{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:55Z","timestamp":1792713655926,"version":"4.5.0"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2012,4,11]],"date-time":"2012-04-11T00:00:00Z","timestamp":1334102400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1038\/npp.2012.43","type":"journal-article","created":{"date-parts":[[2012,4,11]],"date-time":"2012-04-11T07:07:53Z","timestamp":1334128073000},"page":"1963-1971","source":"Crossref","is-referenced-by-count":30,"title":["Acute Tryptophan Depletion Increases Translational Indices of Anxiety but not Fear: Serotonergic Modulation of the Bed Nucleus of the Stria Terminalis?"],"prefix":"10.1038","volume":"37","author":[{"given":"Oliver J","family":"Robinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassie","family":"Overstreet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip S","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S","family":"Pine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Grillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,4,11]]},"reference":[{"key":"BFnpp201243_CR1","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/nn1399","volume":"8","author":"J Amat","year":"2005","unstructured":"Amat J, Baratta MV, Paul E, Bland ST, Watkins LR, Maier SF (2005). Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus. Nat Neurosci 8: 365\u2013371.","journal-title":"Nat Neurosci"},{"key":"BFnpp201243_CR2","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1192\/bjp.180.1.24","volume":"180","author":"Z Bhagwagar","year":"2002","unstructured":"Bhagwagar Z, Whale R, Cowen PJ (2002). State and trait abnormalities in serotonin function in major depression. Br J Psychiatry 180: 24\u201328.","journal-title":"Br J Psychiatry"},{"key":"BFnpp201243_CR3","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1038\/sj.mp.4001423","volume":"8","author":"L Booij","year":"2003","unstructured":"Booij L, Van der Does AJW, Riedel WJ (2003). Monoamine depletion in psychiatric and healthy populations: review. Mol Psychiatry 8: 951\u2013973.","journal-title":"Mol Psychiatry"},{"key":"BFnpp201243_CR4","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/j.biopsych.2004.02.029","volume":"55","author":"NS Burghardt","year":"2004","unstructured":"Burghardt NS, Sullivan GM, McEwen BS, Gorman JM, LeDoux JE (2004). The selective serotonin reuptake inhibitor citalopram increases fear after acute treatment but reduces fear with chronic treatment: a comparison with tianeptine. Biol Psychiatry 55: 1171\u20131178.","journal-title":"Biol Psychiatry"},{"key":"BFnpp201243_CR5","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/S0893-133X(97)00198-X","volume":"19","author":"LL Carpenter","year":"1998","unstructured":"Carpenter LL, Anderson GM, Pelton GH, Gudin JA, Kirwin PD, Price LH et al (1998). Tryptophan depletion during continuous CSF sampling in healthy human subjects. Neuropsychopharmacology 19: 26\u201335.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp201243_CR6","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1007\/BF00432707","volume":"87","author":"JV Cassella","year":"1985","unstructured":"Cassella JV, Davis M (1985). Fear-enhanced acoustic startle is not attenuated by acute or chronic imipramine treatment in rats. Psychopharmacology 87: 278\u2013282.","journal-title":"Psychopharmacology"},{"key":"BFnpp201243_CR7","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1126\/science.1121218","volume":"311","author":"SR Chamberlain","year":"2006","unstructured":"Chamberlain SR, Muller U, Blackwell AD, Clark L, Robbins TW, Sahakian BJ (2006). Neurochemical modulation of response inhibition and probabilistic learning in humans. Science 311: 861\u2013863.","journal-title":"Science"},{"key":"BFnpp201243_CR8","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.tics.2007.10.011","volume":"12","author":"R Cools","year":"2008","unstructured":"Cools R, Roberts AC, Robbins TW (2008a). Serotoninergic regulation of emotional and behavioural control processes. Trends Cogn Sci 12: 31\u201340.","journal-title":"Trends Cogn Sci"},{"key":"BFnpp201243_CR9","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1038\/sj.npp.1301598","volume":"33","author":"R Cools","year":"2008","unstructured":"Cools R, Robinson OJ, Sahakian B (2008b). Acute tryptophan depletion in healthy volunteers enhances punishment prediction but does not affect reward prediction. Neuropsychopharmacology 33: 2291\u20132299.