{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:34:16Z","timestamp":1791480856695,"version":"4.3.4"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T00:00:00Z","timestamp":1446681600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1038\/npp.2015.339","type":"journal-article","created":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T12:02:17Z","timestamp":1446724937000},"page":"1457-1466","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":160,"title":["Autistic-Like Traits and Cerebellar Dysfunction in Purkinje Cell PTEN Knock-Out Mice"],"prefix":"10.1038","volume":"41","author":[{"given":"Dario","family":"Cupolillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriola","family":"Hoxha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9487-1530","authenticated-orcid":false,"given":"Alessio","family":"Faralli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annarita","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinando","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2778-0943","authenticated-orcid":false,"given":"Filippo","family":"Tempia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Carulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,11,5]]},"reference":[{"key":"BFnpp2015339_CR1","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1002\/1526-968X(200011\/12)28:3\/4<93::AID-GENE10>3.0.CO;2-W","volume":"28","author":"JJ Barski","year":"2000","unstructured":"Barski JJ, Dethleffsen K, Meyer M (2000). Cre recombinase expression in cerebellar Purkinje cells. Genesis 28: 93\u201398.","journal-title":"Genesis"},{"key":"BFnpp2015339_CR2","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1126\/science.1224159","volume":"338","author":"SJ Baudouin","year":"2012","unstructured":"Baudouin SJ, Gaudias J, Gerharz S, Hatstatt L, Zhou K, Punnakkal P et al (2012). Shared synaptic pathophysiology in syndromic and nonsyndromic rodent models of autism. Science 338: 128\u2013132.","journal-title":"Science"},{"key":"BFnpp2015339_CR3","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.neuroscience.2009.01.032","volume":"162","author":"LW Bosman","year":"2009","unstructured":"Bosman LW, Konnerth A (2009). Activity-dependent plasticity of developing climbing fiber-Purkinje cell synapses. Neuroscience 162: 612\u2013623.","journal-title":"Neuroscience"},{"key":"BFnpp2015339_CR4","doi-asserted-by":"publisher","first-page":"3490","DOI":"10.1093\/hmg\/ddu057","volume":"23","author":"AE Clipperton-Allen","year":"2014","unstructured":"Clipperton-Allen AE, Page DT (2014). Pten haploinsufficient mice show broad brain overgrowth but selective impairments in autism-relevant behavioral tests. Hum Mol Genet 23: 3490\u20133505.","journal-title":"Hum Mol Genet"},{"key":"BFnpp2015339_CR5","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/gbb.12192","volume":"14","author":"AE Clipperton-Allen","year":"2015","unstructured":"Clipperton-Allen AE, Page DT (2015). Decreased aggression and increased repetitive behavior in Pten haploinsufficient mice. Genes Brain Behav 14: 145\u2013157.","journal-title":"Genes Brain Behav"},{"key":"BFnpp2015339_CR6","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1212\/WNL.57.2.245","volume":"57","author":"E Courchesne","year":"2001","unstructured":"Courchesne E, Karns CM, Davis HR, Ziccardi R, Carper RA, Tigue ZD et al (2001). Unusual brain growth patterns in early life in patients with autistic disorder: an MRI study. Neurology 57: 245\u2013254.","journal-title":"Neurology"},{"key":"BFnpp2015339_CR7","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1007\/s12311-012-0355-9","volume":"11","author":"SH Fatemi","year":"2012","unstructured":"Fatemi SH, Aldinger KA, Ashwood P, Bauman ML, Blaha CD, Blatt GJ et al (2012). Consensus paper: pathological role of the cerebellum in autism. Cerebellum 11: 777\u2013807.","journal-title":"Cerebellum"},{"key":"BFnpp2015339_CR8","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1111\/j.1469-7793.1998.391bw.x","volume":"506","author":"K Hashimoto","year":"1998","unstructured":"Hashimoto K, Kano M (1998). Presynaptic origin of paired-pulse depression at climbing fibre-Purkinje cell synapses in the rat cerebellum. J Physiol 506: 391\u2013405.","journal-title":"J Physiol"},{"key":"BFnpp2015339_CR9","doi-asserted-by":"publisher","first-page":"11300","DOI":"10.1523\/JNEUROSCI.2270-05.2005","volume":"25","author":"J Jaworski","year":"2005","unstructured":"Jaworski J, Spangler S, Seeburg DP, Hoogenraad CC, Sheng M (2005). Control of dendritic arborization by the phosphoinositide-3\u2032-kinase-Akt-mammalian target of rapamycin pathway. J Neurosci 25: 11300\u201311312.","journal-title":"J