{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:55:22Z","timestamp":1790704522858,"version":"4.1.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"13","license":[{"start":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T00:00:00Z","timestamp":1470182400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1038\/npp.2016.144","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T11:02:10Z","timestamp":1470222130000},"page":"3103-3113","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Neuronal Deletion of Kmt2a\/Mll1 Histone Methyltransferase in Ventral Striatum is Associated with Defective Spike-Timing-Dependent Striatal Synaptic Plasticity, Altered Response to Dopaminergic Drugs, and Increased Anxiety"],"prefix":"10.1038","volume":"41","author":[{"given":"Erica Y","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behnam","family":"Javidfar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibi","family":"Kassim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Hwee E","family":"Loh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda C","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venu","family":"Pothula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Francis","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Ernst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Dong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5190-2851","authenticated-orcid":false,"given":"Li","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira","family":"Jakovcevski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schahram","family":"Akbarian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,3]]},"reference":[{"key":"BFnpp2016144_CR1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.biopsych.2014.09.019","volume":"78","author":"R Admon","year":"2015","unstructured":"Admon R, Holsen LM, Aizley H, Remington A, Whitfield-Gabrieli S, Goldstein JM et al (2015). Striatal hypersensitivity during stress in remitted individuals with recurrent depression. Biol Psychiatry 78: 67\u201376.","journal-title":"Biol Psychiatry"},{"key":"BFnpp2016144_CR2","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.biopsych.2013.09.014","volume":"76","author":"A Aguilar-Valles","year":"2014","unstructured":"Aguilar-Valles A, Vaissiere T, Griggs EM, Mikaelsson MA, Takacs IF, Young EJ et al (2014). Methamphetamine-associated memory is regulated by a writer and an eraser of permissive histone methylation. Biol Psychiatry 76: 57\u201365.","journal-title":"Biol Psychiatry"},{"key":"BFnpp2016144_CR3","doi-asserted-by":"publisher","first-page":"4153","DOI":"10.1523\/JNEUROSCI.22-10-04153.2002","volume":"22","author":"S Akbarian","year":"2002","unstructured":"Akbarian S, Rios M, Liu RJ, Gold SJ, Fong HF, Zeiler S et al (2002). Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons. J Neurosci 22: 4153\u20134162.","journal-title":"J Neurosci"},{"key":"BFnpp2016144_CR4","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.molcel.2012.11.006","volume":"48","author":"JC Black","year":"2012","unstructured":"Black JC, Van Rechem C, Whetstine JR (2012). Histone lysine methylation dynamics: establishment, regulation, and biological impact. Mol Cell 48: 491\u2013507.","journal-title":"Mol Cell"},{"key":"BFnpp2016144_CR5","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1113\/jphysiol.1973.sp010273","volume":"232","author":"TV Bliss","year":"1973","unstructured":"Bliss TV, Lomo T (1973). Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol 232: 331\u2013356.","journal-title":"J Physiol"},{"key":"BFnpp2016144_CR6","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1038\/sj.mp.4001852","volume":"11","author":"A Bystritsky","year":"2006","unstructured":"Bystritsky A (2006). Treatment-resistant anxiety disorders. Mol Psychiatry 11: 805\u2013814.","journal-title":"Mol Psychiatry"},{"key":"BFnpp2016144_CR7","first-page":"30","volume":"38","author":"A Bystritsky","year":"2013","unstructured":"Bystritsky A, Khalsa SS, Cameron ME, Schiffman J (2013). Current diagnosis and treatment of anxiety disorders. PT 38: 30\u201357.","journal-title":"PT"},{"key":"BFnpp2016144_CR8","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.molcel.2013.12.001","volume":"53","author":"F Cao","year":"2014","unstructured":"Cao F, Townsend EC, Karatas H, Xu J, Li L, Lee S et al (2014). Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia. Mol Cell 53: 247\u2013261.","journal-title":"Mol Cell"},{"key":"BFnpp2016144_CR9","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/S0006-8993(00)02217-4","volume":"866","author":"RM Carelli","year":"2000","unstructured":"Carelli RM, Ijames SG (2000). Nucleus accumbens cell firing during maintenance, extinction, and reinstatement of cocaine self-administration behavior in rats. Brain Res 866: 44\u201354.","journal-title":"Brain Res"},{"key":"BFnpp2016144_CR10","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.4161\/epi.6.9.16069","volume":"6","author":"PA Del Rizzo","year":"2011","unstructured":"Del Rizzo PA, Trievel RC (2011). Substrate and product specificities of SET domain methyltransferases. Epigenetics 6: 1059\u20131067.","journal-title":"Epigenetics"},{"key":"BFnpp2016144_CR11","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1242\/dev.102681","volume":"141","author":"S Denissov","year":"2014","unstructured":"Denissov S, Hofemeister H, Marks H, Kranz A, Ciotta G, Singh S et al (2014). Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant. Development 141: 526\u2013537.","journal-title":"Development"},{"key":"BFnpp2016144_CR12","doi-asserted-by":"publisher","first-page":"e679","DOI":"10.1038\/tp.2015.169","volume":"5","author":"A Dincer","year":"2015","unstructured":"Dincer A, Gavin DP, Xu K, Zhang B, Dudley JT, Schadt EE et al (2015). Deciphering H3K4me3 broad domains associated with gene-regulatory networks and conserved epigenomic landscapes in the human brain. Transl Psychiatry 5: e679.","journal-title":"Transl Psychiatry"},{"key":"BFnpp2016144_CR13","doi-asserted-by":"publisher","first-page":"e0144398","DOI":"10.1371\/journal.pone.0144398","volume":"10","author":"X Dong","year":"2015","unstructured":"Dong X, Tsuji J, Labadorf A, Roussos P, Chen JF, Myers RH et al (2015). The role of H3K4me3 in transcriptional regulation is altered in Huntington's disease. PLoS One 10: e0144398.","journal-title":"PLoS One"},{"key":"BFnpp2016144_CR14","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1756-8935-2-5","volume":"2","author":"S Glaser","year":"2009","unstructured":"Glaser S, Lubitz S, Loveland KL, Ohbo K, Robb L, Schwenk F et al (2009). The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis. Epigenet Chromatin 2: 5.","journal-title":"Epigenet Chromatin"},{"key":"BFnpp2016144_CR15","doi-asserted-by":"publisher","first-page":"8603","DOI":"10.1073\/pnas.0503072102","volume":"102","author":"MG Guenther","year":"2005","unstructured":"Guenther MG, Jenner RG, Chevalier B, Nakamura T, Croce CM, Canaani E et al (2005). Global and Hox-specific roles for the MLL1 methyltransferase. Proc Natl Acad Sci USA 102: 8603\u20138608.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFnpp2016144_CR16","doi-asserted-by":"publisher","first-page":"3589","DOI":"10.1523\/JNEUROSCI.3732-09.2010","volume":"30","author":"S Gupta","year":"2010","unstructured":"Gupta S, Kim SY, Artis S, Molfese DL, Schumacher A, Sweatt JD et al (2010). Histone methylation regulates memory formation. J Neurosci 30: 3589\u20133599.","journal-title":"J Neurosci"},{"key":"BFnpp2016144_CR17","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1002\/ajmg.b.32212","volume":"165B","author":"MH Hall","year":"2014","unstructured":"Hall MH, Levy DL, Salisbury