{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T23:15:52Z","timestamp":1779923752558,"version":"3.53.1"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T00:00:00Z","timestamp":1390953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1038\/npp.2014.22","type":"journal-article","created":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T13:35:53Z","timestamp":1391002553000},"page":"1743-1753","source":"Crossref","is-referenced-by-count":22,"title":["TOMM40 rs2075650 May Represent a New Candidate Gene for Vulnerability to Major Depressive Disorder"],"prefix":"10.1038","volume":"39","author":[{"given":"Martyn","family":"McFarquhar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane","family":"McKie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darragh","family":"Downey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztina","family":"Mekli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan G","family":"Toth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian M","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JF William","family":"Deakin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Juhasz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,1,29]]},"reference":[{"key":"BFnpp201422_CR1","doi-asserted-by":"publisher","first-page":"506","DOI":"10.4088\/JCP.11r07237","volume":"73","author":"RE Anglin","year":"2012","unstructured":"Anglin RE, Garside SL, Tarnopolsky MA, Mazurek MF, Rosebush PI (2012). The psychiatric manifestations of mitochondrial disorders: a case and review of the literature. J Clin Psychiatry 73: 506\u2013512.","journal-title":"J Clin Psychiatry"},{"key":"BFnpp201422_CR2","first-page":"1265","volume":"12","author":"D Arnone","year":"2012","unstructured":"Arnone D, McKie S, Elliott R, Juhasz G, Thomas EJ, Downey D et al (2012a). State-dependent changes in hippocampal grey matter in depression. Mol Psychiatry 12: 1265\u20131272.","journal-title":"Mol Psychiatry"},{"key":"BFnpp201422_CR3","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1176\/appi.ajp.2012.11121774","volume":"169","author":"D Arnone","year":"2012","unstructured":"Arnone D, McKie S, Elliott R, Thomas EJ, Downey D, Juhasz G et al (2012b). Increased amygdala responses to sad but not fearful faces in major depression: relation to mood state and pharmacological treatment. Am J Psychiatry 169: 841\u2013850.","journal-title":"Am J Psychiatry"},{"key":"BFnpp201422_CR4","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1001\/archgenpsychiatry.2011.1481","volume":"69","author":"DE Barnes","year":"2012","unstructured":"Barnes DE, Yaffe K, Byers AL, McCormick M, Schaefer C, Whitmer RA (2012). Midlife vs late-life depressive symptoms and risk of dementia. Arch Gen Psychiatry 69: 493\u2013498.","journal-title":"Arch Gen Psychiatry"},{"key":"BFnpp201422_CR5","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1017\/S0033291700035662","volume":"26","author":"BC Beats","year":"1996","unstructured":"Beats BC, Sahakian BJ, Levy R (1996). Cognitive performance in tests sensitive to frontal lobe dysfunction in the elderly depressed. Psychol Med 26: 591\u2013603.","journal-title":"Psychol Med"},{"key":"BFnpp201422_CR6","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1002\/ajmg.b.30993","volume":"153B","author":"LM Bekris","year":"2010","unstructured":"Bekris LM, Galloway NM, Montine TJ, Schellenberg GD, Yu CE (2010). APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure. Am J Med Genet B Neuropsychiatr Genet 153B: 409\u2013417.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"BFnpp201422_CR7","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/jhg.2011.123","volume":"57","author":"LM Bekris","year":"2012","unstructured":"Bekris LM, Lutz F, Yu CE (2012). Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE. J Hum Genet 57: 18\u201325.","journal-title":"J Hum Genet"},{"key":"BFnpp201422_CR8","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1093\/scan\/nsq080","volume":"6","author":"MG Berman","year":"2011","unstructured":"Berman MG, Peltier S, Nee DE, Kross E, Deldin PJ, Jonides J (2011). Depression, rumination and the default network. Soc Cogn Affect Neurosci 6: 548\u2013555.","journal-title":"Soc Cogn Affect Neurosci"},{"key":"BFnpp201422_CR9","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1002\/gps.1006","volume":"18","author":"MA Butters","year":"2003","unstructured":"Butters MA, Sweet RA, Mulsant BH, Ilyas Kamboh M, Pollock BG, Begley AE et al (2003). APOE is associated with age-of-onset, but not cognitive functioning, in late-life depression. Int J Geriatr Psychiatry 18: 1075\u20131081.","journal-title":"Int J Geriatr Psychiatry"},{"key":"BFnpp201422_CR10","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.biopsych.2005.10.011","volume":"59","author":"SC Caetano","year":"2006","unstructured":"Caetano SC, Kaur S, Brambilla P, Nicoletti M, Hatch JP, Sassi RB et al (2006). Smaller cingulate volumes in unipolar depressed patients. Biol Psychiatry 59: 702\u2013706.","journal-title":"Biol Psychiatry"},{"key":"BFnpp201422_CR11","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1111\/j.1467-6494.2004.00292.x","volume":"72","author":"T Canli","year":"2004","unstructured":"Canli T (2004). Functional brain mapping of extraversion and neuroticism: learning from individual differences in emotion processing. J Pers 72: 1105\u20131132.","journal-title":"J Pers"},{"key":"BFnpp201422_CR12","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/jhg.2011.135","volume":"57","author":"MM Carrasquillo","year":"2012","unstructured":"Carrasquillo MM, Morgan K (2012). Commentary on \u2018Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE\u2019. J Hum Genet 57: 3\u20134.","journal-title":"J Hum Genet"},{"key":"BFnpp201422_CR13","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1159\/000109150","volume":"24","author":"N Cherbuin","year":"2007","unstructured":"Cherbuin N, Leach LS, Christensen H, Anstey KJ (2007). Neuroimaging and APOE genotype: a systematic qualitative review. Dement Geriatr Cogn Disord 24: 348\u2013362.","journal-title":"Dement Geriatr Cogn Disord"},{"key":"BFnpp201422_CR14","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1017\/S1355617797006310","volume":"3","author":"H Christensen","year":"1997","unstructured":"Christensen H, Griffiths K, MacKinnon A, Jacomb P (1997). A quantitative review of cognitive deficits in depression and Alzheimer-type dementia. J Int Neuropsychol Soc 3: 631\u2013651.","journal-title":"J Int Neuropsychol Soc"},{"key":"BFnpp201422_CR15","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1146\/annurev.neuro.31.060407.125618","volume":"32","author":"L Clark","year":"2009","unstructured":"Clark L, Chamberlain SR, Sahakian BJ (2009). Neurocognitive mechanisms in depression: implications for treatment. Annu Rev Neurosci 32: 57\u201374.","journal-title":"Annu Rev Neurosci"},{"key":"BFnpp201422_CR16","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.comppsych.2004.03.002","volume":"45","author":"BJ Cox","year":"2004","unstructured":"Cox BJ, McWilliams LA, Enns MW, Clara IP (2004). Broad and specific personality dimensions associated with major depression in a nationally representative sample. Compr Psychiatry 45: 246\u2013253.","journal-title":"Compr Psychiatry"},{"key":"BFnpp201422_CR17","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/nrn3027","volume":"12","author":"SG Disner","year":"2011","unstructured":"Disner SG, Beevers CG, Haigh EA, Beck AT (2011). Neural mechanisms of the cognitive model of depression. Nat Rev Neurosci 12: 467\u2013477.","journal-title":"Nat Rev Neurosci"},{"key":"BFnpp201422_CR18","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0006-3223(00)01020-9","volume":"48","author":"WC Drevets","year":"2000","unstructured":"Drevets WC (2000). Neuroimaging studies of mood disorders. Biol Psychiatry 48: 813\u2013829.","journal-title":"Biol Psychiatry"},{"key":"BFnpp201422_CR19","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s00429-008-0189-x","volume":"213","author":"WC Drevets","year":"2008","unstructured":"Drevets WC, Price JL, Furey ML (2008). Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression. Brain Struct Funct 213: 93\u2013118.","journal-title":"Brain Struct Funct"},{"key":"BFnpp201422_CR20","volume-title":"Pictures of Facial Affect","author":"P Ekman","year":"1976","unstructured":"Ekman P, Friesen WV (1976) Pictures of Facial Affect. Consulting Psychologists Press: Palo Alto, CA, USA."