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Lewy body and amyloid \u03b2 (A\u03b2) pathology and cortical atrophy may be involved. The aim of this study was to examine whether medial temporal lobe structural changes may be linked to cerebrospinal fluid (CSF) biomarker levels and cognition in early PD. PD patients had smaller volumes of total hippocampus, presubiculum, subiculum, CA2\u20133, CA4-DG, and hippocampal tail compared with normal controls (NCs). In the PD group, lower CSF A\u03b238 and 42 were significant predictors for thinner perirhinal cortex. Lower A\u03b242 and smaller presubiculum and subiculum predicted poorer verbal learning and delayed verbal recall. Smaller total hippocampus, presubiculum and subiculum predicted poorer visuospatial copying. Lower A\u03b238 and 40 and thinner perirhinal cortex predicted poorer delayed visual reproduction. In conclusion, smaller volumes of hippocampal subfields and subhippocampal cortex thickness linked to lower CSF A\u03b2 levels may contribute to cognitive impairment in early PD. Thirty-three early PD patients (13 without, 5 with subjective, and 15 with mild cognitive impairment) and NC had 3\u2009T magnetic resonance imaging (MRI) scans. The MRI scans were post processed for volumes of hippocampal subfields and entorhinal and perirhinal cortical thickness. Lumbar puncture for CSF biomarkers A\u03b238, 40, 42, total tau, phosphorylated tau (Innogenetics), and total \u03b1-synuclein (Meso Scale Diagnostics) were performed. Multiple regression analyses were used for between-group comparisons of the MRI measurements in the NC and PD groups and for assessment of CSF biomarkers and neuropsychological tests in relation to morphometry in the PD group.<\/jats:p>","DOI":"10.1038\/npjparkd.2015.30","type":"journal-article","created":{"date-parts":[[2016,1,13]],"date-time":"2016-01-13T21:27:23Z","timestamp":1452720443000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Hippocampal subfield atrophy in relation to cerebrospinal fluid biomarkers and cognition in early Parkinson\u2019s disease: a cross-sectional study"],"prefix":"10.1038","volume":"2","author":[{"given":"Ane L\u00f8vli","family":"Stav","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztina Kunszt","family":"Johansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirik","family":"Auning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa Flem","family":"Kalheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Selnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atle","family":"Bj\u00f8rnerud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Hessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dag","family":"Aarsland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tormod","family":"Fladby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,1,14]]},"reference":[{"key":"BFnpjparkd201530_CR1","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s11910-011-0203-1","volume":"11","author":"D Aarsland","year":"2011","unstructured":"Aarsland, D., Br\u00f8nnick, K. & Fladby, T. 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