{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T02:00:38Z","timestamp":1785290438543,"version":"3.55.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2011,2,2]],"date-time":"2011-02-02T00:00:00Z","timestamp":1296604800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1038\/npp.2010.253","type":"journal-article","created":{"date-parts":[[2011,2,2]],"date-time":"2011-02-02T15:09:27Z","timestamp":1296659367000},"page":"1178-1186","source":"Crossref","is-referenced-by-count":64,"title":["Pharmacologically induced alcohol craving in treatment seeking alcoholics correlates with alcoholism severity, but is insensitive to acamprosate"],"prefix":"10.1038","volume":"36","author":[{"given":"John C","family":"Umhau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie L","family":"Schwandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Usala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Geyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick","family":"Singley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Heilig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,2,2]]},"reference":[{"key":"BFnpp2010253_CR1","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1001\/archpsyc.1996.01830030047008","volume":"53","author":"RF Anton","year":"1996","unstructured":"Anton RF, Moak DH, Latham PK (1996). The obsessive compulsive drinking scale: A new method of assessing outcome in alcoholism treatment studies. Arch Gen Psychiatry 53: 225\u2013231.","journal-title":"Arch Gen Psychiatry"},{"key":"BFnpp2010253_CR2","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1111\/j.1530-0277.1998.tb04295.x","volume":"22","author":"J Besson","year":"1998","unstructured":"Besson J, Aeby F, Kasas A, Lehert P, Potgieter A (1998). Combined efficacy of acamprosate and disulfiram in the treatment of alcoholism: A controlled study. Alcohol ClinExp Res 22: 573\u2013579.","journal-title":"Alcohol ClinExp Res"},{"key":"BFnpp2010253_CR3","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1111\/j.1530-0277.1995.tb01554.x","volume":"19","author":"MJ Bohn","year":"1995","unstructured":"Bohn MJ, Krahn DD, Staehler BA (1995). Development and initial validation of a measure of drinking urges in abstinent alcoholics. Alcohol Clin Exp Res 19: 600\u2013606.","journal-title":"Alcohol Clin Exp Res"},{"key":"BFnpp2010253_CR4","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1037\/0003-066X.41.7.765","volume":"41","author":"KD Brownell","year":"1986","unstructured":"Brownell KD, Marlatt GA, Lichtenstein E, Wilson GT (1986). Understanding and preventing relapse. Am Psychol 41: 765\u2013782.","journal-title":"Am Psychol"},{"key":"BFnpp2010253_CR5","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1176\/ajp.144.8.1030","volume":"144","author":"DS Charney","year":"1987","unstructured":"Charney DS, Woods SW, Goodman WK, Heninger GR (1987). Neurobiological mechanisms of panic anxiety: biochemical and behavioral correlates of yohimbine-induced panic attacks. Am J Psychiatry 144: 1030\u20131036.","journal-title":"Am J Psychiatry"},{"key":"BFnpp2010253_CR6","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1093\/alcalc\/35.2.176","volume":"35","author":"J Chick","year":"2000","unstructured":"Chick J, Howlett H, Morgan MY, Ritson B (2000). United Kingdom Multicentre Acamprosate Study (UKMAS): a 6-month prospective study of acamprosate versus placebo in preventing relapse after withdrawal from alcohol. Alcohol Alcohol 35: 176\u2013187.","journal-title":"Alcohol Alcohol"},{"key":"BFnpp2010253_CR7","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1037\/0021-843X.106.2.243","volume":"106","author":"NL Cooney","year":"1997","unstructured":"Cooney NL, Litt MD, Morse PA, Bauer LO, Gaupp L (1997). Alcohol cue reactivity, negative-mood reactivity, and relapse in treated alcoholic men. J Abnorm Psychol 106: 243\u2013250.","journal-title":"J Abnorm Psychol"},{"key":"BFnpp2010253_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00213-006-0529-6","volume":"189","author":"DH Epstein","year":"2006","unstructured":"Epstein DH, Preston KL, Stewart J, Shaham Y (2006). Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure. Psychopharmacology (Berl) 189: 1\u201316.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2010253_CR9","volume-title":"Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Clinician Version","author":"MB First","year":"1997","unstructured":"First MB, Spitzer RL, Gibbon M, Williams JBW (1997). Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Clinician Version. American Psychiatric Press: Washington DC."},{"key":"BFnpp2010253_CR10","doi-asserted-by":"publisher","first-page":"120","DOI":"10.15288\/jsa.2003.64.120","volume":"64","author":"BA Flannery","year":"2003","unstructured":"Flannery BA, Poole SA, Gallop RJ, Volpicelli JR (2003). Alcohol craving predicts drinking during treatment: an analysis of three assessment instruments. J Stud Alcohol 64: 120\u2013126.","journal-title":"J Stud Alcohol"},{"key":"BFnpp2010253_CR11","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1111\/j.1530-0277.1999.tb04349.x","volume":"23","author":"BA Flannery","year":"1999","unstructured":"Flannery BA, Volpicelli JR, Pettinati HM (1999). Psychometric properties of the Penn Alcohol Craving Scale. Alcohol Clin Exp Res 23: 1289\u20131295.","journal-title":"Alcohol Clin Exp Res"},{"key":"BFnpp2010253_CR12","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1111\/j.1530-0277.2006.00320.x","volume":"31","author":"HC Fox","year":"2007","unstructured":"Fox HC, Bergquist KL, Hong KI, Sinha R (2007). Stress-induced and alcohol cue-induced craving in recently abstinent alcohol-dependent individuals. Alcohol: Clin Exp Res 31: 395\u2013403.","journal-title":"Alcohol: Clin Exp Res"},{"key":"BFnpp2010253_CR13","doi-asserted-by":"publisher","first-page":"11324","DOI":"10.1523\/JNEUROSCI.3096-06.2006","volume":"26","author":"CK Funk","year":"2006","unstructured":"Funk CK, O\u2019Dell LE, Crawford EF, Koob GF (2006). Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats. J Neurosci 26: 11324\u201311332.","journal-title":"J Neurosci"},{"key":"BFnpp2010253_CR14","doi-asserted-by":"publisher","first-page":"2718","DOI":"10.1523\/JNEUROSCI.4985-06.2007","volume":"27","author":"DR Gehlert","year":"2007","unstructured":"Gehlert DR, Cippitelli A, Le AD, Hipskind PA, Hamdouchi C et al. (2007). 3-(4-chloro-2morpholin-4-yl-thiazol-5-yl)-8-(1-ethypropyl)-2,6-dimethly-imidazo[1,2-b]pyridazine:a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism. J Neurosci 27: 2718\u20132726.","journal-title":"J Neurosci"},{"key":"BFnpp2010253_CR15","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1176\/ajp.154.12.1752","volume":"154","author":"DT George","year":"1997","unstructured":"George DT, Benkelfat C, Rawlings RR, Eckardt MJ, Phillips MJ, Nutt DJ et al (1997). Behavioral and neuroendocrine responses to m-chlorophenylpiperazine in subtypes of alcoholics and in healthy comparison subjects. Am J Psychiatry 154: 81\u201387.","journal-title":"Am J Psychiatry"},{"key":"BFnpp2010253_CR16","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1126\/science.1153813","volume":"319","author":"DT George","year":"2008","unstructured":"George DT, Gilman J, Hersh J, Thorsell A, Herion D, Geyer C et al (2008). Neurokinin 1 receptor antagonism as a possible therapy for alcoholism. Science 319: 1536\u20131539.","journal-title":"Science"},{"key":"BFnpp2010253_CR17","first-page":"143","volume":"35","author":"MR Goldberg","year":"1983","unstructured":"Goldberg MR, Robertson D (1983). Yohimbine: a pharmacological probe for study of the alpha 