{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:40:18Z","timestamp":1762101618821},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2014,10,23]],"date-time":"2014-10-23T00:00:00Z","timestamp":1414022400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Protoc"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1038\/nprot.2014.178","type":"journal-article","created":{"date-parts":[[2014,10,23]],"date-time":"2014-10-23T15:18:38Z","timestamp":1414077518000},"page":"2682-2692","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["In vivo MRI virtual colonography in a mouse model of colon cancer"],"prefix":"10.1038","volume":"9","author":[{"given":"Lilia V","family":"Ileva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelino","family":"Bernardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew R","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa A","family":"Riffle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James L","family":"Tatum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph D","family":"Kalen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter L","family":"Choyke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,10,23]]},"reference":[{"key":"BFnprot2014178_CR1","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3322\/caac.20073","volume":"60","author":"A Jemal","year":"2010","unstructured":"Jemal, A., Siegel, R., Xu, J. & Ward, E. Cancer statistics, 2010. CA Cancer J. Clin. 60, 277\u2013300 (2010).","journal-title":"CA Cancer J. Clin."},{"key":"BFnprot2014178_CR2","doi-asserted-by":"publisher","first-page":"2900","DOI":"10.1038\/nprot.2006.446","volume":"1","author":"C Becker","year":"2006","unstructured":"Becker, C., Fantini, M.C. & Neurath, M.F. High-resolution colonoscopy in live mice. Nat. Protoc. 1, 2900\u20132904 (2006).","journal-title":"Nat. Protoc."},{"key":"BFnprot2014178_CR3","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1136\/gut.2004.061283","volume":"54","author":"C Becker","year":"2005","unstructured":"Becker, C. et al. In vivo imaging of colitis and colon cancer development in mice using high-resolution chromoendoscopy. Gut 54, 950\u2013954 (2005).","journal-title":"Gut"},{"key":"BFnprot2014178_CR4","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.ymeth.2009.07.008","volume":"50","author":"BY Durkee","year":"2010","unstructured":"Durkee, B.Y., Weichert, J.P. & Halberg, R.B. Small animal micro-CT colonography. Methods 50, 36\u201341 (2010).","journal-title":"Methods"},{"key":"BFnprot2014178_CR5","doi-asserted-by":"publisher","first-page":"3419","DOI":"10.1073\/pnas.0409915102","volume":"102","author":"PJ Pickhardt","year":"2005","unstructured":"Pickhardt, P.J. et al. Microcomputed tomography colonography for polyp detection in an in vivo mouse tumor model. Proc. Natl. Acad. Sci. 102, 3419\u20133422 (2005).","journal-title":"Proc. Natl. Acad. Sci."},{"key":"BFnprot2014178_CR6","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1007\/s00384-011-1181-0","volume":"26","author":"H Boll","year":"2011","unstructured":"Boll, H. et al. Double-contrast micro-CT colonoscopy in live mice. Int. J. Colorectal Dis. 26, 721\u2013727 (2011).","journal-title":"Int. J. Colorectal Dis."},{"key":"BFnprot2014178_CR7","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/nprot.2011.424","volume":"7","author":"AS Krupnick","year":"2012","unstructured":"Krupnick, A.S. et al. Quantitative monitoring of mouse lung tumors by magnetic resonance imaging. Nat. Protoc. 7, 128\u2013142 (2012).","journal-title":"Nat. Protoc."},{"key":"BFnprot2014178_CR8","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1667\/0033-7587(2001)156[0657:IOGEAA]2.0.CO;2","volume":"156","author":"SA Amundson","year":"2001","unstructured":"Amundson, S.A. et al. Induction of gene expression as a monitor of exposure to ionizing radiation. Radiat. Res. 156, 657\u2013661 (2001).","journal-title":"Radiat. Res."},{"key":"BFnprot2014178_CR9","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1259\/bjr\/83959666","volume":"80","author":"B Saar","year":"2007","unstructured":"Saar, B. et al. Prospective study on bright lumen magnetic resonance colonography in comparison with conventional colonoscopy. Br. J. Radiol. 80, 235\u2013241 (2007).","journal-title":"Br. J. Radiol."