{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:24:28Z","timestamp":1790936668293,"version":"4.1.0"},"reference-count":121,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2009,11,25]],"date-time":"2009-11-25T00:00:00Z","timestamp":1259107200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1038\/npp.2009.185","type":"journal-article","created":{"date-parts":[[2009,11,25]],"date-time":"2009-11-25T15:09:13Z","timestamp":1259161753000},"page":"591-604","source":"Crossref","is-referenced-by-count":540,"title":["Probing Compulsive and Impulsive Behaviors, from Animal Models to Endophenotypes: A Narrative Review"],"prefix":"10.1038","volume":"35","author":[{"given":"Naomi A","family":"Fineberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc N","family":"Potenza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel R","family":"Chamberlain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather A","family":"Berlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Menzies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Bechara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara J","family":"Sahakian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor W","family":"Robbins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward T","family":"Bullmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Hollander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,11,25]]},"reference":[{"key":"BFnpp2009185_CR1","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1080\/10673220490910844","volume":"12","author":"B Adinoff","year":"2004","unstructured":"Adinoff B (2004). Neurobiologic processes in drug reward and addiction. Harv Rev Psychiatry 12: 305\u2013320.","journal-title":"Harv Rev Psychiatry"},{"key":"BFnpp2009185_CR2","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1016\/S0006-3223(03)00609-7","volume":"54","author":"AR Aron","year":"2003","unstructured":"Aron AR, Dowson JH, Sahakian BJ, Robbins TW (2003). Methylphenidate improves response inhibition in adults with attention-deficit\/hyperactivity disorder. Biol Psychiatry 54: 1465\u20131468.","journal-title":"Biol Psychiatry"},{"key":"BFnpp2009185_CR3","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1016\/j.biopsych.2004.10.026","volume":"57","author":"AR Aron","year":"2005","unstructured":"Aron AR, Poldrack RA (2005). The cognitive neuroscience of response inhibition: relevance for genetic research in attention-deficit\/hyperactivity disorder. Biol Psychiatry 57: 1285\u20131292.","journal-title":"Biol Psychiatry"},{"key":"BFnpp2009185_CR4","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1001\/archpsyc.1987.01800150017003","volume":"44","author":"LR Baxter Jr","year":"1987","unstructured":"Baxter Jr LR, Phelps ME, Mazziotta JC, Guze BH, Schwartz JM, Selin CE (1987). Local cerebral glucose metabolic rates in obsessive-compulsive disorder. A comparison with rates in unipolar depression and in normal controls. Arch Gen Psychiatry 44: 211\u2013218.","journal-title":"Arch Gen Psychiatry"},{"key":"BFnpp2009185_CR5","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1023\/A:1021223113233","volume":"19","author":"A Bechara","year":"2003","unstructured":"Bechara A (2003). Risky business: emotion, decision-making, and addiction. J Gambl Stud 19: 23\u201351.","journal-title":"J Gambl Stud"},{"key":"BFnpp2009185_CR6","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/0010-0277(94)90018-3","volume":"50","author":"A Bechara","year":"1994","unstructured":"Bechara A, Damasio AR, Damasio H, Anderson SW (1994). Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50: 7\u201315.","journal-title":"Cognition"},{"key":"BFnpp2009185_CR7","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1126\/science.1158136","volume":"320","author":"D Belin","year":"2008","unstructured":"Belin D, Mar AC, Dalley JW, Robbins TW, Everitt BJ (2008). High impulsivity predicts the switch to compulsive cocaine-taking. Science 320: 1352\u20131355.","journal-title":"Science"},{"key":"BFnpp2009185_CR8","volume-title":"Neurocognition and Temperament in Pathological Gambling","author":"HA Berlin","year":"2008","unstructured":"Berlin HA, Hamilton H, Hollander E (2008). Neurocognition and Temperament in Pathological Gambling. American Psychiatric Association, conference poster: Washington DC."},{"issue":"Pt 5","key":"BFnpp2009185_CR9","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1093\/brain\/awh135","volume":"127","author":"HA Berlin","year":"2004","unstructured":"Berlin HA, Rolls ET, Kischka U (2004). Impulsivity, time perception, emotion and reinforcement sensitivity in patients with orbitofrontal cortex lesions. Brain 127 (Pt 5): 1108\u20131126.","journal-title":"Brain"},{"key":"BFnpp2009185_CR10","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.psychres.2008.04.023","volume":"167","author":"C Blanco","year":"2009","unstructured":"Blanco C, Potenza MN, Kim SW, Ibanez A, Zaninelli R, Saiz-Ruiz J et al (2009). A pilot study of impulsivity and compulsivity in pathological gambling. Psychiatry Res 167: 161\u2013168.","journal-title":"Psychiatry Res"},{"key":"BFnpp2009185_CR11","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/sj.mp.4001823","volume":"11","author":"MH Bloch","year":"2006","unstructured":"Bloch MH, Landeros-Weisenberger A, Kelmendi B, Coric V, Bracken MB, Leckman JF (2006). A systematic review: antipsychotic augmentation with treatment refractory obsessive-compulsive disorder. Mol Psychiatry 11: 622\u2013632.","journal-title":"Mol Psychiatry"},{"issue":"Pt 8","key":"BFnpp2009185_CR12","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1093\/brain\/awl050","volume":"129","author":"S Bohlhalter","year":"2006","unstructured":"Bohlhalter S, Goldfine A, Matteson S, Garraux G, Hanakawa T, Kansaku K et al (2006). Neural correlates of tic generation in Tourette syndrome: an event-related functional MRI study. Brain 129 (Pt 8): 2029\u20132037.","journal-title":"Brain"},{"key":"BFnpp2009185_CR13","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.bbr.2007.02.005","volume":"179","author":"V Boulougouris","year":"2007","unstructured":"Boulougouris V, Dalley JW, Robbins TW (2007). Effects of orbitofrontal, infralimbic and prelimbic cortical lesions on serial spatial reversal learning in the rat. Behav Brain Res 179: 219\u2013228.","journal-title":"Behav Brain Res"},{"key":"BFnpp2009185_CR14","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1038\/sj.npp.1301584","volume":"33","author":"V Boulougouris","year":"2008","unstructured":"Boulougouris V, Glennon JC, Robbins TW (2008). Dissociable effects of selective 5-HT2A and 5-HT2C receptor antagonists on serial spatial reversal learning in rats. Neuropsychopharmacology 33: 2007\u20132019.