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp201243_CR10","doi-asserted-by":"publisher","first-page":"470","DOI":"10.3758\/CABN.10.4.470","volume":"10","author":"R Cooney","year":"2010","unstructured":"Cooney R, Joormann J, Eug\u00e8ne F, Dennis E, Gotlib I (2010). Neural correlates of rumination in depression. Cogn Affect Behav Neurosci 10: 470\u2013478.","journal-title":"Cogn Affect Behav Neurosci"},{"key":"BFnpp201243_CR11","doi-asserted-by":"publisher","first-page":"11993","DOI":"10.1523\/JNEUROSCI.2513-09.2009","volume":"29","author":"MJ Crockett","year":"2009","unstructured":"Crockett MJ, Clark L, Robbins TW (2009). Reconciling the role of serotonin in behavioral inhibition and aversion: acute tryptophan depletion abolishes punishment-induced inhibition in humans. J Neurosci 29: 11993\u201311999.","journal-title":"J Neurosci"},{"key":"BFnpp201243_CR12","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/mp.2011.106","volume":"17","author":"MJ Crockett","year":"2012","unstructured":"Crockett MJ, Clark L, Roiser JP, Robinson OJ, Cools R, Chase HW et al (2012). Converging evidence for central 5-HT effects in acute tryptophan depletion. Mol Psychiatry 17: 121\u2013123.","journal-title":"Mol Psychiatry"},{"key":"BFnpp201243_CR13","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/BF00735873","volume":"94","author":"M Davis","year":"1988","unstructured":"Davis M, Cassella JV, Kehne JH (1988). Serotonin does not mediate anxiolytic effects of buspirone in the fear-potentiated startle paradigm: comparison with 8-OH-DPAT and ipsapirone. Psychopharmacology 94: 14\u201320.","journal-title":"Psychopharmacology"},{"key":"BFnpp201243_CR14","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/npp.2009.109","volume":"35","author":"M Davis","year":"2010","unstructured":"Davis M, Walker DL, Miles L, Grillon C (2010). Phasic vs sustained fear in rats and humans: role of the extended amygdala in fear vs anxiety. Neuropsychopharmacology 35: 105\u2013135.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp201243_CR15","doi-asserted-by":"publisher","first-page":"e4","DOI":"10.1371\/journal.pcbi.0040004","volume":"4","author":"P Dayan","year":"2008","unstructured":"Dayan P, Huys QJM (2008). Serotonin, inhibition, and negative mood. PLoS Comput Biol 4: e4.","journal-title":"PLoS Comput Biol"},{"key":"BFnpp201243_CR16","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1146\/annurev.neuro.051508.135607","volume":"32","author":"P Dayan","year":"2009","unstructured":"Dayan P, Huys QJ (2009). Serotonin in affective control. Annu Rev Neurosci 32: 95\u2013126.","journal-title":"Annu Rev Neurosci"},{"key":"BFnpp201243_CR17","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1176\/ajp.150.4.656","volume":"150","author":"MD de Bellis","year":"1993","unstructured":"de Bellis MD, Gold PW, Geracioti TD, Listwak SJ (1993). Association of fluoxetine treatment with reductions in CSF concentrations of corticotropin-releasing hormone and arginine vasopressin in patients with major depression. Am J Psychiatry 150: 656\u2013657.","journal-title":"Am J Psychiatry"},{"key":"BFnpp201243_CR18","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/S0006-3223(03)00468-2","volume":"54","author":"R de Jongh","year":"2003","unstructured":"de Jongh R, Groenink L, van der Gugten J, Olivier B (2003). Light-enhanced and fear-potentiated startle: temporal characteristics and effects of \u03b1-helical corticotropin-releasing hormone. Biol Psychiatry 54: 1041\u20131048.","journal-title":"Biol Psychiatry"},{"key":"BFnpp201243_CR19","volume-title":"Structured Clinical Interview for DSM-IV-TR Axis I Disorders\u2014Patient edition (SCID-I\/P, 11\/2002 Revision)","author":"MB First","year":"2002","unstructured":"First MB, Spitzer RL, Gibbon M, Williams JBW (2002). Structured Clinical Interview for DSM-IV-TR Axis I Disorders\u2014Patient edition (SCID-I\/P, 11\/2002 Revision). New York State Psychiatric Institute: New York."