{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:54:07Z","timestamp":1785894847734,"version":"3.56.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T00:00:00Z","timestamp":1415059200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1038\/npp.2014.295","type":"journal-article","created":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T11:56:15Z","timestamp":1415102175000},"page":"1141-1150","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Involvement of Cholinergic System in Hyperactivity in Dopamine-Deficient Mice"],"prefix":"10.1038","volume":"40","author":[{"given":"Yoko","family":"Hagino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Kasai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayo","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Setogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yamaura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Yanagihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuto","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert Y","family":"Meltzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutaka","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,11,4]]},"reference":[{"key":"BFnpp2014295_CR1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0893-133X(97)00112-7","volume":"18","author":"J Arnt","year":"1998","unstructured":"Arnt J, Skarsfeldt T (1998). Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence. Neuropsychopharmacology 18: 63\u2013101.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2014295_CR2","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1007\/s00221-010-2156-z","volume":"202","author":"WL Au","year":"2010","unstructured":"Au WL, Lei N, Oishi MM, McKeown MJ (2010). L-dopa induces under-damped visually guided motor responses in Parkinson\u2019s disease. Exp Brain Res 202: 553\u2013559.","journal-title":"Exp Brain Res"},{"key":"BFnpp2014295_CR3","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1002\/jnr.20245","volume":"78","author":"ME Avale","year":"2004","unstructured":"Avale ME, Nemirovsky SI, Raisman-Vozari R, Rubinstein M (2004). Elevated serotonin is involved in hyperactivity but not in the paradoxical effect of amphetamine in mice neonatally lesioned with 6-hydroxydopamine. J Neurosci Res 78: 289\u2013296.","journal-title":"J Neurosci Res"},{"key":"BFnpp2014295_CR4","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.bbr.2009.04.006","volume":"204","author":"S Barak","year":"2009","unstructured":"Barak S (2009). Modeling cholinergic aspects of schizophrenia: focus on the antimuscarinic syndrome. Behav Brain Res 204: 335\u2013351.","journal-title":"Behav Brain Res"},{"key":"BFnpp2014295_CR5","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1111\/j.1476-5381.1990.tb14138.x","volume":"101","author":"HH Berendsen","year":"1990","unstructured":"Berendsen HH, Broekkamp CL (1990). Behavioural evidence for functional interactions between 5-HT-receptor subtypes in rats and mice. Br J Pharmacol 101: 667\u2013673.","journal-title":"Br J Pharmacol"},{"key":"BFnpp2014295_CR6","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/j.1471-4159.1992.tb08911.x","volume":"59","author":"R Bertorelli","year":"1992","unstructured":"Bertorelli R, Zambelli M, Di Chiara G, Consolo S (1992). Dopamine depletion preferentially impairs D1- over D2-receptor regulation of striatal in vivo acetylcholine release. J Neurochem 59: 353\u2013357.","journal-title":"J Neurochem"},{"key":"BFnpp2014295_CR7","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.neuron.2008.09.031","volume":"60","author":"P Calabresi","year":"2008","unstructured":"Calabresi P, Di Filippo M (2008). ACh\/dopamine crosstalk in motor control and reward: a crucial role for alpha 6-containing nicotinic receptors? Neuron 60: 4\u20137.","journal-title":"Neuron"},{"key":"BFnpp2014295_CR8","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1111\/j.1472-8206.2009.00798.x","volume":"24","author":"D Devos","year":"2010","unstructured":"Devos D, Defebvre L, Bordet R (2010). Dopaminergic and non-dopaminergic pharmacological hypotheses for gait disorders in Parkinson\u2019s disease. Fundam Clin Pharmacol 24: 407\u20134421.","journal-title":"Fundam Clin Pharmacol"},{"key":"BFnpp2014295_CR9","volume-title":"The Mouse Brain in Stereotaxic Coordinates","author":"KBJ Franklin","year":"1997","unstructured":"Franklin KBJ, Paxinos G (1997) The Mouse Brain in Stereotaxic Coordinates. Academic Press: San Diego, CA, USA."