2-adrenoreceptor. Pharmacol Rev 35: 143\u2013180.","journal-title":"Pharmacol Rev"},{"key":"BFnpp2010253_CR18","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1097\/FTD.0b013e3181e18638","volume":"32","author":"A Hammarberg","year":"2010","unstructured":"Hammarberg A, Beck O, Eksborg S, Jayaram-Lindstrom N, Lindefeldt A, Andersson M et al (2010). Acamprosate determinations in plasma and cerebrospinal fluid after multiple dosing measured by liquid chromatography-mass spectroscopy: a pharmacokinetic study in healthy volunteers. Ther Drug Monit 32: 489\u2013496.","journal-title":"Ther Drug Monit"},{"key":"BFnpp2010253_CR19","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s00213-009-1515-6","volume":"205","author":"A Hammarberg","year":"2009","unstructured":"Hammarberg A, Jayaram-Lindstrom N, Beck O, Franck J, Reid MS (2009). The effects of acamprosate on alcohol-cue reactivity and alcohol priming in dependent patients: a randomized controlled trial. Psychopharmacology (Berl) 205: 53\u201362.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2010253_CR20","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.pharmthera.2006.02.001","volume":"111","author":"M Heilig","year":"2006","unstructured":"Heilig M, Egli M (2006). Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms. Pharm Therap 111: 855\u2013876.","journal-title":"Pharm Therap"},{"key":"BFnpp2010253_CR21","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.tins.2007.06.006","volume":"30","author":"M Heilig","year":"2007","unstructured":"Heilig M, Koob GF (2007). A key role for corticotropin-releasing factor in alcohol dependence. Trends Neurosci 30: 399\u2013406.","journal-title":"Trends Neurosci"},{"key":"BFnpp2010253_CR22","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1093\/alcalc\/agg005","volume":"38","author":"A Heinz","year":"2003","unstructured":"Heinz A, Lober S, Georgi A, Wrase J, Hermann D, Rey ER et al (2003). Reward craving and withdrawal relief craving: assessment of different motivational pathways to alcohol intake. Alcohol Alcohol 38: 35\u201339.","journal-title":"Alcohol Alcohol"},{"key":"BFnpp2010253_CR23","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1159\/000092543","volume":"53","author":"T Hillemacher","year":"2006","unstructured":"Hillemacher T, Bayerlein K, Wilhelm J, Frieling H, Sperling W, Kornhuber J et al (2006). Prolactin serum levels and alcohol craving - an analysis using Lesch's typology. Neuropsychobiology 53: 133\u2013136.","journal-title":"Neuropsychobiology"},{"key":"BFnpp2010253_CR24","first-page":"108","volume":"23","author":"HR Kranzler","year":"1999","unstructured":"Kranzler HR, Mulgrew CL, Modesto-Lowe V, Burleson JA (1999). Validity of the obsessive compulsive drinking scale (OCDS): does craving predict drinking behavior? Alcohol Clin Exp Res 23: 108\u2013114.","journal-title":"Alcohol Clin Exp Res"},{"key":"BFnpp2010253_CR25","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1001\/archpsyc.1994.03950110058008","volume":"51","author":"JH Krystal","year":"1994","unstructured":"Krystal JH, Webb E, Cooney N, Kranzler HR, Charney DS (1994). Specificity of ethanollike effects elicited by serotonergic and noradrenergic mechanisms. Arch Gen Psychiatry 51: 898\u2013911.","journal-title":"Arch Gen Psychiatry"},{"key":"BFnpp2010253_CR26","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1007\/s00213-004-2036-y","volume":"179","author":"AD Le","year":"2005","unstructured":"Le AD, Harding S, Juzytsch W, Funk D, Shaham Y (2005). Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self-administration in rats. Psychopharmacology (Berl) 179: 366\u2013373.