{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:09:27Z","timestamp":1790172567866,"version":"4.1.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T00:00:00Z","timestamp":1478649600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1038\/npp.2016.252","type":"journal-article","created":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T07:01:25Z","timestamp":1478674885000},"page":"1295-1304","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Sex Differences in \u03bc-Opioid Receptor Regulation of the Rat Locus Coeruleus and Their Cognitive Consequences"],"prefix":"10.1038","volume":"42","author":[{"given":"Herminio M","family":"Guajardo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Snyder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita J","family":"Valentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,9]]},"reference":[{"key":"BFnpp2016252_CR1","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/0006-8993(88)91415-1","volume":"441","author":"ED Abercrombie","year":"1988","unstructured":"Abercrombie ED, Jacobs BL (1988). Systemic naloxone administration potentiates locus coeruleus noradrenergic neuronal activity under stressful but not non-stressful conditions. Brain Res 441: 362\u2013366.","journal-title":"Brain Res"},{"key":"BFnpp2016252_CR2","doi-asserted-by":"publisher","first-page":"e89","DOI":"10.1016\/j.biopsych.2011.01.027","volume":"69","author":"AF Arnsten","year":"2011","unstructured":"Arnsten AF (2011). Catecholamine influences on dorsolateral prefrontal cortical networks. Biol Psychiatry 69: e89\u2013e99.","journal-title":"Biol Psychiatry"},{"key":"BFnpp2016252_CR3","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3109\/00952990.2011.596982","volume":"37","author":"SE Back","year":"2011","unstructured":"Back SE, Payne RL, Wahlquist AH, Carter RE, Stroud Z, Haynes L et al. (2011). Comparative profiles of men and women with opioid dependence: results from a national multisite effectiveness trial. Am J Drug Alcohol Abuse 37: 313\u2013323.","journal-title":"Am J Drug Alcohol Abuse"},{"key":"BFnpp2016252_CR4","doi-asserted-by":"publisher","first-page":"6383","DOI":"10.1523\/JNEUROSCI.0831-08.2008","volume":"28","author":"DA Bangasser","year":"2008","unstructured":"Bangasser DA, Shors TJ (2008). The bed nucleus of the stria terminalis modulates learning after stress in masculinized but not cycling females. J Neurosci 28: 6383\u20136387.","journal-title":"J Neurosci"},{"key":"BFnpp2016252_CR5","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1038\/mp.2010.66","volume":"15","author":"DA Bangasser","year":"2010","unstructured":"Bangasser DA, Curtis A, Reyes BA, Bethea TT, Parastatidis I, Ischiropoulos H et al. (2010). Sex differences in corticotropin-releasing factor receptor signaling and trafficking: potential role in female vulnerability to stress-related psychopathology. Mol Psychiatry 15: 896\u2013904.","journal-title":"Mol Psychiatry"},{"key":"BFnpp2016252_CR6","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.yfrne.2007.07.003","volume":"29","author":"JB Becker","year":"2008","unstructured":"Becker JB, Hu M (2008). Sex differences in drug abuse. Front Neuroendocrinol 29: 36\u201347.","journal-title":"Front Neuroendocrinol"},{"key":"BFnpp2016252_CR7","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.biopsych.2008.10.032","volume":"65","author":"RA Bryant","year":"2009","unstructured":"Bryant RA, Creamer M, O'Donnell M, Silove D, McFarlane AC (2009). A study of the protective function of acute morphine administration on subsequent posttraumatic stress disorder. Biol Psychiatry 65: 438\u2013440.","journal-title":"Biol Psychiatry"},{"key":"BFnpp2016252_CR8","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.npep.2004.01.004","volume":"38","author":"J Carretero","year":"2004","unstructured":"Carretero J, Bodego P, Rodriguez RE, Rubio M, Blanco E, Burks DJ (2004). Expression of the mu-opioid