{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:09:50Z","timestamp":1792166990995,"version":"4.4.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1038\/npp.2016.82","type":"journal-article","created":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T19:18:48Z","timestamp":1464808728000},"page":"2638-2646","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":232,"title":["LSD Acutely Impairs Fear Recognition and Enhances Emotional Empathy and Sociality"],"prefix":"10.1038","volume":"41","author":[{"given":"Patrick C","family":"Dolder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Borgwardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias E","family":"Liechti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,6,1]]},"reference":[{"key":"BFnpp201682_CR1","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1016\/j.biopsych.2010.08.003","volume":"68","author":"G Bedi","year":"2010","unstructured":"Bedi G, Hyman D, de Wit H (2010). Is ecstasy an \u2018empathogen\u2019? Effects of \u00b1 3,4-methylenedioxymethamphetamine on prosocial feelings and identification of emotional states in others. Biol Psychiatry 68: 1134\u20131140.","journal-title":"Biol Psychiatry"},{"key":"BFnpp201682_CR2","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1177\/0269881114565144","volume":"29","author":"MP Bogenschutz","year":"2015","unstructured":"Bogenschutz MP, Forcehimes AA, Pommy JA, Wilcox CE, Barbosa PC, Strassman RJ (2015). Psilocybin-assisted treatment for alcohol dependence: a proof-of-concept study. J Psychopharmacol 29: 289\u2013299.","journal-title":"J Psychopharmacol"},{"key":"BFnpp201682_CR3","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1017\/S0033291715002901","volume":"46","author":"RL Carhart-Harris","year":"2016","unstructured":"Carhart-Harris RL, Kaelen M, Bolstridge M, Williams TM, Williams LT, Underwood R et al (2016). The paradoxical psychological effects of lysergic acid diethylamide (LSD). Psychol Med 46: 1379\u20131390.","journal-title":"Psychol Med"},{"key":"BFnpp201682_CR4","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1007\/s00213-014-3714-z","volume":"232","author":"RL Carhart-Harris","year":"2015","unstructured":"Carhart-Harris RL, Kaelen M, Whalley MG, Bolstridge M, Feilding A, Nutt DJ (2015). LSD enhances suggestibility in healthy volunteers. Psychopharmacology 232: 785\u2013794.","journal-title":"Psychopharmacology"},{"key":"BFnpp201682_CR5","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1007\/s00216-014-8388-1","volume":"407","author":"PC Dolder","year":"2015","unstructured":"Dolder PC, Liechti ME, Rentsch KM (2015a). Development and validation of a rapid turboflow LC-MS\/MS method for the quantification of LSD and 2-oxo-3-hydroxy LSD in serum and urine samples of emergency toxicological cases. Anal Bioanal Chem 407: 1577\u20131584.","journal-title":"Anal Bioanal Chem"},{"issue":"1","key":"BFnpp201682_CR6","doi-asserted-by":"publisher","first-page":"pyv072","DOI":"10.1093\/ijnp\/pyv072","volume":"19","author":"Patrick C. Dolder","year":"2015","unstructured":"Dolder PC, Schmid Y, Haschke M, Rentsch KM, Liechti ME (2015b). Pharmacokinetics and concentration-effect relationship of oral LSD in humans. Int J Neuropsychopharmacol (doi:10.1093\/ijnp\/pyv072).","journal-title":"International Journal of Neuropsychopharmacology"},{"key":"BFnpp201682_CR7","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1007\/s10803-007-0486-x","volume":"38","author":"I Dziobek","year":"2008","unstructured":"Dziobek I, Rogers K, Fleck S, Bahnemann M, Heekeren HR, Wolf OT et al (2008). Dissociation of cognitive and emotional empathy in adults with Asperger syndrome using the Multifaceted Empathy Test (MET). J Autism Dev Disord 38: 464\u2013473.","journal-title":"J Autism Dev Disord"},{"key":"BFnpp201682_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pbb.2013.11.030","volume":"117","author":"CG Frye","year":"2014","unstructured":"Frye CG, Wardle MC, Norman GJ, de Wit H (2014). MDMA decreases the effects of simulated social rejection. Pharmacol Biochem Behav 117: 1\u20136.","journal-title":"Pharmacol Biochem Behav"},{"key":"BFnpp201682_CR9","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1097\/NMD.0000000000000113","volume":"202","author":"P