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2010253_CR27","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s002130000411","volume":"150","author":"AD Le","year":"2000","unstructured":"Le AD, Harding S, Juzytsch W, Watchus J, Shalev U, Shaham Y (2000). The role of corticotrophin-releasing factor in stress-induced relapse to alcohol-seeking behavior in rats. Psychopharmacology(Berl) 150: 317\u2013324.","journal-title":"Psychopharmacology(Berl)"},{"key":"BFnpp2010253_CR28","first-page":"174","volume":"23","author":"MD Litt","year":"1999","unstructured":"Litt MD, Cooney NL (1999). Inducing craving for alcohol in the laboratory. Alcohol Res Health 23: 174\u2013178.","journal-title":"Alcohol Res Health"},{"key":"BFnpp2010253_CR29","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1046\/j.1360-0443.2000.9568896.x","volume":"95","author":"MD Litt","year":"2000","unstructured":"Litt MD, Cooney NL, Morse P (2000). Reactivity to alcohol-related stimuli in the laboratory and in the field: predictors of craving in treated alcoholics. Addiction 95: 889\u2013900.","journal-title":"Addiction"},{"issue":"Suppl 1","key":"BFnpp2010253_CR30","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1111\/j.1521-0391.2003.tb00492.x","volume":"12","author":"J Littleton","year":"2003","unstructured":"Littleton J, Zieglgansberger W (2003). Pharmacological mechanisms of naltrexone and acamprosate in the prevention of relapse in alcohol dependence. Am J Addict 12 (Suppl 1): S3\u2013S11.","journal-title":"Am J Addict"},{"key":"BFnpp2010253_CR31","doi-asserted-by":"publisher","first-page":"7856","DOI":"10.1523\/JNEUROSCI.22-18-07856.2002","volume":"22","author":"X Liu","year":"2002","unstructured":"Liu X, Weiss F (2002). Additive effort of stress and drug cues on reinstatement of ethanol seeking:exacerbation by history of dependence and role of concurrent activation of corticotropin-releasing factor and apioid mechanisms. J Neurosci 22: 7856\u20137861.","journal-title":"J Neurosci"},{"key":"BFnpp2010253_CR32","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s00213-007-0905-x","volume":"195","author":"PW Marinelli","year":"2007","unstructured":"Marinelli PW, Funk D, Juzytsch W, Harding S, Rice KC, Shaham Y et al (2007). The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats. Psychopharmacology (Berl) 195: 345\u2013355.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2010253_CR33","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/0740-5472(92)90062-S","volume":"9","author":"AT McLellan","year":"1992","unstructured":"McLellan AT, Kushner H, Metzger D, Peters R, Smith I, Grissom G et al (1992). The fifth edition of the addiction severity index. J Subst Abuse Treat 9: 199\u2013213.","journal-title":"J Subst Abuse Treat"},{"key":"BFnpp2010253_CR34","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1001\/jama.284.13.1689","volume":"284","author":"AT McLellan","year":"2000","unstructured":"McLellan AT, Lewis DC, O\u2032Brien CP, Kleber HD (2000). Drug dependence, a chronic medical illness: implications for treatment, insurance, and outcomes evaluation. JAMA 284: 1689\u20131695.","journal-title":"JAMA"},{"key":"BFnpp2010253_CR35","doi-asserted-by":"publisher","first-page":"235","DOI":"10.15288\/jsa.1993.54.235","volume":"54","author":"PM Monti","year":"1993","unstructured":"Monti PM, Rohsenow DJ, Rubonis AV, Niaura RS, Sirota AD, Colby SM et al (1993). Alcohol cue reactivity: effects of detoxification and extended exposure. J Stud Alcohol 54: 235\u2013245.","journal-title":"J Stud Alcohol"},{"key":"BFnpp2010253_CR36","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1111\/j.1360-0443.2006.01555.x","volume":"101","author":"KC Morley","year":"2006","unstructured":"Morley KC, Teesson M, Reid SC, Sannibale C, Thomson C, Phung N et al (2006). Naltrexone versus acamprosate in the treatment of alcohol dependence: a multi-centre, randomized, double-blind, placebo-controlled trial. Addiction 101: 1451\u20131462.","journal-title":"Addiction"},{"key":"BFnpp2010253_CR37","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s002130100919","volume":"160","author":"SS O\u2019Malley","year":"2002","unstructured":"O\u2019Malley SS, Krishnan-Sarin S, Farren C, Sinha R, Kreek MJ (2002). Naltrexone decreases craving and alcohol self-administration in alcohol-dependent subjects and activates the hypothalamo-pituitary-adrenocortical axis. Psychopharmacology (Berl) 160: 19\u201329.