{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:29:50Z","timestamp":1792081790561,"version":"4.4.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T00:00:00Z","timestamp":1368144000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1038\/npp.2013.114","type":"journal-article","created":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T05:48:44Z","timestamp":1368164924000},"page":"2170-2178","source":"Crossref","is-referenced-by-count":51,"title":["Adenovirus Capsid-Based Anti-Cocaine Vaccine Prevents Cocaine from Binding to the Nonhuman Primate CNS Dopamine Transporter"],"prefix":"10.1038","volume":"38","author":[{"given":"Anat","family":"Maoz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J","family":"Hicks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shankar","family":"Vallabhjosula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Synan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paresh J","family":"Kothari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan P","family":"Dyke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas J","family":"Ballon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M","family":"Kaminsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bishnu P","family":"De","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan B","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George F","family":"Koob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim D","family":"Janda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald G","family":"Crystal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,10]]},"reference":[{"key":"BFnpp2013114_CR1","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/S0006-8993(98)00040-7","volume":"788","author":"BB Anderson","year":"1998","unstructured":"Anderson BB, Chen G, Gutman DA, Ewing AG (1998). Dopamine levels of two classes of vesicles are differentially depleted by amphetamine. Brain Res 788: 294\u2013301.","journal-title":"Brain Res"},{"key":"BFnpp2013114_CR2","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1742-4682-6-21","volume":"6","author":"JA Best","year":"2009","unstructured":"Best JA, Nijhout HF, Reed MC (2009). Homeostatic mechanisms in dopamine synthesis and release: a mathematical model. Theor Biol Med Model 6: 21.","journal-title":"Theor Biol Med Model"},{"key":"BFnpp2013114_CR3","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.cbi.2012.08.015","volume":"203","author":"S Brimijoin","year":"2013","unstructured":"Brimijoin S, Orson F, Kosten TR, Kinsey B, Shen XY, White SJ et al (2013). Anti-cocaine antibody and butyrylcholinesterase-derived cocaine hydrolase exert cooperative effects on cocaine pharmacokinetics and cocaine-induced locomotor activity in mice. Chem Biol Interact 203: 212\u2013216.","journal-title":"Chem Biol Interact"},{"key":"BFnpp2013114_CR4","doi-asserted-by":"publisher","first-page":"e43536","DOI":"10.1371\/journal.pone.0043536","volume":"7","author":"ME Carroll","year":"2012","unstructured":"Carroll ME, Zlebnik NE, Anker JJ, Kosten TR, Orson FM, Shen X et al (2012). Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion. PLoS One 7: e43536.","journal-title":"PLoS One"},{"key":"BFnpp2013114_CR5","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1002\/(SICI)1096-9861(19990621)409:1<38::AID-CNE4>3.0.CO;2-1","volume":"409","author":"BJ Ciliax","year":"1999","unstructured":"Ciliax BJ, Drash GW, Staley JK, Haber S, Mobley CJ, Miller GW et al (1999). Immunocytochemical localization of the dopamine transporter in human brain. J Comp Neurol 409: 38\u201356.","journal-title":"J Comp Neurol"},{"key":"BFnpp2013114_CR6","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1038\/npp.2011.269","volume":"37","author":"PW Czoty","year":"2012","unstructured":"Czoty PW, Roberts DC (2012). Thinking outside the synapse: pharmacokinetic-based