{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:47:35Z","timestamp":1788468455145,"version":"build-2803163510"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T00:00:00Z","timestamp":1485475200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1038\/npp.2017.20","type":"journal-article","created":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T12:00:52Z","timestamp":1485518452000},"page":"1491-1501","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Protein Kinase C \u03b2: a New Target Therapy to Prevent the Long-Term Atypical Antipsychotic-Induced Weight Gain"],"prefix":"10.1038","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7091-5765","authenticated-orcid":false,"given":"Alessandro","family":"Rimessi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Pavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elli","family":"Ioannidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Nigro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Morganti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Brugnoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Longo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Gardin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Ferroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Morari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Vindigni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Zavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Pinton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,27]]},"reference":[{"key":"BFnpp201720_CR1","doi-asserted-by":"publisher","first-page":"2613","DOI":"10.1126\/science.1056843","volume":"291","author":"L Abu-Elheiga","year":"2001","unstructured":"Abu-Elheiga L, Matzuk MM, Abo-Hashema KA, Wakil SJ (2001). Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science 291: 2613\u20132616.","journal-title":"Science"},{"key":"BFnpp201720_CR2","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1073\/pnas.0711402105","volume":"105","author":"P Aguiari","year":"2008","unstructured":"Aguiari P, Leo S, Zavan B, Vindigni V, Rimessi A, Bianchi K et al (2008). High glucose induces adipogenic differentiation of muscle-derived stem cells. Proc Natl Acad Sci USA 105: 1226\u20131231.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFnpp201720_CR3","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1074\/jbc.M707268200","volume":"283","author":"RR Bansode","year":"2008","unstructured":"Bansode RR, Huang W, Roy SK, Mehta M, Mehta KD (2008). Protein kinase C deficiency increases fatty acid oxidation and reduces fat storage. J Biol Chem 283: 231\u2013236.","journal-title":"J Biol Chem"},{"key":"BFnpp201720_CR4","doi-asserted-by":"publisher","first-page":"329098","DOI":"10.4061\/2011\/329098","volume":"2011","author":"A Bononi","year":"2011","unstructured":"Bononi A, Agnoletto C, De Marchi E, Marchi S, Patergnani S, Bonora M et al (2011). Protein kinases and phosphatases in the control of cell fate. Enzyme Res 2011: 329098.","journal-title":"Enzyme Res"},{"key":"BFnpp201720_CR5","doi-asserted-by":"publisher","first-page":"38486","DOI":"10.1074\/jbc.M007322200","volume":"275","author":"DL Brasaemle","year":"2000","unstructured":"Brasaemle DL, Rubin B, Harten IA, Gruia-Gray J, Kimmel AR, Londos C (2000). Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis. J Biol Chem 275: 38486\u201338493.","journal-title":"J Biol Chem"},{"key":"BFnpp201720_CR6","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1091\/mbc.8.1.129","volume":"8","author":"M Brini","year":"1997","unstructured":"Brini M, De Giorgi F, Murgia M, Marsault R, Massimino ML, Cantini M et al (1997). Subcellular analysis of Ca2+ homeostasis in primary cultures of skeletal muscle myotubes. Mol Biol Cell 8: 129\u2013143.","journal-title":"Mol Biol Cell"},{"key":"BFnpp201720_CR7","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.schres.2012.03.017","volume":"140","author":"J