{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:32:53Z","timestamp":1791192773242,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2013,3,19]],"date-time":"2013-03-19T00:00:00Z","timestamp":1363651200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1038\/npp.2013.71","type":"journal-article","created":{"date-parts":[[2013,3,19]],"date-time":"2013-03-19T16:42:56Z","timestamp":1363711376000},"page":"1609-1616","source":"Crossref","is-referenced-by-count":397,"title":["NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL\/6J Mice"],"prefix":"10.1038","volume":"38","author":[{"given":"Adam K","family":"Walker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P","family":"Budac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Bisulco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna W","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin A","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent","family":"Beenders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith W","family":"Kelley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Dantzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,3,19]]},"reference":[{"key":"BFnpp201371_CR1","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nature10130","volume":"475","author":"AE Autry","year":"2011","unstructured":"Autry AE, Adachi M, Nosyreva E, Na ES, Los MF, Cheng PF et al (2011). NMDA receptor blockage at rest triggers rapid behavioural antidepressant responses. Nature 475: 91\u201395.","journal-title":"Nature"},{"key":"BFnpp201371_CR2","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1176\/appi.ajp.160.10.1890","volume":"160","author":"Z Bhagwagar","year":"2003","unstructured":"Bhagwagar Z, Hafizi S, Cowen PJ (2003). Increase in concentration of waking salivary cortisol in recovered patients with depression. Am J Psychiatry 160: 1890\u20131891.","journal-title":"Am J Psychiatry"},{"key":"BFnpp201371_CR3","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/S0893-133X(01)00407-9","volume":"26","author":"L Capuron","year":"2002","unstructured":"Capuron L, Gumnick JF, Musselman DL, Lawson DH, Reemsnyder A, Nemeroff CB et al (2002). Neurobehavioral effects of interferon-\u03b1 in cancer patients: phenomenology and paroxetine responsiveness of symptom dimensions. Neuropsychopharmacol 26: 643\u2013652.","journal-title":"Neuropsychopharmacol"},{"key":"BFnpp201371_CR4","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.neulet.2008.06.007","volume":"441","author":"TJ Connor","year":"2008","unstructured":"Connor TJ, Starr N, O\u2019Sullivan JB, Harkin A (2008). Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: a role for IFN-\u03b3? Neurosci Lett 441: 29\u201334.","journal-title":"Neurosci Lett"},{"key":"BFnpp201371_CR5","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/nrn2297","volume":"9","author":"R Dantzer","year":"2008","unstructured":"Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW (2008). From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9: 46\u201356.","journal-title":"Nat Rev Neurosci"},{"key":"BFnpp201371_CR6","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/978-0-585-37970-8_8","volume":"461","author":"AJ Dunn","year":"1999","unstructured":"Dunn AJ, Wang J, Ando T (1999). Effects of cytokines on cerebral neurotransmission. Comparison with the effects of stress. Adv Exp Med Biol 461: 117\u2013127.","journal-title":"Adv Exp Med Biol"},{"key":"BFnpp201371_CR7","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1111\/j.1471-4159.1991.tb06359.x","volume":"57","author":"AJ Dunn","year":"1991","unstructured":"Dunn AJ, Welch J (1991). Stress- and endotoxin-induced increases in brain tryptophan and serotonin metabolism depend on sympathetic nervous system activity. J Neurochem 57: 1616\u20131622.","journal-title":"J Neurochem"},{"key":"BFnpp201371_CR8","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.psyneuen.2007.03.005","volume":"32","author":"F Frenois","year":"2007","unstructured":"Frenois F, Moreau M, O'Connor J, Lawson M, Micon C, Lestage J et al (2007). Lipopolysaccharide induces delayed FosB\/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior. Psychoneuroendocrinol 32: 516\u2013531.","journal-title":"Psychoneuroendocrinol"},{"key":"BFnpp201371_CR9","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.pnpbp.2007.07.027","volume":"32","author":"LS Garcia","year":"2008","unstructured":"Garcia LS, Comim CM, Valvassori SS, R\u00e9us GZ, Barbosa LM, Andreazza AC et al (2008). Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus. Prog Neuropsychopharmacol Biol Psychiatry 32: 140\u2013144.