{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:33:33Z","timestamp":1782398013037,"version":"3.54.5"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T00:00:00Z","timestamp":1466121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1038\/npp.2016.100","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T12:34:18Z","timestamp":1466166858000},"page":"2882-2892","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":112,"title":["ProBDNF Signaling Regulates Depression-Like Behaviors in Rodents under Chronic Stress"],"prefix":"10.1038","volume":"41","author":[{"given":"Yin-Yin","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Sheng","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Rui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Long","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Qing","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Fu","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa","family":"Bobrovskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Fu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,6,17]]},"reference":[{"key":"BFnpp2016100_CR1","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.biopsych.2009.02.007","volume":"66","author":"AE Autry","year":"2009","unstructured":"Autry AE, Adachi M, Cheng P, Monteggia LM (2009). Gender-specific impact of brain-derived neurotrophic factor signaling on stress-induced depression-like behavior. Biol Psychiatry 66: 84\u201390.","journal-title":"Biol Psychiatry"},{"key":"BFnpp2016100_CR2","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.bbr.2014.02.022","volume":"265","author":"W Cao","year":"2014","unstructured":"Cao W, Duan J, Wang X, Zhong X, Hu Z, Huang F et al (2014). Early enriched environment induces an increased conversion of proBDNF to BDNF in the adult rat's hippocampus. Behav Brain Res 265: 76\u201383.","journal-title":"Behav Brain Res"},{"key":"BFnpp2016100_CR3","doi-asserted-by":"publisher","first-page":"13123","DOI":"10.1073\/pnas.1003825107","volume":"107","author":"Y Chen","year":"2010","unstructured":"Chen Y, Rex CS, Rice CJ, Dub\u00e9 CM, Gall CM, Lynch G et al (2010). Correlated memory defects and hippocampal dendritic spine loss after acute stress involve corticotropin-releasing hormone signaling. Proc Natl Acad Sci USA 107: 13123\u201313128.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFnpp2016100_CR4","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.neubiorev.2010.07.003","volume":"35","author":"S Chourbaji","year":"2011","unstructured":"Chourbaji S, Brandwein C, Gass P (2011). Altering BDNF expression by genetics and\/or environment: impact for emotional and depression-like behaviour in laboratory mice. Neurosci Biobehav Rev 35: 599\u2013611.","journal-title":"Neurosci Biobehav Rev"},{"key":"BFnpp2016100_CR5","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.neuroscience.2012.06.016","volume":"220","author":"S Chourbaji","year":"2012","unstructured":"Chourbaji S, H\u00f6rtnagl H, Molteni R, Riva M, Gass P, Hellweg R (2012). The impact of environmental enrichment on sex-specific neurochemical circuitries\u2013effects on brain-derived neurotrophic factor and the serotonergic system. Neuroscience 220: 267\u2013276.","journal-title":"Neuroscience"},{"key":"BFnpp2016100_CR6","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.biopsych.2006.02.013","volume":"59","author":"RS Duman","year":"2006","unstructured":"Duman RS, Monteggia LM (2006). A neurotrophic model for stress-related mood disorders. Biol Psychiatry 59: 1116\u20131127.","journal-title":"Biol Psychiatry"},{"key":"BFnpp2016100_CR7","doi-asserted-by":"publisher","first-page":"2380","DOI":"10.1111\/j.1460-9568.2008.06215.x","volume":"27","author":"YJ Fan","year":"2008","unstructured":"Fan YJ, Wu LL, HY Li, Wang YJ, Zhou XF (2008). Differential effects of pro-BDNF on sensory neurons after sciatic nerve transection in neonatal rats. Eur J Neurosci 27: 2380\u20132390.","journal-title":"Eur J Neurosci"},{"key":"BFnpp2016100_CR8","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1159\/000054681","volume":"74","author":"L Givalois","year":"2001","unstructured":"Givalois L, Marmigere F, Rage F, Ixart G, Arancibia S, Tapia-Arancibia L (2001). Immobilization stress rapidly and differentially modulates BDNF and TrkB mRNA expression in the pituitary gland of adult male rats. Neuroendocrinology 74: 148\u2013159.","journal-title":"Neuroendocrinology"},{"key":"BFnpp2016100_CR9","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1146\/annurev.neuro.24.1.677","volume":"24","author":"EJ Huang","year":"2001","unstructured":"Huang EJ, Reichardt LF (2001). Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 24: 677.","journal-title":"Annu Rev Neurosci"},{"key":"BFnpp2016100_CR10","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1038\/sj.npp.1300382","volume":"29","author":"UE Lang","year":"2004","unstructured":"Lang UE, Hellweg R, Gallinat J (2004). BDNF serum concentrations in healthy volunteers are associated with depression-related personality traits. Neuropsychopharmacology 29: 795\u2013798.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2016100_CR11","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.jad.2006.11.005","volume":"101","author":"BH Lee","year":"2007","unstructured":"Lee BH, Kim H, Park SH, Kim YK (2007). Decreased plasma BDNF level in depressive patients. J Affect Disord 101: 239\u2013244.","journal-title":"J Affect Disord"},{"key":"BFnpp2016100_CR12","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1126\/science.1065057","volume":"294","author":"R Lee","year":"2001","unstructured":"Lee R, Kermani P, Teng KK, Hempstead BL (2001). Regulation of cell survival by secreted proneurotrophins. Science 294: 1945\u20131948.","journal-title":"Science"},{"key":"BFnpp2016100_CR13","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1146\/annurev.ne.19.030196.001445","volume":"19","author":"GR Lewin","year":"1996","unstructured":"Lewin GR, Barde Y-A (1996). Physiology of the neurotrophins. Annu Rev Neurosci 19: 289\u2013317.","journal-title":"Annu Rev Neurosci"},{"key":"BFnpp2016100_CR14","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/j.biopsych.2010.12.015","volume":"69","author":"N Li","year":"2011","unstructured":"Li N, Liu R-J, Dwyer JM, Banasr M, Lee B, Son H et al (2011). Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure. Biol Psychiatry 69: 754\u2013761.","journal-title":"Biol Psychiatry"},{"key":"BFnpp2016100_CR15","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/jnc.13108","volume":"134","author":"Y Lim","year":"2015","unstructured":"Lim Y, Zhong JH, Zhou XF (2015). Development of mature BDNF-specific sandwich ELISA. J Neurochem 134: 75\u201385.","journal-title":"J Neurochem"},{"key":"BFnpp2016100_CR16","doi-asserted-by":"publisher","first-page":"7539","DOI":"10.1523\/JNEUROSCI.15-11-07539.1995","volume":"15","author":"M Nibuya","year":"1995","unstructured":"Nibuya M, Morinobu S, Duman RS (1995). Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci 15: 7539\u20137547.","journal-title":"J Neurosci"},{"key":"BFnpp2016100_CR17","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1523\/JNEUROSCI.16-07-02365.1996","volume":"16","author":"M Nibuya","year":"1996","unstructured":"Nibuya M, Nestler EJ, Duman RS (1996). Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. J Neurosci 16: 2365\u20132372.","journal-title":"J Neurosci"},{"key":"BFnpp2016100_CR18","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/nature02319","volume":"427","author":"A Nykjaer","year":"2004","unstructured":"Nykjaer A, Lee R, Teng KK, Jansen P, Madsen P, Nielsen MS et al (2004). Sortilin is essential for proNGF-induced neuronal cell death. Nature 427: 843\u2013848.","journal-title":"Nature"},{"key":"BFnpp2016100_CR19","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/j.psyneuen.2005.04.009","volume":"30","author":"M Olff","year":"2005","unstructured":"Olff M, Langeland W, Gersons BP (2005). The psychobiology of PTSD: coping with trauma. Psychoneuroendocrinology 30: 974\u2013982.","journal-title":"Psychoneuroendocrinology"},{"key":"BFnpp2016100_CR20","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.jad.2007.05.005","volume":"105","author":"A Piccinni","year":"2008","unstructured":"Piccinni A, Marazziti D, Catena M, Domenici L, Del Debbio A, Bianchi C et al (2008). Plasma and serum brain-derived neurotrophic factor (BDNF) in depressed patients during 1 year of antidepressant treatments. J Affect Disord 105: 279\u2013283.","journal-title":"J Affect Disord"},{"key":"BFnpp2016100_CR21","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1093\/cercor\/bhi104","volume":"16","author":"JJ Radley","year":"2006","unstructured":"Radley JJ, Rocher AB, Miller M, Janssen WG, Liston C, Hof PR et al (2006). Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex. Cerebral Cortex 16: 313\u2013320.","journal-title":"Cerebral Cortex"},{"key":"BFnpp2016100_CR22","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.neuroscience.2015.02.037","volume":"293","author":"C Ruan","year":"2015","unstructured":"Ruan C, Zhou F, He Z, Wang S, Yang C, Shen Y et al (2015). Mice deficient for wild-type p53-induced phosphatase 1 display elevated anxiety-and depression-like behaviors. Neuroscience 293: 12\u201322.","journal-title":"Neuroscience"},{"key":"BFnpp2016100_CR23","doi-asserted-by":"publisher","first-page":"2680","DOI":"10.1111\/ejn.12618","volume":"40","author":"CS Ruan","year":"2014","unstructured":"Ruan CS, Wang SF, Shen YJ, Guo Y, Yang CR, Zhou FH et al (2014). Deletion of TRIM32 protects mice from anxiety-and depression-like behaviors under mild stress. Eur J Neurosci 40: 2680\u20132690.","journal-title":"Eur J Neurosci"},{"key":"BFnpp2016100_CR24","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.neuroscience.2011.02.055","volume":"180","author":"C Sartori","year":"2011","unstructured":"Sartori C, Vieira A, Ferrari E, Langone F, Tongiorgi E, Parada C (2011). The antidepressive effect of the physical exercise correlates with increased levels of mature BDNF, and proBDNF proteolytic cleavage-related genes, p11 and tPA. Neuroscience 180: 9\u201318.","journal-title":"Neuroscience"},{"key":"BFnpp2016100_CR25","first-page":"29","volume":"2","author":"D Schechter","year":"1998","unstructured":"Schechter D (1998). Estrogen, progesterone, and mood. J Gend Specif Med 2: 29\u201336.","journal-title":"J Gend Specif Med"},{"key":"BFnpp2016100_CR26","doi-asserted-by":"publisher","first-page":"2378","DOI":"10.1038\/npp.2010.114","volume":"35","author":"HD Schmidt","year":"2010","unstructured":"Schmidt HD, Duman RS (2010). Peripheral BDNF produces antidepressant-like effects in cellular and behavioral models. Neuropsychopharmacology 35: 2378\u20132391.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2016100_CR27","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1017\/S1461145712000053","volume":"16","author":"M Segawa","year":"2013","unstructured":"Segawa M, Morinobu S, Matsumoto T, Fuchikami M, Yamawaki S (2013). Electroconvulsive seizure, but not imipramine, rapidly up-regulates pro-BDNF and t-PA, leading to mature BDNF production, in the rat hippocampus. Int J Neuropsychopharmacol 16: 339\u2013350.","journal-title":"Int J Neuropsychopharmacol"},{"key":"BFnpp2016100_CR28","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1210\/jcem-72-2-336","volume":"72","author":"BB Sherwin","year":"1991","unstructured":"Sherwin BB (1991). The impact of different doses of estrogen and progestin on mood and sexual behavior in postmenopausal women. J Clin Endocrinol Metabol 72: 336\u2013343.","journal-title":"J Clin Endocrinol Metabol"},{"key":"BFnpp2016100_CR29","doi-asserted-by":"publisher","first-page":"3251","DOI":"10.1523\/JNEUROSCI.22-08-03251.2002","volume":"22","author":"Y Shirayama","year":"2002","unstructured":"Shirayama Y, AC-H Chen, Nakagawa S, Russell DS, Duman RS (2002). Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J Neurosci 22: 3251\u20133261.","journal-title":"J Neurosci"},{"issue":"12","key":"BFnpp2016100_CR30","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1016\/j.euroneuro.2015.09.002","volume":"25","author":"Yukihiko Shirayama","year":"2015","unstructured":"Shirayama Y, Yang C, Zhang JC, Ren Q, Yao W, Hashimoto K (2015). Alterations in brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain regions of a learned helplessness rat model and the antidepressant effects of a TrkB agonist and antagonist. Eur Neuropsychopharmacol.","journal-title":"European Neuropsychopharmacology"},{"key":"BFnpp2016100_CR31","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/S0091-3057(96)00169-4","volume":"56","author":"JA Siuciak","year":"1997","unstructured":"Siuciak JA, Lewis DR, Wiegand SJ, Lindsay RM (1997). Antidepressant-like effect of brain-derived neurotrophic factor (BDNF). Pharmacol Biochem Behav 56: 131\u2013137.","journal-title":"Pharmacol Biochem Behav"},{"key":"BFnpp2016100_CR32","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1523\/JNEUROSCI.15-03-01768.1995","volume":"15","author":"MA Smith","year":"1995","unstructured":"Smith MA, Makino S, Kvetnansky R, Post RM (1995). Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J Neurosci 15: 1768\u20131777.","journal-title":"J Neurosci"},{"key":"BFnpp2016100_CR33","doi-asserted-by":"publisher","first-page":"e35883","DOI":"10.1371\/journal.pone.0035883","volume":"7","author":"Y Sun","year":"2012","unstructured":"Sun Y, Lim Y, Li F, Liu S, Lu JJ, Haberberger R et al (2012). ProBDNF collapses neurite outgrowth of primary neurons by activating RhoA. PLoS One 7: e35883.","journal-title":"PLoS One"},{"key":"BFnpp2016100_CR34","doi-asserted-by":"publisher","first-page":"5455","DOI":"10.1523\/JNEUROSCI.5123-04.2005","volume":"25","author":"HK Teng","year":"2005","unstructured":"Teng HK, Teng KK, Lee R, Wright S, Tevar S, Almeida RD et al (2005). ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J Neurosci 25: 5455\u20135463.","journal-title":"J Neurosci"},{"key":"BFnpp2016100_CR35","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1523\/JNEUROSCI.17-08-02785.1997","volume":"17","author":"VA Vaidya","year":"1997","unstructured":"Vaidya VA, Marek GJ, Aghajanian GK, Duman RS (1997). 5-HT2A receptor-mediated regulation of brain-derived neurotrophic factor mRNA in the hippocampus and the neocortex. J Neurosci 17: 2785\u20132795.","journal-title":"J Neurosci"},{"key":"BFnpp2016100_CR36","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/0024-3205(74)90345-2","volume":"15","author":"DT Wong","year":"1974","unstructured":"Wong DT, Horng JS, Bymaster FP, Hauser KL, Molloy BB (1974). A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine. Life Sciences 15: 471\u2013479.","journal-title":"Life Sciences"},{"key":"BFnpp2016100_CR37","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/nn1510","volume":"8","author":"NH Woo","year":"2005","unstructured":"Woo NH, Teng HK, Siao CJ, Chiaruttini C, Pang PT, Milner TA et al (2005). Activation of p75NTR by proBDNF facilitates hippocampal long-term depression. Nat Neurosci 8: 1069\u20131077.","journal-title":"Nat Neurosci"},{"key":"BFnpp2016100_CR38","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1111\/j.1460-9568.2011.07635.x","volume":"33","author":"ZQ Xu","year":"2011","unstructured":"Xu ZQ, Sun Y, Li HY, Lim Y, Zhong JH, Zhou XF (2011). Endogenous proBDNF is a negative regulator of migration of cerebellar granule cells in neonatal mice. Eur J Neurosci 33: 1376\u20131384.","journal-title":"Eur J Neurosci"},{"key":"BFnpp2016100_CR39","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s12640-014-9498-4","volume":"27","author":"CR Yang","year":"2015","unstructured":"Yang CR, Bai YY, Ruan CS, Zhou HF, Liu D, Wang XF et al (2015). Enhanced aggressive behaviour in a mouse model of depression. Neurotox Res 27: 129\u2013142.","journal-title":"Neurotox Res"},{"key":"BFnpp2016100_CR40","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s12640-013-9411-6","volume":"25","author":"CR Yang","year":"2014","unstructured":"Yang CR, Zhang ZG, Bai YY, Zhou HF, Zhou L, Ruan CS et al (2014). Foraging activity is reduced in a mouse model of depression. Neurotox Res 25: 235\u2013247.","journal-title":"Neurotox Res"},{"key":"BFnpp2016100_CR41","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/j.jad.2013.03.002","volume":"150","author":"L Zhou","year":"2013","unstructured":"Zhou L, Xiong J, Lim Y, Ruan Y, Huang C, Zhu Y et al (2013). Upregulation of blood proBDNF and its receptors in major depression. J Affect Disord 150: 776\u2013784.","journal-title":"J Affect Disord"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/npp2016100.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2016100","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2016100.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T23:54:51Z","timestamp":1684454091000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/npp2016100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,17]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["BFnpp2016100"],"URL":"https:\/\/doi.org\/10.1038\/npp.2016.100","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,17]]},"assertion":[{"value":"10 January 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}