{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:17:12Z","timestamp":1789942632290,"version":"4.0.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2013,4,19]],"date-time":"2013-04-19T00:00:00Z","timestamp":1366329600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1038\/npp.2013.98","type":"journal-article","created":{"date-parts":[[2013,4,19]],"date-time":"2013-04-19T15:38:03Z","timestamp":1366385883000},"page":"1993-2002","source":"Crossref","is-referenced-by-count":53,"title":["Sociocommunicative and Sensorimotor Impairments in Male P2X4-Deficient Mice"],"prefix":"10.1038","volume":"38","author":[{"given":"Letisha R","family":"Wyatt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean C","family":"Godar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheraz","family":"Khoja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W","family":"Jakowec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald L","family":"Alkana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bortolato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl L","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,4,19]]},"reference":[{"key":"BFnpp201398_CR1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.nbd.2006.08.018","volume":"25","author":"M Andries","year":"2007","unstructured":"Andries M, Van Damme P, Robberecht W, Van Den Bosch L (2007). Ivermectin inhibits AMPA receptor-mediated excitotoxicity in cultured motor neurons and extends the life span of a transgenic mouse model of amyotrophic lateral sclerosis. Neurobiol Dis 25: 8\u201316.","journal-title":"Neurobiol Dis"},{"key":"BFnpp201398_CR2","volume-title":"Methods of Behavior Analysis in Neuroscience","author":"KR Bailey","year":"2009","unstructured":"Bailey KR, Crawley JN (2009). Anxiety-related behaviors in mice. In: Buccafusco JJ (eds) Methods of Behavior Analysis in Neuroscience 2nd edn. CRC Press: Boca Raton, FL, USA."},{"key":"BFnpp201398_CR3","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/j.1460-9568.2011.07763.x","volume":"34","author":"AW Baxter","year":"2011","unstructured":"Baxter AW, Choi SJ, Sim JA, North RA (2011). Role of P2 \u00d7 4 receptors in synaptic strengthening in mouse CA1 hippocampal neurons. Eur J Neurosci 34: 213\u2013220.","journal-title":"Eur J Neurosci"},{"key":"BFnpp201398_CR4","doi-asserted-by":"publisher","first-page":"2674","DOI":"10.1038\/npp.2011.157","volume":"36","author":"M Bortolato","year":"2011","unstructured":"Bortolato M, Chen K, Godar SC, Chen G, Wu W, Rebrin I et al (2011). Social deficits and perseverative behaviors, but not overt aggression, in MAO-A hypomorphic mice. Neuropsychopharmacology 36: 2674\u20132688.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp201398_CR5","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1007\/s00213-003-1589-5","volume":"171","author":"M Bortolato","year":"2004","unstructured":"Bortolato M, Frau R, Aru GN, Orru M, Gessa GL (2004). Baclofen reverses the reduction in prepulse inhibition of the acoustic startle response induced by dizocilpine, but not by apomorphine. Psychopharmacology (Berl) 171: 322\u2013330.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp201398_CR6","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1007\/s12640-009-9024-2","volume":"15","author":"M Bortolato","year":"2009","unstructured":"Bortolato M, Frau R, Piras AP, Luesu W, Bini V, Diaz G et al (2009a). Methamphetamine induces long-term alterations in reactivity to environmental stimuli: correlation with dopaminergic and serotonergic toxicity. Neurotox Res 15: 232\u2013245.","journal-title":"Neurotox Res"},{"key":"BFnpp201398_CR7","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1017\/S1461145712000715","volume":"16","author":"M