{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:39:52Z","timestamp":1792143592151,"version":"4.4.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T00:00:00Z","timestamp":1495670400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol."],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1038\/npp.2017.102","type":"journal-article","created":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T11:01:02Z","timestamp":1495710062000},"page":"342-353","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Anxiety Associated Increased CpG Methylation in the Promoter of Asb1: A Translational Approach Evidenced by Epidemiological and Clinical Studies and a Murine Model"],"prefix":"10.1038","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8780-5439","authenticated-orcid":false,"given":"Rebecca T","family":"Emeny","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Baumert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6897-9652","authenticated-orcid":false,"given":"Anthony S","family":"Zannas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Kunze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Wahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Iurato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Arloth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Erhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Balsevich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias V","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Kretschmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliane","family":"Pfeiffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Kruse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Strauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Roden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Herder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Koenig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gieger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Waldenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth B","family":"Binder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Heinz","family":"Ladwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,5,25]]},"reference":[{"key":"BFnpp2017102_CR1","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1002\/jlb.66.4.588","volume":"66","author":"WS Alexander","year":"1999","unstructured":"Alexander WS, Starr R, Metcalf D, Nicholson SE, Farley A, Elefanty AG et al (1999). Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction. J Leuk Biol 66: 588\u2013592.","journal-title":"J Leuk Biol"},{"key":"BFnpp2017102_CR2","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1074\/jbc.M113.534602","volume":"289","author":"CA Andresen","year":"2014","unstructured":"Andresen CA, Smedegaard S, Sylvestersen KB, Svensson C, Iglesias-Gato D, Cazzamali G et al (2014). Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. J Biol Chem 289: 2043\u20132054.","journal-title":"J Biol Chem"},{"key":"BFnpp2017102_CR3","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1097\/00004850-199506000-00003","volume":"10","author":"B Bandelow","year":"1995","unstructured":"Bandelow B (1995). Assessing the efficacy of treatments for panic disorder and agoraphobia. II. The Panic and Agoraphobia Scale. Int Clin Psychopharmacol 10: 73\u201381.","journal-title":"Int Clin Psychopharmacol"},{"key":"BFnpp2017102_CR4","doi-asserted-by":"publisher","first-page":"e83223","DOI":"10.1371\/journal.pone.0083223","volume":"8","author":"R Bayles","year":"2013","unstructured":"Bayles R, Baker EK, Jowett JB, Barton D, Esler M, El-Osta A et al (2013). Methylation of the SLC6a2 gene promoter in major depression and panic disorder. PLoS ONE 8: e83223.","journal-title":"PLoS ONE"},{"key":"BFnpp2017102_CR5","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.janxdis.2014.06.002","volume":"28","author":"C Beard","year":"2014","unstructured":"Beard C, Bj\u00f6rgvinsson T (2014). Beyond generalized anxiety disorder: psychometric properties of the GAD-7 in a heterogeneous psychiatric sample. J Anxiety Disord 28: 547\u2013552.","journal-title":"J Anxiety