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"BFnpp201371_CR10","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.bbi.2005.04.005","volume":"20","author":"Z Guan","year":"2006","unstructured":"Guan Z, Fang J (2006). Peripheral immune activation by lipopolysaccharide decreases neurotrophins in the cortex and hippocampus in rats. Brain Behav Immun 20: 64\u201371.","journal-title":"Brain Behav Immun"},{"key":"BFnpp201371_CR11","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1046\/j.1471-4159.2001.00498.x","volume":"78","author":"GJ Guillemin","year":"2001","unstructured":"Guillemin GJ, Kerr SJ, Smythe GA, Smith DG, Kapoor V, Armati PJ et al (2001). Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection. J Neurochemistry 78: 842\u2013853.","journal-title":"J Neurochemistry"},{"key":"BFnpp201371_CR12","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1042\/bj3200595","volume":"320","author":"MP Heyes","year":"1996","unstructured":"Heyes MP, Achim CL, Wiley CA, Major EO, Saito K, Markey SP (1996). Human microglia convert L-tryptophan into the neurotoxin quinolinic acid. Biochem J 320: 595\u2013597.","journal-title":"Biochem J"},{"key":"BFnpp201371_CR13","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.2174\/1389450111009011495","volume":"11","author":"A Hoetzel","year":"2010","unstructured":"Hoetzel A, Schmidt R (2010). Regulatory role of anesthetics on heme oxygenase-1. Curr Drug Targets 11: 1495\u20131503.","journal-title":"Curr Drug Targets"},{"key":"BFnpp201371_CR14","doi-asserted-by":"publisher","first-page":"11","DOI":"10.2174\/157488609787354495","volume":"4","author":"JC Ibla","year":"2009","unstructured":"Ibla JC, Hayashi H, Bajic D, Soriano SG (2009). Prolonged exposure to ketamine increases brain derived neurotrophic factor levels in developing rat brains. Curr Drug Saf 4: 11\u201316.","journal-title":"Curr Drug Saf"},{"key":"BFnpp201371_CR15","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1007\/s11920-007-0063-1","volume":"9","author":"S Maeng","year":"2007","unstructured":"Maeng S, Zarate CA Jr (2007). The role of glutamate in mood disorders: results from the ketamine in major depression study and the presumed cellular mechanism underlying its antidepressant effects. Curr Psychiatry Rep 9: 467\u2013474.","journal-title":"Curr Psychiatry Rep"},{"key":"BFnpp201371_CR16","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.biopsych.2007.05.028","volume":"63","author":"S Maeng","year":"2008","unstructured":"Maeng S, Zarate CA Jr, Du J, Schloesser RJ, McCammon J, Chen G et al (2008). Cellular mechanisms underlying the antidepressant effects of ketamine: role of \u03b1-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors. Biol Psychiatry 63: 349\u2013352.","journal-title":"Biol Psychiatry"},{"key":"BFnpp201371_CR17","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/S0028-3908(98)00101-4","volume":"37","author":"AN Mead","year":"1998","unstructured":"Mead AN, Stephens DN (1998). AMPA-receptors are involved in the expression of amphetamine-induced behavioural sensitisation, but not in the expression of amphetamine-induced conditioned activity in mice. Neuropharmacol 37: 1131\u20131138.","journal-title":"Neuropharmacol"},{"key":"BFnpp201371_CR18","first-page":"00778","volume":"S0006-3223","author":"LM Monteggia","year":"2012","unstructured":"Monteggia LM, Gideons E, Kavalali ET (2012). The role of eukaryotic elongation factor 2 kinase in rapid antidepressant action of ketamine. Biol Psychiatry S0006-3223: 00778\u20130.","journal-title":"Biol Psychiatry"},{"key":"BFnpp201371_CR19","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1016\/j.bbi.2008.04.001","volume":"22","author":"M Moreau","year":"2008","unstructured":"Moreau M, Andr\u00e9 C, O\u2019Connor JC, Dumich SA, Woods JA, Kelley KW et al (2008). Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior. Brain Behav Immun 22: 1087\u20131095.","journal-title":"Brain Behav Immun"},{"key":"BFnpp201371_CR20","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/S0889-1591(03)00133-8","volume":"18","author":"C Morm\u00e8de","year":"2004","unstructured":"Morm\u00e8de C, Palin K, Kelley KW, Castanon N, Dantzer R (2004). Conditioned taste aversion with lipopolysaccharide and peptidoglycan does not activate cytokine gene expression in the spleen and hypothalamus of mice. Brain Behav Immun 18: 186\u2013200.","journal-title":"Brain Behav Immun"},{"key":"BFnpp201371_CR21","doi-asserted-by":"publisher","first-page":"4200","DOI":"10.1523\/JNEUROSCI.5032-08.2009","volume":"29","author":"JC O\u2019Connor","year":"2009","unstructured":"O\u2019Connor