{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:09:47Z","timestamp":1792008587386,"version":"4.4.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"13","license":[{"start":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T00:00:00Z","timestamp":1467936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1038\/npp.2016.120","type":"journal-article","created":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T07:01:23Z","timestamp":1467961283000},"page":"3070-3079","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["Brain-Derived Neurotrophic Factor Val66Met Human Polymorphism Impairs the Beneficial Exercise-Induced Neurobiological Changes in Mice"],"prefix":"10.1038","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6737-7695","authenticated-orcid":false,"given":"Alessandro","family":"Ieraci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro I","family":"Madaio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Mallei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis S","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Popoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,8]]},"reference":[{"key":"BFnpp2016120_CR1","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.biopsych.2007.09.019","volume":"63","author":"M Adachi","year":"2008","unstructured":"Adachi M, Barrot M, Autry AE, Theobald D, Monteggia LM (2008). Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy. Biol Psychiatry 63: 642\u2013649.","journal-title":"Biol Psychiatry"},{"key":"BFnpp2016120_CR2","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1002\/jnr.21139","volume":"85","author":"T Aid","year":"2007","unstructured":"Aid T, Kazantseva A, Piirsoo M, Palm K, Timmusk T (2007). Mouse and rat BDNF gene structure and expression revisited. J Neurosci Res 85: 525\u2013535.","journal-title":"J Neurosci Res"},{"key":"BFnpp2016120_CR3","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1038\/npp.2012.5","volume":"37","author":"G Baj","year":"2012","unstructured":"Baj G, D'Alessandro V, Musazzi L, Mallei A, Sartori CR, Sciancalepore M et al (2012). Physical exercise and antidepressants enhance BDNF targeting in hippocampal CA3 dendrites: further evidence of a spatial code for BDNF splice variants. Neuropsychopharmacology 37: 1600\u20131611.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2016120_CR4","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1002\/hipo.22100","volume":"23","author":"G Baj","year":"2013","unstructured":"Baj G, Del Turco D, Schlaudraff J, Torelli L, Deller T, Tongiorgi E (2013). Regulation of the spatial code for BDNF mRNA isoforms in the rat hippocampus following pilocarpine-treatment: a systematic analysis using laser microdissection and quantitative real-time PCR. Hippocampus 23: 413\u2013423.","journal-title":"Hippocampus"},{"key":"BFnpp2016120_CR5","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1038\/npp.2011.318","volume":"37","author":"KG Bath","year":"2012","unstructured":"Bath KG, Jing DQ, Dincheva I, Neeb CC, Pattwell SS, Chao MV et al (2012). BDNF Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticity. Neuropsychopharmacology 37: 1297\u20131304.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2016120_CR6","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nature10777","volume":"481","author":"P Bostrom","year":"2012","unstructured":"Bostrom P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC et al (2012). A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481: 463\u2013468.","journal-title":"Nature"},{"key":"BFnpp2016120_CR7","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1212\/WNL.0000000000000867","volume":"83","author":"BM Brown","year":"2014","unstructured":"Brown BM, Bourgeat P, Peiffer JJ, Burnham S, Laws SM, Rainey-Smith SR et al (2014). Influence of BDNF Val66Met on the relationship between physical activity and brain volume. Neurology 83: 1345\u20131352.","journal-title":"Neurology"},{"key":"BFnpp2016120_CR8","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.expneurol.2012.06.033","volume":"237","author":"O Carreton","year":"2012","unstructured":"Carreton O, Giralt A, Torres-Peraza JF, Brito V, Lucas JJ, Gines S et al (2012). Age-dependent decline of motor neocortex but not hippocampal performance in heterozygous BDNF mice correlates with a decrease of cortical PSD-95 but an increase of hippocampal TrkB levels. Exp Neurol 237: 335\u2013345.","journal-title":"Exp Neurol"},{"key":"BFnpp2016120_CR9","doi-asserted-by":"publisher","first-page":"5761","DOI":"10.1091\/mbc.e05-07-0651","volume":"16","author":"ZY Chen","year":"2005","unstructured":"Chen ZY, Ieraci A, Tanowitz M, Lee FS (2005). A novel endocytic recycling signal distinguishes biological responses of Trk neurotrophin receptors. Mol Biol Cell 16: 5761\u20135772.","journal-title":"Mol Biol Cell"},{"key":"BFnpp2016120_CR10","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1126\/science.1129663","volume":"314","author":"ZY Chen","year":"2006","unstructured":"Chen ZY, Jing D, Bath KG, Ieraci A, Khan T, Siao CJ et al (2006). Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science 314: 140\u2013143.","journal-title":"Science"},{"key":"BFnpp2016120_CR11","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s12017-008-8033-2","volume":"10","author":"BR Christie","year":"2008","unstructured":"Christie BR, Eadie BD, Kannangara TS, Robillard JM, Shin J, Titterness AK (2008). Exercising our brains: how physical activity impacts synaptic plasticity in the dentate gyrus. Neuromolecular Med 10: 47\u201358.","journal-title":"Neuromolecular Med"},{"key":"BFnpp2016120_CR12","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1159\/000223730","volume":"59","author":"A Deslandes","year":"2009","unstructured":"Deslandes A, Moraes H, Ferreira C, Veiga H, Silveira H, Mouta R et al (2009). Exercise and mental health: many reasons to move. Neuropsychobiology 59: 191\u2013198.","journal-title":"Neuropsychobiology"},{"key":"BFnpp2016120_CR13","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.brainres.2007.12.047","volume":"1199","author":"CH Duman","year":"2008","unstructured":"Duman CH, Schlesinger L, Russell DS, Duman RS (2008). Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice. Brain Res 1199: 148\u2013158.","journal-title":"Brain Res"},{"key":"BFnpp2016120_CR14","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0092-8674(03)00035-7","volume":"112","author":"MF Egan","year":"2003","unstructured":"Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A et al (2003). The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112: 257\u2013269.","journal-title":"Cell"},{"key":"BFnpp2016120_CR15","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.neuroscience.2003.09.029","volume":"124","author":"J Farmer","year":"2004","unstructured":"Farmer J, Zhao X, van Praag H, Wodtke K, Gage FH, Christie BR (2004). Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo. Neuroscience 124: 71\u201379.","journal-title":"Neuroscience"},{"key":"BFnpp2016120_CR16","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.psychres.2014.03.028","volume":"218","author":"S Gujral","year":"2014","unstructured":"Gujral S, Manuck SB, Ferrell RE, Flory JD, Erickson KI (2014). The BDNF Val66Met polymorphism does not moderate the effect of self-reported physical activity on depressive symptoms in midlife. Psychiatry Res 218: 93\u201397.","journal-title":"Psychiatry Res"},{"key":"BFnpp2016120_CR17","first-page":"1543","volume":"33","author":"H Hagihara","year":"2009","unstructured":"Hagihara H, Toyama K, Yamasaki N, Miyakawa T (2009). Dissection of hippocampal dentate gyrus from adult mouse. J Vis Exp 33: 1543.","journal-title":"J Vis Exp"},{"key":"BFnpp2016120_CR18","doi-asserted-by":"publisher","first-page":"6690","DOI":"10.1523\/JNEUROSCI.23-17-06690.2003","volume":"23","author":"AR Hariri","year":"2003","unstructured":"Hariri AR, Goldberg TE, Mattay VS, Kolachana BS, Callicott JH, Egan MF et al (2003). Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J Neurosci 23: 6690\u20136694.","journal-title":"J Neurosci"},{"key":"BFnpp2016120_CR19","doi-asserted-by":"publisher","first-page":"2368","DOI":"10.1038\/npp.2015.85","volume":"40","author":"AS Hill","year":"2015","unstructured":"Hill AS, Sahay A, Hen R (2015). Increasing adult hippocampal neurogenesis is sufficient to reduce anxiety and depression-like behaviors. Neuropsychopharmacology 40: 2368\u20132378.