Disord"},{"key":"BFnpp2017102_CR6","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1001\/archgenpsychiatry.2009.177","volume":"67","author":"K Beesdo","year":"2010","unstructured":"Beesdo K, Pine DS, Lieb R, Wittchen H (2010). INcidence and risk patterns of anxiety and depressive disorders and categorization of generalized anxiety disorder. Archiv Gen Psychiatry 67: 47\u201357.","journal-title":"Archiv Gen Psychiatry"},{"key":"BFnpp2017102_CR7","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1007\/s11033-015-3860-3","volume":"42","author":"CS Boosani","year":"2015","unstructured":"Boosani CS, Agrawal DK (2015). Methylation and microRNA-mediated epigenetic regulation of SOCS3. Mol Biol Rep 42: 853\u2013872.","journal-title":"Mol Biol Rep"},{"key":"BFnpp2017102_CR8","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1176\/appi.ajp.2013.12050651","volume":"170","author":"JC Britton","year":"2013","unstructured":"Britton JC, Grillon C, Lissek S, Norcross MA, Szuhany KL, Chen G et al (2013). Response to learned threat: an fMRI study in adolescent and adult anxiety. Am J Psychiatry 170: 1195\u20131204.","journal-title":"Am J Psychiatry"},{"key":"BFnpp2017102_CR9","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.mehy.2013.07.006","volume":"81","author":"A Camacho","year":"2013","unstructured":"Camacho A (2013). Is anxious-depression an inflammatory state? Med Hypotheses 81: 577\u2013581.","journal-title":"Med Hypotheses"},{"key":"BFnpp2017102_CR10","unstructured":"Campos AC, Fogaca MV, Aguiar DC, Guimaraes FS (2013). Animal models of anxiety disorders and stress. Rev Bras Psiquiatr 35: S101\u2013S111.."},{"key":"BFnpp2017102_CR11","doi-asserted-by":"publisher","first-page":"203","DOI":"10.4161\/epi.23470","volume":"8","author":"YA Chen","year":"2013","unstructured":"Chen YA, Lemire M, Choufani S, Butcher DT, Grafodatskaya D, Zanke BW et al (2013). Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray. Epigenetics 8: 203\u2013209.","journal-title":"Epigenetics"},{"key":"BFnpp2017102_CR12","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1177\/0269881111400648","volume":"25","author":"N Chevallier","year":"2011","unstructured":"Chevallier N, Keller E, Maurice T (2011). Behavioural phenotyping of knockout mice for the sigma-1 (sigma(1)) chaperone protein revealed gender-related anxiety, depressive-like and memory alterations. J Psychopharmacol 25: 960\u2013975.","journal-title":"J Psychopharmacol"},{"key":"BFnpp2017102_CR13","doi-asserted-by":"publisher","first-page":"4716","DOI":"10.1128\/MCB.25.11.4716-4726.2005","volume":"25","author":"AS Chung","year":"2005","unstructured":"Chung AS, Guan YJ, Yuan ZL, Albina JE, Chin YE (2005). Ankyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and degradation of tumor necrosis factor receptor II. Mol Cell Biol 25: 4716\u20134726.","journal-title":"Mol Cell Biol"},{"key":"BFnpp2017102_CR14","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1186\/1471-2105-11-587","volume":"11","author":"P Du","year":"2010","unstructured":"Du P, Zhang X, Huang CC, Jafari N, Kibbe WA, Hou L et al (2010). Comparison of beta-value and M-value methods for quantifying methylation levels by microarray analysis. BMC Bioinformatics 11: 587.","journal-title":"BMC Bioinformatics"},{"key":"BFnpp2017102_CR15","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s40880-017-0180-0","volume":"36","author":"WY Du","year":"2017","unstructured":"Du WY, Lu ZH, Ye W, Fu X, Zhou Y, Kuang CM et al (2017). The loss-of-function mutations and down-regulated expression of ASB3 gene promote the growth and metastasis of colorectal cancer cells. Chin J Cancer 36: 11.","journal-title":"Chin J Cancer"},{"key":"BFnpp2017102_CR16","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/2045-5380-2-10","volume":"2","author":"AM El-Sayed","year":"2012","unstructured":"El-Sayed AM, Haloossim MR, Galea S, Koenen KC (2012). Epigenetic modifications associated with suicide and common mood and anxiety disorders: a systematic review of the literature. Biol MoodAnxiety Disord 2: 10.","journal-title":"Biol MoodAnxiety