Bortolato","year":"2012","unstructured":"Bortolato M, Godar SC, Alzghoul L, Zhang J, Darling RD, Simpson KL et al (2012a). Monoamine oxidase A and A\/B knockout mice display autistic-like features. Int J Neuropsychopharmacol 16: 869\u2013888.","journal-title":"Int J Neuropsychopharmacol"},{"key":"BFnpp201398_CR8","doi-asserted-by":"publisher","first-page":"2746","DOI":"10.1038\/npp.2009.118","volume":"34","author":"M Bortolato","year":"2009","unstructured":"Bortolato M, Godar SC, Davarian S, Chen K, Shih JC (2009b). Behavioral disinhibition and reduced anxiety-like behaviors in monoamine oxidase B-deficient mice. Neuropsychopharmacology 34: 2746\u20132757.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp201398_CR9","doi-asserted-by":"crossref","unstructured":"Bortolato M, Yardley M, Khoja S, Godar SC, Asatryan L, Finn DA et al (2012b). Pharmacological insights into the role of P2 \u00d7 4 receptors in behavioral regulation: lessons from ivermectin. Int J Neuropsychopharmacol 1\u201312 advance online publication, 17 September 2012 (e-pub ahead of print).","DOI":"10.1017\/S1461145712000909"},{"key":"BFnpp201398_CR10","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1038\/nprot.2009.125","volume":"4","author":"V Bouet","year":"2009","unstructured":"Bouet V, Boulouard M, Toutain J, Divoux D, Bernaudin M, Schumann-Bard P et al (2009). The adhesive removal test: a sensitive method to assess sensorimotor deficits in mice. Nat Protoc 4: 1560\u20131564.","journal-title":"Nat Protoc"},{"key":"BFnpp201398_CR11","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S0014-2999(03)01274-3","volume":"463","author":"M Bourin","year":"2003","unstructured":"Bourin M, Hascoet M (2003). The mouse light\/dark box test. Eur J Pharmacol 463: 55\u201365.","journal-title":"Eur J Pharmacol"},{"key":"BFnpp201398_CR12","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1111\/j.1460-9568.1996.tb00745.x","volume":"8","author":"G Buell","year":"1996","unstructured":"Buell G, Collo G, Rassendren F (1996). P2X receptors: an emerging channel family. Eur J Neurosci 8: 2221\u20132228.","journal-title":"Eur J Neurosci"},{"key":"BFnpp201398_CR13","first-page":"301","volume":"240","author":"G Burnstock","year":"2004","unstructured":"Burnstock G, Knight GE (2004). Cellular distribution and functions of P2 receptor subtypes in different systems. Int Rev Cytol 240: 301\u2013304.","journal-title":"Int Rev Cytol"},{"key":"BFnpp201398_CR14","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1016\/j.pbb.2011.02.003","volume":"100","author":"GC Carlson","year":"2012","unstructured":"Carlson GC (2012). Glutamate receptor dysfunction and drug targets across models of autism spectrum disorders. Pharmacol Biochem Behav 100: 850\u2013854.","journal-title":"Pharmacol Biochem Behav"},{"key":"BFnpp201398_CR15","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1097\/MPA.0b013e318053e00d","volume":"35","author":"KK Cheung","year":"2007","unstructured":"Cheung KK, Coutinho-Silva R, Chan WY, Burnstock G (2007). Early expression of adenosine 5\u2032-triphosphate-gated P2 \u00d7 7 receptors in the developing rat pancreas. Pancreas 35: 164\u2013168.","journal-title":"Pancreas"},{"key":"BFnpp201398_CR16","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1016\/j.psyneuen.2011.09.018","volume":"37","author":"P Devoto","year":"2011","unstructured":"Devoto P, Frau R, Bini V, Pillolla G, Saba P, Flore G et al (2011). Inhibition of 5alpha-reductase in the nucleus accumbens counters sensorimotor gating deficits induced by dopaminergic activation. Psychoneuroendocrinology 37: 1630\u20131645.","journal-title":"Psychoneuroendocrinology"},{"key":"BFnpp201398_CR17","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.bbr.2004.01.008","volume":"153","author":"GE