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2010253_CR38","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.euroneuro.2007.02.012","volume":"17","author":"W Ooteman","year":"2007","unstructured":"Ooteman W, Koeter MW, Verheul R, Schippers GM, van den Brink W (2007). The effect of naltrexone and acamprosate on cue-induced craving, autonomic nervous system and neuroendocrine reactions to alcohol-related cues in alcoholics. Eur Neuropsychopharmacol 17: 558\u2013566.","journal-title":"Eur Neuropsychopharmacol"},{"key":"BFnpp2010253_CR39","first-page":"239","volume":"30","author":"FM Paille","year":"1995","unstructured":"Paille FM, Guelfi JD, Perkins AC, Royer RJ, Steru L, Parot P (1995). Double-blind randomized multicenter trial of acamprosate in maintaining abstinence from alcohol. Alcohol Alcohol 30: 239\u2013247.","journal-title":"Alcohol Alcohol"},{"key":"BFnpp2010253_CR40","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1192\/bjp.171.1.73","volume":"171","author":"I Pelc","year":"1997","unstructured":"Pelc I, Verbanck P, Lebon O, Gavrilovic M, Lion K, Lehert P (1997). Efficacy and safety of acamprosate in the treatment of detoxified alcohol-dependent patients - A 90-day placebo-controlled dose-finding study. Br J Psychiatry 171: 73\u201377.","journal-title":"Br J Psychiatry"},{"key":"BFnpp2010253_CR41","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/j.1369-1600.2008.00134.x","volume":"14","author":"R Sinha","year":"2009","unstructured":"Sinha R (2009). Modeling stress and drug craving in the laboratory: implications for addiction treatment development. Addict Biol 14: 84\u201398.","journal-title":"Addict Biol"},{"key":"BFnpp2010253_CR42","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1001\/archpsyc.63.3.324","volume":"63","author":"R Sinha","year":"2006","unstructured":"Sinha R, Garcia M, Paliwal P, Kreek MJ, Rounsaville BJ (2006). Stress-induced cocaine craving and hypothalamic-pituitary-adrenal responses are predictive of cocaine relapse outcomes. Arch Gen Psychiatry 63: 324\u2013331.","journal-title":"Arch Gen Psychiatry"},{"key":"BFnpp2010253_CR43","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1093\/alcalc\/34.2.223","volume":"34","author":"R Sinha","year":"1999","unstructured":"Sinha R, O\u2019Malley SS (1999). Craving for alcohol: findings from the clinic and the laboratory. Alcohol Alcohol 34: 223\u2013230.","journal-title":"Alcohol Alcohol"},{"key":"BFnpp2010253_CR44","volume-title":"Alcohol Dependence Scale: User's Guide","author":"H Skinner","year":"1984","unstructured":"Skinner H, Horn J (1984). Alcohol Dependence Scale: User's Guide. Addiction Research Foundation: Toronto."},{"key":"BFnpp2010253_CR45","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/978-1-4612-0357-5_3","volume-title":"Measuring Alcohol Consumption: Psychosocial and Biochemical Methods","author":"LC Sobell","year":"1992","unstructured":"Sobell LC, Sobell MB (1992). Timeline follow-back: a technique for assessing self-reported ethanol consumption. In: Allen J, Litten R (eds). Measuring Alcohol Consumption: Psychosocial and Biochemical Methods. Humana Press: Totowa, NJ. pp 41\u201372."