{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T11:32:49Z","timestamp":1775302369599,"version":"3.50.1"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T00:00:00Z","timestamp":1478649600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1038\/npp.2016.251","type":"journal-article","created":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T12:01:25Z","timestamp":1478692885000},"page":"1070-1081","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Ethanol-Sensitive Pacemaker Neurons in the Mouse External Globus Pallidus"],"prefix":"10.1038","volume":"42","author":[{"given":"Karina P","family":"Abrahao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica H","family":"Chancey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C Savio","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M","family":"Lovinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,11,9]]},"reference":[{"key":"BFnpp2016251_CR1","doi-asserted-by":"publisher","first-page":"6667","DOI":"10.1523\/JNEUROSCI.4662-14.2015","volume":"35","author":"A Abdi","year":"2015","unstructured":"Abdi A, Mallet N, Mohamed FY, Sharott A, Dodson PD, Nakamura KC et al (2015). Prototypic and arkypallidal neurons in the dopamine-intact external globus pallidus. J Neurosci 35: 6667\u20136688.","journal-title":"J Neurosci"},{"key":"BFnpp2016251_CR2","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1523\/JNEUROSCI.4830-11.2012","volume":"32","author":"A Adler","year":"2012","unstructured":"Adler A, Katabi S, Finkes I, Israel Z, Prut Y, Bergman H (2012). Temporal convergence of dynamic cell assemblies in the striato-pallidal network. J Neurosci 32: 2473\u20132484.","journal-title":"J Neurosci"},{"key":"BFnpp2016251_CR3","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/0166-2236(89)90074-X","volume":"12","author":"RL Albin","year":"1989","unstructured":"Albin RL, Young AB, Penney JB (1989). The functional anatomy of basal ganglia disorders. Trends Neurosci 12: 366\u2013375.","journal-title":"Trends Neurosci"},{"key":"BFnpp2016251_CR4","doi-asserted-by":"publisher","first-page":"10047","DOI":"10.1523\/JNEUROSCI.2583-04.2004","volume":"24","author":"D Arkadir","year":"2004","unstructured":"Arkadir D, Morris G, Vaadia E, Bergman H (2004). Independent coding of movement direction and reward prediction by single pallidal neurons. J Neurosci 24: 10047\u201310056.","journal-title":"J Neurosci"},{"key":"BFnpp2016251_CR5","doi-asserted-by":"publisher","first-page":"346","DOI":"10.3389\/fphys.2014.00346","volume":"5","author":"JC Bettinger","year":"2014","unstructured":"Bettinger JC, Davies AG (2014). The role of the BK channel in ethanol response behaviors: evidence from model organism and human studies. Front Physiol 5: 346.","journal-title":"Front Physiol"},{"key":"BFnpp2016251_CR6","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/0006-8993(90)91118-Z","volume":"508","author":"MS Brodie","year":"1990","unstructured":"Brodie MS, Shefner SA, Dunwiddie TV (1990). Ethanol increases the firing rate of dopamine neurons of the rat ventral tegmental area in vitro. Brain Res 508: 65\u201369.","journal-title":"Brain Res"},{"key":"BFnpp2016251_CR7","doi-asserted-by":"publisher","first-page":"9313","DOI":"10.1073\/pnas.1317363111","volume":"111","author":"AN Bukiya","year":"2014","unstructured":"Bukiya AN, Kuntamallappanavar G, Edwards J, Singh AK, Shivakumar B, Dopico AM (2014). An alcohol-sensing site in the calcium- and voltage-gated, large conductance potassium (BK) channel. Proc Natl Acad Sci USA 111: 9313\u20139318.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFnpp2016251_CR8","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.alcohol.2009.05.003","volume":"43","author":"G Chen","year":"2009","unstructured":"Chen G, Reilly MT, Kozell LB, Hitzemann R, Buck KJ (2009). Differential activation of limbic circuitry associated with chronic ethanol withdrawal in DBA\/2J and C57BL\/6J mice. Alcohol 43: 411\u2013420.","journal-title":"Alcohol"},{"key":"BFnpp2016251_CR9","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/S0022-3565(25)09626-0","volume":"273","author":"HE Criswell","year":"1995","unstructured":"Criswell HE, Simson PE, Knapp DJ, Devaud LL, McCown TJ, Duncan GE et al (1995). Effect of zolpidem on gamma-aminobutyric acid (GABA)-induced inhibition predicts the interaction of ethanol with GABA on individual neurons in several rat brain regions. J Pharmacol Exp Ther 273: 526\u2013536.