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2009185_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/ADT.0b013e31803155c2","volume":"7","author":"JA Brewer","year":"2008","unstructured":"Brewer JA, Grant JE, Potenza MN (2008). The treatment of pathological gambling. Addict Disord Treat 7: 1\u201314.","journal-title":"Addict Disord Treat"},{"key":"BFnpp2009185_CR16","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.bcp.2007.06.043","volume":"75","author":"JA Brewer","year":"2008","unstructured":"Brewer JA, Potenza MN (2008). The neurobiology and genetics of impulse control disorders: relationships to drug addictions. Biochem Pharmacol 75: 63\u201375.","journal-title":"Biochem Pharmacol"},{"key":"BFnpp2009185_CR17","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.neubiorev.2004.11.006","volume":"29","author":"SR Chamberlain","year":"2005","unstructured":"Chamberlain SR, Blackwell AD, Fineberg NA, Robbins TW, Sahakian BJ (2005). The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers. Neurosci Biobehav Rev 29: 399\u2013419.","journal-title":"Neurosci Biobehav Rev"},{"key":"BFnpp2009185_CR18","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1017\/S0033291705006124","volume":"36","author":"SR Chamberlain","year":"2006","unstructured":"Chamberlain SR, Blackwell AD, Fineberg NA, Robbins TW, Sahakian BJ (2006a). Strategy implementation in obsessive-compulsive disorder and trichotillomania. Psychol Med 36: 91\u201397.","journal-title":"Psychol Med"},{"key":"BFnpp2009185_CR19","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/j.biopsych.2007.03.003","volume":"62","author":"SR Chamberlain","year":"2007","unstructured":"Chamberlain SR, Del Campo N, Dowson J, Muller U, Clark L, Robbins TW et al (2007a). Atomoxetine improved response inhibition in adults with attention deficit\/hyperactivity disorder. Biol Psychiatry 62: 977\u2013984.","journal-title":"Biol Psychiatry"},{"key":"BFnpp2009185_CR20","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.neuropsychologia.2006.07.016","volume":"45","author":"SR Chamberlain","year":"2007","unstructured":"Chamberlain SR, Fineberg NA, Blackwell AD, Clark L, Robbins TW, Sahakian BJ (2007b). A neuropsychological comparison of obsessive-compulsive disorder and trichotillomania. Neuropsychologia 45: 654\u2013662.","journal-title":"Neuropsychologia"},{"key":"BFnpp2009185_CR21","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1176\/ajp.2006.163.7.1282","volume":"163","author":"SR Chamberlain","year":"2006","unstructured":"Chamberlain SR, Fineberg NA, Blackwell AD, Robbins TW, Sahakian BJ (2006b). Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania. Am J Psychiatry 163: 1282\u20131284.","journal-title":"Am J Psychiatry"},{"key":"BFnpp2009185_CR22","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1176\/ajp.2007.164.2.335","volume":"164","author":"SR Chamberlain","year":"2007","unstructured":"Chamberlain SR, Fineberg NA, Menzies LA, Blackwell AD, Bullmore ET, Robbins TW et al (2007c). Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder. Am J Psychiatry 164: 335\u2013338.","journal-title":"Am J Psychiatry"},{"key":"BFnpp2009185_CR23","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1586\/ern.09.36","volume":"9","author":"SR Chamberlain","year":"2009","unstructured":"Chamberlain SR, Menzies L (2009). Endophenotypes of obsessive-compulsive disorder: rationale, evidence and future potential. Expert Rev Neurother 9: 1133\u20131146.","journal-title":"Expert Rev Neurother"},{"key":"BFnpp2009185_CR24","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1126\/science.1154433","volume":"321","author":"SR Chamberlain","year":"2008","unstructured":"Chamberlain SR, Menzies L, Hampshire A, Suckling J, Fineberg NA, del Campo N et al (2008a). Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives. Science 321: 421\u2013422.","journal-title":"Science"},{"key":"BFnpp2009185_CR25","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1176\/ajp.2007.164.4.568","volume":"164","author":"SR Chamberlain","year":"2007","unstructured":"Chamberlain SR, Menzies L, Sahakian BJ, Fineberg NA (2007d). Lifting the veil on trichotillomania. Am J Psychiatry 164: 568\u2013574.","journal-title":"Am J Psychiatry"},{"key":"BFnpp2009185_CR26","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1192\/bjp.bp.107.048314","volume":"193","author":"SR Chamberlain","year":"2008","unstructured":"Chamberlain SR, Menzies LA, Fineberg NA, Del Campo N, Suckling J, Craig K et al (2008b). Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study. Br J Psychiatry 193: 216\u2013221.","journal-title":"Br J Psychiatry"},{"key":"BFnpp2009185_CR27","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1126\/science.1121218","volume":"311","author":"SR Chamberlain","year":"2006","unstructured":"Chamberlain SR, Muller U, Blackwell AD, Clark L, Robbins TW, Sahakian BJ (2006c). Neurochemical modulation of response inhibition and probabilistic learning in humans. Science 311: 861\u2013863.","journal-title":"Science"},{"key":"BFnpp2009185_CR28","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1177\/0269881107068066","volume":"21","author":"SR Chamberlain","year":"2006","unstructured":"Chamberlain SR, Muller U, Deakin JB, Corlett PR, Dowson J, Cardinal R et al (2006d). Lack of deleterious effects of buspirone on cognition in healthy male volunteers. J Psychopharmacol 21: 210\u2013215.","journal-title":"J