receptor in the anterior pituitary gland is influenced by age and sex. Neuropeptides 38: 63\u201368.","journal-title":"Neuropeptides"},{"key":"BFnpp2016252_CR9","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/0006-8993(96)00492-1","volume":"731","author":"PY Cheng","year":"1996","unstructured":"Cheng PY, Moriwaki A, Wang JB, Uhl GR, Pickel VM (1996). Ultrastructural localization of mu-opioid receptors in the superficial layers of the rat cervical spinal cord: extrasynaptic localization and proximity to Leu5-enkephalin. Brain Res 731: 141\u2013154.","journal-title":"Brain Res"},{"key":"BFnpp2016252_CR10","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1097\/00002508-200305000-00005","volume":"19","author":"RM Craft","year":"2003","unstructured":"Craft RM (2003). Sex differences in opioid analgesia: \u201cfrom mouse to man\u201d. Clin J Pain 19: 175\u2013186.","journal-title":"Clin J Pain"},{"key":"BFnpp2016252_CR11","doi-asserted-by":"publisher","first-page":"RC152","DOI":"10.1523\/JNEUROSCI.21-13-j0001.2001","volume":"21","author":"AL Curtis","year":"2001","unstructured":"Curtis AL, Bello NT, Valentino RJ (2001). Endogenous opioids in the locus coeruleus function to limit the noradrenergic response to stress. J Neurosci 21: RC152.","journal-title":"J Neurosci"},{"key":"BFnpp2016252_CR12","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1038\/sj.npp.1300875","volume":"31","author":"AL Curtis","year":"2006","unstructured":"Curtis AL, Bethea T, Valentino RJ (2006). Sexually dimorphic responses of the brain norepinephrine system to stress and corticotropin-releasing factor. Neuropsychopharmacology 31: 544\u2013554.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2016252_CR13","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0022-3565(24)36621-2","volume":"281","author":"AL Curtis","year":"1997","unstructured":"Curtis AL, Florin-Lechner SM, Pavcovich LA, Valentino RJ (1997). Activation of the locus coeruleus noradrenergic system by intracoerulear microinfusion of corticotropin-releasing factor: effects on discharge rate, cortical norepinephrine levels and cortical electroencephalographic activity. J Pharmacol Exp Ther 281: 163\u2013172.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFnpp2016252_CR14","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1016\/j.neuropharm.2011.11.020","volume":"62","author":"AL Curtis","year":"2012","unstructured":"Curtis AL, Leiser SC, Snyder K, Valentino RJ (2012). Predator stress engages corticotropin-releasing factor and opioid systems to alter the operating mode of locus coeruleus norepinephrine neurons. Neuropharmacology 62: 1737\u20131745.","journal-title":"Neuropharmacology"},{"key":"BFnpp2016252_CR15","doi-asserted-by":"publisher","first-page":"3162","DOI":"10.1523\/JNEUROSCI.12-08-03162.1992","volume":"12","author":"G Drolet","year":"1992","unstructured":"Drolet G, Van Bockstaele EJ, Aston-Jones G. (1992). Robust enkephalin innervation of the locus coeruleus from the rostral medulla. J. Neurosci 12: 3162\u20133174.","journal-title":"J. Neurosci"},{"key":"BFnpp2016252_CR16","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.bbr.2008.02.008","volume":"190","author":"SB Floresco","year":"2008","unstructured":"Floresco SB, Block AE, Tse MT (2008). Inactivation of the medial prefrontal cortex of the rat impairs strategy set-shifting, but not reversal learning, using a novel, automated procedure. Behavioural Brain Res 190: 85\u201396.","journal-title":"Behavioural Brain Res"},{"key":"BFnpp2016252_CR17","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/sj.mp.4001032","volume":"7","author":"PW Gold","year":"2002","unstructured":"Gold PW, Chrousos GP (2002). Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH\/NE states. Mol Psychiatry 7: 254\u2013275.","journal-title":"Mol Psychiatry"},{"key":"BFnpp2016252_CR18","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1056\/NEJMoa0903326","volume":"362","author":"TL Holbrook","year":"2010","unstructured":"Holbrook TL, Galarneau MR, Dye JL, Quinn K, Dougherty AL (2010). Morphine use after combat injury in Iraq and post-traumatic stress disorder. N Engl J Med 362: 110\u2013117.","journal-title":"N Engl J Med"},{"key":"BFnpp2016252_CR19","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/0006-8993(87)90482-3","volume":"425","author":"M Kavaliers","year":"1987","unstructured":"Kavaliers M, Innes D (1987). Stress-induced opioid analgesia and activity in deer mice: sex and population differences. Brain Res 425: 49\u201356.","journal-title":"Brain Res"},{"key":"BFnpp2016252_CR20","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1001\/archpsyc.1995.03950240066012","volume":"52","author":"RC Kessler","year":"1995","unstructured":"Kessler RC, Sonnega A, Bromet E, Hughes M, Nelson CB (1995). Posttraumatic stress disorder in the National Comorbidity Survey. Arch Gen Psychiatry 52: 1048\u20131060.","journal-title":"Arch Gen Psychiatry"},{"key":"BFnpp2016252_CR21","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/0165-0327(94)90147-3","volume":"30","author":"RC Kessler","year":"1994","unstructured":"Kessler RC, McGonagle KA, Nelson CB, Hughes M, Swartz M, Blazer DG (1994). Sex and depression in the National Comorbidity Survey. II: Cohort effects. J Affect Disord 30: 15\u201326.","journal-title":"J Affect Disord"},{"key":"BFnpp2016252_CR22","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1097\/00000542-200008000-00034","volume":"93","author":"B Kest","year":"2000","unstructured":"Kest B, Sarton E, Dahan A (2000). Gender differences in opioid-mediated analgesia: animal and human studies. Anesthesiology 93: 539\u2013547.","journal-title":"Anesthesiology"},{"key":"BFnpp2016252_CR23","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1037\/1064-1297.5.2.99","volume":"5","author":"LC Klein","year":"1997","unstructured":"Klein LC, Popke EJ, Grunberg NE (1997). Sex differences in effects of predictable and unpredictable footshock on fentanyl self-administration in rats. Exp Clin Psychopharmacol 5: 99\u2013106.","journal-title":"Exp Clin Psychopharmacol"},{"key":"BFnpp2016252_CR24","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/S0091-3057(98)00135-X","volume":"61","author":"LC Klein","year":"1998","unstructured":"Klein LC, Popke EJ, Grunberg NE (1998). Sex differences in effects of opioid blockade on stress-induced freezing behavior. Pharmacol Biochem Behav 61: 413\u2013417.","journal-title":"Pharmacol Biochem Behav"},{"key":"BFnpp2016252_CR25","doi-asserted-by":"publisher","first-page":"14007","DOI":"10.1523\/JNEUROSCI.4123-08.2008","volume":"28","author":"DR Loyd","year":"2008","unstructured":"Loyd DR, Wang X, Murphy AZ (2008). Sex differences in micro-opioid receptor expression in the rat midbrain periaqueductal gray are essential for eliciting sex differences in morphine analgesia. J Neurosci 28: 14007\u201314017.","journal-title":"J Neurosci"},{"key":"BFnpp2016252_CR26","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s00213-013-3190-x","volume":"230","author":"MK Mahoney","year":"2013","unstructured":"Mahoney MK, Silveira MM, Olmstead MC (2013). Increased impulsive action in rats: effects of morphine in a short and long fixed-delay response inhibition task. Psychopharmacology (Berl) 230: 569\u2013577.