Duncan","year":"2004","unstructured":"Duncan GE, Moy SS, Perez A, Eddy DM, Zinzow WM, Lieberman JA et al (2004). Deficits in sensorimotor gating and tests of social behavior in a genetic model of reduced NMDA receptor function. Behav Brain Res 153: 507\u2013519.","journal-title":"Behav Brain Res"},{"key":"BFnpp201398_CR18","doi-asserted-by":"publisher","first-page":"3413","DOI":"10.1523\/JNEUROSCI.5429-03.2004","volume":"24","author":"TM Egan","year":"2004","unstructured":"Egan TM, Khakh BS (2004). Contribution of calcium ions to P2X channel responses. J Neurosci 24: 3413\u20133420.","journal-title":"J Neurosci"},{"key":"BFnpp201398_CR19","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1111\/j.1601-183X.2012.00816.x","volume":"11","author":"MJ Gandal","year":"2012","unstructured":"Gandal MJ, Anderson RL, Billingslea EN, Carlson GC, Roberts TP, Siegel SJ (2012). Mice with reduced NMDA receptor expression: more consistent with autism than schizophrenia? Genes Brain Behav 11: 740\u2013750.","journal-title":"Genes Brain Behav"},{"key":"BFnpp201398_CR20","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1016\/j.pnpbp.2006.06.018","volume":"30","author":"K Hashimoto","year":"2006","unstructured":"Hashimoto K, Iwata Y, Nakamura K, Tsujii M, Tsuchiya KJ, Sekine Y et al (2006). Reduced serum levels of brain-derived neurotrophic factor in adult male patients with autism. Prog Neuropsychopharmacol Biol Psychiatry 30: 1529\u20131531.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"BFnpp201398_CR21","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1037\/0033-2909.94.1.3","volume":"94","author":"JR Ison","year":"1983","unstructured":"Ison JR, Hoffman HS (1983). Reflex modification in the domain of startle: II. The anomalous history of a robust and ubiquitous phenomenon. Psychol Bull 94: 3\u201317.","journal-title":"Psychol Bull"},{"key":"BFnpp201398_CR22","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1177\/1362361306066564","volume":"10","author":"JK Kern","year":"2006","unstructured":"Kern JK, Trivedi MH, Garver CR, Grannemann BD, Andrews AA, Savla JS et al (2006). The pattern of sensory processing abnormalities in autism. Autism 10: 480\u2013494.","journal-title":"Autism"},{"key":"BFnpp201398_CR23","doi-asserted-by":"publisher","first-page":"2605","DOI":"10.1038\/npp.2012.99","volume":"37","author":"KA Kerstetter","year":"2012","unstructured":"Kerstetter KA, Ballis MA, Duffin-Lutgen S, Carr AE, Behrens AM, Kippin TE (2012). Sex differences in selecting between food and cocaine reinforcement are mediated by estrogen. Neuropsychopharmacology 37: 2605\u20132614.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp201398_CR24","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/nature04886","volume":"442","author":"BS Khakh","year":"2006","unstructured":"Khakh BS, North RA (2006). P2X receptors as cell-surface ATP sensors in health and disease. Nature 442: 527\u2013532.","journal-title":"Nature"},{"key":"BFnpp201398_CR25","first-page":"290","volume":"39","author":"PG Kostyuk","year":"2007","unstructured":"Kostyuk PG (2007). Key role of calcium signaling in synaptic transmission. Neurophysiology 39: 290\u2013293.","journal-title":"Neurophysiology"},{"key":"BFnpp201398_CR26","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S0306-4522(97)00365-5","volume":"83","author":"TK Le","year":"1998","unstructured":"Le TK, Villeneuve P, Ramjaun AR, McPherson PS, Beaudet A et al (1998). Sensory presynaptic and widespread somatodendritic immunolocalization of central ionotropic P2X ATP receptors. Neuroscience 83: 177\u2013190.","journal-title":"Neuroscience"},{"key":"BFnpp201398_CR27","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1111\/j.1460-9568.2010.07589.x","volume":"33","author":"RA