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFnpp2016251_CR10","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1152\/jn.1971.34.3.414","volume":"34","author":"MR DeLong","year":"1971","unstructured":"DeLong MR (1971). Activity of pallidal neurons during movement. J Neurophysiol 34: 414\u2013427.","journal-title":"J Neurophysiol"},{"key":"BFnpp2016251_CR11","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/0166-2236(90)90110-V","volume":"13","author":"MR DeLong","year":"1990","unstructured":"DeLong MR (1990). Primate models of movement disorders of basal ganglia origin. Trends Neurosci 13: 281\u2013285.","journal-title":"Trends Neurosci"},{"key":"BFnpp2016251_CR12","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.neuron.2015.03.007","volume":"86","author":"PD Dodson","year":"2015","unstructured":"Dodson PD, Larvin JT, Duffell JM, Garas FN, Doig NM, Kessaris N et al (2015). Distinct developmental origins manifest in the specialized encoding of movement by adult neurons of the external globus pallidus. Neuron 86: 501\u2013513.","journal-title":"Neuron"},{"key":"BFnpp2016251_CR13","first-page":"466","volume":"5","author":"AM Dopico","year":"2014","unstructured":"Dopico AM, Bukiya AN, Martin GE (2014). Ethanol modulation of mammalian BK channels in excitable tissues: molecular targets and their possible contribution to alcohol-induced altered behavior. Front Physiol 5: 466.","journal-title":"Front Physiol"},{"key":"BFnpp2016251_CR14","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0026-895X(25)08691-2","volume":"49","author":"AM Dopico","year":"1996","unstructured":"Dopico AM, Lemos JR, Treistman SN (1996). Ethanol increases the activity of large conductance, Ca(2+)-activated K+ channels in isolated neurohypophysial terminals. Mol Pharmacol 49: 40\u201348.","journal-title":"Mol Pharmacol"},{"key":"BFnpp2016251_CR15","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.1523\/JNEUROSCI.4156-06.2007","volume":"27","author":"S Elias","year":"2007","unstructured":"Elias S, Joshua M, Goldberg JA, Heimer G, Arkadir D, Morris G et al (2007). Statistical properties of pauses of the high-frequency discharge neurons in the external segment of the globus pallidus. J Neurosci 27: 2525\u20132538.","journal-title":"J Neurosci"},{"key":"BFnpp2016251_CR16","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1038\/nn1579","volume":"8","author":"BJ Everitt","year":"2005","unstructured":"Everitt BJ, Robbins TW (2005). Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci 8: 1481\u20131489.","journal-title":"Nat Neurosci"},{"key":"BFnpp2016251_CR17","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1152\/jn.2001.85.2.998","volume":"85","author":"MJ Gdowski","year":"2001","unstructured":"Gdowski MJ, Miller LE, Parrish T, Nenonene EK, Houk JC (2001). Context dependency in the globus pallidus internal segment during targeted arm movements. J Neurophysiol 85: 998\u20131004.","journal-title":"J Neurophysiol"},{"key":"BFnpp2016251_CR18","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/0006-8993(85)90381-6","volume":"348","author":"GL Gessa","year":"1985","unstructured":"Gessa GL, Muntoni F, Collu M, Vargiu L, Mereu G (1985). Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area. Brain Res 348: 201\u2013203.","journal-title":"Brain Res"},{"key":"BFnpp2016251_CR19","doi-asserted-by":"publisher","first-page":"5472","DOI":"10.1523\/JNEUROSCI.1720-15.2016","volume":"36","author":"KE Glajch","year":"2016","unstructured":"Glajch KE, Kelver DA, Hegeman DJ, Cui Q, Xenias HS, Augustine EC et al (2016). Npas1+ Pallidal Neurons Target Striatal Projection Neurons. J Neurosci 36: 5472\u20135488.","journal-title":"J Neurosci"},{"key":"BFnpp2016251_CR20","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1111\/add.12899","volume":"110","author":"LR Gowing","year":"2015","unstructured":"Gowing LR, Ali RL, Allsop S, Marsden J, Turf EE, West R et al (2015). Global statistics on addictive behaviours: 2014 status report. Addiction 110: 904\u2013919.","journal-title":"Addiction"},{"issue":"Pt. 3","key":"BFnpp2016251_CR21","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1113\/jphysiol.2006.126367","volume":"580","author":"N Gu","year":"2007","unstructured":"Gu N, Vervaeke K, Storm JF (2007). BK potassium channels facilitate high-frequency firing and cause early spike frequency adaptation in rat CA1 hippocampal pyramidal cells. J Physiol 580 (Pt. 3): 859\u2013882.","journal-title":"J Physiol"},{"key":"BFnpp2016251_CR22","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1111\/ejn.13196","volume":"10","author":"DJ Hegeman","year":"2016","unstructured":"Hegeman DJ, Hong ES, Hernandez VM, Chan CS (2016). The external globus pallidus: progress and perspectives. Eur J Neurosci 10: 1239\u20131265.","journal-title":"Eur J Neurosci"},{"key":"BFnpp2016251_CR23","doi-asserted-by":"publisher","first-page":"11830","DOI":"10.1523\/JNEUROSCI.4672-14.2015","volume":"35","author":"VM Hernandez","year":"2015","unstructured":"Hernandez VM, Hegeman DJ, Cui Q, Kelver DA, Fiske MP, Glajch KE et al (2015). Parvalbumin+ neurons and Npas1+ neurons are distinct neuron classes in the mouse external globus pallidus. J Neurosci 35: 11830\u201311847.","journal-title":"J Neurosci"},{"key":"BFnpp2016251_CR24","first-page":"1497","volume":"21","author":"B Hitzemann","year":"1997","unstructured":"Hitzemann B, Hitzemann R (1997). Genetics ethanol and the Fos response: a comparison of the C57BL\/6J and DBA\/2J inbred mouse strains. Alcohol Clin Exp Res 21: 1497\u20131507.","journal-title":"Alcohol Clin Exp Res"},{"key":"BFnpp2016251_CR25","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1007\/s11064-015-1788-6","volume":"41","author":"M Jamal","year":"2016","unstructured":"Jamal M, Ameno K, Tanaka N, Ito A, Takakura A, Kumihashi M et al (2016). Ethanol and acetaldehyde after intraperitoneal administration to Aldh2-knockout mice-reflection in blood and brain levels. Neurochem Res 41: 1029\u20131034.","journal-title":"Neurochem Res"},{"key":"BFnpp2016251_CR26","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.drugalcdep.2005.02.006","volume":"80","author":"KM Kolodziejska-Akiyama","year":"2005","unstructured":"Kolodziejska-Akiyama KM, Cha YM, Jiang Y, Loh HH, Chang SL (2005). Ethanol-induced FOS immunoreactivity in the brain of mu-opioid receptor knockout mice. Drug Alcohol Depend 80: 161\u2013168.","journal-title":"Drug Alcohol Depend"},{"key":"BFnpp2016251_CR27","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1152\/jn.00270.2006","volume":"97","author":"S Koyama","year":"2007","unstructured":"Koyama S, Brodie MS, Appel SB (2007). Ethanol inhibition of m-current and ethanol-induced direct excitation of ventral tegmental area dopamine neurons. J Neurophysiol 97: 1977\u20131985.","journal-title":"J Neurophysiol"},{"key":"BFnpp2016251_CR28","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.1097\/01.alc.0000187592.57853.12","volume":"29","author":"LB Kozell","year":"2005","unstructured":"Kozell LB, Hitzemann R, Buck KJ (2005). Acute alcohol withdrawal is associated with c-Fos expression in the basal ganglia and associated circuitry: C57BL\/6J and DBA\/2J inbred mouse strain analyses. Alcohol Clin Exp Res 29: 1939\u20131948.","journal-title":"Alcohol Clin Exp Res"},{"key":"BFnpp2016251_CR29","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3389\/fnana.2015.00006","volume":"9","author":"DA Kupferschmidt","year":"2015","unstructured":"Kupferschmidt DA, Cody PA, Lovinger DM, Davis MI (2015). Brain BLAQ: post-hoc thick-section histochemistry for localizing optogenetic constructs in neurons and their distal terminals. Front Neuroanat 9: 6.","journal-title":"Front Neuroanat"},{"key":"BFnpp2016251_CR30","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/978-3-642-28720-6_143","volume":"13","author":"DM Lovinger","year":"2013","unstructured":"Lovinger DM, Roberto M (2013). Synaptic effects induced by alcohol. Curr