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2016120_CR20","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.neuroscience.2012.04.056","volume":"215","author":"ME Hopkins","year":"2012","unstructured":"Hopkins ME, Davis FC, Vantieghem MR, Whalen PJ, Bucci DJ (2012). Differential effects of acute and regular physical exercise on cognition and affect. Neuroscience 215: 59\u201368.","journal-title":"Neuroscience"},{"key":"BFnpp2016120_CR21","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.neuroscience.2011.07.071","volume":"194","author":"ME Hopkins","year":"2011","unstructured":"Hopkins ME, Nitecki R, Bucci DJ (2011). Physical exercise during adolescence versus adulthood: differential effects on object recognition memory and brain-derived neurotrophic factor levels. Neuroscience 194: 84\u201394.","journal-title":"Neuroscience"},{"key":"BFnpp2016120_CR22","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1002\/hipo.22458","volume":"25","author":"A Ieraci","year":"2015","unstructured":"Ieraci A, Mallei A, Musazzi L, Popoli M (2015). Physical exercise and acute restraint stress differentially modulate hippocampal brain-derived neurotrophic factor transcripts and epigenetic mechanisms in mice. Hippocampus 25: 1380\u20131392.","journal-title":"Hippocampus"},{"key":"BFnpp2016120_CR23","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1038\/npp.2013.104","volume":"38","author":"KA Intlekofer","year":"2013","unstructured":"Intlekofer KA, Berchtold NC, Malvaez M, Carlos AJ, McQuown SC, Cunningham MJ et al (2013). Exercise and sodium butyrate transform a subthreshold learning event into long-term memory via a brain-derived neurotrophic factor-dependent mechanism. Neuropsychopharmacology 38: 2027\u20132034.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2016120_CR24","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.jpsychires.2014.05.009","volume":"56","author":"P Jedynak","year":"2014","unstructured":"Jedynak P, Kos T, Sandi C, Kaczmarek L, Filipkowski RK (2014). Mice with ablated adult brain neurogenesis are not impaired in antidepressant response to chronic fluoxetine. J Psychiatr Res 56: 106\u2013111.","journal-title":"J Psychiatr Res"},{"key":"BFnpp2016120_CR25","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1152\/physiolgenomics.00086.2015","volume":"48","author":"JR Lemos Jr","year":"2016","unstructured":"Lemos JR Jr, Alves CR, de Souza SB, Marsiglia JD, Silva MS, Pereira AC et al (2016). Peripheral vascular reactivity and serum BDNF responses to aerobic training are impaired by the BDNF Val66Met polymorphism. Physiol Genomics 48: 116\u2013123.","journal-title":"Physiol Genomics"},{"key":"BFnpp2016120_CR26","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.neuron.2008.06.023","volume":"59","author":"Y Li","year":"2008","unstructured":"Li Y, Luikart BW, Birnbaum S, Chen J, Kwon CH, Kernie SG et al (2008). TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment. Neuron 59: 399\u2013412.","journal-title":"Neuron"},{"key":"BFnpp2016120_CR27","doi-asserted-by":"publisher","first-page":"e86498","DOI":"10.1371\/journal.pone.0086498","volume":"9","author":"YY Lim","year":"2014","unstructured":"Lim YY, Villemagne VL, Laws SM, Ames D, Pietrzak RH, Ellis KA et al (2014). Effect of BDNF Val66Met on memory decline and hippocampal atrophy in prodromal Alzheimer's disease: a preliminary study. PLoS One 9: e86498.","journal-title":"PLoS One"},{"key":"BFnpp2016120_CR28","doi-asserted-by":"publisher","first-page":"143","DOI":"10.3389\/fnbeh.2014.00143","volume":"8","author":"JS Lindholm","year":"2014","unstructured":"Lindholm JS, Castren E (2014). Mice with altered BDNF signaling as models for mood disorders and antidepressant effects. Front Behav Neurosci 8: 143.","journal-title":"Front Behav Neurosci"},{"key":"BFnpp2016120_CR29","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1016\/j.biopsych.2011.09.030","volume":"71","author":"RJ Liu","year":"2012","unstructured":"Liu RJ, Lee FS, Li XY, Bambico F, Duman RS, Aghajanian GK (2012). Brain-derived neurotrophic factor Val66 Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex. Biol Psychiatry 71: 996\u20131005.","journal-title":"Biol Psychiatry"},{"key":"BFnpp2016120_CR30","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.nlm.2008.02.005","volume":"90","author":"YF Liu","year":"2008","unstructured":"Liu YF, Chen HI, Yu L, Kuo YM, Wu FS, Chuang JI et al (2008). Upregulation of hippocampal TrkB and synaptotagmin is involved in treadmill exercise-enhanced aversive memory in mice. Neurobiol Learn Mem 90: 81\u201389.","journal-title":"Neurobiol Learn Mem"},{"key":"BFnpp2016120_CR31","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.pneurobio.2011.05.003","volume":"94","author":"MR Lyons","year":"2011","unstructured":"Lyons MR, West AE (2011). Mechanisms of specificity in neuronal activity-regulated gene transcription. Prog Neurobiol 94: 259\u2013295.","journal-title":"Prog Neurobiol"},{"key":"BFnpp2016120_CR32","doi-asserted-by":"publisher","first-page":"pii: pyv069","DOI":"10.1093\/ijnp\/pyv069","volume":"18","author":"A Mallei","year":"2015","unstructured":"Mallei A, Baj G, Ieraci A, Corna