},{"key":"BFnpp2014295_CR10","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/ncomms1101","volume":"1","author":"M Fujita","year":"2010","unstructured":"Fujita M, Sugama S, Sekiyama K, Sekigawa A, Tsukui T, Nakai M et al (2010). A beta-synuclein mutation linked to dementia produces neurodegeneration when expressed in mouse brain. Nat Commun 1: 110.","journal-title":"Nat Commun"},{"key":"BFnpp2014295_CR11","first-page":"273","volume":"86","author":"N Giladi","year":"2001","unstructured":"Giladi N (2001). Gait disturbances in advanced stages of Parkinson\u2019s disease. Adv Neurol 86: 273\u2013278.","journal-title":"Adv Neurol"},{"key":"BFnpp2014295_CR12","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.conb.2005.10.006","volume":"15","author":"AM Graybiel","year":"2005","unstructured":"Graybiel AM (2005). The basal ganglia: learning new tricks and loving it. Curr Opin Neurobiol 15: 638\u2013644.","journal-title":"Curr Opin Neurobiol"},{"key":"BFnpp2014295_CR13","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/BF00177919","volume":"92","author":"DJ Heal","year":"1987","unstructured":"Heal DJ, Philpot J (1987). A study of the possible influence of central 5-HT function on clonidine-induced hypoactivity responses in mice. Psychopharmacology (Berl) 92: 219\u2013223.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2014295_CR14","doi-asserted-by":"publisher","first-page":"5976","DOI":"10.1073\/pnas.84.16.5976","volume":"84","author":"EC Hirsch","year":"1987","unstructured":"Hirsch EC, Graybiel AM, Duyckaerts C, Javoy-Agid F (1987). Neuronal loss in the pedunculopontine tegmental nucleus in Parkinson disease and in progressive supranuclear palsy. Proc Natl Acad Sci USA 84: 5976\u20135980.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFnpp2014295_CR15","first-page":"19","volume":"45","author":"O Hornykiewicz","year":"1987","unstructured":"Hornykiewicz O, Kish SJ (1987). Biochemical pathophysiology of Parkinson\u2019s disease. Adv Neurol 45: 19\u201334.","journal-title":"Adv Neurol"},{"key":"BFnpp2014295_CR16","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1124\/jpet.111.184093","volume":"339","author":"P Huot","year":"2011","unstructured":"Huot P, Fox SH, Newman-Tancredi A, Brotchie JM (2011). Anatomically selective serotonergic type 1A and serotonergic type 2A therapies for Parkinson\u2019s disease: an approach to reducing dyskinesia without exacerbating parkinsonism? J Pharmacol Exp Ther 339: 2\u20138.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFnpp2014295_CR17","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1111\/j.1755-5949.2010.00142.x","volume":"16","author":"DB Lester","year":"2010","unstructured":"Lester DB, Rogers TD, Blaha CD (2010). Acetylcholine-dopamine interactions in the pathophysiology and treatment of CNS disorders. CNS Neurosci Ther 16: 137\u2013162.","journal-title":"CNS Neurosci Ther"},{"key":"BFnpp2014295_CR18","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/978-3-642-25758-2_9","volume":"213","author":"DL McKinzie","year":"2012","unstructured":"McKinzie DL, Bymaster FP (2012). Muscarinic mechanisms in psychotic disorders. Handb Exp Pharmacol 213: 233\u2013265.","journal-title":"Handb Exp Pharmacol"},{"key":"BFnpp2014295_CR19","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1146\/annurev-med-050911-161504","volume":"64","author":"HY Meltzer","year":"2013","unstructured":"Meltzer HY (2013). Update on typical and atypical antipsychotic drugs. Annu Rev Med 64: 393\u2013406.","journal-title":"Annu Rev Med"},{"key":"BFnpp2014295_CR20","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S0079-6123(08)00909-6","volume":"172","author":"HY Meltzer","year":"2008","unstructured":"Meltzer HY, Huang M (2008). In vivo actions of atypical antipsychotic drug on serotonergic and dopaminergic systems. Prog Brain Res 172: 177\u2013197.","journal-title":"Prog Brain Res"},{"key":"BFnpp2014295_CR21","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1038\/npp.2009.176","volume":"35","author":"HY Meltzer","year":"2010","unstructured":"Meltzer HY, Mills R, Revell S, Williams H, Johnson A, Bahr D et al (2010). Pimavanserin, a serotonin(2A) receptor inverse agonist, for the treatment of Parkinson\u2019s disease psychosis. Neuropsychopharmacology 35: 881\u2013892.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2014295_CR22","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.tins.2004.07.009","volume":"27","author":"J Mena-Segovia","year":"2004","unstructured":"Mena-Segovia J, Bolam JP, Magill PJ (2004). Pedunculopontine nucleus and basal ganglia: distant relatives or part of the same family? Trends Neurosci 27: 585\u2013588.","journal-title":"Trends Neurosci"},{"key":"BFnpp2014295_CR23","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1002\/mds.20278","volume":"20","author":"M Morris","year":"2005","unstructured":"Morris M, Iansek R, McGinley J, Matyas T, Huxham F (2005). Three-dimensional gait biomechanics in Parkinson\u2019s disease: evidence for a centrally mediated amplitude regulation disorder. Mov Disord 20: 40\u201350.","journal-title":"Mov Disord"},{"key":"BFnpp2014295_CR24","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1093\/brain\/117.5.1169","volume":"117","author":"ME Morris","year":"1994","unstructured":"Morris ME, Iansek R, Matyas TA, Summers JJ (1994). The pathogenesis of gait hypokinesia in Parkinson\u2019s disease. Brain 117: 1169\u20131181.","journal-title":"Brain"},{"key":"BFnpp2014295_CR25","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S0014-2999(98)00591-3","volume":"358","author":"I Ninan","year":"1998","unstructured":"Ninan I, Kulkarni SK (1998). 