medications for cocaine addiction. Neuropsychopharmacology 37: 1079\u20131080.","journal-title":"Neuropsychopharmacology"},{"issue":"Suppl 1","key":"BFnpp2013114_CR7","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.neuropharm.2004.06.032","volume":"47","author":"G DiChiara","year":"2004","unstructured":"DiChiara G, Bassareo V, Fenu S, De Luca MA, Spina L, Cadoni C et al (2004). Dopamine and drug addiction: the nucleus accumbens shell connection. Neuropharmacology 47 (Suppl 1): 227\u2013241.","journal-title":"Neuropharmacology"},{"key":"BFnpp2013114_CR8","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1002\/1099-1344(200009)43:10<997::AID-JLCR385>3.0.CO;2-#","volume":"43","author":"F Dolle","year":"2000","unstructured":"Dolle F, Bottlaender M, Demphel S, Emond P, Fuseau C, Coulon C et al (2000). Highly efficient synthesis of [11C]PE2I, a selective radioligand for the quantification of the dopamine transporter using PET. J Labelled Cpd Radiopharm 43: 997\u20131004.","journal-title":"J Labelled Cpd Radiopharm"},{"key":"BFnpp2013114_CR9","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/j.1755-5949.2007.00033.x","volume":"14","author":"P Emond","year":"2008","unstructured":"Emond P, Guilloteau D, Chalon S (2008). PE2I: a radiopharmaceutical for in vivo exploration of the dopamine transporter. CNS Neurosci Ther 14: 47\u201364.","journal-title":"CNS Neurosci Ther"},{"key":"BFnpp2013114_CR10","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1016\/j.addbeh.2012.04.006","volume":"38","author":"AE Goudriaan","year":"2013","unstructured":"Goudriaan AE, Veltman DJ, van den BW, Dom G, Schmaal L (2013). Neurophysiological effects of modafinil on cue-exposure in cocaine dependence: A randomized placebo-controlled cross-over study using pharmacological fMRI. Addict Behav 38: 1509\u20131517.","journal-title":"Addict Behav"},{"key":"BFnpp2013114_CR11","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/7854_2011_168","volume":"11","author":"RW Gould","year":"2012","unstructured":"Gould RW, Porrino LJ, Nader MA (2012). Nonhuman primate models of addiction and PET imaging: dopamine system dysregulation. Curr Top Behav Neurosci 11: 25\u201344.","journal-title":"Curr Top Behav Neurosci"},{"key":"BFnpp2013114_CR12","doi-asserted-by":"publisher","first-page":"e47702","DOI":"10.1371\/journal.pone.0047702","volume":"7","author":"CN Haile","year":"2012","unstructured":"Haile CN, De La Garza R II, Mahoney JJ III, Nielsen DA, Kosten TR, Newton TF (2012a). The impact of disulfiram treatment on the reinforcing effects of cocaine: a randomized clinical trial. PLoS One 7: e47702.","journal-title":"PLoS One"},{"key":"BFnpp2013114_CR13","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.pharmthera.2012.01.010","volume":"134","author":"CN Haile","year":"2012","unstructured":"Haile CN, Mahoney JJ III, Newton TF, De La Garza R II (2012b). Pharmacotherapeutics directed at deficiencies associated with cocaine dependence: focus on dopamine, norepinephrine and glutamate. Pharmacol Ther 134: 260\u2013277.","journal-title":"Pharmacol Ther"},{"key":"BFnpp2013114_CR14","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1007\/s00259-003-1212-3","volume":"30","author":"C Halldin","year":"2003","unstructured":"Halldin C, Erixon-Lindroth N, Pauli S, Chou YH, Okubo Y, Karlsson P et al (2003). [(11)C]PE2I: a highly selective radioligand for PET examination of the dopamine transporter in monkey and human brain. Eur J Nucl Med Mol Imaging 30: 1220\u20131230.