Disord"},{"key":"BFnpp2017102_CR17","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.it.2004.05.012","volume":"25","author":"J Elliott","year":"2004","unstructured":"Elliott J, Johnston JA (2004). SOCS: role in inflammation, allergy and homeostasis. Trends Immunol 25: 434\u2013440.","journal-title":"Trends Immunol"},{"key":"BFnpp2017102_CR18","doi-asserted-by":"publisher","first-page":"e156","DOI":"10.1038\/tp.2012.85","volume":"2","author":"A Erhardt","year":"2012","unstructured":"Erhardt A, Akula N, Schumacher J, Czamara D, Karbalai N, Muller-Myhsok B et al (2012). Replication and meta-analysis of TMEM132D gene variants in panic disorder. Transl Psychiatry 2: e156.","journal-title":"Transl Psychiatry"},{"key":"BFnpp2017102_CR19","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/mp.2010.41","volume":"16","author":"A Erhardt","year":"2011","unstructured":"Erhardt A, Czibere L, Roeske D, Lucae S, Unschuld PG, Ripke S et al (2011). TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies. Mol Psychiatry 16: 647\u2013663.","journal-title":"Mol Psychiatry"},{"key":"BFnpp2017102_CR20","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1186\/s13059-014-0503-2","volume":"15","author":"JP Fortin","year":"2014","unstructured":"Fortin JP, Labbe A, Lemire M, Zanke BW, Hudson TJ, Fertig EJ et al (2014). Functional normalization of 450k methylation array data improves replication in large cancer studies. Genome Biol 15: 503.","journal-title":"Genome Biol"},{"key":"BFnpp2017102_CR21","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.brainresrev.2007.10.014","volume":"58","author":"BW Haas","year":"2008","unstructured":"Haas BW, Canli T (2008). Emotional memory function, personality structure and psychopathology: a neural system approach to the identification of vulnerability markers. Brain Res Rev 58: 71\u201384.","journal-title":"Brain Res Rev"},{"key":"BFnpp2017102_CR22","doi-asserted-by":"publisher","first-page":"3663","DOI":"10.2337\/dc13-0382","volume":"36","author":"C Herder","year":"2013","unstructured":"Herder C, Bongaerts BWC, Rathmann W, Heier M, Kowall B, Koenig W et al (2013). Association of subclinical inflammation with polyneuropathy in the older population: KORA F4 Study. Diabetes Care 36: 3663\u20133670.","journal-title":"Diabetes Care"},{"issue":"Suppl 1","key":"BFnpp2017102_CR23","doi-asserted-by":"publisher","first-page":"S19","DOI":"10.1055\/s-2005-858235","volume":"67","author":"R Holle","year":"2005","unstructured":"Holle R, Happich M, Lowel H, Wichmann HE Group MKS (2005). KORA\u2014a research platform for population based health research. Gesundheitswesen 67 (Suppl 1): S19\u2013S25.","journal-title":"Gesundheitswesen"},{"key":"BFnpp2017102_CR24","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/1471-2105-13-86","volume":"13","author":"EA Houseman","year":"2012","unstructured":"Houseman EA, Accomando WP, Koestler DC, Christensen BC, Marsit CJ, Nelson HH et al (2012). DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinformatics 13: 86.","journal-title":"BMC Bioinformatics"},{"key":"BFnpp2017102_CR25","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/mp.2015.138","volume":"21","author":"AS Howe","year":"2016","unstructured":"Howe AS, Buttenschon HN, Bani-Fatemi A, Maron E, Otowa T, Erhardt A et al (2016). Candidate genes in panic disorder: meta-analyses of 23 common variants in major anxiogenic pathways. Mol Psychiatry 21: 665\u2013679.","journal-title":"Mol Psychiatry"},{"key":"BFnpp2017102_CR26","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1001\/archpsyc.1995.03950170048007","volume":"52","author":"KS Kendler","year":"1995","unstructured":"Kendler KS, Walters EE, Neale MC, Kessler RC, Heath AC, Eaves LJ (1995). The structure of the genetic and environmental risk factors for six major psychiatric disorders in women. Phobia, generalized anxiety disorder, panic disorder, bulimia, major depression, and alcoholism. Archiv Gen Psychiatry 52: 374\u2013383.","journal-title":"Archiv Gen Psychiatry"},{"key":"BFnpp2017102_CR27","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1016\/j.neuron.2015.05.036","volume":"86","author":"T Klengel","year":"2015","unstructured":"Klengel T, Binder EB (2015). Epigenetics of stress-related psychiatric disorders and gene x environment interactions. Neuron 86: 1343\u20131357.","journal-title":"Neuron"},{"key":"BFnpp2017102_CR28","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/nn.3275","volume":"16","author":"T Klengel","year":"2013","unstructured":"Klengel T, Mehta D, Anacker C, Rex-Haffner M, Pruessner JC, Pariante CM et al (2013). Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nature Neurosci 16: 33\u201341.","journal-title":"Nature Neurosci"},{"key":"BFnpp2017102_CR29","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1634\/stemcells.19-5-378","volume":"19","author":"DL Krebs","year":"2001","unstructured":"Krebs DL, Hilton DJ (2001). SOCS proteins: negative regulators of cytokine signaling. Stem cells 19: 378\u2013387.","journal-title":"Stem cells"},{"key":"BFnpp2017102_CR30","doi-asserted-by":"publisher","first-page":"317","DOI":"10.7326\/0003-4819-146-5-200703060-00004","volume":"146","author":"K Kroenke","year":"2007","unstructured":"Kroenke K, Spitzer RL, Williams JB, Monahan PO, Lowe B (2007). Anxiety disorders in primary care: prevalence, impairment, comorbidity, and detection. Ann Intern Med 146: 317\u2013325.","journal-title":"Ann Intern Med"},{"key":"BFnpp2017102_CR31","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/2045-5380-2-18","volume":"2","author":"MP Leussis","year":"2012","unstructured":"Leussis MP, Madison JM, Petryshen TL (2012). Ankyrin 3: genetic association with bipolar disorder and relevance to disease pathophysiology. Biol Mood Anxiety Disord 2: 18.","journal-title":"Biol Mood Anxiety Disord"},{"key":"BFnpp2017102_CR32","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.1016\/j.psyneuen.2013.04.013","volume":"38","author":"MW Logue","year":"2013","unstructured":"Logue MW, Solovieff N, Leussis MP, Wolf EJ, Melista E, Baldwin C et al (2013). The ankyrin-3 gene is associated with posttraumatic stress disorder and externalizing comorbidity. Psychoneuroendocrinology 38: 2249\u20132257.","journal-title":"Psychoneuroendocrinology"},{"key":"BFnpp2017102_CR33","doi-asserted-by":"publisher","first-page":"e0166015","DOI":"10.1371\/journal.pone.0166015","volume":"11","author":"C Marzi","year":"2016","unstructured":"Marzi C, Holdt LM, Fiorito G, Tsai P-C, Kretschmer A, Wahl S et al (2016). Epigenetic signatures at AQP3 and SOCS3 engage in low-grade inflammation across different tissues. PLoS ONE 11: e0166015.","journal-title":"PLoS ONE"},{"key":"BFnpp2017102_CR34","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/npp.2016.146","volume":"42","author":"V Michopoulos","year":"2017","unstructured":"Michopoulos V, Powers A, Gillespie CF, Ressler KJ, Jovanovic T (2017). Inflammation in fear- and anxiety-based disorders: PTSD, GAD, and beyond. Neuropsychopharmacology 42: 254\u2013270.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2017102_CR35","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.jmb.2003.09.012","volume":"333","author":"MK Miller","year":"2003","unstructured":"Miller MK, Bang ML, Witt CC, Labeit D, Trombitas C, Watanabe K et al (2003). The muscle ankyrin repeat proteins: CARP, ankrd2\/Arpp and DARP as a family of titin filament-based stress response molecules. J Mol Biol 333: 951\u2013964.","journal-title":"J Mol Biol"},{"key":"BFnpp2017102_CR36","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1001\/jamapsychiatry.2016.0144","volume":"73","author":"C Montano","year":"2016","unstructured":"Montano C, Taub MA, Jaffe A, Briem E, Feinberg JI, Trygvadottir R et al (2016). Association of DNA methylation differences with schizophrenia in an epigenome-wide association study. JAMA Psychiatry 73: 506\u2013514.","journal-title":"JAMA Psychiatry"},{"key":"BFnpp2017102_CR37","doi-asserted-by":"publisher","first-page":"3166","DOI":"10.1016\/j.jmb.2013.06.015","volume":"425","author":"JR Muniz","year":"2013","unstructured":"Muniz JR, Guo K, Kershaw NJ, Ayinampudi V, von Delft F, Babon JJ et al (2013). Molecular architecture of the ankyrin SOCS box family of Cul5-dependent E3 ubiquitin ligases. J Mol Biol 425: 