Caemmerer","year":"2012","unstructured":"Caemmerer J, Correll CU, Maayan L (2012). Acute and maintenance effects of non-pharmacologic interventions for antipsychotic associated weight gain and metabolic abnormalities: a meta-analytic comparison of randomized controlled trials. Schizophr Res 140: 159\u2013168.","journal-title":"Schizophr Res"},{"key":"BFnpp201720_CR8","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3810\/pgm.2008.07.1786","volume":"120","author":"L Citrome","year":"2008","unstructured":"Citrome L, Vreeland B (2008). Schizophrenia, obesity, and antipsychotic medications: what can we do? Postgrad Med 120: 18\u201333.","journal-title":"Postgrad Med"},{"key":"BFnpp201720_CR9","first-page":"171","volume":"39","author":"RP Danis","year":"1998","unstructured":"Danis RP, Bingaman DP, Jirousek M, Yang Y (1998). Inhibition of intraocular neovascularization caused by retinal ischemia in pigs by PKCbeta inhibition with LY333531. Invest Ophthalmol Vis Sci 39: 171\u2013179.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFnpp201720_CR10","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1159\/000431204","volume":"55","author":"HL Deissler","year":"2016","unstructured":"Deissler HL, Lang GE (2016). The protein kinase C inhibitor: ruboxistaurin. Dev Ophthalmol 55: 295\u2013301.","journal-title":"Dev Ophthalmol"},{"key":"BFnpp201720_CR11","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.ecl.2013.05.006","volume":"42","author":"C Deng","year":"2013","unstructured":"Deng C (2013). Effects of antipsychotic medications on appetite, weight, and insulin resistance. Endocrinol Metab Clin North Am 42: 545\u2013563.","journal-title":"Endocrinol Metab Clin North Am"},{"key":"BFnpp201720_CR12","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0022-1759(86)90368-6","volume":"89","author":"F Denizot","year":"1986","unstructured":"Denizot F, Lang R (1986). Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 89: 271\u2013277.","journal-title":"J Immunol Methods"},{"key":"BFnpp201720_CR13","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1001\/archgenpsychiatry.2011.2","volume":"68","author":"DL Foley","year":"2011","unstructured":"Foley DL, Morley KI (2011). Systematic review of early cardiometabolic outcomes of the first treated episode of psychosis. Arch Gen Psychiatry 68: 609\u2013616.","journal-title":"Arch Gen Psychiatry"},{"key":"BFnpp201720_CR14","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1017\/S146114571100201X","volume":"15","author":"C Frogley","year":"2012","unstructured":"Frogley C, Taylor D, Dickens G, Picchioni M (2012). A systematic review of the evidence of clozapine's anti-aggressive effects. Int J Neuropsychopharmacol 15: 1351\u20131371.","journal-title":"Int J Neuropsychopharmacol"},{"key":"BFnpp201720_CR15","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/j.cell.2014.11.006","volume":"159","author":"L Galluzzi","year":"2014","unstructured":"Galluzzi L, Pietrocola F, Levine B, Kroemer G (2014). Metabolic control of autophagy. Cell 159: 1263\u20131276.","journal-title":"Cell"},{"key":"BFnpp201720_CR16","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1089\/ars.2009.2825","volume":"13","author":"C Giorgi","year":"2010","unstructured":"Giorgi C, Agnoletto C, Baldini C, Bononi A, Bonora M, Marchi S et al (2010). Redox control of protein kinase C: cell- and disease-specific aspects. Antioxid Redox Signal 13: 1051\u20131085.","journal-title":"Antioxid Redox Signal"},{"key":"BFnpp201720_CR17","doi-asserted-by":"publisher","first-page":"843","DOI":"10.4088\/JCP.v62n1102","volume":"62","author":"S Hagg","year":"2001","unstructured":"Hagg S, Soderberg S, Ahren B, Olsson T, Mjorndal T (2001). Leptin concentrations are increased in subjects treated with clozapine or conventional antipsychotics. J Clin Psychiatry 62: 843\u2013848.","journal-title":"J Clin Psychiatry"},{"key":"BFnpp201720_CR18","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s00213-002-1368-8","volume":"167","author":"AW