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"BFnpp2013114_CR15","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.biopsych.2009.08.031","volume":"67","author":"M Haney","year":"2010","unstructured":"Haney M, Gunderson EW, Jiang H, Collins ED, Foltin RW (2010). Cocaine-specific antibodies blunt the subjective effects of smoked cocaine in humans. Biol Psychiatry 67: 59\u201365.","journal-title":"Biol Psychiatry"},{"key":"BFnpp2013114_CR16","doi-asserted-by":"publisher","first-page":"115","DOI":"10.2147\/SAR.S35153","volume":"3","author":"CA Hanlon","year":"2012","unstructured":"Hanlon CA, Canterberry M (2012). The use of brain imaging to elucidate neural circuit changes in cocaine addiction. Subst Abuse Rehabil 3: 115\u2013128.","journal-title":"Subst Abuse Rehabil"},{"key":"BFnpp2013114_CR17","doi-asserted-by":"crossref","first-page":"6729","DOI":"10.1128\/JVI.73.8.6729-6742.1999","volume":"73","author":"BG Harvey","year":"1999","unstructured":"Harvey BG, Hackett NR, El-Sawy T, Rosengart TK, Hirschowitz EA, Lieberman MD et al (1999). Variability of human systemic humoral immune responses to adenovirus gene transfer vectors administered to different organs. J Virol 73: 6729\u20136742.","journal-title":"J Virol"},{"key":"BFnpp2013114_CR18","first-page":"104","volume":"16","author":"F Herodin","year":"2005","unstructured":"Herodin F, Thullier P, Garin D, Drouet M (2005). Nonhuman primates are relevant models for research in hematology, immunology and virology. Eur Cytokine Netw 16: 104\u2013116.","journal-title":"Eur Cytokine Netw"},{"key":"BFnpp2013114_CR19","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/mt.2010.280","volume":"19","author":"MJ Hicks","year":"2011","unstructured":"Hicks MJ, De BP, Rosenberg JB, Davidson JT, Moreno AY, Janda KD et al (2011). Cocaine analog coupled to disrupted adenovirus: a vaccine strategy to evoke high-titer immunity against addictive drugs. Mol Ther 19: 612\u2013619.","journal-title":"Mol Ther"},{"key":"BFnpp2013114_CR20","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.bcp.2007.08.003","volume":"75","author":"LL Howell","year":"2008","unstructured":"Howell LL, Kimmel HL (2008). Monoamine transporters and psychostimulant addiction. Biochem Pharmacol 75: 196\u2013217.","journal-title":"Biochem Pharmacol"},{"key":"BFnpp2013114_CR21","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/syn.890120106","volume":"12","author":"SP Hume","year":"1992","unstructured":"Hume SP, Myers R, Bloomfield PM, Opacka-Juffry J, Cremer JE, Ahier RG et al (1992). Quantitation of carbon-11-labeled raclopride in rat striatum using positron emission tomography. Synapse 12: 47\u201354.","journal-title":"Synapse"},{"key":"BFnpp2013114_CR22","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1038\/sj.jcbfm.9600493","volume":"27","author":"RB Innis","year":"2007","unstructured":"Innis RB, Cunningham VJ, Delforge J, Fujita M, Gjedde A, Gunn RN et al (2007). Consensus nomenclature for in vivo imaging of reversibly binding radioligands. J Cereb Blood Flow Metab 27: 1533\u20131539.","journal-title":"J Cereb Blood Flow Metab"},{"key":"BFnpp2013114_CR23","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.pharmthera.2009.11.002","volume":"125","author":"B Jupp","year":"2010","unstructured":"Jupp B, Lawrence AJ (2010). New horizons for therapeutics in drug and alcohol abuse. Pharmacol Ther 125: 138\u2013168.","journal-title":"Pharmacol Ther"},{"key":"BFnpp2013114_CR24","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.ejphar.2003.08.065","volume":"479","author":"KM Kahlig","year":"2003","unstructured":"Kahlig KM, Galli A (2003). Regulation of dopamine transporter function and plasma membrane expression by dopamine, amphetamine, and cocaine. Eur J Pharmacol 479: 153\u2013158.","journal-title":"Eur J Pharmacol"},{"key":"BFnpp2013114_CR25","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1080\/10550490601184142","volume":"16","author":"PW Kalivas","year":"2007","unstructured":"Kalivas PW (2007). Neurobiology of cocaine addiction: implications for new pharmacotherapy. Am J Addict 16: 71\u201378.","journal-title":"Am J Addict"},{"key":"BFnpp2013114_CR26","doi-asserted-by":"publisher","first-page":"899","DOI":"10.2174\/187152711799219334","volume":"10","author":"G