Top Behav Neurosci 13: 31\u201386.","journal-title":"Curr Top Behav Neurosci"},{"key":"BFnpp2016251_CR31","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1523\/JNEUROSCI.10-04-01372.1990","volume":"10","author":"DM Lovinger","year":"1990","unstructured":"Lovinger DM, White G, Weight FF (1990). NMDA receptor-mediated synaptic excitation selectively inhibited by ethanol in hippocampal slice from adult rat. J Neurosci 10: 1372\u20131379.","journal-title":"J Neurosci"},{"key":"BFnpp2016251_CR32","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.neuron.2015.12.017","volume":"8","author":"N Mallet","year":"2016","unstructured":"Mallet N, Schmidt R, Leventhal D, Chen F, Amer N, Boraud T et al (2016). Arkypallidal cells send a stop signal to striatum. Neuron 8: 308\u2013316.","journal-title":"Neuron"},{"key":"BFnpp2016251_CR33","doi-asserted-by":"publisher","first-page":"6563","DOI":"10.1523\/JNEUROSCI.0684-04.2004","volume":"24","author":"G Martin","year":"2004","unstructured":"Martin G, Puig S, Pietrzykowski A, Zadek P, Emery P, Treistman S (2004). Somatic localization of a specific large-conductance calcium-activated potassium channel subtype controls compartmentalized ethanol sensitivity in the nucleus accumbens. J Neurosci 24: 6563\u20136572.","journal-title":"J Neurosci"},{"key":"BFnpp2016251_CR34","doi-asserted-by":"publisher","first-page":"17543","DOI":"10.1073\/pnas.0801068105","volume":"105","author":"GE Martin","year":"2008","unstructured":"Martin GE, Hendrickson LM, Penta KL, Friesen RM, Pietrzykowski AZ, Tapper AR et al (2008). Identification of a BK channel auxiliary protein controlling molecular and behavioral tolerance to alcohol. Proc Natl Acad Sci USA 105: 17543\u201317548.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFnpp2016251_CR35","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1523\/JNEUROSCI.4646-13.2014","volume":"34","author":"KJ Mastro","year":"2014","unstructured":"Mastro KJ, Bouchard RS, Holt HA, Gittis AH (2014). Transgenic mouse lines subdivide external segment of the globus pallidus (GPe) neurons and reveal distinct GPe output pathways. J Neurosci 34: 2087\u20132099.","journal-title":"J Neurosci"},{"key":"BFnpp2016251_CR36","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/0006-8993(85)91249-1","volume":"360","author":"G Mereu","year":"1985","unstructured":"Mereu G, Gessa GL (1985). Low doses of ethanol inhibit the firing of neurons in the substantia nigra, pars reticulata: a GABAergic effect? Brain Res 360: 325\u2013330.","journal-title":"Brain Res"},{"key":"BFnpp2016251_CR37","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/38738","volume":"389","author":"SJ Mihic","year":"1997","unstructured":"Mihic SJ, Ye Q, Wick MJ, Koltchine VV, Krasowski MD, Finn SE et al (1997). Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors. Nature 389: 385\u2013389.","journal-title":"Nature"},{"key":"BFnpp2016251_CR38","doi-asserted-by":"publisher","first-page":"e76649","DOI":"10.1371\/journal.pone.0076649","volume":"8","author":"K Nikolaou","year":"2013","unstructured":"Nikolaou K, Critchley H, Duka T (2013). Alcohol affects neuronal substrates of response inhibition but not of perceptual processing of stimuli signalling a stop response. PLoS One 8: e76649.","journal-title":"PLoS One"},{"key":"BFnpp2016251_CR39","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.1111\/ejn.13041","volume":"42","author":"MI Noblejas","year":"2015","unstructured":"Noblejas MI, Schechtman E, Adler A, Joshua M, Katabi S, Bergman H (2015). Hold your pauses: external globus pallidus neurons respond to behavioural events by decreasing pause activity. Eur J Neurosci 42: 2415\u20132425.","journal-title":"Eur J Neurosci"},{"key":"BFnpp2016251_CR40","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1152\/jn.00682.2005","volume":"95","author":"T Okamoto","year":"2006","unstructured":"Okamoto T, Harnett MT, Morikawa H (2006). Hyperpolarization-activated cation current (Ih) is an ethanol target in midbrain dopamine neurons of mice. J Neurophysiol 95: 619\u2013626.","journal-title":"J Neurophysiol"},{"key":"BFnpp2016251_CR41","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1038\/npp.2015.353","volume":"41","author":"MH Patton","year":"2016","unstructured":"Patton MH, Roberts BM, Lovinger DM, Mathur BN (2016). Ethanol disinhibits dorsolateral striatal medium spiny neurons through activation of a presynaptic delta opioid receptor. Neuropsychopharmacology 41: 1831\u20131840.