Hartfield","year":"2003","unstructured":"Hartfield AW, Moore NA, Clifton PG (2003). Effects of clozapine, olanzapine and haloperidol on the microstructure of ingestive behaviour in the rat. Psychopharmacology 167: 115\u2013122.","journal-title":"Psychopharmacology"},{"key":"BFnpp201720_CR19","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1038\/sj.mp.4001892","volume":"11","author":"K Hemmrich","year":"2006","unstructured":"Hemmrich K, Gummersbach C, Pallua N, Luckhaus C, Fehsel K (2006). Clozapine enhances differentiation of adipocyte progenitor cells. Mol Psychiatry 11: 980\u2013981.","journal-title":"Mol Psychiatry"},{"key":"BFnpp201720_CR20","first-page":"33","volume":"22","author":"DC Henderson","year":"2010","unstructured":"Henderson DC, Sharma B, Fan X, Copeland PM, Borba CP, Freudenreich O et al (2010). Dietary saturated fat intake and glucose metabolism impairments in nondiabetic, nonobese patients with schizophrenia on clozapine or risperidone. Ann Clin Psychiatry 22: 33\u201342.","journal-title":"Ann Clin Psychiatry"},{"key":"BFnpp201720_CR21","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1002\/hep.22815","volume":"49","author":"W Huang","year":"2009","unstructured":"Huang W, Bansode R, Mehta M, Mehta KD (2009). Loss of protein kinase Cbeta function protects mice against diet-induced obesity and development of hepatic steatosis and insulin resistance. Hepatology 49: 1525\u20131536.","journal-title":"Hepatology"},{"key":"BFnpp201720_CR22","doi-asserted-by":"publisher","first-page":"11059","DOI":"10.1073\/pnas.89.22.11059","volume":"89","author":"T Inoguchi","year":"1992","unstructured":"Inoguchi T, Battan R, Handler E, Sportsman JR, Heath W, King GL (1992). Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci USA 89: 11059\u201311063.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFnpp201720_CR23","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1126\/science.272.5262.728","volume":"272","author":"H Ishii","year":"1996","unstructured":"Ishii H, Jirousek MR, Koya D, Takagi C, Xia P, Clermont A et al (1996). Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science 272: 728\u2013731.","journal-title":"Science"},{"key":"BFnpp201720_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15548627.2015.1100356","volume":"12","author":"DJ Klionsky","year":"2016","unstructured":"Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12: 1\u2013222.","journal-title":"Autophagy"},{"key":"BFnpp201720_CR25","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1097\/jcp.0b013e31815a8872","volume":"27","author":"M Kluge","year":"2007","unstructured":"Kluge M, Schuld A, Himmerich H, Dalal M, Schacht A, Wehmeier PM et al (2007). Clozapine and olanzapine are associated with food craving and binge eating: results from a randomized double-blindstudy. J Clin Psychopharmacol 27: 662\u2013666.","journal-title":"J Clin Psychopharmacol"},{"key":"BFnpp201720_CR26","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.schres.2016.05.002","volume":"174","author":"SE Legge","year":"2016","unstructured":"Legge SE, Hamshere M, Hayes RD, Downs J, O'Donovan MC, Owen MJ et al (2016). Reasons for discontinuing clozapine: a cohort study of patients commencing treatment. Schizophr Res 174: 113\u2013119.","journal-title":"Schizophr Res"},{"key":"BFnpp201720_CR27","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.2337\/db12-1391","volume":"62","author":"S Lei","year":"2013","unstructured":"Lei S, Li H, Xu J, Liu Y, Gao X, Wang J et al (2013). Hyperglycemia-induced protein kinase C beta2 activation induces diastolic cardiac dysfunction in diabetic rats by impairing caveolin-3 expression and Akt\/eNOS signaling. Diabetes 62: 2318\u20132328.","journal-title":"Diabetes"},{"key":"BFnpp201720_CR28","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0140-6736(08)61764-X","volume":"373","author":"S Leucht","year":"2009","unstructured":"Leucht S, Corves C, Arbter D, Engel RR, Li C, Davis JM (2009). Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis. Lancet 373: 31\u201341.","journal-title":"Lancet"},{"key":"BFnpp201720_CR29","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1042\/BJ20091045","volume":"425","author":"M Liu","year":"2010","unstructured":"Liu M, Liu F (2010). Transcriptional and post-translational regulation of adiponectin. Biochem J 425: 41\u201352.","journal-title":"Biochem J"},{"key":"BFnpp201720_CR30","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1083\/jcb.201111079","volume":"197","author":"A Longatti","year":"2012","unstructured":"Longatti A, Lamb CA, Razi M, Yoshimura S, Barr FA, Tooze SA (2012). TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes. J Cell Biol 197: 659\u2013675.","journal-title":"J Cell Biol"},{"key":"BFnpp201720_CR31","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1038\/npp.2010.21","volume":"35","author":"L Maayan","year":"2010","unstructured":"Maayan L, Vakhrusheva J, Correll CU (2010). Effectiveness of medications used to attenuate antipsychotic-related weight gain and metabolic abnormalities: a systematic review and meta-analysis. Neuropsychopharmacology 35: 1520\u20131530.","journal-title":"Neuropsychopharmacology"},{"issue":"Suppl 1","key":"BFnpp201720_CR32","doi-asserted-by":"crossref","first-page":"59S","DOI":"10.1177\/07067437070526S106","volume":"52","author":"DC Mamo","year":"2007","unstructured":"Mamo DC (2007). Managing suicidality in schizophrenia. Can J Psychiatry 52 (Suppl 1): 59S\u201370S.","journal-title":"Can J Psychiatry"},{"key":"BFnpp201720_CR33","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1523\/JNEUROSCI.4346-06.2007","volume":"27","author":"M Marti","year":"2007","unstructured":"Marti M, Trapella C, Viaro R, Morari M (2007). The nociceptin\/orphanin FQ receptor antagonist J-113397 and L-DOPA additively attenuate experimental parkinsonism through overinhibition of the nigrothalamic pathway. J Neurosci 27: 1297\u20131307.","journal-title":"J Neurosci"},{"key":"BFnpp201720_CR34","doi-asserted-by":"publisher","first-page":"134","DOI":"10.3371\/CSRP.6.3.5","volume":"6","author":"HY Meltzer","year":"2012","unstructured":"Meltzer HY (2012). Clozapine: balancing safety with superior antipsychotic efficacy. Clin Schizophr Relat Psychoses 6: 134\u2013144.","journal-title":"Clin Schizophr Relat Psychoses"},{"key":"BFnpp201720_CR35","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.2337\/db09-0432","volume":"58","author":"PR Nagareddy","year":"2009","unstructured":"Nagareddy PR, Soliman H, Lin G, Rajput PS, Kumar U, McNeill JH et al (2009). Selective inhibition of protein kinase C beta(2) attenuates inducible nitric oxide synthase-mediated cardiovascular abnormalities in streptozotocin-induced diabetic rats. Diabetes 58: 2355\u20132364.","journal-title":"Diabetes"},{"key":"BFnpp201720_CR36","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/ncb2741","volume":"15","author":"EJ O'Rourke","year":"2013","unstructured":"O'Rourke EJ, Ruvkun G (2013). MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nat Cell Biol 15: 668\u2013676.","journal-title":"Nat Cell Biol"},{"key":"BFnpp201720_CR37","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.4161\/auto.25239","volume":"9","author":"S Patergnani","year":"2013","unstructured":"Patergnani S, Marchi S, Rimessi A, Bonora M, Giorgi C, Mehta KD et al (2013). PRKCB\/protein kinase C, beta and the mitochondrial axis as key regulators of autophagy. Autophagy 9: 1367\u20131385.","journal-title":"Autophagy"},{"key":"BFnpp201720_CR38","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1038\/tpj.2009.67","volume":"10","author":"C Pavan","year":"2010","unstructured":"Pavan C, Vindigni V, Michelotto L, Rimessi A, Abatangelo G, Cortivo R et al (2010). Weight gain related to treatment with atypical antipsychotics is due to activation of