Koob","year":"2011","unstructured":"Koob G, Hicks MJ, Wee S, Rosenberg JB, De BP, Kaminsky SM et al (2011). Anti-cocaine vaccine based on coupling a cocaine analog to a disrupted adenovirus. CNS Neurol Disord Drug Targets 10: 899\u2013904.","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"BFnpp2013114_CR27","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1176\/appi.ajp.2007.05030503","volume":"164","author":"G Koob","year":"2007","unstructured":"Koob G, Kreek MJ (2007). Stress, dysregulation of drug reward pathways, and the transition to drug dependence. Am J Psychiatry 164: 1149\u20131159.","journal-title":"Am J Psychiatry"},{"key":"BFnpp2013114_CR28","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/npp.2009.110","volume":"35","author":"GF Koob","year":"2010","unstructured":"Koob GF, Volkow ND (2010). Neurocircuitry of addiction. Neuropsychopharmacology 35: 217\u2013238.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2013114_CR29","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1097\/00004647-199601000-00005","volume":"16","author":"AA Lammertsma","year":"1996","unstructured":"Lammertsma AA, Bench CJ, Hume SP, Osman S, Gunn K, Brooks DJ et al (1996). Comparison of methods for analysis of clinical [11C]raclopride studies. J Cereb Blood Flow Metab 16: 42\u201352.","journal-title":"J Cereb Blood Flow Metab"},{"key":"BFnpp2013114_CR30","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1124\/jpet.103.060293","volume":"309","author":"KP Lindsey","year":"2004","unstructured":"Lindsey KP, Wilcox KM, Votaw JR, Goodman MM, Plisson C, Carroll FI et al (2004). Effects of dopamine transporter inhibitors on cocaine self-administration in rhesus monkeys: relationship to transporter occupancy determined by positron emission tomography neuroimaging. J Pharmacol Exp Ther 309: 959\u2013969.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFnpp2013114_CR31","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1001\/archgenpsychiatry.2009.128","volume":"66","author":"BA Martell","year":"2009","unstructured":"Martell BA, Orson FM, Poling J, Mitchell E, Rossen RD, Gardner T et al (2009). Cocaine vaccine for the treatment of cocaine dependence in methadone-maintained patients: a randomized, double-blind, placebo-controlled efficacy trial. Arch Gen Psychiatry 66: 1116\u20131123.","journal-title":"Arch Gen Psychiatry"},{"key":"BFnpp2013114_CR32","unstructured":"Moeller SJ, Honorio J, Tomasi D, Parvaz MA, Woicik PA, Volkow ND et al (2012). Methylphenidate enhances executive function and optimizes prefrontal function in both health and cocaine addiction. Cereb Cortex (doi:10.1093\/cercor\/bhs345); e-pub ahead of print."},{"key":"BFnpp2013114_CR33","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1176\/appi.ajp.162.8.1473","volume":"162","author":"MA Nader","year":"2005","unstructured":"Nader MA, Czoty PW (2005). PET imaging of dopamine D2 receptors in monkey models of cocaine abuse: genetic predisposition versus environmental modulation. Am J Psychiatry 162: 1473\u20131482.","journal-title":"Am J Psychiatry"},{"key":"BFnpp2013114_CR34","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1093\/ilar.49.1.89","volume":"49","author":"MA Nader","year":"2008","unstructured":"Nader MA, Czoty PW (2008). Brain imaging in nonhuman primates: insights into drug addiction. ILAR J 49: 89\u2013102.","journal-title":"ILAR J"},{"key":"BFnpp2013114_CR35","unstructured":"National Institute on Drug Abuse (2010) Cocaine: Abuse and Addiction. National Institute on Drug Abuse."},{"key":"BFnpp2013114_CR36","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1124\/jpet.106.111781","volume":"320","author":"AB Norman","year":"2007","unstructured":"Norman AB, Tabet MR, Norman MK, Buesing WR, Pesce AJ, Ball WJ (2007). A chimeric human\/murine anticocaine monoclonal antibody inhibits the distribution of cocaine to the brain in mice. J Pharmacol Exp Ther 320: 145\u2013153.