},{"key":"BFnprot2014178_CR10","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1136\/gut.52.12.1738","volume":"52","author":"W Ajaj","year":"2003","unstructured":"Ajaj, W. et al. Dark lumen magnetic resonance colonography: comparison with conventional colonoscopy for the detection of colorectal pathology. Gut 52, 1738\u20131743 (2003).","journal-title":"Gut"},{"key":"BFnprot2014178_CR11","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1016\/j.ejrad.2011.02.067","volume":"81","author":"FM Zijta","year":"2012","unstructured":"Zijta, F.M. et al. Feasibility of using automated insufflated carbon dioxide (CO2) for luminal distension in 3.0T MR colonography. Eur. J. Radiol. 81, 1128\u20131133 (2012).","journal-title":"Eur. J. Radiol."},{"key":"BFnprot2014178_CR12","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.ejrad.2010.10.028","volume":"81","author":"AN Keeling","year":"2012","unstructured":"Keeling, A.N. et al. Intravenous, contrast-enhanced MR colonography using air as endoluminal contrast agent: impact on colorectal polyp detection. Eur. J. Radiol. 81, 31\u201338 (2012).","journal-title":"Eur. J. Radiol."},{"key":"BFnprot2014178_CR13","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.rcl.2012.10.001","volume":"51","author":"A Graser","year":"2013","unstructured":"Graser, A. Magnetic Resonance colonography. Radiol. Clin. N. Am. 51, 113\u2013120 (2013).","journal-title":"Radiol. Clin. N. Am."},{"key":"BFnprot2014178_CR14","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1007\/s00261-001-0121-9","volume":"4","author":"TC Lauenstein","year":"2002","unstructured":"Lauenstein, T.C., Goehde, S.C. & Debatin, J.F. Fecal tagging: MR colonography without colonic cleansing. Abdom. Imaging 4, 410\u2013417 (2002).","journal-title":"Abdom. Imaging"},{"key":"BFnprot2014178_CR15","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1002\/mrm.20175","volume":"52","author":"HH Hensley","year":"2004","unstructured":"Hensley, H.H., Chang, W.C. & Clapper, M.L. Detection and volume determination of colonic tumors in Min mice by magnetic resonance micro-imaging. Magn. Reson. Med. 52, 524\u2013529 (2004).","journal-title":"Magn. Reson. Med."},{"key":"BFnprot2014178_CR16","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1016\/j.bbrc.2007.02.090","volume":"355","author":"S Melgar","year":"2007","unstructured":"Melgar, S., Gillberg, P.G., Hockings, P.D. & Olsson, L.E. High-throughput magnetic resonance imaging in murine colonic inflammation. Biochem. Biophys. Res. Commun. 355, 1102\u20131107 (2007).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFnprot2014178_CR17","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1097\/00054725-200606000-00006","volume":"12","author":"AE Larsson","year":"2006","unstructured":"Larsson, A.E. et al. Magnetic resonance imaging of experimental mouse colitis and association with inflammatory activity. Inflamm. Bowel Dis. 12, 478\u2013485 (2006).","journal-title":"Inflamm. Bowel Dis."},{"key":"BFnprot2014178_CR18","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1097\/00004424-200412000-00003","volume":"39","author":"CU Herborn","year":"2004","unstructured":"Herborn, C.U. et al. Dark lumen magnetic resonance colonography in a rodent polyp model: initial experience and demonstration of feasibility. Invest. Radiol. 39, 723\u2013727 (2004).","journal-title":"Invest. Radiol."},{"key":"BFnprot2014178_CR19","doi-asserted-by":"publisher","first-page":"e68876","DOI":"10.1371\/journal.pone.0068876","volume":"8","author":"C Breynaert","year":"2013","unstructured":"Breynaert, C. et al. Unique gene expression and MR T2 relaxometry patterns define chronic murine dextran sodium sulphate colitis as a model for connective tissue changes in human Crohn's disease. PLoS ONE 8, e68876 (2013).","journal-title":"PLoS ONE"},{"key":"BFnprot2014178_CR20","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1593\/neo.81326","volume":"11","author":"MR Young","year":"2009","unstructured":"Young, M.R. et al. Monitoring of tumor promotion and progression in a mouse model of inflammation-induced colon cancer with magnetic resonance colonography. Neoplasia 11, 237\u2013246 (2009).","journal-title":"Neoplasia"},{"key":"BFnprot2014178_CR21","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1111\/j.1349-7006.2003.tb01386.x","volume":"94","author":"T Tanaka","year":"2003","unstructured":"Tanaka, T. et al. A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate. Cancer Sci. 94, 965\u2013973 (2003).","journal-title":"Cancer Sci."