},{"key":"BFnpp201243_CR20","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1037\/1528-3542.8.3.410","volume":"8","author":"C Grillon","year":"2008","unstructured":"Grillon C (2008a). Greater sustained anxiety but not phasic fear in women compared to men. Emotion 8: 410\u2013413.","journal-title":"Emotion"},{"key":"BFnpp201243_CR21","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s00213-007-1019-1","volume":"199","author":"C Grillon","year":"2008","unstructured":"Grillon C (2008b). Models and mechanisms of anxiety: evidence from startle studies. Psychopharmacology 199: 421\u2013437.","journal-title":"Psychopharmacology"},{"key":"BFnpp201243_CR22","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.biopsych.2006.03.072","volume":"60","author":"C Grillon","year":"2006","unstructured":"Grillon C, Baas JMP, Cornwell B, Johnson L (2006a). Context conditioning and behavioral avoidance in a virtual reality environment: effect of predictability. Biol Psychiatry 60: 752\u2013759.","journal-title":"Biol Psychiatry"},{"key":"BFnpp201243_CR23","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.biopsych.2005.11.027","volume":"60","author":"C Grillon","year":"2006","unstructured":"Grillon C, Baas JMP, Pine DS, Lissek S, Lawley M, Ellis V et al (2006b). The benzodiazepine alprazolam dissociates contextual fear from cued fear in humans as assessed by fear-potentiated startle. Biol Psychiatry 60: 760\u2013766.","journal-title":"Biol Psychiatry"},{"key":"BFnpp201243_CR24","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1037\/0735-7044.118.5.916","volume":"118","author":"C Grillon","year":"2004","unstructured":"Grillon C, Baas JP, Lissek S, Smith K, Milstein J (2004). Anxious responses to predictable and unpredictable aversive events. Behav Neurosci 118: 916\u2013924.","journal-title":"Behav Neurosci"},{"key":"BFnpp201243_CR25","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1038\/npp.2008.141","volume":"34","author":"C Grillon","year":"2008","unstructured":"Grillon C, Chavis C, Covington MF, Pine DS (2008a). Two-week treatment with the selective serotonin reuptake inhibitor citalopram reduces contextual anxiety but not cued fear in healthy volunteers: a fear-potentiated startle study. Neuropsychopharmacology 34: 964\u2013971.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp201243_CR26","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.biopsych.2010.12.013","volume":"69","author":"C Grillon","year":"2011","unstructured":"Grillon C, Heller R, Hirschhorn E, Kling MA, Pine DS, Schulkin J et al (2011a). Acute hydrocortisone treatment increases anxiety but not fear in healthy volunteers: a fear-potentiated startle study. Biol Psychiatry 69: 549\u2013555.","journal-title":"Biol Psychiatry"},{"key":"BFnpp201243_CR27","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.biopsych.2010.12.013","volume":"69","author":"C Grillon","year":"2011","unstructured":"Grillon C, Heller R, Hirschhorn E, Kling MA, Pine DS, Schulkin J et al (2011b). Acute hydrocortisone treatment increases anxiety but not fear in healthy volunteers: a fear-potentiated startle study. Biol Psychiatry 69: 549\u2013555.","journal-title":"Biol Psychiatry"},{"key":"BFnpp201243_CR28","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/sj.npp.1301204","volume":"32","author":"C Grillon","year":"2006","unstructured":"Grillon C, Levenson J, Pine DS (2006c). A single dose of the selective serotonin reuptake inhibitor citalopram exacerbates anxiety in humans: a fear-potentiated startle study. Neuropsychopharmacology 32: 225\u2013231.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp201243_CR29","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1176\/appi.ajp.2007.07101581","volume":"165","author":"C Grillon","year":"2008","unstructured":"Grillon C, Lissek S, Rabin S, McDowell D, Dvir S, Pine DS (2008b). Increased anxiety during anticipation of unpredictable but not predictable aversive stimuli as a psychophysiologic marker of panic disorder. Am J Psychiatry 165: 898\u2013904.","journal-title":"Am J Psychiatry"},{"key":"BFnpp201243_CR30","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.biopsych.2008.12.028","volume":"66","author":"C Grillon","year":"2009","unstructured":"Grillon C, Pine DS, Lissek S, Rabin S, Bonne