Gasser","year":"2014","unstructured":"Gasser P, Holstein D, Michel Y, Doblin R, Yazar-Klosinski B, Passie T et al (2014). Safety and efficacy of lysergic acid diethylamide-assisted psychotherapy for anxiety associated with life-threatening diseases. J Nerv Ment Dis 202: 513\u2013520.","journal-title":"J Nerv Ment Dis"},{"key":"BFnpp201682_CR10","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1177\/0269881114555249","volume":"29","author":"P Gasser","year":"2015","unstructured":"Gasser P, Kirchner K, Passie T (2015). LSD-assisted psychotherapy for anxiety associated with a life-threatening disease: a qualitative study of acute and sustained subjective effects. J Psychopharmacol 29: 57\u201368.","journal-title":"J Psychopharmacol"},{"key":"BFnpp201682_CR11","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1007\/s00213-011-2358-5","volume":"218","author":"RR Griffiths","year":"2011","unstructured":"Griffiths RR, Johnson MW, Richards WA, Richards BD, McCann U, Jesse R (2011). Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects. Psychopharmacology 218: 649\u2013665.","journal-title":"Psychopharmacology"},{"key":"BFnpp201682_CR12","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1007\/s00213-006-0457-5","volume":"187","author":"RR Griffiths","year":"2006","unstructured":"Griffiths RR, Richards WA, McCann U, Jesse R (2006). Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance. Psychopharmacology 187: 268\u2013283 discussion 284-292.","journal-title":"Psychopharmacology"},{"key":"BFnpp201682_CR13","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1001\/archgenpsychiatry.2010.116","volume":"68","author":"CS Grob","year":"2011","unstructured":"Grob CS, Danforth AL, Chopra GS, Hagerty M, McKay CR, Halberstadt AL et al (2011). Pilot study of psilocybin treatment for anxiety in patients with advanced-stage cancer. Arch Gen Psychiatry 68: 71\u201378.","journal-title":"Arch Gen Psychiatry"},{"key":"BFnpp201682_CR14","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1176\/appi.ajp.161.7.1256","volume":"161","author":"CJ Harmer","year":"2004","unstructured":"Harmer CJ, Shelley NC, Cowen PJ, Goodwin GM (2004). Increased positive versus negative affective perception and memory in healthy volunteers following selective serotonin and norepinephrine reuptake inhibition. Am J Psychiatry 161: 1256\u20131263.","journal-title":"Am J Psychiatry"},{"key":"BFnpp201682_CR15","doi-asserted-by":"publisher","first-page":"4999","DOI":"10.1523\/JNEUROSCI.5538-09.2010","volume":"30","author":"R Hurlemann","year":"2010","unstructured":"Hurlemann R, Patin A, Onur OA, Cohen MX, Baumgartner T, Metzler S et al (2010). Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans. J Neurosci 30: 4999\u20135007.","journal-title":"J Neurosci"},{"key":"BFnpp201682_CR16","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s00213-012-2645-9","volume":"222","author":"CM Hysek","year":"2012","unstructured":"Hysek CM, Domes G, Liechti ME (2012). MDMA enhances \u2018mind reading\u2019 of positive emotions and impairs \u2018mind reading\u2019 of negative emotions. Psychopharmacology 222: 293\u2013302.","journal-title":"Psychopharmacology"},{"key":"BFnpp201682_CR17","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1093\/scan\/nst161","volume":"9","author":"CM Hysek","year":"2014","unstructured":"Hysek CM, Schmid Y, Simmler LD, Domes G, Heinrichs M, Eisenegger C et al (2014a). MDMA enhances emotional empathy and prosocial behavior. Soc Cogn Affect Neurosci 9: 1645\u20131652.","journal-title":"Soc Cogn Affect Neurosci"},{"key":"BFnpp201682_CR18","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1017\/S1461145713001132","volume":"17","author":"CM Hysek","year":"2014","unstructured":"Hysek CM, Simmler LD, Schillinger N, Meyer N, Schmid Y, Donzelli M et al (2014b). Pharmacokinetic and pharmacodynamic effects of methylphenidate and MDMA administered alone and in combination. Int J Neuropsychopharmacol 17: 371\u2013381.","journal-title":"Int J Neuropsychopharmacol"},{"key":"BFnpp201682_CR19","volume-title":"Die Eigenschaftsw\u00f6rterliste","author":"W Janke","year":"1978","unstructured":"Janke W, Debus G (1978) Die Eigenschaftsw\u00f6rterliste. Hogrefe: G\u00f6ttingen."