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2016252_CR27","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/0304-3959(93)90050-Y","volume":"53","author":"JS Mogil","year":"1993","unstructured":"Mogil JS, Sternberg WF, Kest B, Marek P, Liebeskind JC (1993). Sex differences in the antagonism of swim stress-induced analgesia: effects of gonadectomy and estrogen replacement. Pain 53: 17\u201325.","journal-title":"Pain"},{"key":"BFnpp2016252_CR28","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.physbeh.2009.02.037","volume":"97","author":"AZ Murphy","year":"2009","unstructured":"Murphy AZ, Suckow SK, Johns M, Traub RJ (2009). Sex differences in the activation of the spinoparabrachial circuit by visceral pain. Physiol Behav 97: 205\u2013212.","journal-title":"Physiol Behav"},{"key":"BFnpp2016252_CR29","doi-asserted-by":"publisher","first-page":"e4410","DOI":"10.1371\/journal.pone.0004410","volume":"4","author":"MC Olmstead","year":"2009","unstructured":"Olmstead MC, Ouagazzal AM, Kieffer BL (2009). Mu and delta opioid receptors oppositely regulate motor impulsivity in the signaled nose poke task. PLoS ONE 4: e4410.","journal-title":"PLoS ONE"},{"key":"BFnpp2016252_CR30","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s00213-009-1558-8","volume":"205","author":"T Pattij","year":"2009","unstructured":"Pattij T, Schetters D, Janssen MC, Wiskerke J, Schoffelmeer AN (2009). Acute effects of morphine on distinct forms of impulsive behavior in rats. Psychopharmacology (Berl) 205: 489\u2013502.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2016252_CR31","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.drugalcdep.2012.01.013","volume":"124","author":"J Peng","year":"2012","unstructured":"Peng J, Sarkar S, Chang SL (2012). Opioid receptor expression in human brain and peripheral tissues using absolute quantitative real-time RT-PCR. Drug Alcohol Depend 124: 223\u2013228.","journal-title":"Drug Alcohol Depend"},{"key":"BFnpp2016252_CR32","doi-asserted-by":"publisher","first-page":"3729","DOI":"10.1073\/pnas.73.10.3729","volume":"73","author":"CB Pert","year":"1976","unstructured":"Pert CB, Kuhar MJ, Snyder SH (1976). Opiate receptor: autoradiographic localization in rat brain. Proc Natl Acad Sci USA 73: 3729\u20133733.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFnpp2016252_CR33","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/S0031-9384(86)80009-9","volume":"37","author":"MT Romero","year":"1986","unstructured":"Romero MT, Bodnar RJ (1986). Gender differences in two forms of cold-water swim analgesia. Physiol Behav 37: 893\u2013897.","journal-title":"Physiol Behav"},{"key":"BFnpp2016252_CR34","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nprot.2008.73","volume":"3","author":"TD Schmittgen","year":"2008","unstructured":"Schmittgen TD, Livak KJ (2008). Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3: 1101\u20131108.","journal-title":"Nat Protoc"},{"key":"BFnpp2016252_CR35","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/npp.2011.218","volume":"37","author":"K Snyder","year":"2012","unstructured":"Snyder K, Wang WW, Han R, McFadden K, Valentino RJ (2012). Corticotropin-releasing factor in the norepinephrine nucleus, locus coeruleus, facilitates behavioral flexibility. Neuropsychopharmacology 37: 520\u2013530.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2016252_CR36","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s00213-014-3654-7","volume":"232","author":"KP Snyder","year":"2015","unstructured":"Snyder KP, Barry M, Valentino RJ (2015). Cognitive impact of social stress and coping strategy throughout development. Psychopharmacology (Berl) 232: 185\u2013195.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFnpp2016252_CR37","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1097\/BCR.0b013e3181b48102","volume":"30","author":"FJ Stoddard Jr","year":"2009","unstructured":"Stoddard FJ Jr, Sorrentino EA, Ceranoglu TA, Saxe G, Murphy JM, Drake JE et al. (2009). Preliminary evidence for the effects of morphine on posttraumatic stress disorder symptoms in one- to four-year-olds with burns. J Burn Care Res 30: 836\u2013843.","journal-title":"J Burn Care Res"},{"key":"BFnpp2016252_CR38","doi-asserted-by":"crossref","first-page":"20548","DOI":"10.1016\/S0021-9258(17)32028-8","volume":"269","author":"CK Surratt","year":"1994","unstructured":"Surratt CK, Johnson PS, Moriwaki A, Seidleck BK, Blaschak CJ, Wang JB et al. (1994). \u03bc-Opiate receptor. Charged transmembrane domain