Lorca","year":"2011","unstructured":"Lorca RA, Rozas C, Loyola S, Moreira-Ramos S, Zeise ML, Kirkwood A et al (2011). Zinc enhances long-term potentiation through P2X receptor modulation in the hippocampal CA1 region. Eur J Neurosci 33: 1175\u20131185.","journal-title":"Eur J Neurosci"},{"key":"BFnpp201398_CR28","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/S0387-7604(03)00168-2","volume":"26","author":"K Miyazaki","year":"2004","unstructured":"Miyazaki K, Narita N, Sakuta R, Miyahara T, Naruse H, Okado N et al (2004). Serum neurotrophin concentrations in autism and mental retardation: a pilot study. Brain Dev 26: 292\u2013295.","journal-title":"Brain Dev"},{"key":"BFnpp201398_CR29","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1002\/hipo.1069","volume":"11","author":"JW Newcomer","year":"2001","unstructured":"Newcomer JW, Krystal JH (2001). NMDA receptor regulation of memory and behavior in humans. Hippocampus 11: 529\u2013542.","journal-title":"Hippocampus"},{"key":"BFnpp201398_CR30","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1152\/physrev.00015.2002","volume":"82","author":"RA North","year":"2002","unstructured":"North RA (2002). Molecular physiology of P2X receptors. Physiol Rev 82: 1013\u20131067.","journal-title":"Physiol Rev"},{"key":"BFnpp201398_CR31","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.biopsych.2005.09.025","volume":"61","author":"W Perry","year":"2007","unstructured":"Perry W, Minassian A, Lopez B, Maron L, Lincoln A (2007). Sensorimotor gating deficits in adults with autism. Biol Psychiatry 61: 482\u2013486.","journal-title":"Biol Psychiatry"},{"key":"BFnpp201398_CR32","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1212\/WNL.57.9.1618","volume":"57","author":"AE Purcell","year":"2001","unstructured":"Purcell AE, Jeon OH, Zimmerman AW, Blue ME, Pevsner J (2001). Postmortem brain abnormalities of the glutamate neurotransmitter system in autism. Neurology 57: 1618\u20131628.","journal-title":"Neurology"},{"key":"BFnpp201398_CR33","doi-asserted-by":"publisher","first-page":"9006","DOI":"10.1523\/JNEUROSCI.2370-06.2006","volume":"26","author":"JA Sim","year":"2006","unstructured":"Sim JA, Chaumont S, Jo J, Ulmann L, Young MT, Cho K et al (2006). Altered hippocampal synaptic potentiation in P2 \u00d7 4 knock-out mice. J Neurosci 26: 9006\u20139009.","journal-title":"J Neurosci"},{"key":"BFnpp201398_CR34","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1006\/bbrc.1996.0915","volume":"223","author":"F Soto","year":"1996","unstructured":"Soto F, Garcia-Guzman M, Karschin C, Stnhmer W (1996). Cloning and tissue distribution of a novel P2X receptor from rat brain. Biochem Biophys Res Commun 223: 456\u2013460.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFnpp201398_CR35","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1161\/HYPERTENSIONAHA.111.176180","volume":"58","author":"L Stokes","year":"2011","unstructured":"Stokes L, Scurrah K, Ellis JA, Cromer BA, Skarratt KK, Gu BJ et al (2011). A loss-of-function polymorphism in the human P2 \u00d7 4 receptor is associated with increased pulse pressure. Hypertension 58: 1086\u20131092.","journal-title":"Hypertension"},{"key":"BFnpp201398_CR36","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/0091-3057(93)90193-W","volume":"44","author":"NR Swerdlow","year":"1993","unstructured":"Swerdlow NR, Geyer MA (1993). Clozapine and haloperidol in an animal model of sensorimotor gating deficits in schizophrenia. Pharmacol Biochem Behav 44: 741\u2013744.","journal-title":"Pharmacol Biochem Behav"},{"key":"BFnpp201398_CR37","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1007\/s00213-003-1480-4","volume":"174","author":"NR Swerdlow","year":"2004","unstructured":"Swerdlow NR, Shoemaker JM, Auerbach PP, Pitcher L, Goins J, Platten A (2004). Heritable differences in the dopaminergic regulation of sensorimotor gating. II. Temporal, pharmacologic and generational analyses of apomorphine effects on prepulse inhibition. Psychopharmacology (Berl) 174: 452\u2013462.