},{"key":"BFnpp2010253_CR46","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1001\/archpsyc.1997.01830200083012","volume":"54","author":"SM Southwick","year":"1997","unstructured":"Southwick SM, Krystal JH, Bremner JD, Morgan III CA, Nicolaou AL, Nagy LM et al (1997). Noradrenergic and serotonergic function in posttraumatic stress disorder. Arch Gen Psychiatry 54: 749\u2013758.","journal-title":"Arch Gen Psychiatry"},{"key":"BFnpp2010253_CR47","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/s002130050730","volume":"139","author":"R Spanagel","year":"1998","unstructured":"Spanagel R, Sillaber I, Zieglgansberger W, Corrigall WA, Stewart J, Shaham Y (1998). Acamprosate suppresses the expression of morphine-induced sensitization in rats but does not affect heroin self-administration or relapse induced by heroin or stress. Psychopharmacology (Berl) 139: 391\u2013401.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2010253_CR48","volume-title":"Manual for the State-Trait Anxiety Inventory","author":"CD Spielberger","year":"1970","unstructured":"Spielberger CD, Gorsuch RL, Lushene RE (1970). Manual for the State-Trait Anxiety Inventory. Consulting Psychologist Press: Palo Alto."},{"key":"BFnpp2010253_CR49","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/S0006-3223(01)01292-6","volume":"51","author":"SM Stine","year":"2002","unstructured":"Stine SM, Southwick SM, Petrakis IL, Kosten TR, Charney DS, Krystal JH (2002). Yohimbine-induced withdrawal and anxiety symptoms in opioid-dependent patients. Biol Psychiatry 51: 642\u2013651.","journal-title":"Biol Psychiatry"},{"key":"BFnpp2010253_CR50","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1111\/j.1360-0443.1989.tb00737.x","volume":"84","author":"JT Sullivan","year":"1989","unstructured":"Sullivan JT, Sykora K, Schneiderman J, Naranjo CA, Sellers EM (1989). Assessment of alcohol withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA-Ar). Br J Addict 84: 1353\u20131357.","journal-title":"Br J Addict"},{"key":"BFnpp2010253_CR51","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1093\/alcalc\/35.2.202","volume":"35","author":"E Tempesta","year":"2000","unstructured":"Tempesta E, Janiri L, Bignamini A, Chabac S, Potgieter A (2000). Acamprosate and relapse prevention in the treatment of alcohol dependence: a placebo-controlled study. Alcohol Alcohol 35: 202\u2013209.","journal-title":"Alcohol Alcohol"},{"key":"BFnpp2010253_CR52","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1037\/0033-295X.97.2.147","volume":"97","author":"ST Tiffany","year":"1990","unstructured":"Tiffany ST (1990). A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. Psychol Rev 97: 147\u2013168.","journal-title":"Psychol Rev"},{"key":"BFnpp2010253_CR53","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1111\/j.1360-0443.2009.02588.x","volume":"104","author":"ST Tiffany","year":"2009","unstructured":"Tiffany ST, Wray J (2009). The continuing conundrum of craving. Addiction 104: 1618\u20131619.","journal-title":"Addiction"},{"key":"BFnpp2010253_CR54","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.2165\/00003495-199753060-00008","volume":"53","author":"MI Wilde","year":"1997","unstructured":"Wilde MI, Wagstaff AJ (1997). Acamprosate. A review of its pharmacology and clinical potential in the management of alcohol dependence after detoxification. Drugs 53: 1038\u20131053.","journal-title":"Drugs"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/npp2010253.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2010253","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2010253.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:23:13Z","timestamp":1684455793000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/npp2010253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,2]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["BFnpp2010253"],"URL":"https:\/\/doi.org\/10.1038\/npp.2010.253","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,2]]}}}