},{"key":"BFnpp201422_CR21","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1017\/S0033291700035303","volume":"26","author":"R Elliott","year":"1996","unstructured":"Elliott R, Sahakian BJ, McKay AP, Herrod JJ, Robbins TW, Paykel ES (1996). Neuropsychological impairments in unipolar depression: the influence of perceived failure on subsequent performance. Psychol Med 26: 975\u2013989.","journal-title":"Psychol Med"},{"key":"BFnpp201422_CR22","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/npp.2010.77","volume":"36","author":"R Elliott","year":"2011","unstructured":"Elliott R, Zahn R, Deakin JF, Anderson IM (2011). Affective cognition and its disruption in mood disorders. Neuropsychopharmacol 36: 153\u2013182.","journal-title":"Neuropsychopharmacol"},{"key":"BFnpp201422_CR23","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1002\/da.10102","volume":"17","author":"T Ellwart","year":"2003","unstructured":"Ellwart T, Rinck M, Becker ES (2003). Selective memory and memory deficits in depressed inpatients. Depress Anxiety 17: 197\u2013206.","journal-title":"Depress Anxiety"},{"key":"BFnpp201422_CR24","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1017\/S0007125000161823","volume":"181","author":"AE Farmer","year":"2002","unstructured":"Farmer AE, Redman K, Harris T, Mahmood A, Sadler S, Pickering A et al (2002). Neuroticism, extraversion, life events and depression. Br J Psychiatry 181: 118\u2013122.","journal-title":"Br J Psychiatry"},{"key":"BFnpp201422_CR25","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1017\/S1092852900015303","volume":"12","author":"O Fattal","year":"2007","unstructured":"Fattal O, Link J, Quinn K, Cohen BH, Franco K (2007). Psychiatric comorbidity in 36 adults with mitochondrial cytopathies. CNS Spectr 12: 429\u2013438.","journal-title":"CNS Spectr"},{"key":"BFnpp201422_CR26","first-page":"421452","volume":"2012","author":"B Ferencz","year":"2012","unstructured":"Ferencz B, Karlsson S, Kalpouzos G (2012). Promising genetic biomarkers of preclinical Alzheimer\u2019s disease: the influence of APOE and TOMM40 on brain integrity. Int J Geriatr Psychiatry 2012: 421452.","journal-title":"Int J Geriatr Psychiatry"},{"key":"BFnpp201422_CR27","volume-title":"Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version (SCID-I)","author":"MB First","year":"2002","unstructured":"First MB, Spitzer RL, Gibbon M, Williams JBW (2002) Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version (SCID-I). State Psychiatric Institute: New York, NY, USA."},{"key":"BFnpp201422_CR28","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.biopsych.2008.04.033","volume":"64","author":"CH Fu","year":"2008","unstructured":"Fu CH, Williams SC, Cleare AJ, Scott J, Mitterschiffthaler MT, Walsh ND et al (2008). Neural responses to sad facial expressions in major depression following cognitive behavioral therapy. Biol Psychiatry 64: 505\u2013512.","journal-title":"Biol Psychiatry"},{"key":"BFnpp201422_CR29","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1001\/archpsyc.61.9.877","volume":"61","author":"CHY Fu","year":"2004","unstructured":"Fu CHY, Williams SCR, Cleare AJ, Brammer MJ, Walsh ND, Kim J et al (2004). Attenuation of the neural response to sad faces in major depression by antidepressant treatment. Arch Gen Psychiatry 61: 877\u2013889.","journal-title":"Arch Gen Psychiatry"},{"key":"BFnpp201422_CR30","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1001\/archneur.60.5.753","volume":"60","author":"RC Green","year":"2003","unstructured":"Green RC, Cupples A, Kurz A, Auerbach S, Go R, Sadovnick D et al (2003). Depression as a risk factor for Alzheimer disease: the MIRAGE study. Arch Neurol 60: 753\u2013759.","journal-title":"Arch Neurol"},{"key":"BFnpp201422_CR31","doi-asserted-by":"publisher","first-page":"11661","DOI":"10.1073\/pnas.97.21.11661","volume":"97","author":"PM Greenwood","year":"2000","unstructured":"Greenwood PM, Sunderland T, Friz JL, Parasuraman R (2000). Genetics and visual attention: Selective deficits in healthy adult carriers of the E4 allele of the apolipoprotein E gene. Proc Natl Acad Sci USA 97: 11661\u201311666.