S, Musazzi L, Lee FS et al (2015). Expression and dendritic trafficking of BDNF-6 splice variant are impaired in knock-in mice carrying human BDNF Val66Met polymorphism. Int J Neuropsychopharmacol 18: pii: pyv069.","journal-title":"Int J Neuropsychopharmacol"},{"key":"BFnpp2016120_CR33","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1037\/a0017261","volume":"29","author":"J Mata","year":"2010","unstructured":"Mata J, Thompson RJ, Gotlib IH (2010). BDNF genotype moderates the relation between physical activity and depressive symptoms. Health Psychol 29: 130\u2013133.","journal-title":"Health Psychol"},{"key":"BFnpp2016120_CR34","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.arr.2014.12.011","volume":"20","author":"MP Mattson","year":"2015","unstructured":"Mattson MP (2015). Lifelong brain health is a lifelong challenge: from evolutionary principles to empirical evidence. Ageing Res Rev 20: 37\u201345.","journal-title":"Ageing Res Rev"},{"key":"BFnpp2016120_CR35","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1038\/nn1696","volume":"9","author":"D Meshi","year":"2006","unstructured":"Meshi D, Drew MR, Saxe M, Ansorge MS, David D, Santarelli L et al (2006). Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment. Nat Neurosci 9: 729\u2013731.","journal-title":"Nat Neurosci"},{"key":"BFnpp2016120_CR36","doi-asserted-by":"publisher","first-page":"10827","DOI":"10.1073\/pnas.0402141101","volume":"101","author":"LM Monteggia","year":"2004","unstructured":"Monteggia LM, Barrot M, Powell CM, Berton O, Galanis V, Gemelli T et al (2004). Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci USA 101: 10827\u201310832.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFnpp2016120_CR37","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.biopsych.2006.03.021","volume":"61","author":"LM Monteggia","year":"2007","unstructured":"Monteggia LM, Luikart B, Barrot M, Theobold D, Malkovska I, Nef S et al (2007). Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors. Biol Psychiatry 61: 187\u2013197.","journal-title":"Biol Psychiatry"},{"key":"BFnpp2016120_CR38","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/1471-2202-10-48","volume":"10","author":"L Musazzi","year":"2009","unstructured":"Musazzi L, Cattaneo A, Tardito D, Barbon A, Gennarelli M, Barlati S et al (2009). Early raise of BDNF in hippocampus suggests induction of posttranscriptional mechanisms by antidepressants. BMC Neurosci 10: 48.","journal-title":"BMC Neurosci"},{"key":"BFnpp2016120_CR39","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3233\/JAD-140576","volume":"43","author":"CM Nascimento","year":"2015","unstructured":"Nascimento CM, Pereira JR, Pires de Andrade L, Garuffi M, Ayan C, Kerr DS et al (2015). Physical exercise improves peripheral BDNF levels and cognitive functions in mild cognitive impairment elderly with different bdnf Val66Met genotypes. J Alzheimers Dis 43: 81\u201391.","journal-title":"J Alzheimers Dis"},{"key":"BFnpp2016120_CR40","doi-asserted-by":"publisher","first-page":"8866","DOI":"10.1523\/JNEUROSCI.1405-10.2010","volume":"30","author":"I Ninan","year":"2010","unstructured":"Ninan I, Bath KG, Dagar K, Perez-Castro R, Plummer MR, Lee FS et al (2010). The BDNF Val66Met polymorphism impairs NMDA receptor-dependent synaptic plasticity in the hippocampus. J Neurosci 30: 8866\u20138870.","journal-title":"J Neurosci"},{"key":"BFnpp2016120_CR41","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1038\/mp.2015.27","volume":"20","author":"M Notaras","year":"2015","unstructured":"Notaras M, Hill R, van den Buuse M (2015). The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder susceptibility: progress and controversy. Mol Psychiatry 20: 916\u2013930.","journal-title":"Mol Psychiatry"},{"key":"BFnpp2016120_CR42","doi-asserted-by":"publisher","first-page":"170","DOI":"10.3389\/fncel.2014.00170","volume":"8","author":"C Phillips","year":"2014","unstructured":"Phillips C, Baktir MA, Srivatsan M, Salehi A (2014). Neuroprotective effects of physical activity on the brain: a closer look at trophic factor signaling. Front Cell Neurosci 8: 170.","journal-title":"Front Cell Neurosci"},{"key":"BFnpp2016120_CR43","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/nature09817","volume":"472","author":"A Sahay","year":"2011","unstructured":"Sahay A, Scobie KN, Hill AS, O'Carroll CM, Kheirbek MA, Burghardt NS et al (2011). Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation. Nature 472: 466\u2013470.","journal-title":"Nature"},{"key":"BFnpp2016120_CR44","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1126\/science.1083328","volume":"301","author":"L Santarelli","year":"2003","unstructured":"Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S et al (2003). Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301: 805\u2013809.","journal-title":"Science"},{"key":"BFnpp2016120_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neubiorev.2015.11.012","volume":"61","author":"FB Schuch","year":"2016","unstructured":"Schuch FB, Deslandes AC, Stubbs B, Gosmann NP, Silva CT, Fleck MP (2016). Neurobiological effects of exercise on major depressive disorder: A systematic review. Neurosci Biobehav Rev 61: 1\u201311.","journal-title":"Neurosci Biobehav Rev"},{"key":"BFnpp2016120_CR46","doi-asserted-by":"publisher","first-page":"8982","DOI":"10.1074\/jbc.275.12.8982","volume":"275","author":"MT Sommerfeld","year":"2000","unstructured":"Sommerfeld MT, Schweigreiter R, Barde YA, Hoppe E (2000). Down-regulation of the neurotrophin receptor TrkB following ligand binding. Evidence for an involvement of the proteasome and differential regulation of TrkA and TrkB. J Biol Chem 275: 8982\u20138990.","journal-title":"J Biol Chem"},{"key":"BFnpp2016120_CR47","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1002\/hipo.20348","volume":"17","author":"AM Stranahan","year":"2007","unstructured":"Stranahan AM, Khalil D, Gould E (2007). Running induces widespread structural alterations in the hippocampus and entorhinal cortex. Hippocampus 17: 1017\u20131022.","journal-title":"Hippocampus"},{"key":"BFnpp2016120_CR48","doi-asserted-by":"publisher","first-page":"13427","DOI":"10.1073\/pnas.96.23.13427","volume":"96","author":"H van Praag","year":"1999","unstructured":"van Praag H, Christie BR, Sejnowski TJ, Gage FH (1999). Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc Natl Acad Sci USA 96: 13427\u201313431.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFnpp2016120_CR49","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.1111\/j.1460-9568.2004.03720.x","volume":"20","author":"S Vaynman","year":"2004","unstructured":"Vaynman S, Ying Z, Gomez-Pinilla F (2004). Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur J Neurosci 20: 2580\u20132590.","journal-title":"Eur J Neurosci"},{"key":"BFnpp2016120_CR50","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/mp.2008.109","volume":"15","author":"M Verhagen","year":"2010","unstructured":"Verhagen M, van der Meij A, van Deurzen PA, Janzing JG, Arias-Vasquez A, Buitelaar JK et al (2010). Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity. Mol Psychiatry 15: 260\u2013271.","journal-title":"Mol Psychiatry"},{"key":"BFnpp2016120_CR51","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/7854_2012_220","volume":"15","author":"C Vivar","year":"2013","unstructured":"Vivar C, Potter MC, van Praag H (2013). All about running: synaptic plasticity, growth factors and adult hippocampal neurogenesis. Curr Top Behav Neurosci 15: 189\u2013210.","journal-title":"Curr Top Behav Neurosci"},{"key":"BFnpp2016120_CR52","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.tics.2013.08.001","volume":"17","author":"MW Voss","year":"2013","unstructured":"Voss MW, Vivar C, Kramer AF, van Praag H (2013). Bridging animal and human models of exercise-induced brain plasticity. Trends Cogn Sci 17: 525\u2013544.","journal-title":"Trends Cogn Sci"},{"key":"BFnpp2016120_CR53","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.cmet.2013.09.008","volume":"18","author":"CD Wrann","year":"2013","unstructured":"Wrann CD, White JP, Salogiannnis J, Laznik-Bogoslavski D, Wu J, Ma D et al (2013). Exercise induces hippocampal BDNF through a PGC-1alpha\/FNDC5 pathway. Cell Metab 18: 649\u2013659.","journal-title":"Cell Metab"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/npp2016120.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2016120","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2016120.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T19:55:01Z","timestamp":1684439701000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/npp2016120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,8]]},"references-count":53,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["BFnpp2016120"],"URL":"https:\/\/doi.org\/10.1038\/npp.2016.120","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726490332.793532666","asserted-by":"object"}]},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,8]]},"assertion":[{"value":"3 May 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}