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFnpp2013114_CR37","doi-asserted-by":"publisher","first-page":"e40518","DOI":"10.1371\/journal.pone.0040518","volume":"7","author":"M Ramakrishnan","year":"2012","unstructured":"Ramakrishnan M, ves De MF, Kinsey BM, Ladbury JE, Kosten TR, Orson FM (2012). Probing cocaine-antibody interactions in buffer and human serum. PLoS One 7: e40518.","journal-title":"PLoS One"},{"key":"BFnpp2013114_CR38","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1089\/hum.2011.178","volume":"23","author":"JB Rosenberg","year":"2012","unstructured":"Rosenberg JB, Hicks MJ, De BP, Pagovich O, Frenk E, Janda KD et al (2012). AAVrh.10-mediated expression of an anti-cocaine antibody mediates persistent passive immunization that suppresses cocaine-induced behavior. Hum Gene Ther 23: 451\u2013459.","journal-title":"Hum Gene Ther"},{"key":"BFnpp2013114_CR39","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/0092-8674(92)90213-V","volume":"68","author":"MA Rosenfeld","year":"1992","unstructured":"Rosenfeld MA, Yoshimura K, Trapnell BC, Yoneyama K, Rosenthal ER, Dalemans W et al (1992). In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium. Cell 68: 143\u2013155.","journal-title":"Cell"},{"key":"BFnpp2013114_CR40","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.2967\/jnumed.111.101626","volume":"53","author":"T Sasaki","year":"2012","unstructured":"Sasaki T, Ito H, Kimura Y, Arakawa R, Takano H, Seki C et al (2012). Quantification of dopamine transporter in human brain using PET with 18F-FE-PE2I. J Nucl Med 53: 1065\u20131073.","journal-title":"J Nucl Med"},{"key":"BFnpp2013114_CR41","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s12149-010-0364-z","volume":"24","author":"C Seki","year":"2010","unstructured":"Seki C, Ito H, Ichimiya T, Arakawa R, Ikoma Y, Shidahara M et al (2010). Quantitative analysis of dopamine transporters in human brain using [11C]PE2I and positron emission tomography: evaluation of reference tissue models. Ann Nucl Med 24: 249\u2013260.","journal-title":"Ann Nucl Med"},{"key":"BFnpp2013114_CR42","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1038\/clpt.2011.281","volume":"91","author":"XY Shen","year":"2012","unstructured":"Shen XY, Orson FM, Kosten TR (2012). Vaccines against drug abuse. Clin Pharmacol Ther 91: 60\u201370.","journal-title":"Clin Pharmacol Ther"},{"key":"BFnpp2013114_CR43","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s00259-006-0277-1","volume":"34","author":"HU Shetty","year":"2007","unstructured":"Shetty HU, Zoghbi SS, Liow JS, Ichise M, Hong J, Musachio JL et al (2007). Identification and regional distribution in rat brain of radiometabolites of the dopamine transporter PET radioligand [11C]PE2I. Eur J Nucl Med Mol Imaging 34: 667\u2013678.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"BFnpp2013114_CR44","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/1741-7015-9-119","volume":"9","author":"D Shorter","year":"2011","unstructured":"Shorter D, Kosten TR (2011). Novel pharmacotherapeutic treatments for cocaine addiction. BMC Med 9: 119.","journal-title":"BMC Med"},{"key":"BFnpp2013114_CR45","unstructured":"Substance Abuse and Mental Health Services Administration (2012) Results from the 2011 National Survey on Drug Use and Health: Summary of National Findings NSDUH Series H-44, HHS Publication No. (SMA) 12-4713. Rockville, MD: Substance Abuse and Mental Health Services Administration. http:\/\/www.samhsa.gov\/data\/nsduh\/2k11results\/nsduhresults2011.pdf ."