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFnpp201422_CR32","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/j.biopsych.2007.12.015","volume":"63","author":"JP Hamilton","year":"2008","unstructured":"Hamilton JP, Gotlib IH (2008). Neural substrates of increased memory sensitivity for negative stimuli in major depression. Biol Psychiatry 63: 1155\u20131162.","journal-title":"Biol Psychiatry"},{"key":"BFnpp201422_CR33","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1176\/appi.ajp.2009.09020149","volume":"166","author":"CJ Harmer","year":"2009","unstructured":"Harmer CJ, O\u2019Sullivan U, Favaron E, Massey-Chase R, Ayres R, Reinecke A et al (2009). Effect of acute antidepressant administration on negative affective bias in depressed patients. Am J Psychiatry 166: 1178\u20131184.","journal-title":"Am J Psychiatry"},{"key":"BFnpp201422_CR34","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/ng.440","volume":"41","author":"D Harold","year":"2009","unstructured":"Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML et al (2009). Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer\u2019s disease. Nat Genetics 41: 1088\u20131093.","journal-title":"Nat Genetics"},{"key":"BFnpp201422_CR35","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/j.neuroimage.2005.02.048","volume":"26","author":"PO Harvey","year":"2005","unstructured":"Harvey PO, Fossati P, Pochon JB, Levy R, Lebastard G, Lehericy S et al (2005). Cognitive control and brain resources in major depression: an fMRI study using the n-back task. Neuroimage 26: 860\u2013869.","journal-title":"Neuroimage"},{"key":"BFnpp201422_CR36","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1038\/mp.2010.90","volume":"16","author":"V Heise","year":"2011","unstructured":"Heise V, Filippini N, Ebmeier KP, Mackay CE (2011). The APOE \u025b4 allele modulates brain white matter integrity in healthy adults. Mol Psychiatry 16: 908\u2013916.","journal-title":"Mol Psychiatry"},{"key":"BFnpp201422_CR37","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/jhg.2010.92","volume":"55","author":"MG Hong","year":"2010","unstructured":"Hong MG, Alexeyenko A, Lambert JC, Amouyel P, Prince JA (2010). Genome-wide pathway analysis implicates intracellular transmembrane protein transport in Alzheimer disease. J Hum Genet 55: 707\u2013709.","journal-title":"J Hum Genet"},{"key":"BFnpp201422_CR38","volume-title":"The Big Five Inventory: Versions 4a and 54","author":"OP John","year":"1991","unstructured":"John OP, Donahue EM, Kentle RL (1991) The Big Five Inventory: Versions 4a and 54. Technical report. University of California, Insititute of Personality and Social Research: Berkeley, CA, USA."},{"key":"BFnpp201422_CR39","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1093\/scan\/nsp022","volume":"4","author":"MK Johnson","year":"2009","unstructured":"Johnson MK, Nolen-Hoeksema S, Mitchell KJ, Levin Y (2009). Medial cortex activity, self-reflection and depression. Soc Cogn Affect Neurosci 4: 313\u2013327.","journal-title":"Soc Cogn Affect Neurosci"},{"key":"BFnpp201422_CR40","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.jalz.2010.11.012","volume":"7","author":"SC Johnson","year":"2011","unstructured":"Johnson SC, La Rue A, Hermann BP, Xu G, Koscik RL, Jonaitis EM et al (2011). The effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE epsilon3\/epsilon3 genotype. Alzheimers Dement 7: 456\u2013465.","journal-title":"Alzheimers Dement"},{"key":"BFnpp201422_CR41","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1046\/j.1440-1614.2001.00967.x","volume":"35","author":"AF Jorm","year":"2001","unstructured":"Jorm AF (2001). History of depression as a risk factor for dementia: an updated review. Aust N Z J Psychiatry 35: 776\u2013781.","journal-title":"Aust N Z J Psychiatry"},{"key":"BFnpp201422_CR42","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1038\/npp.2009.19","volume":"34","author":"G Juhasz","year":"2009","unstructured":"Juhasz G, Chase