Neurosci"},{"key":"BFnpp2015339_CR10","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.neuron.2006.03.023","volume":"50","author":"CH Kwon","year":"2006","unstructured":"Kwon CH, Luikart BW, Powell CM, Zhou J, Matheny SA, Zhang W et al (2006). Pten regulates neuronal arborization and social interaction in mice. Neuron 50: 377\u2013388.","journal-title":"Neuron"},{"key":"BFnpp2015339_CR11","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/S0140-6736(13)61539-1","volume":"383","author":"MC Lai","year":"2014","unstructured":"Lai MC, Lombardo MV, Baron-Cohen S (2014). Autism. Lancet 383: 896\u2013910.","journal-title":"Lancet"},{"key":"BFnpp2015339_CR12","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1126\/science.275.5308.1943","volume":"275","author":"J Li","year":"1997","unstructured":"Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI et al (1997). PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275: 1943\u20131947.","journal-title":"Science"},{"key":"BFnpp2015339_CR13","doi-asserted-by":"publisher","first-page":"4587","DOI":"10.1523\/JNEUROSCI.2757-14.2015","volume":"35","author":"Y Liu","year":"2015","unstructured":"Liu Y, Lee JW, Ackerman SL (2015). Mutations in the microtubule-associated protein 1A (Map1a) gene cause purkinje cell degeneration. J Neurosci 35: 4587\u20134598.","journal-title":"J Neurosci"},{"key":"BFnpp2015339_CR14","doi-asserted-by":"publisher","first-page":"e416","DOI":"10.1038\/tp.2014.55","volume":"4","author":"LT Lotta","year":"2014","unstructured":"Lotta LT, Conrad K, Cory-Slechta D, Schor NF (2014). Cerebellar Purkinje cell p75 neurotrophin receptor and autistic behavior. Transl Psychiatry 4: e416.","journal-title":"Transl Psychiatry"},{"key":"BFnpp2015339_CR15","doi-asserted-by":"publisher","first-page":"4345","DOI":"10.1523\/JNEUROSCI.0061-11.2011","volume":"31","author":"BW Luikart","year":"2011","unstructured":"Luikart BW, Schnell E, Washburn EK, Bensen AL, Tovar KR, Westbrook GL (2011). Pten knockdown in vivo increases excitatory drive onto dentate granule cells. J Neurosci 31: 4345\u20134354.","journal-title":"J Neurosci"},{"key":"BFnpp2015339_CR16","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1242\/dev.129.14.3513","volume":"129","author":"S Marino","year":"2002","unstructured":"Marino S, Krimpenfort P, Leung C, van der Korput HA, Trapman J, Camenisch I et al (2002). PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum. Development 129: 3513\u20133522.","journal-title":"Development"},{"key":"BFnpp2015339_CR17","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1093\/brain\/awu394","volume":"138","author":"MK Marko","year":"2015","unstructured":"Marko MK, Crocetti D, Hulst T, Donchin O, Shadmehr R, Mostofsky SH (2015). Behavioural and neural basis of anomalous motor learning in children with autism. Brain 138: 784\u2013797.","journal-title":"Brain"},{"key":"BFnpp2015339_CR18","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1111\/j.1460-9568.2009.07073.x","volume":"31","author":"LA Martin","year":"2010","unstructured":"Martin LA, Goldowitz D, Mittleman G (2010). Repetitive behavior and increased activity in mice with Purkinje cell loss: a model for understanding the role of cerebellar pathology in autism. Eur J Neurosci 31: 544\u2013555.","journal-title":"Eur J Neurosci"},{"key":"BFnpp2015339_CR19","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1002\/aur.132","volume":"3","author":"KL McBride","year":"2010","unstructured":"McBride KL, Varga EA, Pastore MT, Prior TW, Manickam K, Atkin JF et al (2010). Confirmation study of PTEN mutations among individuals with autism or developmental delays\/mental retardation and macrocephaly. Autism Res 3: 137\u2013141.","journal-title":"Autism Res"},{"key":"BFnpp2015339_CR20","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1002\/syn.20525","volume":"62","author":"G Mittleman","year":"2008","unstructured":"Mittleman G, Goldowitz D, Heck DH, Blaha CD (2008). Cerebellar modulation of frontal cortex dopamine efflux in mice: relevance to autism and schizophrenia. Synapse 62: 544\u2013550.","journal-title":"Synapse"},{"key":"BFnpp2015339_CR21","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1113\/jphysiol.1982.sp014409","volume":"332","author":"PG Montarolo","year":"1982","unstructured":"Montarolo PG, Palestini M, Strata P (1982). The inhibitory effect of the olivocerebellar input on the cerebellar Purkinje cells in the rat. J Physiol 332: 187\u2013202.","journal-title":"J Physiol"},{"key":"BFnpp2015339_CR22","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1111\/j.1365-2788.2011.01519.x","volume":"56","author":"AM Muehlmann","year":"2012","unstructured":"Muehlmann AM, Lewis MH (2012). Abnormal repetitive behaviours: shared phenomenology and pathophysiology. J Intellect Disabil Res 56: 427\u2013440.","journal-title":"J Intellect Disabil Res"},{"key":"BFnpp2015339_CR23","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/mrdd.20141","volume":"13","author":"RA Muller","year":"2007","unstructured":"Muller RA (2007). The study of autism as a distributed disorder. Ment Retard Dev Disabil Res Rev 13: 85\u201395.","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"BFnpp2015339_CR24","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.mcn.2006.11.014","volume":"34","author":"N Nayeem","year":"2007","unstructured":"Nayeem N, Kerr F, Naumann H, Linehan J, Lovestone S, Brandner S (2007). Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1\/2 in PTEN-deficient cerebella. Mol Cell Neurosci 34: 400\u2013408.","journal-title":"Mol Cell Neurosci"},{"key":"BFnpp2015339_CR25","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1126\/science.2109351","volume":"248","author":"J Oberdick","year":"1990","unstructured":"Oberdick J, Smeyne RJ, Mann JR, Zackson S, Morgan JI (1990). A promoter that drives transgene expression in cerebellar Purkinje and retinal bipolar neurons. Science 248: 223\u2013226.","journal-title":"Science"},{"key":"BFnpp2015339_CR26","doi-asserted-by":"publisher","first-page":"2572","DOI":"10.1093\/brain\/awh287","volume":"127","author":"SJ Palmen","year":"2004","unstructured":"Palmen SJ, van Engeland H, Hof PR, Schmitz C (2004). Neuropathological findings in autism. Brain 127: 2572\u20132583.","journal-title":"Brain"},{"key":"BFnpp2015339_CR27","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1126\/science.1161566","volume":"322","author":"KK Park","year":"2008","unstructured":"Park KK, Liu K, Hu Y, Smith PD, Wang C, Cai B et al (2008). Promoting axon regeneration in the adult CNS by modulation of the PTEN\/mTOR pathway. Science 322: 963\u2013966.","journal-title":"Science"},{"key":"BFnpp2015339_CR28","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.nlm.2015.07.013","volume":"124","author":"E Pasciuto","year":"2015","unstructured":"Pasciuto E, Borrie SC, Kanellopoulos AK, Santos AR, Cappuyns E, D'Andrea L et al (2015). Autism spectrum disorders: translating human deficits into mouse behavior. Neurobiol Learn Mem 124: 71\u201387.","journal-title":"Neurobiol Learn Mem"},{"key":"BFnpp2015339_CR29","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3389\/fnana.2013.00004","volume":"7","author":"ME Porras-Garc\u00eda","year":"2013","unstructured":"Porras-Garc\u00eda ME, Ruiz R, P\u00e9rez-Villegas EM, Armengol J\u00c1 (2013). Motor learning of mice lacking cerebellar Purkinje cells. Front Neuroanat 7: 4.","journal-title":"Front Neuroanat"},{"key":"BFnpp2015339_CR30","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3389\/fnsys.2013.00083","volume":"7","author":"SL Reeber","year":"2013","unstructured":"Reeber SL, Otis TS, Sillitoe RV (2013). New roles for the cerebellum in health and disease. Front Syst Neurosci 7: 83.","journal-title":"Front Syst Neurosci"},{"key":"BFnpp2015339_CR31","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.nbd.2012.10.014","volume":"51","author":"RM Reith","year":"2013","unstructured":"Reith RM, McKenna J, Wu H, Hashmi SS, Cho SH, Dash PK et al (2013). Loss of Tsc2 in Purkinje cells is associated with autistic-like behavior in a mouse model of tuberous sclerosis complex. Neurobiol Dis 51: 93\u2013103.","journal-title":"Neurobiol Dis"},{"key":"BFnpp2015339_CR32","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.nbd.2011.02.014","volume":"43","author":"RM Reith","year":"2011","unstructured":"Reith RM, Way S, McKenna J 3rd, Haines K, Gambello MJ (2011). Loss of the tuberous sclerosis complex protein tuberin causes Purkinje cell degeneration. Neurobiol Dis 43: 113\u2013122.","journal-title":"Neurobiol Dis"},{"key":"BFnpp2015339_CR33","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1002\/syn.20960","volume":"65","author":"TD Rogers","year":"2011","unstructured":"Rogers TD, Dickson PE, Heck DH, Goldowitz D, Mittleman G, Blaha CD (2011). Connecting the dots of the cerebro-cerebellar role in cognitive function: neuronal pathways for cerebellar modulation of dopamine release in the prefrontal cortex. Synapse 65: 1204\u20131212.","journal-title":"Synapse"},{"key":"BFnpp2015339_CR34","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.bbr.2009.11.031","volume":"208","author":"BC Ryan","year":"2010","unstructured":"Ryan BC, Young NB, Crawley JN, Bodfish JW, Moy SS (2010). Social deficits, stereotypy and early emergence of repetitive behavior in the C58\/J inbred mouse strain. Behav Brain Res 208: 