DF, Haddad S, Gallagher P, Lohan M et al (2014). Neurophysiologic effect of GWAS derived schizophrenia and bipolar risk variants. Am J Med Genet B 165B: 9\u201318.","journal-title":"Am J Med Genet B"},{"key":"BFnpp2016144_CR18","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1016\/j.jmb.2014.10.016","volume":"427","author":"MG Hagglund","year":"2015","unstructured":"Hagglund MG, Hellsten SV, Bagchi S, Philippot G, Lofqvist E, Nilsson VC et al (2015). Transport of L-glutamine, L-alanine, L-arginine and L-histidine by the neuron-specific Slc38a8 (SNAT8) in CNS. J Mol Biol 427: 1495\u20131512.","journal-title":"J Mol Biol"},{"key":"BFnpp2016144_CR19","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/S0006-8993(01)03396-0","volume":"929","author":"JA Hollander","year":"2002","unstructured":"Hollander JA, Ijames SG, Roop RG, Carelli RM (2002). An examination of nucleus accumbens cell firing during extinction and reinstatement of water reinforcement behavior in rats. Brain Res 929: 226\u2013235.","journal-title":"Brain Res"},{"issue":"2","key":"BFnpp2016144_CR20","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.nlm.2005.04.002","volume":"84","author":"M Hotte","year":"2005","unstructured":"Hotte M, Naudon L, Jay TM (2005). Modulation of recognition and temporal order memory retrieval by dopamine D1 receptor in rats. Neurobiol Learn Mem 84 (2): 85\u201392.","journal-title":"Neurobiol Learn Mem"},{"key":"BFnpp2016144_CR21","doi-asserted-by":"crossref","unstructured":"Ipser JC, Carey P, Dhansay Y, Fakier N, Seedat S, Stein DJ (2006). Pharmacotherapy augmentation strategies in treatment-resistant anxiety disorders. Cochrane Database Syst Rev CD005473.","DOI":"10.1002\/14651858.CD005473.pub2"},{"key":"BFnpp2016144_CR22","doi-asserted-by":"publisher","first-page":"5097","DOI":"10.1523\/JNEUROSCI.3004-14.2015","volume":"35","author":"M Jakovcevski","year":"2015","unstructured":"Jakovcevski M, Ruan H, Shen EY, Dincer A, Javidfar B, Ma Q et al (2015). Neuronal Kmt2a\/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory. J Neurosci 35: 5097\u20135108.","journal-title":"J Neurosci"},{"key":"BFnpp2016144_CR23","doi-asserted-by":"publisher","first-page":"3615","DOI":"10.1111\/ejn.12002","volume":"36","author":"X Ji","year":"2012","unstructured":"Ji X, Martin GE (2012). New rules governing synaptic plasticity in core nucleus accumbens medium spiny neurons. Eur J Neurosci 36: 3615\u20133627.","journal-title":"Eur J Neurosci"},{"key":"BFnpp2016144_CR24","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.stem.2007.05.019","volume":"1","author":"CD Jude","year":"2007","unstructured":"Jude CD, Climer L, Xu D, Artinger E, Fisher JK, Ernst P (2007). Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors. Cell Stem Cell. 1: 324\u2013337.","journal-title":"Cell Stem Cell."},{"key":"BFnpp2016144_CR25","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.alcohol.2012.03.001","volume":"46","author":"HM Kamens","year":"2012","unstructured":"Kamens HM, Hoft NR, Cox RJ, Miyamoto JH, Ehringer MA (2012). The alpha6 nicotinic acetylcholine receptor subunit influences ethanol-induced sedation. Alcohol 46: 463\u2013471.","journal-title":"Alcohol"},{"key":"BFnpp2016144_CR26","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1021\/ja306028q","volume":"135","author":"H Karatas","year":"2013","unstructured":"Karatas H, Townsend EC, Cao F, Chen Y, Bernard D, Liu L et al (2013). High-affinity, small-molecule peptidomimetic inhibitors of MLL1\/WDR5 protein-protein interaction. J Am Chem Soc. 135: 669\u2013682.","journal-title":"J Am Chem Soc."