},{"key":"BFnpp201682_CR20","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1177\/0269881114548296","volume":"28","author":"MW Johnson","year":"2014","unstructured":"Johnson MW, Garcia-Romeu A, Cosimano MP, Griffiths RR (2014). Pilot study of the 5-HT2AR agonist psilocybin in the treatment of tobacco addiction. J Psychopharmacol 28: 983\u2013992.","journal-title":"J Psychopharmacol"},{"key":"BFnpp201682_CR21","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s00213-011-2383-4","volume":"219","author":"MG Kirkpatrick","year":"2012","unstructured":"Kirkpatrick MG, Gunderson EW, Perez AY, Haney M, Foltin RW, Hart CL (2012). A direct comparison of the behavioral and physiological effects of methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) in humans. Psychopharmacology 219: 109\u2013122.","journal-title":"Psychopharmacology"},{"key":"BFnpp201682_CR22","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1038\/npp.2014.12","volume":"39","author":"MG Kirkpatrick","year":"2014","unstructured":"Kirkpatrick MG, Lee R, Wardle MC, Jacob S, de Wit H (2014). Effects of MDMA and intranasal oxytocin on social and emotional processing. Neuropsychopharmacology 39: 1654\u20131663.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp201682_CR23","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.biopsych.2012.04.005","volume":"72","author":"M Kometer","year":"2012","unstructured":"Kometer M, Schmidt A, Bachmann R, Studerus E, Seifritz E, Vollenweider FX (2012). Psilocybin biases facial recognition, goal-directed behavior, and mood state toward positive relative to negative emotions through different serotonergic subreceptors. Biol Psychiatry 72: 898\u2013906.","journal-title":"Biol Psychiatry"},{"key":"BFnpp201682_CR24","doi-asserted-by":"publisher","first-page":"e100719","DOI":"10.1371\/journal.pone.0100719","volume":"9","author":"KP Kuypers","year":"2014","unstructured":"Kuypers KP, de la Torre R, Farre M, Yubero-Lahoz S, Dziobek I, Van den Bos W et al (2014). No evidence that MDMA-induced enhancement of emotional empathy is related to peripheral oxytocin levels or 5-HT1a receptor activation. PLoS One 9: e100719.","journal-title":"PLoS One"},{"key":"BFnpp201682_CR25","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1177\/0269881111420188","volume":"25","author":"KA MacLean","year":"2011","unstructured":"MacLean KA, Johnson MW, Griffiths RR (2011). Mystical experiences occasioned by the hallucinogen psilocybin lead to increases in the personality domain of openness. J Psychopharmacol 25: 1453\u20131461.","journal-title":"J Psychopharmacol"},{"key":"BFnpp201682_CR26","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1177\/0269881110378371","volume":"25","author":"MC Mithoefer","year":"2010","unstructured":"Mithoefer MC, Wagner MT, Mithoefer AT, Jerome I, Doblin R (2010). The safety and efficacy of \u00b13,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study. J Psychopharmacol 25: 439\u2013452.","journal-title":"J Psychopharmacol"},{"key":"BFnpp201682_CR27","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1177\/0269881112456611","volume":"27","author":"MC Mithoefer","year":"2013","unstructured":"Mithoefer MC, Wagner MT, Mithoefer AT, Jerome L, Martin SF, Yazar-Klosinski B et al (2013). Durability of improvement in post-traumatic stress disorder symptoms and absence of harmful effects or drug dependency after 3,4-methylenedioxymethamphetamine-assisted psychotherapy: a prospective long-term follow-up study. J Psychopharmacol 27: 28\u201339.","journal-title":"J Psychopharmacol"},{"key":"BFnpp201682_CR28","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1017\/S1930297500004204","volume":"6","author":"RO Murphy","year":"2011","unstructured":"Murphy RO, Ackermann KA, Handgraaf MJJ (2011). Measuring social value orientation. Judgm Decis Mak 6: 771\u2013781.","journal-title":"Judgm Decis Mak"},{"key":"BFnpp201682_CR29","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1124\/pr.115.011478","volume":"68","author":"DE Nichols","year":"2016","unstructured":"Nichols DE (2016). Psychedelics. Pharmacol Rev 68: 264\u2013355.","journal-title":"Pharmacol Rev"},{"key":"BFnpp201682_CR30","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1177\/0269881112464827","volume":"27","author":"P