{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:44:22Z","timestamp":1790891062947,"version":"4.1.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2008,8,27]],"date-time":"2008-08-27T00:00:00Z","timestamp":1219795200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1038\/npp.2008.139","type":"journal-article","created":{"date-parts":[[2008,8,27]],"date-time":"2008-08-27T14:15:52Z","timestamp":1219846552000},"page":"767-774","source":"Crossref","is-referenced-by-count":53,"title":["Olfactory Receptor Neuron Dysfunction in Schizophrenia"],"prefix":"10.1038","volume":"34","author":[{"given":"Bruce I","family":"Turetsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Gyu","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J","family":"Moberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,8,27]]},"reference":[{"key":"BFnpp2008139_CR1","volume-title":"The Scale for the Assessment of Negative Symptoms (SANS)","author":"NC Andreasen","year":"1983","unstructured":"Andreasen NC (1983). The Scale for the Assessment of Negative Symptoms (SANS). The University of Iowa: Iowa City, IA."},{"key":"BFnpp2008139_CR2","volume-title":"The Scale for the Assessment of Positive Symptoms (SAPS)","author":"NC Andreasen","year":"1984","unstructured":"Andreasen NC (1984). The Scale for the Assessment of Positive Symptoms (SAPS). The University of Iowa: Iowa City, IA."},{"key":"BFnpp2008139_CR3","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1001\/archpsyc.58.9.829","volume":"58","author":"SE Arnold","year":"2001","unstructured":"Arnold SE, Han LY, Moberg PJ, Turetsky BI, Gur RE, Trojanowski JQ et al (2001). Dysregulation of olfactory receptor neuron lineage in schizophrenia. Arch Gen Psychiatry 58: 829\u2013835.","journal-title":"Arch Gen Psychiatry"},{"key":"BFnpp2008139_CR4","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1176\/appi.ajp.160.10.1790","volume":"160","author":"WJ Brewer","year":"2003","unstructured":"Brewer WJ, Wood SJ, McGorry PD, Francey SM, Phillips LJ, Yung AR et al (2003). Impairment of olfactory identification ability in individuals at ultra-high risk for psychosis who later develop schizophrenia. Am J Psychiatry 160: 1790\u20131794.","journal-title":"Am J Psychiatry"},{"key":"BFnpp2008139_CR5","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1111\/j.1471-4159.1993.tb09836.x","volume":"61","author":"DM Chetkovich","year":"1993","unstructured":"Chetkovich DM, Sweatt JD (1993). NMDA receptor activation increases cyclic AMP in area CA1 of the hippocampus via calcium\/calmodulin stimulation of adenylyl cyclase. J Neurochem 61: 1933\u20131942.","journal-title":"J Neurochem"},{"key":"BFnpp2008139_CR6","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1046\/j.1471-4159.1996.66031222.x","volume":"66","author":"DE Dluzen","year":"1996","unstructured":"Dluzen DE, Kreutzberg JD (1996). Norepinephrine is lateralized within the olfactory bulbs of male mice. J Neurochem 66: 1222\u20131226.","journal-title":"J Neurochem"},{"key":"BFnpp2008139_CR7","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S0166-4115(97)80081-7","volume-title":"Cerebral Asymmetries in Sensory and Perceptual Processing","author":"RL Doty","year":"1997","unstructured":"Doty RL, Bromley SM, Moberg PJ, Hummel T (1997). Laterality in human nasal chemoreception. In: Christman S (ed). Cerebral Asymmetries in Sensory and Perceptual Processing. North-Holland: Amsterdam. pp 497\u2013542."},{"key":"BFnpp2008139_CR8","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1126\/science.6505700","volume":"226","author":"RL Doty","year":"1984","unstructured":"Doty RL, Shaman P, Applebaum SL, Giberson R, Siksorski L, Rosenberg L (1984). Smell identification ability: changes with age. Science 226: 1441\u20131443.","journal-title":"Science"},{"key":"BFnpp2008139_CR9","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S0920-9964(99)00055-9","volume":"40","author":"F F\u00e9ron","year":"1999","unstructured":"F\u00e9ron F, Perry C, Hirning MH, McGrath J, Mackay-Sim A (1999). Altered adhesion, proliferation and death in neural cultures from adults with