{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:37:35Z","timestamp":1789594655308,"version":"build-2803163510"},"reference-count":88,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T00:00:00Z","timestamp":1319587200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1038\/npp.2011.254","type":"journal-article","created":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T14:16:17Z","timestamp":1319638577000},"page":"770-786","source":"Crossref","is-referenced-by-count":146,"title":["Selective Blockade of Dopamine D3 Receptors Enhances while D2 Receptor Antagonism Impairs Social Novelty Discrimination and Novel Object Recognition in Rats: A Key Role for the Prefrontal Cortex"],"prefix":"10.1038","volume":"37","author":[{"given":"David JG","family":"Watson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Loiseau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Ingallinesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J","family":"Millan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A","family":"Marsden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin CF","family":"Fone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,10,26]]},"reference":[{"key":"BFnpp2011254_CR1","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.neulet.2003.11.049","volume":"356","author":"H Abe","year":"2004","unstructured":"Abe H, Ishida Y, Iwasaki T (2004). Perirhinal N-methyl-D-aspartate and muscarinic systems participate in object recognition in rats. Neurosci Lett 356: 191\u2013194.","journal-title":"Neurosci Lett"},{"key":"BFnpp2011254_CR2","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1073\/pnas.93.5.1945","volume":"93","author":"D Accili","year":"1996","unstructured":"Accili D, Fishburn CS, Drago J, Steiner H, Lachowicz JE, Park BH et al (1996). A targeted mutation of the D-3 dopamine receptor gene is associated with hyperactivity in mice. Proc Natl Acad Sci USA 93: 1945\u20131949.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFnpp2011254_CR3","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/S0361-9230(97)00007-5","volume":"43","author":"JP Aggleton","year":"1997","unstructured":"Aggleton JP, Keen S, Warburton EC, Bussey TJ (1997). Extensive cytotoxic lesions involving both the rhinal cortices and area TE impair recognition but spare spatial alternation in the rat. Brain Res Bull 43: 279\u2013287.","journal-title":"Brain Res Bull"},{"key":"BFnpp2011254_CR4","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.bbr.2005.09.005","volume":"167","author":"JA Ainge","year":"2006","unstructured":"Ainge JA, Heron-Maxwell C, Theofilas P, Wright P, de Hoz L, Wood ER (2006). The role of the hippocampus in object recognition in rats: examination of the influence of task parameters and lesion size. Behav Brain Res 167: 183\u2013195.","journal-title":"Behav Brain Res"},{"key":"BFnpp2011254_CR5","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.tins.2011.02.003","volume":"34","author":"F Baluch","year":"2011","unstructured":"Baluch F, Itti L (2011). Mechanisms of top-down attention. Trends Neurosci 34: 210\u2013224.","journal-title":"Trends Neurosci"},{"key":"BFnpp2011254_CR6","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/j.biopsych.2006.04.022","volume":"60","author":"CW Berridge","year":"2006","unstructured":"Berridge CW, Devilbiss DM, Andrzejewski ME, Arnsten AFT, Kelley AE, Schmeichel B et al (2006). Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function. Biol Psychiatry 60: 1111\u20131120.","journal-title":"Biol Psychiatry"},{"key":"BFnpp2011254_CR7","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0166-4328(99)00021-2","volume":"103","author":"J Besheer","year":"1999","unstructured":"Besheer J, Jensen HC, Bevins RA (1999). Dopamine antagonism in a novel-object recognition and a novel-object place conditioning preparation with rats. Behav Brain Res 103: 35\u201344.","journal-title":"Behav Brain Res"},{"key":"BFnpp2011254_CR8","doi-asserted-by":"publisher","first-page":"2894","DOI":"10.1111\/j.1460-9568.2006.05170.x","volume":"24","author":"M Bianchi","year":"2006","unstructured":"Bianchi M, Fone KCF, Azmi N, Heidbreder CA, Hagan JJ, Marsden CA (2006). Isolation rearing induces recognition memory deficits accompanied by cytoskeletal alterations in rat hippocampus. Eur J Neurosci 24: 2894\u20132902.","journal-title":"Eur J Neurosci"},{"key":"BFnpp2011254_CR9","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/syn.20614","volume":"63","author":"M Bianchi","year":"2009","unstructured":"Bianchi M, Shah AJ, Fone KCF, Atkins AR, Dawson LA, Heidbreder CA et al (2009). Fluoxetine administration modulates the cytoskeletal microtubular system in the rat hippocampus. Synapse 63: 359\u2013364.","journal-title":"Synapse"},{"key":"BFnpp2011254_CR10","doi-asserted-by":"publisher","first-page":"17113","DOI":"10.1073\/pnas.012260599","volume":"99","author":"KJ Black","year":"2002","unstructured":"Black KJ, Hershey T, Koller JM, Videen TO, Mintun MA, Price JL et al (2002). A possible substrate for dopamine-related changes in mood and behavior: prefrontal and limbic effects of a D3-preferring dopamine agonist. Proc Natl Acad Sci USA 99: 17113\u201317118.