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2016251_CR42","doi-asserted-by":"publisher","first-page":"8322","DOI":"10.1523\/JNEUROSCI.1536-04.2004","volume":"24","author":"AZ Pietrzykowski","year":"2004","unstructured":"Pietrzykowski AZ, Martin GE, Puig SI, Knott TK, Lemos JR, Treistman SN (2004). Alcohol tolerance in large-conductance, calcium-activated potassium channels of CNS terminals is intrinsic and includes two components: decreased ethanol potentiation and decreased channel density. J Neurosci 24: 8322\u20138332.","journal-title":"J Neurosci"},{"key":"BFnpp2016251_CR43","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0014-2999(96)00696-6","volume":"317","author":"J Putzke","year":"1996","unstructured":"Putzke J, Spanagel R, Tolle TR, Zieglgansberger W (1996). The anti-craving drug acamprosate reduces c-fos expression in rats undergoing ethanol withdrawal. Eur J Pharmacol 317: 39\u201348.","journal-title":"Eur J Pharmacol"},{"key":"BFnpp2016251_CR44","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.neuroscience.2016.02.032","volume":"322","author":"MH Qiu","year":"2016","unstructured":"Qiu MH, Chen MC, Wu J, Nelson D, Lu J (2016). Deep brain stimulation in the globus pallidus externa promotes sleep. Neuroscience 322: 115\u2013120.","journal-title":"Neuroscience"},{"key":"BFnpp2016251_CR45","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1093\/cercor\/bhu241","volume":"26","author":"MH Qiu","year":"2014","unstructured":"Qiu MH, Yao QL, Vetrivelan R, Chen MC, Lu J (2014). Nigrostriatal dopamine acting on globus pallidus regulates sleep. Cereb Cortex 26: 1430\u20131439.","journal-title":"Cereb Cortex"},{"key":"BFnpp2016251_CR46","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1007\/s00418-005-0124-7","volume":"125","author":"U Sausbier","year":"2006","unstructured":"Sausbier U, Sausbier M, Sailer CA, Arntz C, Knaus HG, Neuhuber W et al (2006). Ca2+ -activated K+ channels of the BK-type in the mouse brain. Histochem Cell Biol 125: 725\u2013741.","journal-title":"Histochem Cell Biol"},{"key":"BFnpp2016251_CR47","doi-asserted-by":"publisher","first-page":"6744","DOI":"10.1523\/JNEUROSCI.5232-14.2015","volume":"35","author":"E Schechtman","year":"2015","unstructured":"Schechtman E, Adler A, Deffains M, Gabbay H, Katabi S, Mizrahi A et al (2015). Coinciding decreases in discharge rate suggest that spontaneous pauses in firing of external pallidum neurons are network driven. J Neurosci 35: 6744\u20136751.","journal-title":"J Neurosci"},{"key":"BFnpp2016251_CR48","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.neuroimage.2015.07.061","volume":"122","author":"H Schroll","year":"2015","unstructured":"Schroll H, Horn A, Groschel C, Brucke C, Lutjens G, Schneider GH et al (2015). Differential contributions of the globus pallidus and ventral thalamus to stimulus-response learning in humans. NeuroImage 122: 233\u2013245.","journal-title":"NeuroImage"},{"key":"BFnpp2016251_CR49","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/0741-8329(85)90052-7","volume":"2","author":"SA Shefner","year":"1985","unstructured":"Shefner SA, Tabakoff B (1985). Basal firing rate of rat locus coeruleus neurons affects sensitivity to ethanol. Alcohol 2: 239\u2013243.","journal-title":"Alcohol"},{"key":"BFnpp2016251_CR50","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/S0306-4522(97)00608-8","volume":"86","author":"Y Smith","year":"1998","unstructured":"Smith Y, Bevan MD, Shink E, Bolam JP (1998). Microcircuitry of the direct and indirect pathways of the basal ganglia. Neuroscience 86: 353\u2013387.","journal-title":"Neuroscience"},{"key":"BFnpp2016251_CR51","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1016\/j.neuroscience.2010.06.026","volume":"169","author":"X