O, Vythilingam M (2009). Increased anxiety during anticipation of unpredictable aversive stimuli in posttraumatic stress disorder but not in generalized anxiety disorder. Biol Psychiatry 66: 47\u201353.","journal-title":"Biol Psychiatry"},{"key":"BFnpp201243_CR31","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1016\/j.pnpbp.2009.05.013","volume":"33","author":"SE Hammack","year":"2009","unstructured":"Hammack SE, Guo J-D, Hazra R, Dabrowska J, Myers KM, Rainnie DG (2009). The response of neurons in the bed nucleus of the stria terminalis to serotonin: implications for anxiety. Prog Neuropsychopharmacol Biol Psychiatry 33: 1309\u20131320.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"BFnpp201243_CR32","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/j.neuropharm.2008.06.036","volume":"55","author":"CJ Harmer","year":"2008","unstructured":"Harmer CJ (2008). Serotonin and emotional processing: does it help explain antidepressant drug action? Neuropharmacology 55: 1023\u20131028.","journal-title":"Neuropharmacology"},{"key":"BFnpp201243_CR33","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1016\/j.pnpbp.2011.09.002","volume":"35","author":"T Inoue","year":"2011","unstructured":"Inoue T, Kitaichi Y, Koyama T (2011). SSRIs and conditioned fear. Prog Neuropsychopharmacol Biol Psychiatry 35: 1810\u20131819.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"BFnpp201243_CR34","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1176\/appi.ajp.2010.09091379","volume":"167","author":"T Insel","year":"2010","unstructured":"Insel T, Cuthbert B, Garvey M, Heinssen R, Pine DS, Quinn K et al (2010). Research domain criteria (RDoC): toward a new classification framework for research on mental disorders. Am J Psychiatry 167: 748\u2013751.","journal-title":"Am J Psychiatry"},{"key":"BFnpp201243_CR35","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1007\/BF02246344","volume":"126","author":"R Joordens","year":"1996","unstructured":"Joordens R, Hijzen T, Olivier B, Peeters B (1996). Fear-potentiated startle response is remarkably similar in two laboratories. Psychopharmacology 126: 104\u2013109.","journal-title":"Psychopharmacology"},{"key":"BFnpp201243_CR36","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/sj.npp.1300774","volume":"31","author":"KC Klemenhagen","year":"2005","unstructured":"Klemenhagen KC, Gordon JA, David DJ, Hen R, Gross CT (2005). Increased fear response to contextual cues in mice lacking the 5-HT1A receptor. Neuropsychopharmacology 31: 101\u2013111.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp201243_CR37","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.neuroscience.2004.06.037","volume":"128","author":"L Levita","year":"2004","unstructured":"Levita L, Hammack SE, Mania I, Li XY, Davis M, Rainnie DG (2004). 5-hydroxytryptamine1a-likereceptor activation in the bed nucleus of the stria terminalis: electrophysiological and behavioral studies. Neuroscience 128: 583\u2013596.","journal-title":"Neuroscience"},{"key":"BFnpp201243_CR38","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.neubiorev.2004.03.005","volume":"28","author":"N McNaughton","year":"2004","unstructured":"McNaughton N, Corr PJ (2004). A two-dimensional neuropsychology of defense: fear\/anxiety and defensive distance. Neurosci Biobehav Rev 28: 285\u2013305.","journal-title":"Neurosci Biobehav Rev"},{"key":"BFnpp201243_CR39","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.biopsych.2006.10.011","volume":"62","author":"MR Milad","year":"2007","unstructured":"Milad MR, Wright CI, Orr SP, Pitman RK, Quirk GJ, Rauch SL (2007). Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert. Biol Psychiatry 62: 446\u2013454.","journal-title":"Biol Psychiatry"},{"key":"BFnpp201243_CR40","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1038\/npp.2011.29","volume":"36","author":"L Miles","year":"2011","unstructured":"Miles L, Davis M, Walker D (2011). Phasic and sustained fear are pharmacologically dissociable in rats. Neuropsychopharmacology 36: 1563\u20131574.