amino acids are critical for agonist recognition and intrinsic activity. J Biol Chem 269: 20548\u201320553.","journal-title":"J Biol Chem"},{"key":"BFnpp2016252_CR39","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/0006-8993(76)90207-9","volume":"110","author":"LW Swanson","year":"1976","unstructured":"Swanson LW (1976). The locus coeruleus: a cytoarchitectonic, Golgi and immunohistochemical study in the albino rat. Brain Res 110: 39\u201356.","journal-title":"Brain Res"},{"key":"BFnpp2016252_CR40","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/0006-8993(89)90701-4","volume":"488","author":"RJ Valentino","year":"1989","unstructured":"Valentino RJ, Wehby RG (1989). Locus coeruleus discharge characteristics of morphine-dependent rats: Effects of naltrexone. Brain Res. 488: 126\u2013134.","journal-title":"Brain Res."},{"key":"BFnpp2016252_CR41","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.ejphar.2007.11.062","volume":"583","author":"RJ Valentino","year":"2008","unstructured":"Valentino RJ, Van Bockstaele E (2008). Convergent regulation of locus coeruleus activity as an adaptive response to stress. Eur J Pharmacol 583: 194\u2013203.","journal-title":"Eur J Pharmacol"},{"key":"BFnpp2016252_CR42","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1002\/(SICI)1096-9861(19961202)376:1<65::AID-CNE4>3.0.CO;2-M","volume":"376","author":"EJ Van Bockstaele","year":"1996","unstructured":"Van Bockstaele EJ, Colago EE, Moriwaki A, Uhl GR (1996). Mu-opioid receptor is located on the plasma membrane of dendrites that receive asymmetric synapses from axon terminals containing leucine-enkephalin in the rat nucleus locus coeruleus. J Comp Neurol 376: 65\u201374.","journal-title":"J Comp Neurol"},{"key":"BFnpp2016252_CR43","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/0005-2736(89)90456-2","volume":"987","author":"C Ventura","year":"1989","unstructured":"Ventura C, Bastagli L, Bernardi P, Caldarera CM, Guarnieri C (1989). Opioid receptors in rat cardiac sarcolemma: effect of phenylephrine and isoproterenol. Biochim Biophys Acta 987: 69\u201374.","journal-title":"Biochim Biophys Acta"},{"key":"BFnpp2016252_CR44","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1111\/j.1369-1600.2012.00484.x","volume":"19","author":"YJ Wang","year":"2014","unstructured":"Wang YJ, Huang P, Blendy JA, Liu-Chen LY (2014). Brain region- and sex-specific alterations in DAMGO-stimulated [(35) S]GTPgammaS binding in mice with Oprm1 A112G. Addict Biol 19: 354\u2013361.","journal-title":"Addict Biol"},{"key":"BFnpp2016252_CR45","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0026-895X(25)15048-7","volume":"26","author":"JT Williams","year":"1984","unstructured":"Williams JT, North RA (1984). Opiate receptor interactions on single locus coeruleus neurons. Mol. Pharm 26: 489\u2013497.","journal-title":"Mol. Pharm"},{"key":"BFnpp2016252_CR46","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1073\/pnas.97.1.325","volume":"97","author":"ML Wong","year":"2000","unstructured":"Wong ML, Kling MA, Munson PJ, Listwak S, Licinio J, Prolo P et al. (2000). Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: relation to hypercortisolism and corticotropin-releasing hormone. Proc Natl Acad Sci USA 97: 325\u2013330.","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/npp2016252.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2016252","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2016252.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T02:54:54Z","timestamp":1749696894000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/npp2016252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,9]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["BFnpp2016252"],"URL":"https:\/\/doi.org\/10.1038\/npp.2016.252","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,9]]},"assertion":[{"value":"25 June 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}