Psychopharmacol"},{"key":"BFnpp2009185_CR29","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1016\/j.biopsych.2007.04.009","volume":"61","author":"SR Chamberlain","year":"2007","unstructured":"Chamberlain SR, Robbins TW, Sahakian BJ (2007e). The neurobiology of attention-deficit\/hyperactivity disorder. Biol Psychiatry 61: 1317\u20131319.","journal-title":"Biol Psychiatry"},{"key":"BFnpp2009185_CR30","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1097\/YCO.0b013e3280ba4989","volume":"20","author":"SR Chamberlain","year":"2007","unstructured":"Chamberlain SR, Sahakian BJ (2007). The neuropsychiatry of impulsivity. Curr Opin Psychiatry 20: 255\u2013261.","journal-title":"Curr Opin Psychiatry"},{"key":"BFnpp2009185_CR31","doi-asserted-by":"publisher","first-page":"5829","DOI":"10.1021\/jm040863t","volume":"47","author":"MS Chambers","year":"2004","unstructured":"Chambers MS, Atack JR, Carling RW, Collinson N, Cook SM, Dawson GR et al (2004). An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties. J Med Chem 47: 5829\u20135832.","journal-title":"J Med Chem"},{"key":"BFnpp2009185_CR32","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/S0031-9384(03)00047-7","volume":"78","author":"JM Chou-Green","year":"2003","unstructured":"Chou-Green JM, Holscher TD, Dallman MF, Akana SF (2003). Compulsive behavior in the 5-HT2C receptor knockout mouse. Physiol Behav 78: 641\u2013649.","journal-title":"Physiol Behav"},{"key":"BFnpp2009185_CR33","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.biopsych.2005.11.007","volume":"60","author":"L Clark","year":"2006","unstructured":"Clark L, Robbins TW, Ersche KD, Sahakian BJ (2006). Reflection impulsivity in current and former substance users. Biol Psychiatry 60: 515\u2013522.","journal-title":"Biol Psychiatry"},{"key":"BFnpp2009185_CR34","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1007\/s00213-005-0104-6","volume":"182","author":"L Clark","year":"2005","unstructured":"Clark L, Roiser JP, Cools R, Rubinsztein DC, Sahakian BJ, Robbins TW (2005). Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsivity. Psychopharmacology (Berl) 182: 570\u2013578.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2009185_CR35","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1126\/science.1094987","volume":"304","author":"HF Clarke","year":"2004","unstructured":"Clarke HF, Dalley JW, Crofts HS, Robbins TW, Roberts AC (2004). Cognitive inflexibility after prefrontal serotonin depletion. Science 304: 878\u2013880.","journal-title":"Science"},{"key":"BFnpp2009185_CR36","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1523\/JNEUROSCI.3690-04.2005","volume":"25","author":"HF Clarke","year":"2005","unstructured":"Clarke HF, Walker SC, Crofts HS, Dalley JW, Robbins TW, Roberts AC (2005). Prefrontal serotonin depletion affects reversal learning but not attentional set shifting. J Neurosci 25: 532\u2013538.","journal-title":"J Neurosci"},{"key":"BFnpp2009185_CR37","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1093\/cercor\/bhj120","volume":"17","author":"HF Clarke","year":"2007","unstructured":"Clarke HF, Walker SC, Dalley JW, Robbins TW, Roberts AC (2007). Cognitive inflexibility after prefrontal serotonin depletion is behaviorally and neurochemically specific. Cereb Cortex 17: 18\u201327.","journal-title":"Cereb Cortex"},{"key":"BFnpp2009185_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neubiorev.2005.03.024","volume":"30","author":"R Cools","year":"2006","unstructured":"Cools R (2006). Dopaminergic modulation of cognitive function-implications for L-DOPA treatment in Parkinson's disease. Neurosci Biobehav Rev 30: 1\u201323.","journal-title":"Neurosci Biobehav Rev"},{"key":"BFnpp2009185_CR39","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1016\/j.neuropsychologia.2006.03.030","volume":"44","author":"R Cools","year":"2006","unstructured":"Cools R, Altamirano L, D'Esposito M (2006). Reversal learning in Parkinson's disease depends on medication status and outcome valence. Neuropsychologia 44: 1663\u20131673.","journal-title":"Neuropsychologia"},{"key":"BFnpp2009185_CR40","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1111\/j.1524-4733.2007.00256.x","volume":"11","author":"S Cottrell","year":"2008","unstructured":"Cottrell S, Tilden D, Robinson P, Bae J, Arellano J, Edgell E et al (2008). A modeled economic evaluation comparing atomoxetine with stimulant therapy in the treatment of children with attention-deficit\/hyperactivity disorder in the United Kingdom. Value Health 11: 376\u2013388.","journal-title":"Value Health"},{"key":"BFnpp2009185_CR41","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1111\/j.1469-7610.2005.01419.x","volume":"46","author":"S Crawford","year":"2005","unstructured":"Crawford S, Channon S, Robertson MM (2005). Tourette's syndrome: performance on tests of behavioural inhibition, working memory and gambling. J Child Psychol Psychiatry 46: 1327\u20131336.","journal-title":"J Child Psychol Psychiatry"},{"key":"BFnpp2009185_CR42","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1176\/appi.ajp.158.11.1884","volume":"158","author":"J Crosbie","year":"2001","unstructured":"Crosbie J, Schachar R (2001). Deficient inhibition as a marker for familial ADHD. Am J Psychiatry 158: 1884\u20131890.","journal-title":"Am J Psychiatry"},{"issue":"Suppl 14","key":"BFnpp2009185_CR43","first-page":"11","volume":"65","author":"D Denys","year":"2004","unstructured":"Denys D, Zohar J, Westenberg HG (2004). The role of dopamine in obsessive-compulsive disorder: preclinical and clinical evidence. J Clin Psychiatry 65 (Suppl 14): 11\u201317.","journal-title":"J Clin Psychiatry"},{"key":"BFnpp2009185_CR44","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/380069a0","volume":"380","author":"R Dias","year":"1996","unstructured":"Dias R, Robbins TW, Roberts AC (1996). Dissociation in prefrontal cortex of affective and attentional shifts. Nature 380: 69\u201372.","journal-title":"Nature"},{"key":"BFnpp2009185_CR45","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1038\/sj.npp.1300663","volume":"30","author":"EA Evers","year":"2005","unstructured":"Evers EA, Cools R, Clark L, van der Veen FM, Jolles J, Sahakian BJ et al (2005). Serotonergic modulation of prefrontal cortex during negative feedback in probabilistic reversal learning. Neuropsychopharmacology 30: 1138\u20131147.