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp201243_CR41","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1146\/annurev.ps.36.020185.002431","volume":"36","author":"S Mineka","year":"1985","unstructured":"Mineka S, Hendersen RW (1985). Controllability and predictability in acquired motivation. Annu Rev Psychol 36: 495\u2013529.","journal-title":"Annu Rev Psychol"},{"key":"BFnpp201243_CR42","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.biopsych.2011.07.003","volume":"70","author":"JW Murrough","year":"2011","unstructured":"Murrough JW, Huang Y, Hu J, Henry S, Williams W, Gallezot J-D et al (2011). Reduced amygdala serotonin transporter binding in posttraumatic stress disorder. Biol Psychiatry 70: 1033\u20131038.","journal-title":"Biol Psychiatry"},{"key":"BFnpp201243_CR43","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1037\/0021-843X.109.3.504","volume":"109","author":"S Nolen-Hoeksema","year":"2000","unstructured":"Nolen-Hoeksema S (2000). The role of rumination in depressive disorders and mixed anxiety\/depressive symptoms. J Abnorm Psychol 109: 504\u2013511.","journal-title":"J Abnorm Psychol"},{"key":"BFnpp201243_CR44","doi-asserted-by":"publisher","first-page":"6603","DOI":"10.1523\/JNEUROSCI.1056-06.2006","volume":"26","author":"T Otto","year":"2006","unstructured":"Otto T, Poon P (2006). Dorsal hippocampal contributions to unimodal contextual conditioning. J Neurosci 26: 6603\u20136609.","journal-title":"J Neurosci"},{"key":"BFnpp201243_CR45","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.biopsych.2011.07.033","volume":"71","author":"L Passamonti","year":"2012","unstructured":"Passamonti L, Crockett MJ, Apergis-Schoute AM, Clark L, Rowe JB, Calder AJ et al (2012). Effects of acute tryptophan depletion on prefrontal-amygdala connectivity while viewing facial signals of aggression. Biol Psychiatry 71: 36\u201343.","journal-title":"Biol Psychiatry"},{"key":"BFnpp201243_CR46","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1016\/0361-9230(92)90217-L","volume":"28","author":"CF Phelix","year":"1992","unstructured":"Phelix CF, Liposits Z, Paull WK (1992). Serotonin-CRF interaction in the bed nucleus of the stria terminalis: a light microscopic double-label immunocytochemical analysis. Brain Res Bull 28: 943\u2013948.","journal-title":"Brain Res Bull"},{"key":"BFnpp201243_CR47","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/478459b","volume":"478","author":"OJ Robinson","year":"2011","unstructured":"Robinson OJ (2011). Brain burdens: boost resilience to tackle mental illness. Nature 478: 459.","journal-title":"Nature"},{"key":"BFnpp201243_CR48","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s00213-011-2410-5","volume":"219","author":"OJ Robinson","year":"2011","unstructured":"Robinson OJ, Cools R, Sahakian BJ (2011). Tryptophan depletion disinhibits punishment but not reward prediction: implications for resilience. Psychopharmacology 219: 599\u2013605.","journal-title":"Psychopharmacology"},{"key":"BFnpp201243_CR49","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s00213-009-1533-4","volume":"205","author":"OJ Robinson","year":"2009","unstructured":"Robinson OJ, Sahakian BJ (2009). Acute tryptophan depletion evokes negative mood in healthy females who have previously experienced concurrent negative mood and tryptophan depletion. Psychopharmacology (Berl) 205: 227\u2013235.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp201243_CR50","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1037\/a0020909","volume":"119","author":"CA Sanislow","year":"2010","unstructured":"Sanislow CA, Pine DS, Quinn KJ, Kozak MJ, Garvey MA, Heinssen RK et al (2010). Developing constructs for psychopathology research: research domain criteria. J Abnorm Psychol 119: 631\u2013639.","journal-title":"J Abnorm Psychol"},{"key":"BFnpp201243_CR51","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/nprot.2012.001","volume":"7","author":"A Schmitz","year":"2012","unstructured":"Schmitz A, Grillon C (2012). The NPU-threat test: assessing fear and anxiety in humans using threat of predictable and unpredictable aversive events. Nat Protoc 7: 527\u2013532.","journal-title":"Nat Protoc"},{"key":"BFnpp201243_CR52","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.tins.2005.09.009","volume":"28","author":"J Schulkin","year":"2005","unstructured":"Schulkin J, Morgan MA, Rosen JB (2005). A