Oehen","year":"2013","unstructured":"Oehen P, Traber R, Widmer V, Schnyder U (2013). A randomized, controlled pilot study of MDMA (\u00b13,4-methylenedioxymethamphetamine)-assisted psychotherapy for treatment of resistant, chronic post-traumatic stress disorder (PTSD). J Psychopharmacol 27: 40\u201352.","journal-title":"J Psychopharmacol"},{"key":"BFnpp201682_CR31","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/j.1755-5949.2008.00059.x","volume":"14","author":"T Passie","year":"2008","unstructured":"Passie T, Halpern JH, Stichtenoth DO, Emrich HM, Hintzen A (2008). The pharmacology of lysergic acid diethylamide: a review. CNS Neurosci Ther 14: 295\u2013314.","journal-title":"CNS Neurosci Ther"},{"issue":"Suppl. 1","key":"BFnpp201682_CR32","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/S0924-9338(15)30017-1","volume":"30","author":"KH Preller","year":"2015","unstructured":"Preller KH, Pokorny T, Kr\u00e4henmann R, Dziobek I, St\u00e4mpfli P, Vollenweider FX (2015). The effect of 5-HT2A\/1a agonist treatment on social cognition, empathy, and social decision-making. Eur Psychiatry 30 (Suppl. 1): 22.","journal-title":"Eur Psychiatry"},{"issue":"8","key":"BFnpp201682_CR33","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.biopsych.2014.11.015","volume":"78","author":"Y Schmid","year":"2015","unstructured":"Schmid Y, Enzler F, Gasser P, Grouzmann E, Preller KH, Vollenweider FX et al (2015). Acute effects of lysergic acid diethylamide in healthy subjects. Biol Psychiatry 78 (8): 544\u2013553.","journal-title":"Biol Psychiatry"},{"key":"BFnpp201682_CR34","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1177\/0269881114542454","volume":"28","author":"Y Schmid","year":"2014","unstructured":"Schmid Y, Hysek CM, Simmler LD, Crockett MJ, Quednow BB, Liechti ME (2014). Differential effects of MDMA and methylphenidate on social cognition. J Psychopharmacol 28: 847\u2013856.","journal-title":"J Psychopharmacol"},{"issue":"3","key":"BFnpp201682_CR35","doi-asserted-by":"publisher","first-page":"n\/a-n\/a","DOI":"10.1111\/jne.12374","volume":"28","author":"P. Strajhar","year":"2016","unstructured":"Strajhar P, Schmid Y, Liakoni E, Dolder PC, Rentsch KM, Kratschmar DV et al (2016). Acute effects of LSD on circulating steroid levels in healthy subjects. J Neuroendocrinol (doi:10.1111\/jne.12374).","journal-title":"Journal of Neuroendocrinology"},{"key":"BFnpp201682_CR36","doi-asserted-by":"publisher","first-page":"3897","DOI":"10.1097\/00001756-199812010-00024","volume":"9","author":"FX Vollenweider","year":"1998","unstructured":"Vollenweider FX, Vollenweider-Scherpenhuyzen MF, Babler A, Vogel H, Hell D (1998). Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action. Neuroreport 9: 3897\u20133902.","journal-title":"Neuroreport"},{"key":"BFnpp201682_CR37","doi-asserted-by":"publisher","first-page":"4219","DOI":"10.1007\/s00213-014-3570-x","volume":"231","author":"MC Wardle","year":"2014","unstructured":"Wardle MC, de Wit H (2014). MDMA alters emotional processing and facilitates positive social interaction. Psychopharmacology 231: 4219\u20134229.","journal-title":"Psychopharmacology"},{"key":"BFnpp201682_CR38","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1093\/scan\/nsu035","volume":"9","author":"MC Wardle","year":"2014","unstructured":"Wardle MC, Kirkpatrick MG, de Wit H (2014). 'Ecstasy' as a social drug: MDMA preferentially affects responses to emotional stimuli with social content. Soc Cogn Affect Neurosci 9: 1076\u20131081.","journal-title":"Soc Cogn Affect Neurosci"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/npp201682.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp201682","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp201682.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T14:20:44Z","timestamp":1692368444000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/npp201682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,1]]},"references-count":38,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["BFnpp201682"],"URL":"https:\/\/doi.org\/10.1038\/npp.2016.82","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,1]]},"assertion":[{"value":"4 March 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}