schizophrenia. Schizophr Res 40: 211\u2013218.","journal-title":"Schizophr Res"},{"key":"BFnpp2008139_CR10","doi-asserted-by":"publisher","first-page":"3127","DOI":"10.1016\/0306-4522(82)90235-4","volume":"7","author":"RC Gesteland","year":"1982","unstructured":"Gesteland RC, Yancey RA, Farbman AI (1982). Development of olfactory receptor neuron selectivity in the rat fetus. Neuroscience 7: 3127\u20133136.","journal-title":"Neuroscience"},{"key":"BFnpp2008139_CR11","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1176\/appi.ajp.162.3.616","volume":"162","author":"CG Hahn","year":"2005","unstructured":"Hahn CG, Gomez G, Restrepo D, Friedman E, Josiassen R, Pribitkin EA et al (2005). Aberrant intracellular calcium signaling in olfactory neurons from patients with bipolar disorder. Am J Psychiatry 162: 616\u2013618.","journal-title":"Am J Psychiatry"},{"key":"BFnpp2008139_CR12","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1152\/jn.00670.2003","volume":"91","author":"CC Hegg","year":"2004","unstructured":"Hegg CC, Lucero MT (2004). Dopamine reduces odor- and elevated-K+-induced calcium responses in mouse olfactory receptor neurons in situ. J Neurophysiol 91: 1492\u20131499.","journal-title":"J Neurophysiol"},{"key":"BFnpp2008139_CR13","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/0014-4886(86)90078-6","volume":"91","author":"O Heine","year":"1986","unstructured":"Heine O, Galaburda AM (1986). Olfactory asymmetry in the rat brain. Exp Neurol 91: 392\u2013398.","journal-title":"Exp Neurol"},{"key":"BFnpp2008139_CR14","doi-asserted-by":"publisher","first-page":"5641","DOI":"10.1073\/pnas.86.14.5641","volume":"86","author":"G Lowe","year":"1989","unstructured":"Lowe G, Nakamura T, Gold GH (1989). Adenylate cyclase mediates olfactory transduction for a wide variety of odorants. Proc Natl Acad Sci USA 86: 5641\u20135645.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFnpp2008139_CR15","volume-title":"Maxwell Family Interview for Genetic Studies (FIGS): A Manual for FIGS","author":"ME Maxwell","year":"1992","unstructured":"Maxwell ME (1992). Maxwell Family Interview for Genetic Studies (FIGS): A Manual for FIGS. Clinical Neurogenetics Branch Intramural Research Program, National Institute of Mental Health: Bethesda, MD."},{"key":"BFnpp2008139_CR16","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.schres.2005.10.012","volume":"82","author":"RD McCurdy","year":"2006","unstructured":"McCurdy RD, F\u00e9ron F, Perry C, Chant DC, McLean D, Matigian N et al (2006). Cell cycle alterations in biopsied olfactory neuroepithelium in schizophrenia and bipolar I disorder using cell culture and gene expression analyses. Schizophr Res 82: 163\u2013173.","journal-title":"Schizophr Res"},{"key":"BFnpp2008139_CR17","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1126\/science.1112915","volume":"310","author":"JK Millar","year":"2005","unstructured":"Millar JK, Pickard BS, Mackie S, James R, Christie S, Buchanan SR et al (2005). DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science 310: 1187\u20131191.","journal-title":"Science"},{"key":"BFnpp2008139_CR18","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1037\/0021-843X.110.1.40","volume":"110","author":"GA Miller","year":"2001","unstructured":"Miller GA, Chapman JP (2001). Misunderstanding analysis of covariance. J Abnorm Psychol 110: 40\u201348.","journal-title":"J Abnorm Psychol"},{"key":"BFnpp2008139_CR19","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.neulet.2005.12.028","volume":"397","author":"P Minoretti","year":"2006","unstructured":"Minoretti P, Politi P, Coen E, Di Vito C, Bertona M, Bianchi M et al (2006). The T393C polymorphism of the GNAS1 gene is associated with deficit schizophrenia in an Italian population sample. Neurosci Lett 397: 159\u2013163.","journal-title":"Neurosci Lett"},{"key":"BFnpp2008139_CR20","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/S0893-133X(99)00019-6","volume":"21","author":"PJ Moberg","year":"1999","unstructured":"Moberg PJ, Agrin R, Gur RE, Gur RC, Turetsky BI, Doty RL (1999). Olfactory dysfunction in schizophrenia: a qualitative and quantitative review. Neuropsychopharmacology 21: 325\u2013340.