D, Pegg E, Downey D, Toth ZG, Stones K et al (2009). CNR1 gene is associated with high neuroticism and low agreeableness and interacts with recent negative life events to predict current depressive symptoms. Neuropsychopharmacol 34: 2019\u20132027.","journal-title":"Neuropsychopharmacol"},{"key":"BFnpp201422_CR43","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.biopsych.2010.11.019","volume":"69","author":"G Juhasz","year":"2011","unstructured":"Juhasz G, Dunham JS, McKie S, Thomas E, Downey D, Chase D et al (2011). The CREB1-BDNF-NTRK2 pathway in depression: multiple gene-cognition-environment interactions. Biol Psychiatry 69: 762\u2013771.","journal-title":"Biol Psychiatry"},{"key":"BFnpp201422_CR44","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1002\/da.20167","volume":"23","author":"P Jylha","year":"2006","unstructured":"Jylha P, Isometsa E (2006). The relationship of neuroticism and extraversion to symptoms of anxiety and depression in the general population. Depress Anxiety 23: 281\u2013289.","journal-title":"Depress Anxiety"},{"key":"BFnpp201422_CR45","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1002\/da.20385","volume":"26","author":"P Jylha","year":"2009","unstructured":"Jylha P, Melartin T, Rytsala H, Isometsa E (2009). Neuroticism, introversion, and major depressive disorder\u2014traits, states, or scars? Depress Anxiety 26: 325\u2013334.","journal-title":"Depress Anxiety"},{"key":"BFnpp201422_CR46","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1001\/archpsyc.63.10.1113","volume":"63","author":"KS Kendler","year":"2006","unstructured":"Kendler KS, Gatz M, Gardner CO, Pedersen NL (2006a). Personality and major depression. Arch Gen Psychiatry 63: 1113\u20131120.","journal-title":"Arch Gen Psychiatry"},{"key":"BFnpp201422_CR47","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1001\/archpsyc.63.10.1113","volume":"63","author":"KS Kendler","year":"2006","unstructured":"Kendler KS, Gatz M, Gardner CO, Pedersen NL (2006b). Personality and major depression: a Swedish Longitudinal, Population-Based Twin Study. Arch Gen Psychiatry 63: 1113\u20131120.","journal-title":"Arch Gen Psychiatry"},{"key":"BFnpp201422_CR48","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1001\/archneurol.2007.3","volume":"65","author":"H Li","year":"2008","unstructured":"Li H, Wetten S, Li L, St. Jean PL, Upmanyu R, Surh L et al (2008). Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. Arch Neurol 65: 45\u201353.","journal-title":"Arch Neurol"},{"key":"BFnpp201422_CR49","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/mp.2010.80","volume":"16","author":"G Macqueen","year":"2011","unstructured":"Macqueen G, Frodl T (2011). The hippocampus in major depression: evidence for the convergence of the bench and bedside in psychiatric research? Mol Psychiatry 16: 252\u2013264.","journal-title":"Mol Psychiatry"},{"key":"BFnpp201422_CR50","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/nrd3628","volume":"11","author":"MJ Millan","year":"2012","unstructured":"Millan MJ, Agid Y, Brune M, Bullmore ET, Carter CS, Clayton NS et al (2012). Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy. Nat Rev Drug Discov 11: 141\u2013168.","journal-title":"Nat Rev Drug Discov"},{"key":"BFnpp201422_CR51","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/ana.410420114","volume":"42","author":"S Minoshima","year":"1997","unstructured":"Minoshima S, Giordani B, Berent S, Frey KA, Foster NL, Kuhl DE (1997). Metabolic reduction in the posterior cingulate cortex in very early Alzheimer\u2019s disease. Ann Neurol 42: 85\u201394.","journal-title":"Ann Neurol"},{"key":"BFnpp201422_CR52","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1192\/bjp.134.4.382","volume":"134","author":"SA Montgomery","year":"1979","unstructured":"Montgomery SA, \u00c5sberg M (1979). A new depression scale designed to be sensitive to change. Br J Psychiatry 134: 382\u2013389.","journal-title":"Br J Psychiatry"},{"key":"BFnpp201422_CR53","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1016\/j.neurobiolaging.2012.01.005","volume":"33","author":"S Morbelli","year":"2012","unstructured":"Morbelli S, Drzezga A, Perneczky R, Frisoni GB, Caroli A, van Berckel BN et al (2012). Resting metabolic connectivity in prodromal Alzheimer's disease. A European Alzheimer Disease Consortium (EADC) project. Neurobiol Aging 33: 2533\u20132550.","journal-title":"Neurobiol Aging"},{"key":"BFnpp201422_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pgen.1001130","volume":"6","author":"AC Naj","year":"2010","unstructured":"Naj AC, Beecham GW, Martin ER, Gallins PJ, Powell EH, Konidari I et al (2010). Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities. PloS Genet 6: 1\u201310.","journal-title":"PloS Genet"},{"key":"BFnpp201422_CR55","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1002\/hbm.20131","volume":"25","author":"AM Owen","year":"2005","unstructured":"Owen AM, McMillan KM, Laird AR, Bullmore E (2005). N-back working memory paradigm: a meta-analysis of normative functional neuroimaging studies. Hum Brain Mapp 25: 46\u201359.","journal-title":"Hum Brain Mapp"},{"key":"BFnpp201422_CR56","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1001\/archpsyc.63.5.530","volume":"63","author":"RL Ownby","year":"2006","unstructured":"Ownby RL, Crocco E, Acevedo A, John V, Loewenstein D (2006). Depression and risk for Alzheimer disease. Arch Gen Psychiatry 63: 530\u2013538.","journal-title":"Arch Gen Psychiatry"},{"key":"BFnpp201422_CR57","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1146\/annurev.cellbio.13.1.25","volume":"13","author":"N Pfanner","year":"1997","unstructured":"Pfanner N, Craig EA, H\u00f6nlinger A (1997). Mitochondrial preprotein translocase. Annu Rev Cell Dev Biol 13: 25\u201351.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"BFnpp201422_CR58","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1176\/appi.ajp.158.3.405","volume":"158","author":"D Pizzagalli","year":"2001","unstructured":"Pizzagalli D, Pascual-Marqui RD, Nitschke JB, Oakes TR, Larson CL, Abercrombie HC et al (2001). Anterior cingulate activity as a predictor of degree of treatment response in major depression: evidence from brain electrical tomography analysis. Am J Psychiatry 158: 405\u2013415.","journal-title":"Am J Psychiatry"},{"key":"BFnpp201422_CR59","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/npp.2010.166","volume":"36","author":"DA Pizzagalli","year":"2011","unstructured":"Pizzagalli DA (2011). Frontocingulate dysfunction in depression: toward biomarkers of treatment response. Neuropsychopharmacol 36: 183\u2013206.","journal-title":"Neuropsychopharmacol"},{"key":"BFnpp201422_CR60","doi-asserted-by":"publisher","first-page":"e6501","DOI":"10.1371\/journal.pone.0006501","volume":"4","author":"SG Potkin","year":"2009","unstructured":"Potkin SG, Guffanti G, Lakatos A, Turner JA, Kruggel F, Fallon JH et al (2009). Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. PLoS One 4: e6501.","journal-title":"PLoS One"},{"key":"BFnpp201422_CR61","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s11682-009-9065-4","volume":"3","author":"ML Ries","year":"2009","unstructured":"Ries ML, Wichmann A, Bendlin BB, Johnson SC (2009). Posterior cingulate and lateral parietal gray matter volume in older adults with depressive symptoms. Brain Imaging Behav 3: 233\u2013239.","journal-title":"Brain Imaging Behav"},{"key":"BFnpp201422_CR62","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1002\/gps.2655","volume":"26","author":"TB Robins Wahlin","year":"2011","unstructured":"Robins Wahlin TB, Byrne GJ (2011). Personality changes in Alzheimer\u2019s disease: a systematic review. Int J Geriatr Psychiatry 26: 1019\u20131029.","journal-title":"Int J Geriatr Psychiatry"},{"key":"BFnpp201422_CR63","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1001\/archneurol.2010.88","volume":"67","author":"AD Roses","year":"2010","unstructured":"Roses AD (2010). An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease. Arch Neurol 67: 536\u2013541.","journal-title":"Arch Neurol"},{"key":"BFnpp201422_CR64","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1212\/WNL.0b013e3181e62138","volume":"75","author":"JS Saczynski","year":"2010","unstructured":"Saczynski JS, Beiser A, Seshadri