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFnpp2011254_CR11","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.pharmthera.2006.04.007","volume":"112","author":"F Boeckler","year":"2006","unstructured":"Boeckler F, Gmeiner P (2006). The structural evolution of dopamine D-3 receptor ligands: structure-activity relationships and selected neuropharmacological aspects. Pharmacol Ther 112: 281\u2013333.","journal-title":"Pharmacol Ther"},{"key":"BFnpp2011254_CR12","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/0006-8993(91)91456-B","volume":"564","author":"ML Bouthenet","year":"1991","unstructured":"Bouthenet ML, Souil E, Martres MP, Sokoloff P, Giros B, Schwartz JC (1991). Localization of dopamine D3 receptor messenger RNA in the rat brain using in situ hybridization histochemistry - comparison with dopamine D2 receptor messenger. Brain Res 564: 203\u2013219.","journal-title":"Brain Res"},{"key":"BFnpp2011254_CR13","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1007\/s11064-010-0359-0","volume":"36","author":"A Castorina","year":"2011","unstructured":"Castorina A, Leggio GM, Giunta S, Magro G, Scapagnini G, Drago F et al (2011). Neurofibromin and amyloid precursor protein expression in dopamine d3 receptor knock-out mice brains. Neurochem Res 36: 426\u2013434.","journal-title":"Neurochem Res"},{"key":"BFnpp2011254_CR14","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.neuroimage.2005.10.029","volume":"30","author":"JK Choi","year":"2006","unstructured":"Choi JK, Chen YI, Hamel E, Jenkins BG (2006). Brain hemodynamic changes mediated by dopamine receptors: Role of the cerebral microvasculature in dopamine-mediated neurovascular coupling. Neuroimage 30: 700\u2013712.","journal-title":"Neuroimage"},{"key":"BFnpp2011254_CR15","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1038\/sj.npp.1300490","volume":"29","author":"Y Chudasama","year":"2004","unstructured":"Chudasama Y, Robbins TW (2004). Dopaminergic modulation of visual attention and working memory in the rodent prefrontal cortex. Neuropsychopharmacology 29: 1628\u20131636.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2011254_CR16","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/nature711","volume":"415","author":"RM Costa","year":"2002","unstructured":"Costa RM, Federov NB, Kogan JH, Murphy GG, Stern J, Ohno M et al (2002). Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature 415: 526\u2013530.","journal-title":"Nature"},{"key":"BFnpp2011254_CR17","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0014-2999(00)00149-7","volume":"394","author":"D Cussac","year":"2000","unstructured":"Cussac D, Newman-Tancredi A, Sezgin L, Millan MJ (2000). The novel antagonist, S33084, and GR218,231 interact selectively with cloned and native, rat dopamine D(3) receptors as compared with native, rat dopamine D(2) receptors. Eur J Pharmacol 394: 47\u201350.","journal-title":"Eur J Pharmacol"},{"key":"BFnpp2011254_CR18","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.neuron.2004.09.008","volume":"44","author":"RL Davis","year":"2004","unstructured":"Davis RL (2004). Olfactory learning. Neuron 44: 31\u201348.","journal-title":"Neuron"},{"key":"BFnpp2011254_CR19","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.neuroscience.2009.04.052","volume":"162","author":"DA DeSteno","year":"2009","unstructured":"DeSteno DA, Schmauss C (2009). A role for dopamine D2 receptors in reversal learning. Neuroscience 162: 118\u2013127.","journal-title":"Neuroscience"},{"key":"BFnpp2011254_CR20","doi-asserted-by":"publisher","first-page":"8677","DOI":"10.1523\/JNEUROSCI.20-23-08677.2000","volume":"20","author":"J Diaz","year":"2000","unstructured":"Diaz J, Pilon C, Le Foll B, Gros C, Triller A, Schwartz JC et al (2000). Dopamine D-3 receptors expressed by all mesencephalic dopamine neurons. J Neurosci 20: 8677\u20138684.","journal-title":"J Neurosci"},{"key":"BFnpp2011254_CR21","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1471-2202-7-22","volume":"7","author":"EA Donarum","year":"2006","unstructured":"Donarum EA, Halperin