PKC-\u03b2. Pharmacogenomics J 10: 408\u2013417.","journal-title":"Pharmacogenomics J"},{"key":"BFnpp201720_CR39","doi-asserted-by":"publisher","first-page":"453","DOI":"10.2217\/pgs.11.25","volume":"12","author":"P Pinton","year":"2011","unstructured":"Pinton P, Pavan C, Zavan B (2011). PKC-beta activation and pharmacologically induced weight gain during antipsychotic treatment. Pharmacogenomics 12: 453\u2013455.","journal-title":"Pharmacogenomics"},{"key":"BFnpp201720_CR40","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.4161\/auto.24795","volume":"9","author":"A Rimessi","year":"2013","unstructured":"Rimessi A, Bonora M, Marchi S, Patergnani S, Marobbio CM, Lasorsa FM et al (2013). Perturbed mitochondrial Ca2+ signals as causes or consequences of mitophagy induction. Autophagy 9: 1677\u20131686.","journal-title":"Autophagy"},{"key":"BFnpp201720_CR41","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1379\/CSC-211.1","volume":"12","author":"A Rimessi","year":"2007","unstructured":"Rimessi A, Rizzuto R, Pinton P (2007). Differential recruitment of PKC isoforms in HeLa cells during redox stress. Cell Stress Chaperones 12: 291\u2013298.","journal-title":"Cell Stress Chaperones"},{"key":"BFnpp201720_CR42","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1001\/archpsyc.64.10.1123","volume":"64","author":"S Saha","year":"2007","unstructured":"Saha S, Chant D, McGrath J (2007). A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time? Arch Gen Psychiatry 64: 1123\u20131131.","journal-title":"Arch Gen Psychiatry"},{"key":"BFnpp201720_CR43","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/0014-4886(79)90003-7","volume":"64","author":"T Schallert","year":"1979","unstructured":"Schallert T, De Ryck M, Whishaw IQ, Ramirez VD, Teitelbaum P (1979). Excessive bracing reactions and their control by atropine and L-DOPA in an animal analog of Parkinsonism. Exp Neurol 64: 33\u201343.","journal-title":"Exp Neurol"},{"key":"BFnpp201720_CR44","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/ncb2718","volume":"15","author":"C Settembre","year":"2013","unstructured":"Settembre C, De Cegli R, Mansueto G, Saha PK, Vetrini F, Visvikis O et al (2013). TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. Nat Cell Biol 15: 647\u2013658.","journal-title":"Nat Cell Biol"},{"key":"BFnpp201720_CR45","first-page":"670","volume":"84","author":"J Seufert","year":"1999","unstructured":"Seufert J, Kieffer TJ, Leech CA, Holz GG, Moritz W, Ricordi C et al (1999). Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus. J Clin Endocrinol Metab 84: 670\u2013676.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFnpp201720_CR46","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1186\/s12888-014-0253-4","volume":"14","author":"D Sinclair","year":"2014","unstructured":"Sinclair D, Adams CE (2014). Treatment resistant schizophrenia: a comprehensive survey of randomised controlled trials. BMC Psychiatry 14: 253.","journal-title":"BMC Psychiatry"},{"key":"BFnpp201720_CR47","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1038\/nature07976","volume":"458","author":"R Singh","year":"2009","unstructured":"Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, Komatsu M et al (2009). Autophagy regulates lipid metabolism. Nature 458: 1131\u20131135.","journal-title":"Nature"},{"key":"BFnpp201720_CR48","doi-asserted-by":"publisher","first-page":"e0156208","DOI":"10.1371\/journal.pone.0156208","volume":"11","author":"DJ Siskind","year":"2016","unstructured":"Siskind DJ, Leung J, Russell AW, Wysoczanski D, Kisely S (2016). Metformin for clozapine associated obesity: a systematic review and meta-analysis. PLoS ONE 11: e0156208.","journal-title":"PLoS ONE"},{"key":"BFnpp201720_CR49","doi-asserted-by":"publisher","first-page":"80","DOI":"10.4161\/adip.22864","volume":"2","author":"JR Skinner","year":"2013","unstructured":"Skinner JR, Harris LA, Shew TM, Abumrad NA, Wolins NE (2013). Perilipin 