S, Auerbach S, Wolf PA, Au R (2010). Depressive symptoms and risk of dementia: the Framingham heart study. Neurology 75: 35\u201341.","journal-title":"Neurology"},{"key":"BFnpp201422_CR65","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.neuroimage.2010.02.019","volume":"53","author":"C Scharinger","year":"2010","unstructured":"Scharinger C, Rabl U, Sitte HH, Pezawas L (2010). Imaging genetics of mood disorders. Neuroimage 53: 810\u2013821.","journal-title":"Neuroimage"},{"key":"BFnpp201422_CR66","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/mp.2010.137","volume":"17","author":"OJ Schiepers","year":"2011","unstructured":"Schiepers OJ, Harris SE, Gow AJ, Pattie A, Brett CE, Starr JM et al (2011). APOE E4 status predicts age-related cognitive decline in the ninth decade: longitudinal follow-up of the Lothian Birth Cohort 1921. Mol Psychiatry 17: 315\u2013324.","journal-title":"Mol Psychiatry"},{"key":"BFnpp201422_CR67","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1001\/jama.2010.574","volume":"303","author":"S Seshadri","year":"2010","unstructured":"Seshadri S, Fitzpatrick AL, Ikram MA, DeStefano AL, Gudnason V, Boada M et al (2010). Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA 303: 1832\u20131840.","journal-title":"JAMA"},{"key":"BFnpp201422_CR68","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1016\/j.neuroimage.2010.01.042","volume":"53","author":"L Shen","year":"2010","unstructured":"Shen L, Kim S, Risacher SL, Nho K, Swaminathan S, West JD et al (2010). Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: a study of the ADNI cohort. Neuroimage 53: 1051\u20131063.","journal-title":"Neuroimage"},{"key":"BFnpp201422_CR69","doi-asserted-by":"publisher","first-page":"9440","DOI":"10.1073\/pnas.1530509100","volume":"100","author":"JD Storey","year":"2003","unstructured":"Storey JD, Tibshirani R (2003). Statistical significance for genomewide studies. Proc Natl Acad Sci USA 100: 9440\u20139445.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFnpp201422_CR70","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1017\/S0033291711000043","volume":"41","author":"EJ Thomas","year":"2011","unstructured":"Thomas EJ, Elliott R, McKie S, Arnone D, Downey D, Juhasz G et al (2011). Interaction between a history of depression and rumination on neural response to emotional faces. Psychol Med 41: 1845\u20131855.","journal-title":"Psychol Med"},{"key":"BFnpp201422_CR71","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.neuroimage.2005.07.048","volume":"29","author":"BA Vogt","year":"2006","unstructured":"Vogt BA, Vogt L, Laureys S (2006). Cytology and functionally correlated circuits of human posterior cingulate areas. Neuroimage 29: 452\u2013466.","journal-title":"Neuroimage"},{"key":"BFnpp201422_CR72","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1037\/0894-4105.18.2.296","volume":"18","author":"JA Waltz","year":"2004","unstructured":"Waltz JA, Knowlton BJ, Holyoak KJ, Boone KB, Back-Madruga C, McPherson S et al (2004). Relational integration and executive function in Alzheimer's disease. Neuropsychol 18: 296\u2013305.","journal-title":"Neuropsychol"},{"key":"BFnpp201422_CR73","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1097\/JGP.0b013e3180f63373","volume":"15","author":"Y-C Yen","year":"2007","unstructured":"Yen Y-C, Rebok GW, Gallo JJ, Yang M-J, Lung F-W, Shih C-H (2007). ApoE4 allele is associated with late-life depression: a population-based study. Am J Geriatr Psychiatry 15: 858\u2013868.","journal-title":"Am J Geriatr Psychiatry"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/npp201422.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp201422","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp201422.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T23:49:10Z","timestamp":1684453750000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/npp201422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,29]]},"references-count":73,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["BFnpp201422"],"URL":"https:\/\/doi.org\/10.1038\/npp.2014.22","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,29]]}}}