RF, Stephan DA, Narayanan V (2006). Cognitive dysfunction in NF1 knock-out mice may result from altered vesicular trafficking of APP\/DRD3 complex. BMC Neurosci 7: 22.","journal-title":"BMC Neurosci"},{"key":"BFnpp2011254_CR22","doi-asserted-by":"publisher","first-page":"4923","DOI":"10.1021\/jm900690y","volume":"52","author":"K Ehrlich","year":"2009","unstructured":"Ehrlich K, Gotz A, Bollinger S, Tschammer N, Bettinetti L, Harterich S et al (2009). Dopamine D-2, D-3, and D-4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. J Med Chem 52: 4923\u20134935.","journal-title":"J Med Chem"},{"key":"BFnpp2011254_CR23","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/0031-9384(95)00053-L","volume":"58","author":"M Engelmann","year":"1995","unstructured":"Engelmann M, Wotjak CT, Landgraf R (1995). Social discrimination procedure - an alternative method to investigate juvenile recognition abilities in rats. Physiol Behav 58: 315\u2013321.","journal-title":"Physiol Behav"},{"key":"BFnpp2011254_CR24","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0166-4328(97)02297-3","volume":"88","author":"A Ennaceur","year":"1997","unstructured":"Ennaceur A, Aggleton JP (1997). The effects of neurotoxic lesions of the perirhinal cortex combined to fornix transection on object recognition memory in the rat. Behav Brain Res 88: 181\u2013193.","journal-title":"Behav Brain Res"},{"key":"BFnpp2011254_CR25","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0166-4328(88)90157-X","volume":"31","author":"A Ennaceur","year":"1988","unstructured":"Ennaceur A, Delacour J (1988). A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. Behav Brain Res 31: 47\u201359.","journal-title":"Behav Brain Res"},{"key":"BFnpp2011254_CR26","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/77040","volume":"25","author":"JN Ferguson","year":"2000","unstructured":"Ferguson JN, Young LJ, Hearn EF, Matzuk MM, Insel TR, Winslow JT (2000). Social amnesia in mice lacking the oxytocin gene. Nat Genet 25: 284\u2013288.","journal-title":"Nat Genet"},{"key":"BFnpp2011254_CR27","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1006\/frne.2002.0229","volume":"23","author":"JN Ferguson","year":"2002","unstructured":"Ferguson JN, Young LJ, Insel TR (2002). The neuroendocrine basis of social recognition. Front Neuroendocrinol 23: 200\u2013224.","journal-title":"Front Neuroendocrinol"},{"key":"BFnpp2011254_CR28","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1016\/j.neubiorev.2008.03.003","volume":"32","author":"KCF Fone","year":"2008","unstructured":"Fone KCF, Porkess MV (2008). Behavioural and neurochemical effects of post-weaning social isolation in rodents-Relevance to developmental neuropsychiatric disorders. Neurosci Biobehav Rev 32: 1087\u20131102.","journal-title":"Neurosci Biobehav Rev"},{"key":"BFnpp2011254_CR29","unstructured":"Fossat P, Turpin FR, Sacchi S, Dulong J, Rivet JM, Polleioni L et al (2011). Glial D-serine gates NMDA receptors at excitatory synapses in prefrontal cortex. Cereb Cortex (in press)."},{"key":"BFnpp2011254_CR30","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1093\/cercor\/bhh202","volume":"15","author":"SB Glickstein","year":"2005","unstructured":"Glickstein SB, Desteno DA, Hof PR, Schmauss C (2005). Mice lacking dopamine D2 and D3 receptors exhibit differential activation of prefrontal cortical neurons during tasks requiring attention. Cereb Cortex 15: 1016\u20131024.","journal-title":"Cereb Cortex"},{"key":"BFnpp2011254_CR31","doi-asserted-by":"publisher","first-page":"5619","DOI":"10.1523\/JNEUROSCI.22-13-05619.2002","volume":"22","author":"SB Glickstein","year":"2002","unstructured":"Glickstein SB, Hof PR, Schmauss C (2002). Mice lacking dopamine D2 and D3 receptors have spatial working memory deficits. J Neurosci 22: 5619\u20135629.","journal-title":"J Neurosci"},{"key":"BFnpp2011254_CR32","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s11920-010-0124-8","volume":"12","author":"G Gonzalez-Burgos","year":"2010","unstructured":"Gonzalez-Burgos G, Hashimoto T, Lewis DA (2010). Alterations of cortical GABA neurons and network oscillations in schizophrenia. Curr Psychiatry Rep 12: 335\u2013344.","journal-title":"Curr Psychiatry Rep"},{"key":"BFnpp2011254_CR33","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.conb.2010.08.020","volume":"20","author":"JL Goodson","year":"2010","unstructured":"Goodson JL, Thompson RR (2010). Nonapeptide mechanisms of social cognition, behavior and species-specific social systems. Curr Opin Neurobiol 20: 784\u2013794.","journal-title":"Curr Opin