178\u2013188.","journal-title":"Behav Brain Res"},{"key":"BFnpp2015339_CR35","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1080\/14734220600791477","volume":"5","author":"PK Safo","year":"2006","unstructured":"Safo PK, Cravatt BF, Regehr WG (2006). Retrograde endocannabinoid signaling in the cerebellar cortex. Cerebellum 5: 134\u2013145.","journal-title":"Cerebellum"},{"key":"BFnpp2015339_CR36","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/S1364-6613(98)01218-2","volume":"2","author":"JD Schmahmann","year":"1998","unstructured":"Schmahmann JD (1998). Dysmetria of thought: clinical consequences of cerebellar dysfunction on cognition and affect. Trends Cogn Sci 2: 362\u2013371.","journal-title":"Trends Cogn Sci"},{"key":"BFnpp2015339_CR37","doi-asserted-by":"publisher","first-page":"e81255","DOI":"10.1371\/journal.pone.0081255","volume":"9","author":"J Skefos","year":"2014","unstructured":"Skefos J, Cummings C, Enzer K, Holiday J, Weed K, Levy E et al (2014). Regional alterations in purkinje cell density in patients with autism. PLoS One 9: e81255.","journal-title":"PLoS One"},{"key":"BFnpp2015339_CR38","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/nrm3330","volume":"13","author":"MS Song","year":"2012","unstructured":"Song MS, Salmena L, Pandolfi PP (2012). The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol 13: 283\u2013296.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFnpp2015339_CR39","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1146\/annurev.neuro.31.060407.125606","volume":"32","author":"PL Strick","year":"2009","unstructured":"Strick PL, Dum RP, Fiez JA (2009). Cerebellum and nonmotor function. Annu Rev Neurosci 32: 413\u2013434.","journal-title":"Annu Rev Neurosci"},{"key":"BFnpp2015339_CR40","doi-asserted-by":"publisher","first-page":"4738","DOI":"10.1073\/pnas.1222803110","volume":"110","author":"K Takeuchi","year":"2013","unstructured":"Takeuchi K, Gertner MJ, Zhou J, Parada LF, Bennett MV, Zukin RS (2013). Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism. Proc Natl Acad Sci USA 110: 4738\u20134743.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFnpp2015339_CR41","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/nature11310","volume":"488","author":"PT Tsai","year":"2012","unstructured":"Tsai PT, Hull C, Chu Y, Greene-Colozzi E, Sadowski AR, Leech JM et al (2012). Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice. Nature 488: 647\u2013651.","journal-title":"Nature"},{"key":"BFnpp2015339_CR42","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.neuron.2014.07.016","volume":"83","author":"SS Wang","year":"2014","unstructured":"Wang SS, Kloth AD, Badura A (2014). The cerebellum, sensitive periods, and autism. Neuron 83: 518\u2013532.","journal-title":"Neuron"},{"key":"BFnpp2015339_CR43","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/s40478-014-0141-7","volume":"2","author":"J Wegiel","year":"2014","unstructured":"Wegiel J, Flory M, Kuchna I, Nowicki K, Ma SY, Imaki H et al (2014). Stereological study of the neuronal number and volume of 38 brain subdivisions of subjects diagnosed with autism reveals significant alterations restricted to the striatum, amygdala and cerebellum. Acta Neuropathol Commun 2: 141.","journal-title":"Acta Neuropathol Commun"},{"key":"BFnpp2015339_CR44","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1007\/s12311-008-0043-y","volume":"7","author":"ER Whitney","year":"2008","unstructured":"Whitney ER, Kemper TL, Bauman ML, Rosene DL, Blatt GJ (2008). Cerebellar Purkinje cells are reduced in a subpopulation of autistic brains: a stereological experiment using calbindin-D28k. Cerebellum 7: 406\u2013416.","journal-title":"Cerebellum"},{"key":"BFnpp2015339_CR45","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/nature11208","volume":"486","author":"H Won","year":"2012","unstructured":"Won H, Lee HR, Gee HY, Mah W, Kim JI, Lee J et al (2012). Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function. Nature 486: 261\u2013265.","journal-title":"Nature"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/npp2015339.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2015339","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2015339.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T23:53:39Z","timestamp":1684454019000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/npp2015339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,5]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["BFnpp2015339"],"URL":"https:\/\/doi.org\/10.1038\/npp.2015.339","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,5]]},"assertion":[{"value":"5 July 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}