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp201398_CR38","doi-asserted-by":"publisher","first-page":"3518","DOI":"10.1523\/JNEUROSCI.5714-08.2009","volume":"29","author":"T Trang","year":"2009","unstructured":"Trang T, Beggs S, Wan X, Salter MW (2009). P2 \u00d7 4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation. J Neurosci 29: 3518\u20133528.","journal-title":"J Neurosci"},{"key":"BFnpp201398_CR39","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1038\/nature01786","volume":"424","author":"M Tsuda","year":"2003","unstructured":"Tsuda M, Shigemoto-Mogami Y, Koizumi S, Mizokoshi A, Kohsaka S, Salter MW et al (2003). P2 \u00d7 4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature 424: 778\u2013783.","journal-title":"Nature"},{"key":"BFnpp201398_CR40","doi-asserted-by":"publisher","first-page":"11263","DOI":"10.1523\/JNEUROSCI.2308-08.2008","volume":"28","author":"L Ulmann","year":"2008","unstructured":"Ulmann L, Hatcher JP, Hughes JP, Chaumont S, Green PJ, Conquet F et al (2008). Up-regulation of P2 \u00d7 4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain. J Neurosci 28: 11263\u201311268.","journal-title":"J Neurosci"},{"key":"BFnpp201398_CR41","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/nature11208","volume":"486","author":"H Won","year":"2012","unstructured":"Won H, Lee HR, Gee HY, Mah W, Kim JI, Lee J et al (2012). Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function. Nature 486: 261\u2013265.","journal-title":"Nature"},{"key":"BFnpp201398_CR42","doi-asserted-by":"publisher","first-page":"H69","DOI":"10.1152\/ajpheart.01035.2010","volume":"301","author":"T Wu","year":"2011","unstructured":"Wu T, Dai M, Shi XR, Jiang ZG, Nuttall AL (2011). Functional expression of P2 \u00d7 4 receptor in capillary endothelial cells of the cochlear spiral ligament and its role in regulating the capillary diameter. Am J Physiol Heart Circ Physiol 301: H69\u2013H78.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"BFnpp201398_CR43","doi-asserted-by":"publisher","first-page":"E644","DOI":"10.1152\/ajpendo.00558.2009","volume":"298","author":"H Zemkova","year":"2010","unstructured":"Zemkova H, Kucka M, Li S, Gonzalez-Iglesias AE, Tomic M, Stojilkovic SS (2010). Characterization of purinergic P2 \u00d7 4 receptor channels expressed in anterior pituitary cells. Am J Physiol Endocrinol Metab 298: E644\u2013E651.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFnpp201398_CR44","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.expneurol.2005.09.015","volume":"197","author":"Z Zhang","year":"2006","unstructured":"Zhang Z, Artelt M, Burnet M, Trautmann K, Schluesener HJ (2006). Lesional accumulation of P2 \u00d7 4 receptor+ monocytes following experimental traumatic brain injury. Exp Neurol 197: 252\u2013257.","journal-title":"Exp Neurol"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/npp201398.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp201398","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp201398.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T23:47:46Z","timestamp":1684453666000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/npp201398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,19]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["BFnpp201398"],"URL":"https:\/\/doi.org\/10.1038\/npp.2013.98","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,19]]}}}