Neurobiol"},{"key":"BFnpp2011254_CR34","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/S0361-9230(02)00832-8","volume":"58","author":"TJ Gould","year":"2002","unstructured":"Gould TJ, Rowe WB, Heman KL, Mesches MH, Young DA, Rose GM et al (2002). Effects of hippocampal lesions on patterned motor learning in the rat. Brain Res Bull 58: 581\u2013586.","journal-title":"Brain Res Bull"},{"key":"BFnpp2011254_CR35","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.bbr.2007.06.012","volume":"184","author":"B Grayson","year":"2007","unstructured":"Grayson B, Idris NF, Neill JC (2007). Atypical antipsychotics attenuate a sub-chronic PCP-induced cognitive deficit in the novel object recognition task in the rat. Behav Brain Res 184: 31\u201338.","journal-title":"Behav Brain Res"},{"key":"BFnpp2011254_CR36","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.bmcl.2006.10.076","volume":"17","author":"P Grundt","year":"2007","unstructured":"Grundt P, Husband SLJ, Luedtke RR, Taylor M, Newman AH (2007). Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR. Bioorg Med Chem Lett 17: 745\u2013749.","journal-title":"Bioorg Med Chem Lett"},{"key":"BFnpp2011254_CR37","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.nlm.2004.03.005","volume":"82","author":"RS Hammond","year":"2004","unstructured":"Hammond RS, Tull LE, Stackman RW (2004). On the delay-dependent involvement of the hippocampus in object recognition memory. Neurobiol Learn Mem 82: 26\u201334.","journal-title":"Neurobiol Learn Mem"},{"key":"BFnpp2011254_CR38","first-page":"4","volume":"1187","author":"CA Heidbreder","year":"2010","unstructured":"Heidbreder CA, Newman AH (2010). Current perspectives on selective dopamine D-3 receptor antagonists as pharmacotherapeutics for addictions and related disorders. Addict Rev 2 1187: 4\u201334.","journal-title":"Addict Rev 2"},{"key":"BFnpp2011254_CR39","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/0006-8993(94)91121-5","volume":"648","author":"L Herroelen","year":"1994","unstructured":"Herroelen L, Debacker JP, Wilczak N, Flamez A, Vauquelin G, Dekeyser J (1994). Autoradiographic distribution of D-3-type dopamine receptors in human brain using [H-3] 7-Hydroxy-N,N-di-N-propyl-2-aminotetralin. Brain Res 648: 222\u2013228.","journal-title":"Brain Res"},{"key":"BFnpp2011254_CR40","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.neuropharm.2004.07.034","volume":"47","author":"A Holmes","year":"2004","unstructured":"Holmes A, Lachowicz JE, Sibley DR (2004). Phenotypic analysis of dopamine receptor knockout mice; recent insights into the functional specificity of dopamine receptor subtypes. Neuropharmacology 47: 1117\u20131134.","journal-title":"Neuropharmacology"},{"key":"BFnpp2011254_CR41","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.nlm.2005.04.002","volume":"84","author":"M Hotte","year":"2005","unstructured":"Hotte M, Naudon L, Jay TM (2005). Modulation of recognition and temporal order memory retrieval by dopamine D1 receptor in rats. Neurobiol Learn Mem 84: 85\u201392.","journal-title":"Neurobiol Learn Mem"},{"key":"BFnpp2011254_CR42","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.bbr.2006.03.026","volume":"171","author":"M Hotte","year":"2006","unstructured":"Hotte M, Thuault S, Lachaise F, Dineley KT, Hemmings HC, Nairn AC et al (2006). D1 receptor modulation of memory retrieval performance is associated with changes in pCREB and pDARPP-32 in rat prefrontal cortex. Behav Brain Res 171: 127\u2013133.","journal-title":"Behav Brain Res"},{"key":"BFnpp2011254_CR43","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1146\/annurev.neuro.27.070203.144148","volume":"27","author":"TR Insel","year":"2004","unstructured":"Insel TR, Fernald RD (2004). How the brain processes social information: searching for the social brain. Ann Rev Neurosci 27: 697\u2013722.","journal-title":"Ann Rev Neurosci"},{"key":"BFnpp2011254_CR44","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s00213-010-1931-7","volume":"214","author":"CA Jones","year":"2011","unstructured":"Jones CA, Brown AM, Auer DP, Fone KC (2011). The mGluR2\/3 agonist LY379268 reverses post-weaning social isolation-induced recognition memory deficits in the rat. Psychopharmacology (Berl) 214: 269\u2013283.