1 moves between the fat droplet and the endoplasmic reticulum. Adipocyte 2: 80\u201386.","journal-title":"Adipocyte"},{"key":"BFnpp201720_CR50","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1111\/j.1600-0447.2008.01334.x","volume":"119","author":"SM Stahl","year":"2009","unstructured":"Stahl SM, Mignon L, Meyer JM (2009). Which comes first: atypical antipsychotic treatment or cardiometabolic risk? Acta Psychiatr Scand 119: 171\u2013179.","journal-title":"Acta Psychiatr Scand"},{"key":"BFnpp201720_CR51","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.2337\/db13-1489","volume":"64","author":"J Stockli","year":"2015","unstructured":"Stockli J, Meoli CC, Hoffman NJ, Fazakerley DJ, Pant H, Cleasby ME et al (2015). The RabGAP TBC1D1 plays a central role in exercise-regulated glucose metabolism in skeletal muscle. Diabetes 64: 1914\u20131922.","journal-title":"Diabetes"},{"key":"BFnpp201720_CR52","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1093\/hmg\/ddl204","volume":"15","author":"S Stone","year":"2006","unstructured":"Stone S, Abkevich V, Russell DL, Riley R, Timms K, Tran T et al (2006). TBC1D1 is a candidate for a severe obesity gene and evidence for a gene\/gene interaction in obesity predisposition. Hum Mol Genet 15: 2709\u20132720.","journal-title":"Hum Mol Genet"},{"key":"BFnpp201720_CR53","doi-asserted-by":"publisher","first-page":"E524","DOI":"10.1152\/ajpendo.00605.2011","volume":"303","author":"F Szekeres","year":"2012","unstructured":"Szekeres F, Chadt A, Tom RZ, Deshmukh AS, Chibalin AV, Bjornholm M et al (2012). The Rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism. Am J Physiol Endocrinol Metab 303: E524\u2013E533.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFnpp201720_CR54","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.nbd.2008.02.011","volume":"30","author":"R Viaro","year":"2008","unstructured":"Viaro R, Sanchez-Pernaute R, Marti M, Trapella C, Isacson O, Morari M (2008). Nociceptin\/orphanin FQ receptor blockade attenuates MPTP-induced parkinsonism. Neurobiol Dis 30: 430\u2013438.","journal-title":"Neurobiol Dis"},{"key":"BFnpp201720_CR55","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1038\/31474","volume":"393","author":"J Wang","year":"1998","unstructured":"Wang J, Liu R, Hawkins M, Barzilai N, Rossetti L (1998). A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature 393: 684\u2013688.","journal-title":"Nature"},{"key":"BFnpp201720_CR56","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.cyto.2012.08.021","volume":"60","author":"E Wolsk","year":"2012","unstructured":"Wolsk E, Mygind H, Grondahl TS, Pedersen BK, van Hall G (2012). Human skeletal muscle releases leptin in vivo. Cytokine 60: 667\u2013673.","journal-title":"Cytokine"},{"key":"BFnpp201720_CR57","doi-asserted-by":"publisher","first-page":"R226","DOI":"10.1152\/ajpregu.00392.2001","volume":"282","author":"Y Zhang","year":"2002","unstructured":"Zhang Y, Guo KY, Diaz PA, Heo M, Leibel RL (2002). Determinants of leptin gene expression in fat depots of lean mice. Am J Physiol Regul Integr Compar Physiol 282: R226\u2013R234.","journal-title":"Am J Physiol Regul Integr Compar Physiol"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/npp201720.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/npp201720","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/npp.2017.20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/npp201720.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T20:41:56Z","timestamp":1749933716000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/npp201720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,27]]},"references-count":57,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["BFnpp201720"],"URL":"https:\/\/doi.org\/10.1038\/npp.2017.20","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,27]]},"assertion":[{"value":"8 October 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}