neuroendocrine mechanism for sustaining fear. Trends Neurosci 28: 629\u2013635.","journal-title":"Trends Neurosci"},{"key":"BFnpp201243_CR53","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.bbr.2003.08.015","volume":"151","author":"RCB Silva","year":"2004","unstructured":"Silva RCB, G\u00e1rgaro AC, Brand\u00e3o ML (2004). Differential regulation of the expression of contextual freezing and fear-potentiated startle by 5-HT mechanisms of the median raphe nucleus. Behav Brain Res 151: 93\u2013101.","journal-title":"Behav Brain Res"},{"key":"BFnpp201243_CR54","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1017\/S0140525X00022871","volume":"9","author":"P Soubri\u00e9","year":"1986","unstructured":"Soubri\u00e9 P (1986). Reconciling the role of central serotonin neurons in human and animal behaviour. Behav Brain Sci 9: 319\u2013364.","journal-title":"Behav Brain Sci"},{"key":"BFnpp201243_CR55","volume-title":"State Trait Anxiety Inventory","author":"CD Spielberger","year":"1996","unstructured":"Spielberger CD (1996). State Trait Anxiety Inventory. John Wiley & Sons: New York, NY."},{"key":"BFnpp201243_CR56","doi-asserted-by":"publisher","first-page":"10280","DOI":"10.1523\/JNEUROSCI.1386-04.2004","volume":"24","author":"DJ Toufexis","year":"2004","unstructured":"Toufexis DJ, Davis C, Hammond A, Davis M (2004). Progesterone attenuates corticotropin-releasing factor-enhanced but not fear-potentiated startle via the activity of its neuroactive metabolite, allopregnanolone. J Neurosci 24: 10280\u201310287.","journal-title":"J Neurosci"},{"key":"BFnpp201243_CR57","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.biopsych.2004.06.035","volume":"56","author":"AR Tyrka","year":"2004","unstructured":"Tyrka AR, Carpenter LL, McDougle CJ, Kirwin PD, Owens MJ, Nemeroff CB et al (2004). Increased cerebrospinal fluid corticotropin-releasing factor concentrations during tryptophan depletion in healthy adults. Biol Psychiatry 56: 531\u2013534.","journal-title":"Biol Psychiatry"},{"key":"BFnpp201243_CR58","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/mp.2011.9","volume":"16","author":"EL van Donkelaar","year":"2011","unstructured":"van Donkelaar EL, Blokland A, Ferrington L, Kelly PAT, Steinbusch HWM, Prickaerts J (2011). Mechanism of acute tryptophan depletion: is it only serotonin? Mol Psychiatry 16: 695\u2013713.","journal-title":"Mol Psychiatry"},{"key":"BFnpp201243_CR59","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.biopsycho.2007.08.012","volume":"77","author":"D Vansteenwegen","year":"2008","unstructured":"Vansteenwegen D, Iberico C, Vervliet B, Marescau V, Hermans D (2008). Contextual fear induced by unpredictability in a human fear conditioning preparation is related to the chronic expectation of a threatening US. Biol Psychology 77: 39\u201346.","journal-title":"Biol Psychology"},{"key":"BFnpp201243_CR60","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/BF00431803","volume":"87","author":"SN Young","year":"1985","unstructured":"Young SN, Smith SE, Pihl RO, Ervin FR (1985). Tryptophan depletion causes a rapid lowering of mood in normal males. Psychopharmacology 87: 173\u2013177.","journal-title":"Psychopharmacology"},{"key":"BFnpp201243_CR61","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/S0149-7634(01)00047-1","volume":"25","author":"H Zangrossi Jr","year":"2001","unstructured":"Zangrossi Jr H, Viana MB, Zanoveli JN, Bueno CN, Nogueira RL, Graeff FG (2001). Serotonergic regulation of inhibitory avoidance and one-way escape in the rat elevated T-maze. Neurosci Biobehav Rev 25: 637\u2013645.","journal-title":"Neurosci Biobehav Rev"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/npp201243.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp201243","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp201243.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T23:43:52Z","timestamp":1684453432000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/npp201243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,11]]},"references-count":61,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["BFnpp201243"],"URL":"https:\/\/doi.org\/10.1038\/npp.2012.43","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,11]]}}}