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2009185_CR46","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1017\/S1461145704004675","volume":"8","author":"NA Fineberg","year":"2005","unstructured":"Fineberg NA, Gale TM (2005). Evidence-based pharmacotherapy of obsessivecompulsive disorder. Int J Neuropsychopharmacol 8: 107\u2013129.","journal-title":"Int J Neuropsychopharmacol"},{"key":"BFnpp2009185_CR47","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1017\/S1092852900021167","volume":"12","author":"NA Fineberg","year":"2007","unstructured":"Fineberg NA, Saxena S, Zohar J, Craig KJ (2007a). Obsessive-compulsive disorder: boundary issues. CNS Spectr 12: 359\u2013364, 367\u2013375.","journal-title":"CNS Spectr"},{"key":"BFnpp2009185_CR48","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1017\/S1092852900015340","volume":"12","author":"NA Fineberg","year":"2007","unstructured":"Fineberg NA, Sharma P, Sivakumaran T, Sahakian B, Chamberlain SR (2007b). Does obsessive-compulsive personality disorder belong within the obsessive-compulsive spectrum? CNS Spectr 12: 467\u2013482.","journal-title":"CNS Spectr"},{"key":"BFnpp2009185_CR49","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1097\/00004850-200507000-00005","volume":"20","author":"NA Fineberg","year":"2005","unstructured":"Fineberg NA, Sivakumaran T, Roberts A, Gale T (2005). Adding quetiapine to SRI in treatment-resistant obsessive-compulsive disorder: a randomized controlled treatment study. Int Clin Psychopharmacol 20: 223\u2013226.","journal-title":"Int Clin Psychopharmacol"},{"key":"BFnpp2009185_CR50","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.pbb.2007.12.025","volume":"89","author":"T Fong","year":"2008","unstructured":"Fong T, Kalechstein A, Bernhard B, Rosenthal R, Rugle L (2008). A double-blind, placebo-controlled trial of olanzapine for the treatment of video poker pathological gamblers. Pharmacol Biochem Behav 89: 298\u2013303.","journal-title":"Pharmacol Biochem Behav"},{"key":"BFnpp2009185_CR51","doi-asserted-by":"publisher","first-page":"16311","DOI":"10.1073\/pnas.0706111104","volume":"104","author":"MJ Frank","year":"2007","unstructured":"Frank MJ, Moustafa AA, Haughey HM, Curran T, Hutchison KE (2007). Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning. Proc Natl Acad Sci USA 104: 16311\u201316316.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFnpp2009185_CR52","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1002\/ana.20765","volume":"59","author":"G Garraux","year":"2006","unstructured":"Garraux G, Goldfine A, Bohlhalter S, Lerner A, Hanakawa T, Hallett M (2006). Increased midbrain gray matter in Tourette's syndrome. Ann Neurol 59: 381\u2013385.","journal-title":"Ann Neurol"},{"key":"BFnpp2009185_CR53","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1176\/appi.ajp.160.4.636","volume":"160","author":"II Gottesman","year":"2003","unstructured":"Gottesman II, Gould TD (2003). The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160: 636\u2013645.","journal-title":"Am J Psychiatry"},{"key":"BFnpp2009185_CR54","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1080\/10673220701298407","volume":"15","author":"JE Grant","year":"2007","unstructured":"Grant JE, Odlaug BL, Potenza MN (2007). Addicted to hair pulling? How an alternate model of trichotillomania may improve treatment outcome. Harv Rev Psychiatry 15: 80\u201385.","journal-title":"Harv Rev Psychiatry"},{"key":"BFnpp2009185_CR55","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.psc.2006.02.002","volume":"29","author":"JE Grant","year":"2006","unstructured":"Grant JE, Potenza MN (2006). Compulsive aspects of impulse-control disorders. Psychiatr Clin North Am 29: 539\u2013551.","journal-title":"Psychiatr Clin North Am"},{"key":"BFnpp2009185_CR56","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1097\/jcp.0b013e3181602fab","volume":"28","author":"A Hamidovic","year":"2008","unstructured":"Hamidovic A, Kang UJ, de Wit H (2008). Effects of low to moderate acute doses of pramipexole on impulsivity and cognition in healthy volunteers. J Clin Psychopharmacol 28: 45\u201351.","journal-title":"J Clin Psychopharmacol"},{"key":"BFnpp2009185_CR57","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1093\/cercor\/bhj116","volume":"16","author":"A Hampshire","year":"2006","unstructured":"Hampshire A, Owen AM (2006). Fractionating attentional control using event-related fMRI. Cereb Cortex 16: 1679\u20131689.","journal-title":"Cereb Cortex"},{"key":"BFnpp2009185_CR58","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s002130050410","volume":"133","author":"AA Harrison","year":"1997","unstructured":"Harrison AA, Everitt BJ, Robbins TW (1997). Central 5-HT depletion enhances impulsive responding without affecting the accuracy of attentional performance: interactions with dopaminergic mechanisms. Psychopharmacology (Berl) 133: 329\u2013342.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2009185_CR59","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s00213-005-2261-z","volume":"181","author":"PD Hatcher","year":"2005","unstructured":"Hatcher PD, Brown VJ, Tait DS, Bate S, Overend P, Hagan JJ et al (2005). 5-HT6 receptor antagonists improve performance in an attentional set shifting task in rats. Psychopharmacology (Berl) 181: 253\u2013259.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2009185_CR60","unstructured":"Hollander E, Berlin HA, Bartz J, Anagnostou E, Pallanti S, Simeon D et al (2007a). The impulsive-compulsive spectrum: neurocognitive, functional imaging and treatment findings inform the phenotype. ACNP presentation. Scientific Abstracts ACNP 2007 Annual Meeting, p 50."},{"key":"BFnpp2009185_CR61","volume-title":"Impulsivity and Compulsivity","author":"E Hollander","year":"1996","unstructured":"Hollander E, Cohen LJ (1996). Impulsivity and Compulsivity. American Psychiatric Press Inc, Washington DC."