},{"key":"BFnpp2016144_CR27","doi-asserted-by":"publisher","first-page":"3452","DOI":"10.1523\/JNEUROSCI.3356-12.2013","volume":"33","author":"C Kerimoglu","year":"2013","unstructured":"Kerimoglu C, Agis-Balboa RC, Kranz A, Stilling R, Bahari-Javan S, Benito-Garagorri E et al (2013). Histone-methyltransferase MLL2 (KMT2B) is required for memory formation in mice. J Neurosci 33: 3452\u20133464.","journal-title":"J Neurosci"},{"key":"BFnpp2016144_CR28","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/368242a0","volume":"368","author":"SB Kombian","year":"1994","unstructured":"Kombian SB, Malenka RC (1994). Simultaneous LTP of non-NMDA and LTD of NMDA-receptor-mediated responses in the nucleus accumbens. Nature 368: 242\u2013246.","journal-title":"Nature"},{"key":"BFnpp2016144_CR29","doi-asserted-by":"publisher","first-page":"4746","DOI":"10.1523\/JNEUROSCI.0197-10.2010","volume":"30","author":"M Krause","year":"2010","unstructured":"Krause M, German PW, Taha SA, Fields HL (2010). A pause in nucleus accumbens neuron firing is required to initiate and maintain feeding. J Neurosci 30: 4746\u20134756.","journal-title":"J Neurosci"},{"key":"BFnpp2016144_CR30","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1176\/appi.ajp.2009.10030434","volume":"167","author":"V Krishnan","year":"2010","unstructured":"Krishnan V, Nestler EJ (2010). Linking molecules to mood: new insight into the biology of depression. Am J Psychiatry 167: 1305\u20131320.","journal-title":"Am J Psychiatry"},{"key":"BFnpp2016144_CR31","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1128\/MCB.01721-12","volume":"33","author":"V Ladopoulos","year":"2013","unstructured":"Ladopoulos V, Hofemeister H, Hoogenkamp M, Riggs AD, Stewart AF, Bonifer C (2013). The histone methyltransferase KMT2B is required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter. Mol Cell Biol 33: 1383\u20131393.","journal-title":"Mol Cell Biol"},{"key":"BFnpp2016144_CR32","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1037\/0735-7044.121.5.1125","volume":"121","author":"KM Lattal","year":"2007","unstructured":"Lattal KM, Barrett RM, Wood MA (2007). Systemic or intra hippocampal delivery of histone deacetylase inhibitors facilitates fear extinction. Behav Neurosci 121: 1125\u20131131.","journal-title":"Behav Neurosci"},{"key":"BFnpp2016144_CR33","doi-asserted-by":"publisher","first-page":"R29","DOI":"10.1186\/gb-2014-15-2-r29","volume":"15","author":"CW Law","year":"2014","unstructured":"Law CW, Chen Y, Shi W, Smyth GK (2014). voom: Precision weights unlock linear model analysis tools for RNA-seq read counts. Genome Biol 15: R29.","journal-title":"Genome Biol"},{"key":"BFnpp2016144_CR34","doi-asserted-by":"publisher","first-page":"E168","DOI":"10.1073\/pnas.1319138111","volume":"111","author":"KM Lu","year":"2014","unstructured":"Lu KM, Evans SM, Hirano S, Liu FC (2014). Dual role for Islet-1 in promoting striatonigral and repressing striatopallidal genetic programs to specify striatonigral cell identity. Proc Natl Acad Sci USA 111: E168\u2013E177.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFnpp2016144_CR35","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1007\/s13311-013-0213-6","volume":"10","author":"M Mahgoub","year":"2013","unstructured":"Mahgoub M, Monteggia LM (2013). Epigenetics and psychiatry. Neurotherapeutics 10: 734\u2013741.","journal-title":"Neurotherapeutics"},{"key":"BFnpp2016144_CR36","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.jbiotec.2011.10.003","volume":"157","author":"H Nakajima","year":"2012","unstructured":"Nakajima H, Kubo T, Semi Y, Itakura M, Kuwamura M, Izawa T et al (2012). A rapid, targeted, neuron-selective, in vivo knockdown following a single intracerebroventricular injection of a novel chemically modified siRNA in the adult rat brain. J Biotechnol 157: 326\u2013333.","journal-title":"J Biotechnol"},{"key":"BFnpp2016144_CR37","doi-asserted-by":"publisher","first-page":"11043","DOI":"10.1523\/JNEUROSCI.1682-10.2010","volume":"30","author":"F Napolitano","year":"2010","unstructured":"Napolitano F, Bonito-Oliva