{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T14:49:21Z","timestamp":1781016561528,"version":"3.54.1"},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T00:00:00Z","timestamp":1392163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1038\/npp.2013.272","type":"journal-article","created":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T10:46:40Z","timestamp":1392202000000},"page":"781-782","source":"Crossref","is-referenced-by-count":12,"title":["Acamprosate: An Alcoholism Treatment That May Not Be What We Thought"],"prefix":"10.1038","volume":"39","author":[{"given":"Markus","family":"Heilig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,2,12]]},"reference":[{"key":"BFnpp2013272_CR1","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.2174\/138161210791516341","volume":"16","author":"F Kiefer","year":"2010","unstructured":"Kiefer F, Mann K (2010). Acamprosate: how, where, and for whom does it work? Mechanism of action, treatment targets, and individualized therapy. Curr Pharm Des 16: 2098\u20132102.","journal-title":"Curr Pharm Des"},{"key":"BFnpp2013272_CR2","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1111\/j.1530-0277.2011.01616.x","volume":"36","author":"BJ Mason","year":"2012","unstructured":"Mason BJ, Lehert P (2012). Acamprosate for alcohol dependence: a sex-specific meta-analysis based on individual patient data. Alcohol Clin Exp Res 36: 497\u2013508.","journal-title":"Alcohol Clin Exp Res"},{"key":"BFnpp2013272_CR3","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1096\/fj.01-0593com","volume":"16","author":"R Rimondini","year":"2002","unstructured":"Rimondini R, Arlinde C, Sommer W, Heilig M (2002). Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. FASEB J 16: 27\u201335.","journal-title":"FASEB J"},{"key":"BFnpp2013272_CR4","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/nm1163","volume":"11","author":"R Spanagel","year":"2005","unstructured":"Spanagel R, Pendyala G, Abarca C, Zghoul T, Sanchis-Segura C, Magnone MC et al (2005). The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption. Nat Med 11: 35\u201342.","journal-title":"Nat Med"},{"key":"BFnpp2013272_CR5","unstructured":"Spanagel R, Vengeliene V, Jandeleit B, Fischer WF, Grindstaff K, Zhang X et al (2013). Acamprosate produces its anti-relapse effects via calcium. Neuropsychopharmacology."},{"key":"BFnpp2013272_CR6","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1001\/archgenpsychiatry.2010.125","volume":"67","author":"JC Umhau","year":"2010","unstructured":"Umhau JC, Momenan R, Schwandt ML, Singley E, Lifshitz M, Doty L et al (2010). Effect of acamprosate on magnetic resonance spectroscopy measures of central glutamate in detoxified alcohol-dependent individuals: a randomized controlled experimental medicine study. Arch Gen Psychiatry 67: 1069\u20131077.","journal-title":"Arch Gen Psychiatry"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/npp2013272.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2013272","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2013272.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T23:46:09Z","timestamp":1684453569000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/npp2013272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,12]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["BFnpp2013272"],"URL":"https:\/\/doi.org\/10.1038\/npp.2013.272","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,12]]}}}