},{"key":"BFnpp2009185_CR62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0165-1781(91)90113-4","volume":"36","author":"E Hollander","year":"1991","unstructured":"Hollander E, DeCaria C, Gully R, Nitescu A, Suckow RF, Gorman JM et al (1991a). Effects of chronic fluoxetine treatment on behavioral and neuroendocrine responses to meta-chlorophenylpiperazine in obsessive-compulsive disorder. Psychiatry Res 36: 1\u201317.","journal-title":"Psychiatry Res"},{"key":"BFnpp2009185_CR63","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/0165-1781(91)90073-X","volume":"37","author":"E Hollander","year":"1991","unstructured":"Hollander E, DeCaria C, Nitescu A, Cooper T, Stover B, Gully R et al (1991b). Noradrenergic function in obsessive-compulsive disorder: behavioral and neuroendocrine responses to clonidine and comparison to healthy controls. Psychiatry Res 37: 161\u2013177.","journal-title":"Psychiatry Res"},{"issue":"2 Suppl 3","key":"BFnpp2009185_CR64","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1017\/S1092852900002467","volume":"12","author":"E Hollander","year":"2007","unstructured":"Hollander E, Kim S, Khanna S, Pallanti S (2007b). Obsessive-compulsive disorder and obsessive-compulsive spectrum disorders: diagnostic and dimensional issues. CNS Spectr 12 (2 Suppl 3): 5\u201313.","journal-title":"CNS Spectr"},{"issue":"Suppl 4","key":"BFnpp2009185_CR65","first-page":"3","volume":"56","author":"E Hollander","year":"1995","unstructured":"Hollander E, Wong CM (1995). Obsessive-compulsive spectrum disorders. J Clin Psychiatry 56 (Suppl 4): 3\u20136; discussion 53\u20135.","journal-title":"J Clin Psychiatry"},{"key":"BFnpp2009185_CR66","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1111\/j.1460-9568.2007.05839.x","volume":"26","author":"JR Homberg","year":"2007","unstructured":"Homberg JR, Pattij T, Janssen MC, Ronken E, De Boer SF, Schoffelmeer AN et al (2007). Serotonin transporter deficiency in rats improves inhibitory control but not behavioural flexibility. Eur J Neurosci 26: 2066\u20132073.","journal-title":"Eur J Neurosci"},{"key":"BFnpp2009185_CR67","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1162\/089892904322926791","volume":"16","author":"J Hornak","year":"2004","unstructured":"Hornak J, O'Doherty J, Bramham J, Rolls ET, Morris RG, Bullock PR et al (2004). Reward-related reversal learning after surgical excisions in orbito-frontal or dorsolateral prefrontal cortex in humans. J Cogn Neurosci 16: 463\u2013478.","journal-title":"J Cogn Neurosci"},{"key":"BFnpp2009185_CR68","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1176\/ajp.140.9.1219","volume":"140","author":"TR Insel","year":"1983","unstructured":"Insel TR, Pickar D (1983). Naloxone administration in obsessive-compulsive disorder: report of two cases. Am J Psychiatry 140: 1219\u20131220.","journal-title":"Am J Psychiatry"},{"key":"BFnpp2009185_CR69","doi-asserted-by":"publisher","first-page":"14128","DOI":"10.1073\/pnas.0706583104","volume":"104","author":"A Izquierdo","year":"2007","unstructured":"Izquierdo A, Newman TK, Higley JD, Murray EA (2007). Genetic modulation of cognitive flexibility and socioemotional behavior in rhesus monkeys. Proc Natl Acad Sci USA 104: 14128\u201314133.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFnpp2009185_CR70","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.pnpbp.2005.11.006","volume":"30","author":"D Joel","year":"2006","unstructured":"Joel D (2006). Current animal models of obsessive compulsive disorder: a critical review. Prog Neuropsychopharmacol Biol Psychiatry 30: 374\u2013388.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"BFnpp2009185_CR71","doi-asserted-by":"publisher","first-page":"407","DOI":"10.4088\/JCP.v67n0311","volume":"67","author":"A Kolevzon","year":"2006","unstructured":"Kolevzon A, Mathewson KA, Hollander E (2006). Selective serotonin reuptake inhibitors in autism: a review of efficacy and tolerability. J Clin Psychiatry 67: 407\u2013414.","journal-title":"J Clin Psychiatry"},{"key":"BFnpp2009185_CR72","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1126\/science.278.5335.52","volume":"278","author":"GF Koob","year":"1997","unstructured":"Koob GF, Le Moal M (1997). Drug abuse: hedonic homeostatic dysregulation. Science 278: 52\u201358.","journal-title":"Science"},{"key":"BFnpp2009185_CR73","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.drugalcdep.2006.09.006","volume":"88","author":"S Krishnan-Sarin","year":"2007","unstructured":"Krishnan-Sarin S, Reynolds B, Duhig AM, Smith A, Liss T, McFetridge A et al (2007). Behavioral impulsivity predicts treatment outcome in a smoking cessation program for adolescent smokers. Drug Alcohol Depend 88: 79\u201382.","journal-title":"Drug Alcohol Depend"},{"key":"BFnpp2009185_CR74","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s00213-008-1224-6","volume":"202","author":"MD Lapiz-Bluhm","year":"2009","unstructured":"Lapiz-Bluhm MD, Soto-Pina AE, Hensler JG, Morilak DA (2009). Chronic intermittent cold stress and serotonin depletion induce deficits of reversal learning in an attentional set-shifting test in rats. Psychopharmacology (Berl) 202: 329\u2013341.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2009185_CR75","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1176\/jnp.2006.18.3.417","volume":"18","author":"CS Li","year":"2006","unstructured":"Li CS, Chang HL, Hsu YP, Wang HS, Ko NC (2006). Motor response inhibition in children with Tourette's disorder. J Neuropsychiatry Clin Neurosci 18: 417\u2013419.","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"BFnpp2009185_CR76","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1037\/0021-843X.114.2.216","volume":"114","author":"M Lijffijt","year":"2005","unstructured":"Lijffijt M, Kenemans JL, Verbaten MN, van Engeland H (2005). A meta-analytic review of stopping performance in attention-deficit\/hyperactivity disorder: deficient inhibitory motor control? J Abnorm Psychol 114: 216\u2013222.","journal-title":"J Abnorm Psychol"},{"key":"BFnpp2009185_CR77","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/0306-4522(94)90181-3","volume":"59","author":"E Lynd-Balta","year":"1994","unstructured":"Lynd-Balta E, Haber SN (1994). The organization of midbrain projections to the ventral striatum in the primate. Neuroscience 59: 609\u2013623.","journal-title":"Neuroscience"},{"key":"BFnpp2009185_CR78","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s00213-006-0559-0","volume":"189","author":"D Masaki","year":"2006","unstructured":"Masaki D, Yokoyama C, Kinoshita S, Tsuchida H, Nakatomi Y, Yoshimoto K et al (2006). Relationship between limbic and cortical 5-HT neurotransmission and acquisition and reversal learning in a go\/no-go task in rats. Psychopharmacology (Berl) 189: 249\u2013258.