A, Federici M, Carta M, Errico F, Magara S et al (2010). Role of aberrant striatal dopamine D1 receptor\/cAMP\/protein kinase A\/DARPP32 signaling in the paradoxical calming effect of amphetamine. J Neurosci 30: 11043\u201311056.","journal-title":"J Neurosci"},{"key":"BFnpp2016144_CR38","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3389\/fnhum.2015.00058","volume":"9","author":"H Okon-Singer","year":"2015","unstructured":"Okon-Singer H, Hendler T, Pessoa L, Shackman AJ (2015). The neurobiology of emotion\u2013cognition interactions: fundamental questions and strategies for future research. Front Hum Neurosci 9: 58.","journal-title":"Front Hum Neurosci"},{"key":"BFnpp2016144_CR39","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1007\/BF00231053","volume":"86","author":"CMA Pennartz","year":"1991","unstructured":"Pennartz CMA, Boejinga PH, Lopes da silva FH (1991). Contributions of NMDA receptors to postsynaptic potentials and paired-pluses facilitation in identified neurons of the rat nucleus accumbens in vitro. Exp Brain Res 86: 190\u2013198.","journal-title":"Exp Brain Res"},{"key":"BFnpp2016144_CR40","unstructured":"Psychiatric Genomics Consortium, Network and Pathway Analysis Subgroup (2015). Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nat Neurosci 18: 199\u2013209."},{"key":"BFnpp2016144_CR41","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1038\/nrc3929","volume":"15","author":"RC Rao","year":"2015","unstructured":"Rao RC, Dou Y (2015). Hijacked in cancer: the KMT2 (MLL) family of methyltrans-ferases. Nat Rev Cancer 15: 334\u2013346.","journal-title":"Nat Rev Cancer"},{"key":"BFnpp2016144_CR42","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.neuroscience.2013.12.013","volume":"260","author":"K Sakata","year":"2014","unstructured":"Sakata K, Duke SM (2014). Lack of BDNF expression through promoter IV disturbs expression of monoamine genes in the frontal cortex and hippocampus. Neuroscience 260: 265\u2013275.","journal-title":"Neuroscience"},{"key":"BFnpp2016144_CR43","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/npp.2009.93","volume":"35","author":"SR Sesack","year":"2010","unstructured":"Sesack SR, Grace AA (2010). Cortico-basal ganglia reward network: microcircuitry. Neuropsychopharmacology 35: 27\u201347.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2016144_CR44","doi-asserted-by":"publisher","first-page":"20130514","DOI":"10.1098\/rstb.2013.0514","volume":"369","author":"E Shen","year":"2014","unstructured":"Shen E, Shulha H, Weng Z, Akbarian S (2014). Regulation of histone H3K4 methylation in brain development and disease. Philos Trans R Soc Lond Ser B 369: 20130514.","journal-title":"Philos Trans R Soc Lond Ser B"},{"key":"BFnpp2016144_CR45","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/nn.4267","volume":"19","author":"T Singh","year":"2016","unstructured":"Singh T, Kurki MI, Curtis D, Purcell SM, Crooks L, McRae J et al (2016). Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders. Nat Neurosci 19: 571\u2013577.","journal-title":"Nat Neurosci"},{"key":"BFnpp2016144_CR46","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/j.neuron.2016.02.024","volume":"89","author":"A Takata","year":"2016","unstructured":"Takata A, Ionita-Laza I, Gogos JA, Xu B, Karayiorgou M (2016). De novo synonymous mutations in regulatory elements contribute to the genetic etiology of autism and schizophrenia. Neuron 89: 940\u2013947.","journal-title":"Neuron"},{"key":"BFnpp2016144_CR47","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","volume":"25","author":"C Trapnell","year":"2009","unstructured":"Trapnell C, Pachter L, Salzberg SL (2009). TopHat: discovering splice junctions with RNA-Seq. Bioinformatics 25: 1105\u20131111.","journal-title":"Bioinformatics"},{"key":"BFnpp2016144_CR48","doi-asserted-by":"publisher","first-page":"E3027","DOI":"10.1073\/pnas.1311323110","volume":"110","author":"M Vashishtha","year":"2013","unstructured":"Vashishtha M, Ng CW, Yildirim F, Gipson TA, Kratter IH, Bodai L et al (2013). Targeting H3K4 trimethylation in Huntington disease. Proc Natl Acad Sci USA 110: E3027\u2013E3036.