3166\u20133177.","journal-title":"J Mol Biol"},{"key":"BFnpp2017102_CR38","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1097\/YPG.0000000000000055","volume":"25","author":"TM Murphy","year":"2015","unstructured":"Murphy TM, O'Donovan A, Mullins N, O'Farrelly C, McCann A, Malone K (2015). Anxiety is associated with higher levels of global DNA methylation and altered expression of epigenetic and interleukin-6 genes. Psychiatr Genet 25: 71\u201378.","journal-title":"Psychiatr Genet"},{"key":"BFnpp2017102_CR39","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/nature11011","volume":"485","author":"BM Neale","year":"2012","unstructured":"Neale BM, Kou Y, Liu L, Ma'ayan A, Samocha KE, Sabo A et al (2012). Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature 485: 242\u2013245.","journal-title":"Nature"},{"key":"BFnpp2017102_CR40","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1177\/1073858415608147","volume":"22","author":"EJ Nestler","year":"2015","unstructured":"Nestler EJ, Pena CJ, Kundakovic M, Mitchell A, Akbarian S (2015). Epigenetic basis of mental illness. Neuroscientist 22: 447\u2013463.","journal-title":"Neuroscientist"},{"key":"BFnpp2017102_CR41","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1161\/CIRCGENETICS.114.000804","volume":"8","author":"L Pfeiffer","year":"2015","unstructured":"Pfeiffer L, Wahl S, Pilling LC, Reischl E, Sandling JK, Kunze S et al (2015). DNA methylation of lipid-related genes affects blood lipid levels. Circ Cardiovasc Genet 8: 334\u2013342.","journal-title":"Circ Cardiovasc Genet"},{"key":"BFnpp2017102_CR42","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/sj.mp.4001636","volume":"10","author":"RH Segman","year":"2005","unstructured":"Segman RH, Shefi N, Goltser-Dubner T, Friedman N, Kaminski N, Shalev AY (2005). Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors. Mol Psychiatry 10: 500\u2013513 425.","journal-title":"Mol Psychiatry"},{"key":"BFnpp2017102_CR43","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1111\/pcn.12291","volume":"69","author":"M Shimada-Sugimoto","year":"2015","unstructured":"Shimada-Sugimoto M, Otowa T, Hettema JM (2015). Genetics of anxiety disorders: genetic epidemiological and molecular studies in humans. Psychiatry Clin Neurosci 69: 388\u2013401.","journal-title":"Psychiatry Clin Neurosci"},{"key":"BFnpp2017102_CR44","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1037\/a0035302","volume":"140","author":"GM Slavich","year":"2014","unstructured":"Slavich GM, Irwin MR (2014). From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychol Bull 140: 774\u2013815.","journal-title":"Psychol Bull"},{"key":"BFnpp2017102_CR45","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1002\/ajmg.b.31212","volume":"156B","author":"AK Smith","year":"2011","unstructured":"Smith AK, Conneely KN, Kilaru V, Mercer KB, Weiss TE, Bradley B et al (2011). Differential immune system DNA methylation and cytokine regulation in post-traumatic stress disorder. Am J Med GenetB Neuropsychiatr Genet 156B: 700\u2013708.","journal-title":"Am J Med GenetB Neuropsychiatr Genet"},{"key":"BFnpp2017102_CR46","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/npp.2015.266","volume":"41","author":"JW Smoller","year":"2016","unstructured":"Smoller JW (2016). The genetics of stress-related disorders: PTSD, depression, and anxiety disorders. Neuropsychopharmacology 41: 297\u2013319.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2017102_CR47","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1001\/archinte.166.10.1092","volume":"166","author":"RL Spitzer","year":"2006","unstructured":"Spitzer RL, Kroenke K, Williams JB, Lowe B (2006). A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med 166: 1092\u20131097.","journal-title":"Arch Intern Med"},{"key":"BFnpp2017102_CR48","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1038\/npp.2016.129","volume":"42","author":"JR Swartz","year":"2017","unstructured":"Swartz JR, Prather AA, Di Iorio CR, Bogdan R, Hariri AR (2017). A functional interleukin-18 haplotype predicts depression and anxiety through increased threat-related amygdala reactivity in women but not men. Neuropsychopharmacology 42: 419\u2013426.