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2009185_CR79","doi-asserted-by":"publisher","first-page":"433","DOI":"10.4088\/JCP.v69n0314","volume":"69","author":"SL McElroy","year":"2008","unstructured":"McElroy SL, Nelson EB, Welge JA, Kaehler L, Keck Jr PE (2008). Olanzapine in the treatment of pathological gambling: a negative randomized placebo-controlled trial. J Clin Psychiatry 69: 433\u2013440.","journal-title":"J Clin Psychiatry"},{"issue":"Suppl 1","key":"BFnpp2009185_CR80","doi-asserted-by":"publisher","first-page":"S250","DOI":"10.1016\/j.neuroimage.2004.07.020","volume":"23","author":"AR McIntosh","year":"2004","unstructured":"McIntosh AR, Lobaugh NJ (2004). Partial least squares analysis of neuroimaging data: applications and advances. Neuroimage 23 (Suppl 1): S250\u2013S263.","journal-title":"Neuroimage"},{"issue":"Pt 12","key":"BFnpp2009185_CR81","doi-asserted-by":"publisher","first-page":"3223","DOI":"10.1093\/brain\/awm205","volume":"130","author":"L Menzies","year":"2007","unstructured":"Menzies L, Achard S, Chamberlain SR, Fineberg N, Chen CH, del Campo N et al (2007a). Neurocognitive endophenotypes of obsessive-compulsive disorder. Brain 130 (Pt 12): 3223\u20133236.","journal-title":"Brain"},{"key":"BFnpp2009185_CR82","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.neubiorev.2007.09.005","volume":"32","author":"L Menzies","year":"2008","unstructured":"Menzies L, Chamberlain SR, Laird AR, Thelen SM, Sahakian BJ, Bullmore ET (2008a). Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: The orbitofronto-striatal model revisited. Neurosci Biobehav Rev 32: 525\u2013549.","journal-title":"Neurosci Biobehav Rev"},{"key":"BFnpp2009185_CR83","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1176\/appi.ajp.2008.07101677","volume":"165","author":"L Menzies","year":"2008","unstructured":"Menzies L, Williams GB, Chamberlain SR, Ooi C, Fineberg N, Suckling J et al (2008b). White matter abnormalities in patients with obsessive-compulsive disorder and their first-degree relatives. Am J Psychiatry 165: 1308\u20131315.","journal-title":"Am J Psychiatry"},{"key":"BFnpp2009185_CR84","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1126\/science.1135926","volume":"315","author":"NH Naqvi","year":"2007","unstructured":"Naqvi NH, Rudrauf D, Damasio H, Bechara A (2007). Damage to the insula disrupts addiction to cigarette smoking. Science 315: 531\u2013534.","journal-title":"Science"},{"key":"BFnpp2009185_CR85","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0028-3908(94)90089-2","volume":"33","author":"SB Park","year":"1994","unstructured":"Park SB, Coull JT, McShane RH, Young AH, Sahakian BJ, Robbins TW et al (1994). Tryptophan depletion in normal volunteers produces selective impairments in learning and memory. Neuropharmacology 33: 575\u2013588.","journal-title":"Neuropharmacology"},{"key":"BFnpp2009185_CR86","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1007\/s00213-002-1227-7","volume":"165","author":"F Passetti","year":"2003","unstructured":"Passetti F, Dalley JW, Robbins TW (2003). Double dissociation of serotonergic and dopaminergic mechanisms on attentional performance using a rodent five-choice reaction time task. Psychopharmacology (Berl) 165: 136\u2013145.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2009185_CR87","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s00213-007-0957-y","volume":"196","author":"DA Pizzagalli","year":"2008","unstructured":"Pizzagalli DA, Evins AE, Schetter EC, Frank MJ, Pajtas PE, Santesso DL et al (2008). Single dose of a dopamine agonist impairs reinforcement learning in humans: behavioral evidence from a laboratory-based measure of reward responsiveness. Psychopharmacology (Berl) 196: 221\u2013232.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2009185_CR88","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1590\/S1516-44462007000200004","volume":"29","author":"MN Potenza","year":"2007","unstructured":"Potenza MN (2007a). Impulsivity and compulsivity in pathological gambling and obsessive-compulsive disorder. Rev Bras Psiquiatr 29: 105\u2013106.","journal-title":"Rev Bras Psiquiatr"},{"key":"BFnpp2009185_CR89","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1176\/ajp.2007.164.1.4","volume":"164","author":"MN Potenza","year":"2007","unstructured":"Potenza MN (2007b). To do or not to do? The complexities of addiction, motivation, self-control, and impulsivity. Am J Psychiatry 164: 4\u20136.","journal-title":"Am J Psychiatry"},{"key":"BFnpp2009185_CR90","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1176\/appi.ajp.160.11.1990","volume":"160","author":"MN Potenza","year":"2003","unstructured":"Potenza MN, Leung HC, Blumberg HP, Peterson BS, Fulbright RK, Lacadie CM et al (2003a). An FMRI Stroop task study of ventromedial prefrontal cortical function in pathological gamblers. Am J Psychiatry 160: 1990\u20131994.","journal-title":"Am J Psychiatry"},{"key":"BFnpp2009185_CR91","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1001\/archpsyc.60.8.828","volume":"60","author":"MN Potenza","year":"2003","unstructured":"Potenza MN, Steinberg MA, Skudlarski P, Fulbright RK, Lacadie CM, Wilber MK et al (2003b). Gambling urges in pathological gambling: a functional magnetic resonance