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2008139_CR21","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1176\/ajp.154.7.1016","volume":"154","author":"PJ Moberg","year":"1997","unstructured":"Moberg PJ, Doty RL, Turetsky BI, Arnold SE, Mahr RN, Gur RC et al (1997). Olfactory identification deficits in schizophrenia: correlation with duration of illness. Am J Psychiatry 154: 1016\u20131018.","journal-title":"Am J Psychiatry"},{"key":"BFnpp2008139_CR22","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s002130050234","volume":"130","author":"N Natsukari","year":"1997","unstructured":"Natsukari N, Kulaga H, Baker I, Wyatt RJ, Masserano JM (1997). Increased cyclic AMP response to forskolin in Epstein\u2013Barr virus-transformed human B-lymphocytes derived from schizophrenics. Psychopharmacology (Berl) 130: 235\u2013241.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2008139_CR23","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1126\/science.1071550","volume":"296","author":"SR Neves","year":"2002","unstructured":"Neves SR, Ram PT, Iyengar R (2002). G protein pathways. Science 296: 1636\u20131639.","journal-title":"Science"},{"key":"BFnpp2008139_CR24","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1001\/archpsyc.1994.03950110009002","volume":"51","author":"JI Nurnberger Jr","year":"1994","unstructured":"Nurnberger Jr JI, Blehar MC, Kaufmann CA, York-Cooler C, Simpson SG, Harkavy-Friedman J et al (1994). Diagnostic Interview for Genetic Studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch Gen Psychiatry 51: 849\u2013859.","journal-title":"Arch Gen Psychiatry"},{"key":"BFnpp2008139_CR25","doi-asserted-by":"publisher","first-page":"799","DOI":"10.2466\/pr0.1962.10.3.799","volume":"10","author":"JR Overall","year":"1962","unstructured":"Overall JR, Gorham DR (1962). The Brief Psychiatric Rating Scale. Psychol Rep 10: 799\u2013812.","journal-title":"Psychol Rep"},{"key":"BFnpp2008139_CR26","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1002\/cne.902250403","volume":"225","author":"PD Prasada Rao","year":"1984","unstructured":"Prasada Rao PD, Finger TE (1984). Asymmetry of the olfactory system in the brain of the winter flounder, Pseudopleuronectes americanus. J Comp Neurol 225: 492\u2013510.","journal-title":"J Comp Neurol"},{"key":"BFnpp2008139_CR27","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1111\/j.1749-6632.1998.tb10648.x","volume":"855","author":"NE Rawson","year":"1998","unstructured":"Rawson NE, Gomez G, Cowart B, Restrepo D (1998). The use of olfactory receptor neurons (ORNs) from biopsies to study changes in aging and neurodegenerative diseases. Ann N Y Acad Sci 855: 701\u2013707.","journal-title":"Ann N Y Acad Sci"},{"key":"BFnpp2008139_CR28","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0891-0618(00)00047-8","volume":"19","author":"FJ Rodriguez-Gomez","year":"2000","unstructured":"Rodriguez-Gomez FJ, Rendon-Unceta MC, Sarasquete C, Munoz-Cueto JA (2000). Localization of tyrosine hydroxylase-immunoreactivity in the brain of the Senegalese sole, Solea senagalensis. J Chem Neuroanat 19: 17\u201332.","journal-title":"J Chem Neuroanat"},{"key":"BFnpp2008139_CR29","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1146\/annurev.physiol.64.082701.102219","volume":"64","author":"GV Ronnett","year":"2002","unstructured":"Ronnett GV, Moon C (2002). G proteins and olfactory signal transduction. Annu Rev Physiol 64: 189\u2013222.","journal-title":"Annu Rev Physiol"},{"key":"BFnpp2008139_CR30","doi-asserted-by":"crossref","first-page":"15538","DOI":"10.1016\/S0021-9258(18)66747-X","volume":"261","author":"PB Sklar","year":"1986","unstructured":"Sklar PB, Anholt RR, Snyder SH (1986). The odorant-sensitive adenylate cyclase of olfactory receptor cells. Differential stimulation by distinct classes of odorants. J Biol Chem 261: 15538\u201315543.","journal-title":"J Biol Chem"},{"key":"BFnpp2008139_CR31","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.1176\/appi.ajp.162.12.2322","volume":"162","author":"BE