},{"key":"BFnpp2013114_CR46","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1021\/mp200588v","volume":"9","author":"JB Treweek","year":"2012","unstructured":"Treweek JB, Janda KD (2012). An antidote for acute cocaine toxicity. Mol Pharm 9: 969\u2013978.","journal-title":"Mol Pharm"},{"key":"BFnpp2013114_CR47","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1001\/jama.2009.351","volume":"301","author":"ND Volkow","year":"2009","unstructured":"Volkow ND, Fowler JS, Logan J, Alexoff D, Zhu W, Telang F et al (2009). Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications. JAMA 301: 1148\u20131154.","journal-title":"JAMA"},{"key":"BFnpp2013114_CR48","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/386827a0","volume":"386","author":"ND Volkow","year":"1997","unstructured":"Volkow ND, Wang GJ, Fischman MW, Foltin RW, Fowler JS, Abumrad NN et al (1997a). Relationship between subjective effects of cocaine and dopamine transporter occupancy. Nature 386: 827\u2013830.","journal-title":"Nature"},{"key":"BFnpp2013114_CR49","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1038\/386830a0","volume":"386","author":"ND Volkow","year":"1997","unstructured":"Volkow ND, Wang GJ, Fowler JS, Logan J, Gatley SJ, Hitzemann R et al (1997b). Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects. Nature 386: 830\u2013833.","journal-title":"Nature"},{"key":"BFnpp2013114_CR50","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1002\/syn.10068","volume":"44","author":"JR Votaw","year":"2002","unstructured":"Votaw JR, Howell LL, Martarello L, Hoffman JM, Kilts CD, Lindsey KP et al (2002). Measurement of dopamine transporter occupancy for multiple injections of cocaine using a single injection of [F-18]FECNT. Synapse 44: 203\u2013210.","journal-title":"Synapse"},{"key":"BFnpp2013114_CR51","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1124\/dmd.32.6.603","volume":"32","author":"KW Ward","year":"2004","unstructured":"Ward KW, Smith BR (2004). A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. I. Clearance. Drug Metab Dispos 32: 603\u2013611.","journal-title":"Drug Metab Dispos"},{"key":"BFnpp2013114_CR52","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1038\/npp.2011.200","volume":"37","author":"S Wee","year":"2012","unstructured":"Wee S, Hicks MJ, De BP, Rosenberg JB, Moreno AY, Kaminsky SM et al (2012). Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing effects. Neuropsychopharmacology 37: 1083\u20131091.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2013114_CR53","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1002\/syn.10018","volume":"43","author":"KM Wilcox","year":"2002","unstructured":"Wilcox KM, Lindsey KP, Votaw JR, Goodman MM, Martarello L, Carroll FI et al (2002). Self-administration of cocaine and the cocaine analog RTI-113: relationship to dopamine transporter occupancy determined by PET neuroimaging in rhesus monkeys. Synapse 43: 78\u201385.","journal-title":"Synapse"},{"key":"BFnpp2013114_CR54","doi-asserted-by":"publisher","first-page":"125","DOI":"10.4155\/fmc.11.171","volume":"4","author":"F Zheng","year":"2012","unstructured":"Zheng F, Zhan CG (2012). Are pharmacokinetic approaches feasible for treatment of cocaine addiction and overdose? Future Med Chem 4: 125\u2013128.","journal-title":"Future Med Chem"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/npp2013114.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2013114","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2013114.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T19:44:31Z","timestamp":1684439071000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/npp2013114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,10]]},"references-count":54,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["BFnpp2013114"],"URL":"https:\/\/doi.org\/10.1038\/npp.2013.114","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718237713.793489630","asserted-by":"object"}]},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,10]]}}}