imaging study. Arch Gen Psychiatry 60: 828\u2013836.","journal-title":"Arch Gen Psychiatry"},{"key":"BFnpp2009185_CR92","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.psychres.2007.06.010","volume":"159","author":"M Poyurovsky","year":"2008","unstructured":"Poyurovsky M, Faragian S, Shabeta A, Kosov A (2008). Comparison of clinical characteristics, co-morbidity and pharmacotherapy in adolescent schizophrenia patients with and without obsessive-compulsive disorder. Psychiatry Res 159: 133\u2013139.","journal-title":"Psychiatry Res"},{"key":"BFnpp2009185_CR93","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/nn1378","volume":"8","author":"J Reuter","year":"2005","unstructured":"Reuter J, Raedler T, Rose M, Hand I, Glascher J, Buchel C (2005). Pathological gambling is linked to reduced activation of the mesolimbic reward system. Nat Neurosci 8: 147\u2013148.","journal-title":"Nat Neurosci"},{"key":"BFnpp2009185_CR94","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1007\/s00213-002-1154-7","volume":"163","author":"TW Robbins","year":"2002","unstructured":"Robbins TW (2002). The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry. Psychopharmacology (Berl) 163: 362\u2013380.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2009185_CR95","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1098\/rstb.2007.2097","volume":"362","author":"TW Robbins","year":"2007","unstructured":"Robbins TW (2007). Shifting and stopping: fronto-striatal substrates, neurochemical modulation and clinical implications. Philos Trans R Soc Lond B Biol Sci 362: 917\u2013932.","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"BFnpp2009185_CR96","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/0165-0173(93)90013-P","volume":"18","author":"TE Robinson","year":"1993","unstructured":"Robinson TE, Berridge KC (1993). The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev 18: 247\u2013291.","journal-title":"Brain Res Brain Res Rev"},{"key":"BFnpp2009185_CR97","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1007\/PL00005494","volume":"146","author":"RD Rogers","year":"1999","unstructured":"Rogers RD, Blackshaw AJ, Middleton HC, Matthews K, Hawtin K, Crowley C et al (1999a). Tryptophan depletion impairs stimulus-reward learning while methylphenidate disrupts attentional control in healthy young adults: implications for the monoaminergic basis of impulsive behaviour. Psychopharmacology (Berl) 146: 482\u2013491.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2009185_CR98","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/S0893-133X(98)00091-8","volume":"20","author":"RD Rogers","year":"1999","unstructured":"Rogers RD, Everitt BJ, Baldacchino A, Blackshaw AJ, Swainson R, Wynne K et al (1999b). Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: evidence for monoaminergic mechanisms. Neuropsychopharmacology 20: 322\u2013339.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2009185_CR99","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/S1053-8119(03)00275-1","volume":"20","author":"K Rubia","year":"2003","unstructured":"Rubia K, Smith AB, Brammer MJ, Taylor E (2003). Right inferior prefrontal cortex mediates response inhibition while mesial prefrontal cortex is responsible for error detection. Neuroimage 20: 351\u2013358.","journal-title":"Neuroimage"},{"key":"BFnpp2009185_CR100","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.neulet.2007.12.024","volume":"432","author":"EA Schilman","year":"2008","unstructured":"Schilman EA, Uylings HB, Galis-de Graaf Y, Joel D, Groenewegen HJ (2008). The orbital cortex in rats topographically projects to central parts of the caudate-putamen complex. Neurosci Lett 432: 40\u201345.","journal-title":"Neurosci Lett"},{"key":"BFnpp2009185_CR101","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/S0896-6273(02)00967-4","volume":"36","author":"W Schultz","year":"2002","unstructured":"Schultz W (2002). Getting formal with dopamine and reward. Neuron 36: 241\u2013263.","journal-title":"Neuron"},{"key":"BFnpp2009185_CR102","doi-asserted-by":"publisher","first-page":"4826","DOI":"10.1523\/JNEUROSCI.0400-07.2007","volume":"27","author":"B Seymour","year":"2007","unstructured":"Seymour B, Daw N, Dayan P, Singer T, Dolan R (2007). Differential encoding of losses and gains in the human striatum. J Neurosci 27: 4826\u20134831.","journal-title":"J Neurosci"},{"key":"BFnpp2009185_CR103","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1017\/S1092852900014978","volume":"11","author":"DJ Stein","year":"2006","unstructured":"Stein DJ, Chamberlain SR, Fineberg N (2006). An A-B-C model of habit disorders: hair-pulling, skin-picking, and other stereotypic conditions. CNS Spectr 11: 824\u2013827.","journal-title":"CNS Spectr"},{"key":"BFnpp2009185_CR104","first-page":"265","volume":"56","author":"DJ Stein","year":"1995","unstructured":"Stein DJ, Hollander E (1995). Obsessive-compulsive spectrum disorders. J Clin Psychiatry 56: 265\u2013266.","journal-title":"J Clin Psychiatry"},{"key":"BFnpp2009185_CR105","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1001\/archpsyc.62.7.782","volume":"62","author":"PR Szeszko","year":"2005","unstructured":"Szeszko PR, Ardekani BA, Ashtari M, Malhotra AK, Robinson DG, Bilder RM et al (2005). White matter abnormalities in obsessive-compulsive disorder: a diffusion tensor imaging study. Arch Gen Psychiatry 62: 782\u2013790.","journal-title":"Arch Gen Psychiatry"},{"key":"BFnpp2009185_CR106","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1038\/sj.npp.1300980","volume":"31","author":"PS Talbot","year":"2006","unstructured":"Talbot PS, Watson DR, Barrett SL, Cooper SJ (2006). Rapid tryptophan depletion improves decision-making cognition in healthy humans without affecting reversal learning or set shifting. Neuropsychopharmacology 31: 1519\u20131525.