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2011254_CR45","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/S0163-7258(01)00139-5","volume":"90","author":"JN Joyce","year":"2001","unstructured":"Joyce JN (2001). Dopamine D3 receptor as a therapeutic target for antipsychotic and antiparkinsonian drugs. Pharmacol Ther 90: 231\u2013259.","journal-title":"Pharmacol Ther"},{"key":"BFnpp2011254_CR46","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/S1359-6446(05)03491-4","volume":"10","author":"JN Joyce","year":"2005","unstructured":"Joyce JN, Millan MJ (2005). Dopamine D-3 receptor antagonists as therapeutic agents. Drug Discov Today 10: 917\u2013925.","journal-title":"Drug Discov Today"},{"key":"BFnpp2011254_CR47","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1001\/archpsyc.64.6.633","volume":"64","author":"RSE Keefe","year":"2007","unstructured":"Keefe RSE, Bilder RM, Davis SM, Harvey PD, Palmer BW, Gold JM et al (2007). Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE trial. Arch Gen Psychiatry 64: 633\u2013647.","journal-title":"Arch Gen Psychiatry"},{"key":"BFnpp2011254_CR48","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1002\/syn.20624","volume":"63","author":"MV King","year":"2009","unstructured":"King MV, Seeman P, Marsden CA, Fone KCF (2009). Increased dopamine D-2(high) receptors in rats reared in social isolation. Synapse 63: 476\u2013483.","journal-title":"Synapse"},{"key":"BFnpp2011254_CR49","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.neuropharm.2004.03.012","volume":"47","author":"MV King","year":"2004","unstructured":"King MV, Sleight AJ, Woolley ML, Topham IA, Marsden CA, Fone KC (2004). 5-HT6 receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing consolidation--an effect sensitive to NMDA receptor antagonism. Neuropharmacology 47: 195\u2013204.","journal-title":"Neuropharmacology"},{"key":"BFnpp2011254_CR50","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.bbr.2010.11.033","volume":"221","author":"I Klinkenberg","year":"2011","unstructured":"Klinkenberg I, Sambeth A, Blokland A (2011). Acetylcholine and attention. Behav Brain Res 221: 430\u2013442.","journal-title":"Behav Brain Res"},{"key":"BFnpp2011254_CR51","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1021\/jm9600712","volume":"39","author":"JJ Kulagowski","year":"1996","unstructured":"Kulagowski JJ, Broughton HB, Curtis NR, Mawer IM, Ridgill MP, Baker R et al (1996). 3-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine: An antagonist with high affinity and selectivity for the human dopamine D-4 receptor. J Med Chem 39: 1941\u20131942.","journal-title":"J Med Chem"},{"key":"BFnpp2011254_CR52","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/sj.npp.1300114","volume":"28","author":"LP Lacroix","year":"2003","unstructured":"Lacroix LP, Hows MEP, Shah AJ, Hagan JJ, Heidbreder CA (2003). Selective antagonism at dopamine D-3 receptors enhances monoaminergic and cholinergic neurotransmission in the rat anterior cingulate cortex. Neuropsychopharmacology 28: 839\u2013849.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2011254_CR53","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1007\/s002130000534","volume":"152","author":"MD Lapiz","year":"2000","unstructured":"Lapiz MD, Mateo Y, Parker T, Marsden C (2000). Effects of noradrenaline depletion in the brain on response on novelty in isolation-reared rats. Psychopharmacology (Berl) 152: 312\u2013320.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2011254_CR54","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1007\/s00213-004-2096-z","volume":"179","author":"J Laszy","year":"2005","unstructured":"Laszy J, Laszlovszky I, Gyertyan I (2005). Dopamine D3 receptor antagonists improve the learning performance in memory-impaired rats. Psychopharmacology (Berl) 179: 567\u2013575.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2011254_CR55","doi-asserted-by":"publisher","first-page":"12107","DOI":"10.1073\/pnas.1109718108","volume":"108","author":"Y-C Li","year":"2011","unstructured":"Li Y-C, Kellendonk C, Simpson EH, Kandel ER, Gao W-J (2011). D2 receptor overexpression in the striatum leads to a deficit in inhibitory transmission and dopamine sensitivity in mouse prefrontal cortex. Proc Natl Acad Sci USA 108: 12107\u201312112.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFnpp2011254_CR56","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.euroneuro.2008.07.012","volume":"19","author":"F Loiseau","year":"2009","unstructured":"Loiseau F, Millan MJ (2009). Blockade of dopamine D-3 receptors in frontal cortex, but not in sub-cortical structures, enhances social recognition in rats: Similar actions of D-1 receptor agonists, but not of D-2 antagonists. Eur Neuropsychopharmacol 19: 23\u201333.","journal-title":"Eur Neuropsychopharmacol"},{"key":"BFnpp2011254_CR57","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/0893-133X(95)00150-C","volume":"15","author":"JH Meador-Woodruff","year":"1996","unstructured":"Meador-Woodruff JH, Damask SP, Wang J, Haroutunian V, Davis KL, Watson SJ (1996). Dopamine receptor mRNA expression in human striatum and neocortex. Neuropsychopharmacology 15: 17\u201329.