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2017102_CR49","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1016\/S0140-6736(06)69865-6","volume":"368","author":"P Tyrer","year":"2006","unstructured":"Tyrer P, Baldwin D (2006). Generalised anxiety disorder. Lancet 368: 2156\u20132166.","journal-title":"Lancet"},{"key":"BFnpp2017102_CR50","doi-asserted-by":"publisher","first-page":"9470","DOI":"10.1073\/pnas.0910794107","volume":"107","author":"M Uddin","year":"2010","unstructured":"Uddin M, Aiello AE, Wildman DE, Koenen KC, Pawelec G, de Los Santos R et al (2010). Epigenetic and immune function profiles associated with posttraumatic stress disorder. Proc Natl Acad Sci USA 107: 9470\u20139475.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"BFnpp2017102_CR51","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1038\/nn.3395","volume":"16","author":"Xiao-Dong Wang","year":"2013","unstructured":"Wang XD, Su YA, Wagner KV, Avrabos C, Scharf SH, Hartmann J et al (2013). Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss. Nat Neurosci 16: 706\u2013713..","journal-title":"Nature Neuroscience"},{"key":"BFnpp2017102_CR52","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1038\/ejhg.2012.47","volume":"20","author":"BT Webb","year":"2012","unstructured":"Webb BT, Guo AY, Maher BS, Zhao Z, van den Oord EJ, Kendler KS et al (2012). Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes. Eur J Hum Genet 20: 1078\u20131084.","journal-title":"Eur J Hum Genet"},{"issue":"Suppl 1","key":"BFnpp2017102_CR53","doi-asserted-by":"publisher","first-page":"S26","DOI":"10.1055\/s-2005-858226","volume":"67","author":"HE Wichmann","year":"2005","unstructured":"Wichmann HE, Gieger C, Illig T, Group MKS (2005). KORA-gen\u2014resource for population genetics, controls and a broad spectrum of disease phenotypes. Gesundheitswesen 67 (Suppl 1): S26\u2013S30.","journal-title":"Gesundheitswesen"},{"key":"BFnpp2017102_CR54","volume-title":"DIA-X-Interviews: Manual f\u00fcr Screening-Verfahren und Interview","author":"H Wittchen","year":"1997","unstructured":"Wittchen H (1997) DIA-X-Interviews: Manual f\u00fcr Screening-Verfahren und Interview. Frankfurt."},{"key":"BFnpp2017102_CR55","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/mp.2016.46","volume":"21","author":"ML Wong","year":"2016","unstructured":"Wong ML, Inserra A, Lewis MD, Mastronardi CA, Leong L, Choo J et al (2016). Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition. Mol Psychiatry 21: 797\u2013805.","journal-title":"Mol Psychiatry"},{"key":"BFnpp2017102_CR56","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/npp.2015.235","volume":"41","author":"AS Zannas","year":"2015","unstructured":"Zannas AS, Wiechmann T, Gassen NC, Binder EB (2015). Gene-stress-epigenetic regulation of FKBP5: clinical and translational implications. Neuropsychopharmacology 41: 261\u2013274.","journal-title":"Neuropsychopharmacology"},{"key":"BFnpp2017102_CR57","doi-asserted-by":"publisher","first-page":"e63812","DOI":"10.1371\/journal.pone.0063812","volume":"8","author":"S Zeilinger","year":"2013","unstructured":"Zeilinger S, Kuhnel B, Klopp N, Baurecht H, Kleinschmidt A, Gieger C et al (2013). Tobacco smoking leads to extensive genome-wide changes in DNA methylation. PLoS ONE 8: e63812.","journal-title":"PLoS ONE"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/npp2017102.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp2017102","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/npp.2017.102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/npp2017102.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T23:57:28Z","timestamp":1684454248000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/npp2017102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,25]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["BFnpp2017102"],"URL":"https:\/\/doi.org\/10.1038\/npp.2017.102","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,25]]},"assertion":[{"value":"18 May 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}