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2009185_CR107","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1016\/j.biopsych.2005.02.020","volume":"57","author":"E Tsaltas","year":"2005","unstructured":"Tsaltas E, Kontis D, Chrysikakou S, Giannou H, Biba A, Pallidi S et al (2005). Reinforced spatial alternation as an animal model of obsessive-compulsive disorder (OCD): investigation of 5-HT2C and 5-HT1D receptor involvement in OCD pathophysiology. Biol Psychiatry 57: 1176\u20131185.","journal-title":"Biol Psychiatry"},{"key":"BFnpp2009185_CR108","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.bbr.2007.07.017","volume":"186","author":"G van der Plasse","year":"2008","unstructured":"van der Plasse G, Feenstra MG (2008). Serial reversal learning and acute tryptophan depletion. Behav Brain Res 186: 23\u201331.","journal-title":"Behav Brain Res"},{"key":"BFnpp2009185_CR109","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1002\/syn.10279","volume":"51","author":"RP Vertes","year":"2004","unstructured":"Vertes RP (2004). Differential projections of the infralimbic and prelimbic cortex in the rat. Synapse 51: 32\u201358.","journal-title":"Synapse"},{"key":"BFnpp2009185_CR110","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1177\/026988119901300406","volume":"13","author":"ND Volkow","year":"1999","unstructured":"Volkow ND, Fowler JS, Wang GJ (1999). Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans. J Psychopharmacol 13: 337\u2013345.","journal-title":"J Psychopharmacol"},{"key":"BFnpp2009185_CR111","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1093\/cercor\/bhn136","volume":"19","author":"SC Walker","year":"2009","unstructured":"Walker SC, Robbins TW, Roberts AC (2009). Differential contributions of dopamine and serotonin to orbitofrontal cortex function in the marmoset. Cereb Cortex 19: 889\u2013898.","journal-title":"Cereb Cortex"},{"key":"BFnpp2009185_CR112","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1017\/S0033291704003691","volume":"35","author":"LH Watkins","year":"2005","unstructured":"Watkins LH, Sahakian BJ, Robertson MM, Veale DM, Rogers RD, Pickard KM et al (2005). Executive function in Tourette's syndrome and obsessive-compulsive disorder. Psychol Med 35: 571\u2013582.","journal-title":"Psychol Med"},{"issue":"2 Suppl 3","key":"BFnpp2009185_CR113","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1017\/S1092852900002479","volume":"12","author":"HG Westenberg","year":"2007","unstructured":"Westenberg HG, Fineberg NA, Denys D (2007). Neurobiology of obsessive-compulsive disorder: serotonin and beyond. CNS Spectr 12 (2 Suppl 3): 14\u201327.","journal-title":"CNS Spectr"},{"key":"BFnpp2009185_CR114","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1007\/s00213-003-1398-x","volume":"167","author":"CA Winstanley","year":"2003","unstructured":"Winstanley CA, Chudasama Y, Dalley JW, Theobald DE, Glennon JC, Robbins TW (2003). Intra-prefrontal 8-OH-DPAT and M100907 improve visuospatial attention and decrease impulsivity on the five-choice serial reaction time task in rats. Psychopharmacology (Berl) 167: 304\u2013314.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2009185_CR115","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.cpr.2006.01.001","volume":"26","author":"CA Winstanley","year":"2006","unstructured":"Winstanley CA, Eagle DM, Robbins TW (2006). Behavioral models of impulsivity in relation to ADHD: translation between clinical and preclinical studies. Clin Psychol Rev 26: 379\u2013395.","journal-title":"Clin Psychol Rev"},{"key":"BFnpp2009185_CR116","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1007\/s00213-004-1884-9","volume":"176","author":"CA Winstanley","year":"2004","unstructured":"Winstanley CA, Theobald DE, Dalley JW, Glennon JC, Robbins TW (2004). 5-HT2A and 5-HT2C receptor antagonists have opposing effects on a measure of impulsivity: interactions with global 5-HT depletion. Psychopharmacology (Berl) 176: 376\u2013385.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2009185_CR117","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S0896-6273(02)00965-0","volume":"36","author":"RA Wise","year":"2002","unstructured":"Wise RA (2002). Brain reward circuitry: insights from unsensed incentives. Neuron 36: 229\u2013240.","journal-title":"Neuron"},{"key":"BFnpp2009185_CR118","unstructured":"World Health Organisation (1992). International Classification of Diseases, 10th edition (ICD-10). World Health Organisation, Geneva."},{"key":"BFnpp2009185_CR119","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1001\/archpsyc.64.8.946","volume":"64","author":"M Yucel","year":"2007","unstructured":"Yucel M, Harrison BJ, Wood SJ, Fornito A, Wellard RM, Pujol J et al (2007). Functional and biochemical alterations of the medial frontal cortex in obsessive-compulsive disorder. Arch Gen Psychiatry 64: 946\u2013955.","journal-title":"Arch Gen Psychiatry"},{"key":"BFnpp2009185_CR120","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1038\/sj.npp.1301295","volume":"32","author":"M Zack","year":"2007","unstructured":"Zack M, Poulos CX (2007). A D2 antagonist enhances the rewarding and priming effects of a gambling episode in pathological gamblers. Neuropsychopharmacology 32: 1678\u20131686.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2009185_CR121","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1001\/archpsyc.1988.01800260081011","volume":"45","author":"J Zohar","year":"1988","unstructured":"Zohar J, Insel TR, Zohar-Kadouch RC, Hill JL, Murphy DL (1988). Serotonergic responsivity in obsessive-compulsive disorder. Effects of chronic clomipramine treatment. Arch Gen Psychiatry 45: 167\u2013172.","journal-title":"Arch Gen Psychiatry"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/npp2009185.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2009185","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2009185.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T20:20:10Z","timestamp":1684441210000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/npp2009185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,25]]},"references-count":121,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["BFnpp2009185"],"URL":"https:\/\/doi.org\/10.1038\/npp.2009.185","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,25]]}}}