JC, Andr\u00e9 C, Wang Y, Lawson MA, Szegedi SS, Lestage J et al (2009a). Interferon-\u03b3 and tumor necrosis factor-\u03b1 mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin. J Neurosci 29: 4200\u20134209.","journal-title":"J Neurosci"},{"key":"BFnpp201371_CR22","doi-asserted-by":"publisher","first-page":"3202","DOI":"10.4049\/jimmunol.0802722","volume":"182","author":"JC O\u2019Connor","year":"2009","unstructured":"O\u2019Connor JC, Lawson MA, Andr\u00e9 C, Briley EM, Szegedi SS, Lestage J et al (2009b). Induction of IDO by Bacille Calmette-Gu\u00e9rin is responsible for development of murine depressive-like behavior. J Immunol 182: 3202\u20133212.","journal-title":"J Immunol"},{"key":"BFnpp201371_CR23","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/sj.mp.4002148","volume":"14","author":"JC O\u2019Connor","year":"2009","unstructured":"O\u2019Connor JC, Lawson MA, Andr\u00e9 C, Moreau M, Lestage J, Castanon N et al (2009c). Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice. Mol Psychiatry 14: 511\u2013522.","journal-title":"Mol Psychiatry"},{"key":"BFnpp201371_CR24","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.tins.2008.06.006","volume":"31","author":"CM Pariante","year":"2008","unstructured":"Pariante CM, Lightman SL (2008). The HPA axis in major depression: classical theories and new developments. Trends Neurosci 31: 464\u2013468.","journal-title":"Trends Neurosci"},{"key":"BFnpp201371_CR25","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/1742-2094-8-179","volume":"8","author":"SE Park","year":"2011","unstructured":"Park SE, Lawson M, Dantzer R, Kelley KW, McCusker RH (2011). Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharide. J Neuroinflamm 8: 179.","journal-title":"J Neuroinflamm"},{"key":"BFnpp201371_CR26","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1001\/archpsyc.58.5.445","volume":"58","author":"A Reichenberg","year":"2001","unstructured":"Reichenberg A, Yirmiya R, Schuld A, Kraus T, Haack M, Morag A et al (2001). Cytokine-associated emotional and cognitive disturbances in humans. Arch Gen Psychiatry 58: 445\u2013452.","journal-title":"Arch Gen Psychiatry"},{"key":"BFnpp201371_CR27","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/0306-4522(92)90467-G","volume":"51","author":"K Saito","year":"1992","unstructured":"Saito K, Markey SP, Heyes MP (1992). Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse. Neurosci 51: 25\u201339.","journal-title":"Neurosci"},{"key":"BFnpp201371_CR28","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.neuron.2009.11.032","volume":"65","author":"J Serrats","year":"2010","unstructured":"Serrats J, Schiltz JC, Garc\u00eda-Bueno B, van Rooijen N, Reyes TM, van Dam AM et al (2010). Dual roles for perivascular macrophages in immune-to-brain signaling. Neuron 65: 94\u2013106.","journal-title":"Neuron"},{"key":"BFnpp201371_CR29","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/0006-8993(92)91588-6","volume":"588","author":"AM van Dam","year":"1992","unstructured":"van Dam AM, Brouns M, Louisse S, Berkenbosch F (1992). Appearance of interleukin-1 in macrophages and in ramified microglia in the brain of endotoxin-treated rats: a pathway for the induction of non-specific symptoms of sickness? Brain Res 588: 291\u2013296.","journal-title":"Brain Res"},{"key":"BFnpp201371_CR30","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.bbi.2004.10.003","volume":"19","author":"CE Wright","year":"2005","unstructured":"Wright CE, Strike PC, Brydon L, Steptoe A (2005). Acute inflammation and negative mood: mediation by cytokine activation. Brain Behav Immun 19: 345\u2013350.","journal-title":"Brain Behav Immun"},{"key":"BFnpp201371_CR31","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.bbi.2010.09.006","volume":"25","author":"SY Wu","year":"2011","unstructured":"Wu SY, Wang TF, Yu L, Jen CJ, Chuang JI, Wu FS et al (2011). Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway. Brain Behav Immun 25: 135\u2013146.","journal-title":"Brain Behav Immun"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/npp201371.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp201371","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp201371.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T23:47:27Z","timestamp":1684453647000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/npp201371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,19]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["BFnpp201371"],"URL":"https:\/\/doi.org\/10.1038\/npp.2013.71","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,19]]}}}