Snitz","year":"2005","unstructured":"Snitz BE, MacDonald III A, Cohen JD, Cho RY, Becker T, Carter CS (2005). Lateral and medial hypofrontality in first-episode schizophrenia: functional activity in a medication-naive state and effects of short-term atypical antipsychotic treatment. Am J Psychiatry 162: 2322\u20132329.","journal-title":"Am J Psychiatry"},{"key":"BFnpp2008139_CR32","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.biopsych.2006.07.033","volume":"61","author":"RA Sweet","year":"2007","unstructured":"Sweet RA, Bergen SE, Sun Z, Marcsisin MJ, Sampson AR, Lewis DA (2007). Anatomical evidence of impaired feedforward auditory processing in schizophrenia. Biol Psychiatry 61: 854\u2013864.","journal-title":"Biol Psychiatry"},{"key":"BFnpp2008139_CR33","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1085\/jgp.200308867","volume":"122","author":"H Takeuchi","year":"2003","unstructured":"Takeuchi H, Imanaka Y, Hirono J, Kurahashi T (2003). Cross-adaptation between olfactory responses induced by two subgroups of odorant molecules. J Gen Physiol 122: 255\u2013264.","journal-title":"J Gen Physiol"},{"key":"BFnpp2008139_CR34","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.schres.2008.03.013","volume":"102","author":"BI Turetsky","year":"2008","unstructured":"Turetsky BI, Kohler CG, Gur RE, Moberg PJ (2008). Olfactory physiological impairment in first-degree relatives of schizophrenia patients. Schizophr Res 102: 220\u2013229.","journal-title":"Schizophr Res"},{"key":"BFnpp2008139_CR35","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1176\/appi.ajp.160.4.703","volume":"160","author":"BI Turetsky","year":"2003","unstructured":"Turetsky BI, Moberg PJ, Arnold SE, Doty RL, Gur RE (2003a). Low olfactory bulb volume in first-degree relatives of patients with schizophrenia. Am J Psychiatry 160: 703\u2013708. Schizophr Res 102: 220\u20139.","journal-title":"Am J Psychiatry"},{"key":"BFnpp2008139_CR36","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0006-3223(02)01865-6","volume":"53","author":"BI Turetsky","year":"2003","unstructured":"Turetsky BI, Moberg PJ, Owzar K, Johnson SC, Doty RL, Gur RE (2003b). Physiologic impairment of olfactory stimulus processing in schizophrenia. Biol Psychiatry 53: 403\u2013411.","journal-title":"Biol Psychiatry"},{"key":"BFnpp2008139_CR37","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1001\/archpsyc.60.12.1193","volume":"60","author":"BI Turetsky","year":"2003","unstructured":"Turetsky BI, Moberg PJ, Roalf DR, Arnold SE, Gur RE (2003c). Decrements in volume of anterior ventromedial temporal lobe and olfactory dysfunction in schizophrenia. Arch Gen Psychiatry 60: 1193\u20131200.","journal-title":"Arch Gen Psychiatry"},{"key":"BFnpp2008139_CR38","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1176\/appi.ajp.157.5.828","volume":"157","author":"BI Turetsky","year":"2000","unstructured":"Turetsky BI, Moberg PJ, Yousem DM, Doty RL, Arnold SE, Gur RE (2000). Reduced olfactory bulb volume in patients with schizophrenia. Am J Psychiatry 157: 828\u2013830.","journal-title":"Am J Psychiatry"},{"key":"BFnpp2008139_CR39","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1016\/j.biopsych.2006.06.025","volume":"60","author":"AP Weiss","year":"2006","unstructured":"Weiss AP, Goff D, Schacter DL, Ditman T, Freudenreich O, Henderson D et al (2006). Fronto-hippocampal function during temporal context monitoring in schizophrenia. Biol Psychiatry 60: 1268\u20131277.","journal-title":"Biol Psychiatry"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/npp2008139.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2008139","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2008139.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:17:21Z","timestamp":1684455441000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/npp2008139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,27]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["BFnpp2008139"],"URL":"https:\/\/doi.org\/10.1038\/npp.2008.139","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,27]]}}}