454558000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nn805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2,4]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,3]]}},"alternative-id":["BFnn805"],"URL":"https:\/\/doi.org\/10.1038\/nn805","relation":{},"ISSN":["1097-6256","1546-1726"],"issn-type":[{"value":"1097-6256","type":"print"},{"value":"1546-1726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,2,4]]}}}