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFnpp2016144_CR49","doi-asserted-by":"publisher","first-page":"10471","DOI":"10.1523\/JNEUROSCI.0670-13.2013","volume":"33","author":"LM Valor","year":"2013","unstructured":"Valor LM, Guiretti D, Lopez-Atalaya JP, Barco A (2013). Genomic landscape of transcriptional and epigenetic dysregulation in early onset polyglutamine disease. J Neurosci 33: 10471\u201310482.","journal-title":"J Neurosci"},{"key":"BFnpp2016144_CR50","doi-asserted-by":"publisher","first-page":"961","DOI":"10.2174\/1871527313666140612122929","volume":"13","author":"B Velasques","year":"2014","unstructured":"Velasques B, Diniz C, Teixeira S, Cartier C, Peressutti C, Silva F et al (2014). Deep brain stimulation: a new treatment in mood and anxiety disorders. CNS Neurol Disord Drug Targets 13: 961\u2013971.","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"BFnpp2016144_CR51","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1146\/annurev-pharmtox-010611-134540","volume":"53","author":"V Vialou","year":"2013","unstructured":"Vialou V, Feng J, Robison AJ, Nestler EJ (2013). Epigenetic mechanisms of depression and antidepressant action. Annu Rev Pharmacol Toxicol 53: 59\u201387.","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"BFnpp2016144_CR52","doi-asserted-by":"publisher","first-page":"14585","DOI":"10.1523\/JNEUROSCI.2496-10.2010","volume":"30","author":"V Vialou","year":"2010","unstructured":"Vialou V, Maze I, Renthal W, LaPlant QC, Watts EL, Mouzon E et al (2010). Serum response factor promotes resilience to chronic social stress through the induction of DeltaFosB. J Neurosci 30: 14585\u201314592.","journal-title":"J Neurosci"},{"key":"BFnpp2016144_CR53","doi-asserted-by":"publisher","first-page":"6074","DOI":"10.1128\/MCB.00924-09","volume":"29","author":"P Wang","year":"2009","unstructured":"Wang P, Lin C, Smith ER, Guo H, Sanderson BW, Wu M et al (2009). Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II. Mol Cell Biol 29: 6074\u20136085.","journal-title":"Mol Cell Biol"},{"key":"BFnpp2016144_CR54","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/nrg2905","volume":"12","author":"VW Zhou","year":"2011","unstructured":"Zhou VW, Goren A, Bernstein BE (2011). Charting histone modifications and the functional organization of mammalian genomes. Nat Rev Genet 12: 7\u201318.","journal-title":"Nat Rev Genet"},{"key":"BFnpp2016144_CR55","doi-asserted-by":"publisher","first-page":"9410","DOI":"10.1523\/JNEUROSCI.1041-12.2012","volume":"32","author":"J Zhu","year":"2012","unstructured":"Zhu J, Zhang X, Xu Y, Spencer TJ, Biederman J, Bhide PG (2012). Prenatal nicotine exposure mouse model showing hyperactivity, reduced cingulate cortex volume, reduced dopamine turnover, and responsiveness to oral methylphenidate treatment. J Neurosci 32: 9410\u20139418.","journal-title":"J Neurosci"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/npp2016144.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2016144","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2016144.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T23:55:12Z","timestamp":1684454112000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/npp2016144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,3]]},"references-count":55,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["BFnpp2016144"],"URL":"https:\/\/doi.org\/10.1038\/npp.2016.144","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,3]]},"assertion":[{"value":"6 February 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}