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2011254_CR58","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.phrs.2010.02.003","volume":"61","author":"V Micale","year":"2010","unstructured":"Micale V, Cristino L, Tamburella A, Petrosino S, Leggio GM, Di Marzo V et al (2010). Enhanced cognitive performance of dopamine D3 receptor \u2033knock-out\u2033 mice in the step-through passive-avoidance test: Assessing the role of the endocannabinoid\/endovanilloid systems. Pharmacol Res 61: 531\u2013536.","journal-title":"Pharmacol Res"},{"key":"BFnpp2011254_CR59","doi-asserted-by":"publisher","first-page":"187","DOI":"10.2515\/therapie:2008041","volume":"63","author":"MJ Millan","year":"2008","unstructured":"Millan MJ, Brocco M (2008). Cognitive impairment in schizophrenia: a review of developmental and genetic models, and pro-cognitive profile of the optimised D(3) &gt; D(2) antagonist, S33138. Therapie 63: 187\u2013229.","journal-title":"Therapie"},{"key":"BFnpp2011254_CR60","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1017\/S1461145710000775","volume":"13","author":"MJ Millan","year":"2010","unstructured":"Millan MJ, Buccafusco JJ, Loiseau F, Watson DJ, Decamp E, Fone KC et al (2010). The dopamine D(3) receptor antagonist, S33138, counters cognitive impairment in a range of rodent and primate procedures. Int J Neuropsychopharmacol 13: 1035\u20131051.","journal-title":"Int J Neuropsychopharmacol"},{"key":"BFnpp2011254_CR61","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/S0022-3565(24)39333-4","volume":"293","author":"MJ Millan","year":"2000","unstructured":"Millan MJ, Dekeyne A, Rivet JM, Dubuffet T, Lavielle G, Brocco M (2000a). S33084, a novel, potent, selective, and competitive antagonist at dopamine D-3-receptors: II. Functional and behavioral profile compared with GR 218, 231 and L741, 626. J Pharmacol Exp Ther 293: 1063\u20131073.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFnpp2011254_CR62","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1111\/j.1471-4159.2006.04262.x","volume":"100","author":"MJ Millan","year":"2007","unstructured":"Millan MJ, Di Cara B, Dekeyne A, Panayi F, De Groote L, Sicard D et al (2007). Selective blockade of dopamine D(3) versus D(2) receptors enhances frontocortical cholinergic transmission and social memory in rats: a parallel neurochemical and behavioural analysis. J Neurochem 100: 1047\u20131061.","journal-title":"J Neurochem"},{"key":"BFnpp2011254_CR63","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/S0022-3565(24)39332-2","volume":"293","author":"MJ Millan","year":"2000","unstructured":"Millan MJ, Gobert A, Newman-Tancredi A, Lejeune F, Cussac D, Rivet JM et al (2000b). S33084, a novel, potent, selective, and competitive antagonist at dopamine D-3-receptors: I. Receptorial, electrophysiological and neurochemical profile compared with GR 218, 231 and L741,626. J Pharmacol Exp Ther 293: 1048\u20131062.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFnpp2011254_CR64","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1124\/jpet.107.126706","volume":"324","author":"MJ Millan","year":"2008","unstructured":"Millan MJ, Mannoury la Cour C, Novi F, Maggio R, Audinot V, Newman-Tancredi A et al (2008). S33138 [N-[4-[2-(3aS,9bR)-8-cyano-1,3a,4,9b-tetrahydro[1]-benzopyrano[3,4-c]pyrr ol-2(3H)-yl]-ethyl]phenylacetamide], a preferential dopamine D3 versus D2 receptor antagonist and potential antipsychotic agent: I. Receptor-binding profile and functional actions at G-protein-coupled receptors. J Pharmacol Exp Ther 324: 587\u2013599.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFnpp2011254_CR65","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s00213-003-1770-x","volume":"174","author":"MJ Millan","year":"2004","unstructured":"Millan MJ, Seguin L, Gobert A, Cussac D, Brocco M (2004). The role of dopamine D-3 compared with D-2 receptors in the control of locomotor activity: a combined behavioural and neurochemical analysis with novel, selective antagonists in rats. Psychopharmacology 174: 341\u2013357.","journal-title":"Psychopharmacology"},{"key":"BFnpp2011254_CR66","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1101\/lm.461407","volume":"14","author":"T Nagai","year":"2007","unstructured":"Nagai T, Takuma K, Kamei H, Ito Y, Nakamichi N, Ibi D et al (2007). Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1\/2 in the prefrontal cortex. Learn Mem 14: 117\u2013125.","journal-title":"Learn Mem"},{"key":"BFnpp2011254_CR67","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.conb.2010.02.003","volume":"20","author":"B Noudoost","year":"2010","unstructured":"Noudoost B, Chang MH, Steinmetz NA, Moore T (2010). Top-down control of visual attention. Curr Opin Neurobiol 20: 183\u2013190.","journal-title":"Curr Opin Neurobiol"},{"key":"BFnpp2011254_CR68","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"G Paxinos","year":"1997","unstructured":"Paxinos G, Watson C (1997). The Rat Brain in Stereotaxic Coordinates. Compact 3rd edn, Academic Press: San Diego, London. xxxiii, [78] p. of plates."},{"key":"BFnpp2011254_CR69","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/S0022-3565(25)12192-7","volume":"275","author":"TA Pugsley","year":"1995","unstructured":"Pugsley TA, Davis MD, Akunne HC, MacKenzie RG, Shih YH, Damsma G et al (1995). Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907. J Pharmacol Exp Ther 275: 1355\u20131366.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFnpp2011254_CR70","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1002\/syn.20658","volume":"63","author":"EA Rabiner","year":"2009","unstructured":"Rabiner EA, Slifstein M, Nobrega J, Plisson C, Huiban M, Raymond R et al (2009). In vivo quantification of regional dopamine-D3 receptor binding potential of (+)-PHNO: studies in non-human primates and transgenic mice. Synapse 63: 782\u2013793.","journal-title":"Synapse"},{"key":"BFnpp2011254_CR71","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1016\/j.neubiorev.2010.12.011","volume":"35","author":"K Rauss","year":"2011","unstructured":"Rauss K, Schwartz S, Pourtois G (2011). Top-down effects on early visual processing in humans: a predictive coding framework. Neurosci Biobehav Rev 35: 1237\u20131253.","journal-title":"Neurosci Biobehav Rev"},{"key":"BFnpp2011254_CR72","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/S0022-3565(24)39184-0","volume":"294","author":"C Reavill","year":"2000","unstructured":"Reavill C, Taylor SG, Wood MD, Ashmeade T, Austin NE, Avenell KY et al (2000). Pharmacological actions of a novel, high-affinity, and selective human dopamine D(3) receptor antagonist, SB-277011-A. J Pharmacol Exp Ther 294: 1154\u20131165.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFnpp2011254_CR73","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s00221-008-1642-z","volume":"192","author":"AF Rossi","year":"2009","unstructured":"Rossi AF, Pessoa L, Desimone R, Ungerleider LG (2009). The prefrontal cortex and the executive control of attention. Exp Brain Res 192: 489\u2013497.","journal-title":"Exp Brain Res"},{"key":"BFnpp2011254_CR74","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s00213-008-1216-6","volume":"202","author":"M Sarter","year":"2009","unstructured":"Sarter M, Martinez V, Kozak R (2009). A neurocognitive animal model dissociating between acute illness and remission periods of schizophrenia. Psychopharmacology 202: 237\u2013258.","journal-title":"Psychopharmacology"},{"key":"BFnpp2011254_CR75","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s00213-010-1794-y","volume":"209","author":"T Shimazaki","year":"2010","unstructured":"Shimazaki T, Kaku A, Chaki S (2010). d-Serine and a glycine transporter-1 inhibitor enhance social memory in rats. Psychopharmacology 209: 263\u2013270.","journal-title":"Psychopharmacology"},{"key":"BFnpp2011254_CR76","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1037\/0735-7044.121.5.815","volume":"121","author":"P Singer","year":"2007","unstructured":"Singer P, Boison D, Mohler H, Feldon J, Yee BK (2007). Enhanced recognition memory following glycine transporter 1 deletion in forebrain neurons. Behav Neurosci 121: 815\u2013825.","journal-title":"Behav Neurosci"},{"key":"BFnpp2011254_CR77","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/S0091-3057(98)00230-5","volume":"63","author":"AG Smith","year":"1999","unstructured":"Smith AG, Neill JC, Costall B (1999). The dopamine D3\/D2 receptor agonist 7-OH-DPAT induces cognitive impairment in the marmoset. Pharmacol Biochem Behav 63: 201\u2013211.","journal-title":"Pharmacol Biochem Behav"},{"key":"BFnpp2011254_CR78","doi-asserted-by":"publisher","first-page":"25","DOI":"10.2174\/187152706784111551","volume":"5","author":"P Sokoloff","year":"2006","unstructured":"Sokoloff P, Diaz J, Le Foll B, Guillin O, Leriche L, Bezard E et al (2006). The dopamine D3 receptor: a therapeutic target for the treatment of neuropsychiatric disorders. CNS Neurol Disord Drug Targets 5: 25\u201343.","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"BFnpp2011254_CR79","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/347146a0","volume":"347","author":"P Sokoloff","year":"1990","unstructured":"Sokoloff P, Giros B, Martres MP, Bouthenet ML, Schwartz JC (1990). Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics. Nature 347: 146\u2013151.","journal-title":"Nature"},{"key":"BFnpp2011254_CR80","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.bbr.2006.10.029","volume":"177","author":"JS Sutcliffe","year":"2007","unstructured":"Sutcliffe JS, Marshall KM, Neill JC (2007). Influence of gender on working and spatial memory in the novel object recognition task in the rat. Behav Brain Res 177: 117\u2013125.","journal-title":"Behav Brain Res"},{"key":"BFnpp2011254_CR81","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1007\/s00213-005-2268-5","volume":"181","author":"JP Terranova","year":"2005","unstructured":"Terranova JP, Chabot C, Barnouin MC, Perrault G, Depoortere R, Griebel G et al (2005). SSR181507, a dopamine D(2) receptor antagonist and 5-HT(1A) receptor agonist, alleviates disturbances of novelty discrimination in a social context in rats, a putative model of selective attention deficit. Psychopharmacology (Berl) 181: 134\u2013144.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2011254_CR82","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0014-2999(97)00075-7","volume":"324","author":"M Ukai","year":"1997","unstructured":"Ukai M, Tanaka T, Kameyama T (1997). Effects of the dopamine D3 receptor agonist, R(+)-7-hydroxy-N,N-di-n-propyl-2-aminotetralin, on memory processes in mice. Eur J Pharmacol 324: 147\u2013151.","journal-title":"Eur J Pharmacol"},{"key":"BFnpp2011254_CR83","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1097\/00008877-200409000-00018","volume":"15","author":"R Ventura","year":"2004","unstructured":"Ventura R, Pascucci T, Catania MV, Musumeci SA, Puglisi-Allegra S (2004). Object recognition impairment in Fmr1 knockout mice is reversed by amphetamine: involvement of dopamine in the medial prefrontal cortex. Behav Pharmacol 15: 433\u2013442.","journal-title":"Behav Pharmacol"},{"key":"BFnpp2011254_CR84","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1007\/s00213-005-0058-8","volume":"181","author":"JL Waddington","year":"2005","unstructured":"Waddington JL, O\u2032Tuathaigh C, O\u2032Sullivan G, Tomiyama K, Koshikawa N, Croke DT (2005). Phenotypic studies on dopamine receptor subtype and associated signal transduction mutants: insights and challenges from 10 years at the psychopharmacology-molecular biology interface. Psychopharmacology 181: 611\u2013638.","journal-title":"Psychopharmacology"},{"key":"BFnpp2011254_CR85","unstructured":"Watson DJ, Marsden CA, Millan MJ, Fone KC (2011). Blockade of dopamine D3 but not D2 receptors reverses the novel object discrimination impairment produced by post-weaning social isolation: implications for schizophrenia and its treatment. Int J Neuropsychopharmacol. doi:10\/S1461145711000435."},{"key":"BFnpp2011254_CR86","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1007\/s00213-003-1552-5","volume":"170","author":"ML Woolley","year":"2003","unstructured":"Woolley ML, Marsden CA, Sleight AJ, Fone KCF (2003). Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04\u20136790. Psychopharmacology 170: 358\u2013367.","journal-title":"Psychopharmacology"},{"key":"BFnpp2011254_CR87","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.pharmthera.2009.02.004","volume":"122","author":"JW Young","year":"2009","unstructured":"Young JW, Powell SB, Risbrough V, Marston HM, Geyer MA (2009). Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia. Pharmacol Ther 122: 150\u2013202.","journal-title":"Pharmacol Ther"},{"key":"BFnpp2011254_CR88","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/nn.2773","volume":"14","author":"TP Zanto","year":"2011","unstructured":"Zanto TP, Rubens MT, Thangavel A, Gazzaley A (2011). Causal role of the prefrontal cortex in top-down modulation of visual processing and working memory. Nat Neurosci 14: 656\u2013661.","journal-title":"Nat Neurosci"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/npp2011254.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2011254","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2011254.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T08:50:41Z","timestamp":1741855841000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/npp2011254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,26]]},"references-count":88,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["BFnpp2011254"],"URL":"https:\/\/doi.org\/10.1038\/npp.2011.254","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,26]]}}}