5-HT2A receptor antagonists block MK-801-induced stereotypy and hyperlocomotion. Eur J Pharmacol 358: 111\u2013116.","journal-title":"Eur J Pharmacol"},{"key":"BFnpp2014295_CR26","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1002\/(SICI)1097-4547(19981115)54:4<450::AID-JNR3>3.0.CO;2-B","volume":"54","author":"K Nishii","year":"1998","unstructured":"Nishii K, Matsushita N, Sawada H, Sano H, Noda Y, Mamiya T et al (1998). Motor and learning dysfunction during postnatal development in mice defective in dopamine neuronal transmission. J Neurosci Res 54: 450\u2013464.","journal-title":"J Neurosci Res"},{"key":"BFnpp2014295_CR27","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1093\/brain\/123.9.1767","volume":"123","author":"PA Pahapill","year":"2000","unstructured":"Pahapill PA, Lozano AM (2000). The pedunculopontine nucleus and Parkinson\u2019s disease. Brain 123: 1767\u20131783.","journal-title":"Brain"},{"key":"BFnpp2014295_CR28","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.tins.2007.07.008","volume":"30","author":"A Pisani","year":"2007","unstructured":"Pisani A, Bernardi G, Ding J, Surmeier DJ (2007). Re-emergence of striatal cholinergic interneurons in movement disorders. Trends Neurosci 30: 545\u2013553.","journal-title":"Trends Neurosci"},{"key":"BFnpp2014295_CR29","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/sj.mp.4001924","volume":"12","author":"TJ Raedler","year":"2007","unstructured":"Raedler TJ, Bymaster FP, Tandon R, Copolov D, Dean B (2007). Towards a muscarinic hypothesis of schizophrenia. Mol Psychiatry 12: 232\u2013246.","journal-title":"Mol Psychiatry"},{"key":"BFnpp2014295_CR30","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.parkreldis.2008.01.006","volume":"14","author":"JO Rinne","year":"2008","unstructured":"Rinne JO, Ma SY, Lee MS, Collan Y, Roytta M (2008). Loss of cholinergic neurons in the pedunculopontine nucleus in Parkinson\u2019s disease is related to disability of the patients. Parkinsonism Relat Disord 14: 553\u2013557.","journal-title":"Parkinsonism Relat Disord"},{"key":"BFnpp2014295_CR31","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s00213-007-0810-3","volume":"194","author":"L Salomon","year":"2007","unstructured":"Salomon L, Lanteri C, Godeheu G, Blanc G, Gingrich J, Tassin JP (2007). Paradoxical constitutive behavioral sensitization to amphetamine in mice lacking 5-HT2A receptors. Psychopharmacology (Berl) 194: 11\u201320.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2014295_CR32","doi-asserted-by":"publisher","first-page":"12138","DOI":"10.1073\/pnas.96.21.12138","volume":"96","author":"MS Szczypka","year":"1999","unstructured":"Szczypka MS, Rainey MA, Kim DS, Alaynick WA, Marck BT, Matsumoto AM et al (1999). Feeding behavior in dopamine-deficient mice. Proc Natl Acad Sci USA 96: 12138\u201312143.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFnpp2014295_CR33","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/sj.npp.1380235","volume":"12","author":"JS Yeomans","year":"1995","unstructured":"Yeomans JS (1995). Role of tegmental cholinergic neurons in dopaminergic activation, antimuscarinic psychosis and schizophrenia. Neuropsychopharmacology 12: 3\u201316.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2014295_CR34","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/0092-8674(95)90145-0","volume":"83","author":"QY Zhou","year":"1995","unstructured":"Zhou QY, Palmiter RD (1995). Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic. Cell 83: 1197\u20131209.","journal-title":"Cell"},{"key":"BFnpp2014295_CR35","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1097\/YCO.0b013e328336661b","volume":"23","author":"H Ziauddeen","year":"2010","unstructured":"Ziauddeen H, Murray GK (2010). The relevance of reward pathways for schizophrenia. Curr Opin Psychiatry 23: 91\u201396.","journal-title":"Curr Opin Psychiatry"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/npp2014295.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2014295","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2014295.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T23:50:05Z","timestamp":1684453805000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/npp2014295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,4]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["BFnpp2014295"],"URL":"https:\/\/doi.org\/10.1038\/npp.2014.295","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,4]]},"assertion":[{"value":"4 July 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}