Song","year":"2010","unstructured":"Song X, Su W, Chen L, Ji JJ (2010). Functional expression of large-conductance Ca2+-activated potassium channels in lateral globus pallidus neurons. Neuroscience 169: 1548\u20131556.","journal-title":"Neuroscience"},{"key":"BFnpp2016251_CR52","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.tins.2009.08.001","volume":"32","author":"SN Treistman","year":"2009","unstructured":"Treistman SN, Martin GE (2009). BK Channels: mediators and models for alcohol tolerance. Trends Neurosci 32: 629\u2013637.","journal-title":"Trends Neurosci"},{"key":"BFnpp2016251_CR53","doi-asserted-by":"publisher","first-page":"29261","DOI":"10.1074\/jbc.M114.604306","volume":"289","author":"C Velazquez-Marrero","year":"2014","unstructured":"Velazquez-Marrero C, Seale GE, Treistman SN, Martin GE (2014). Large conductance voltage- and Ca2+-gated potassium (BK) channel beta4 subunit influences sensitivity and tolerance to alcohol by altering its response to kinases. J Biol Chem 289: 29261\u201329272.","journal-title":"J Biol Chem"},{"key":"BFnpp2016251_CR54","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/bjp.2008.30","volume":"154","author":"V Vengeliene","year":"2008","unstructured":"Vengeliene V, Bilbao A, Molander A, Spanagel R (2008). Neuropharmacology of alcohol addiction. Br J Pharmacol 154: 299\u2013315.","journal-title":"Br J Pharmacol"},{"key":"BFnpp2016251_CR55","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1111\/j.1530-0277.2009.00916.x","volume":"33","author":"C Vilpoux","year":"2009","unstructured":"Vilpoux C, Warnault V, Pierrefiche O, Daoust M, Naassila M (2009). Ethanol-sensitive brain regions in rat and mouse: a cartographic review, using immediate early gene expression. Alcohol Clin Exp Res 33: 945\u2013969.","journal-title":"Alcohol Clin Exp Res"},{"key":"BFnpp2016251_CR56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/alcalc\/agr147","volume":"47","author":"A Wadleigh","year":"2012","unstructured":"Wadleigh A, Valenzuela CF (2012). Ethanol increases GABAergic transmission and excitability in cerebellar molecular layer interneurons from GAD67-GFP knock-in mice. Alcohol Alcohol 47: 1\u20138.","journal-title":"Alcohol Alcohol"},{"key":"BFnpp2016251_CR57","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/npp.2013.230","volume":"39","author":"MV Wilcox","year":"2014","unstructured":"Wilcox MV, Cuzon Carlson VC, Sherazee N, Sprow GM, Bock R, Thiele TE et al (2014). Repeated binge-like ethanol drinking alters ethanol drinking patterns and depresses striatal GABAergic transmission. Neuropsychopharmacology 39: 579\u2013594.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2016251_CR58","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.neuroscience.2009.05.016","volume":"162","author":"MD Womack","year":"2009","unstructured":"Womack MD, Hoang C, Khodakhah K (2009). Large conductance calcium-activated potassium channels affect both spontaneous firing and intracellular calcium concentration in cerebellar Purkinje neurons. Neuroscience 162: 989\u20131000.","journal-title":"Neuroscience"},{"key":"BFnpp2016251_CR59","first-page":"682","volume":"24","author":"X Yang","year":"2000","unstructured":"Yang X, Criswell HE, Breese GR (2000). Ethanol modulation of gamma-aminobutyric acid (GABA)-mediated inhibition of cerebellar Purkinje neurons: relationship to GABAb receptor input. Alcohol Clin Exp Res 24: 682\u2013690.","journal-title":"Alcohol Clin Exp Res"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/npp2016251.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2016251","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2016251.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T06:54:54Z","timestamp":1749711294000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/npp2016251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,9]]},"references-count":59,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["BFnpp2016251"],"URL":"https:\/\/doi.org\/10.1038\/npp.2016.251","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,9]]},"assertion":[{"value":"8 March 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}