},{"key":"BFnprot2014178_CR22","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1038\/nprot.2007.279","volume":"2","author":"C Neufert","year":"2007","unstructured":"Neufert, C., Becker, C. & Neurath, M.F. An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression. Nat. Protoc. 2, 1998\u20132004 (2007).","journal-title":"Nat. Protoc."},{"key":"BFnprot2014178_CR23","doi-asserted-by":"publisher","first-page":"5473","DOI":"10.1158\/0008-5472.CAN-13-0525","volume":"73","author":"S Saud","year":"2013","unstructured":"Saud, S. et al. Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and \u03b2-catenin. Cancer Res. 73, 5473\u20135484 (2013).","journal-title":"Cancer Res."},{"key":"BFnprot2014178_CR24","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1593\/tlo.12226","volume":"5","author":"SJ Miller","year":"2012","unstructured":"Miller, S.J. et al. Multimodal imaging of growth and rapamycin-induced regression of colonic adenomas in Apc mutation\u2013dependent mouse. Transl. Oncol. 5, 313\u2013320 (2012).","journal-title":"Transl. Oncol."},{"key":"BFnprot2014178_CR25","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1002\/mrm.21724","volume":"60","author":"CC Quarles","year":"2008","unstructured":"Quarles, C.C. et al. Functional colonography of Min mice using dark lumen dynamic contrast-enhanced MRI. Magn. Reson. Med. 60, 718\u2013726 (2008).","journal-title":"Magn. Reson. Med."},{"key":"BFnprot2014178_CR26","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.3109\/10731199409138801","volume":"22","author":"SF Flaim","year":"1994","unstructured":"Flaim, S.F. Pharmacokinetics and side effects of perfluorocarbon-based blood substitutes. Artif. Cells Blood Substit. Immobil. Biotechnol. 22, 1043\u20131054 (1994).","journal-title":"Artif. Cells Blood Substit. Immobil. Biotechnol."},{"key":"BFnprot2014178_CR27","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1007\/s10753-013-9678-z","volume":"36","author":"SJ Chu","year":"2013","unstructured":"Chu, S.J. et al. Systemic administration of FC-77 dampens ischemia-reperfusion-induced acute lung injury in rats. Inflammation 36, 1383\u20131392 (2013).","journal-title":"Inflammation"},{"key":"BFnprot2014178_CR28","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1097\/CCM.0b013e31816a04d3","volume":"36","author":"H Chang","year":"2008","unstructured":"Chang, H. et al. Intravascular FC-77 attenuates phorbol myristate acetate-induced acute lung injury in isolated rat lungs. Crit. Care Med. 36, 1222\u20131229 (2008).","journal-title":"Crit. Care Med."},{"key":"BFnprot2014178_CR29","first-page":"123","volume":"125","author":"YB Zhu","year":"2012","unstructured":"Zhu, Y.B. et al. Partial liquid ventilation decreases tissue and serum tumor necrosis factor-\u03b1 concentrations in acute lung injury model of immature piglet induced by oleic acid. Chin. Med. J. (Engl) 125, 123\u2013128 (2012).","journal-title":"Chin. Med. J. (Engl)"},{"key":"BFnprot2014178_CR30","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1097\/01.CCM.0000142576.59654.BC","volume":"32","author":"Y Hirayama","year":"2004","unstructured":"Hirayama, Y. et al. Partial liquid ventilation with FC-77 suppresses the release of lipid mediators in rat acute lung injury model. Crit. Care Med. 32, 2085\u20132089 (2004).","journal-title":"Crit. Care Med."},{"key":"BFnprot2014178_CR31","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1081\/BIO-200046654","volume":"33","author":"E Maevsky","year":"2005","unstructured":"Maevsky, E., Ivanitsky, G. & Bogdanova, L. Clinical results of Perftoran application: present and future. Artif. Cells Blood Substit. Immobil. Biotechnol. 33, 37\u201346 (2005).","journal-title":"Artif. Cells Blood Substit. Immobil. Biotechnol."},{"key":"BFnprot2014178_CR32","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.1007\/s10439-009-9643-z","volume":"37","author":"MM Kaneda","year":"2009","unstructured":"Kaneda, M.M., Caruthers, S., Lanza, G.M. & Wickline, S.A. Perfluorocarbon nanoemulsions for quantitative molecular imaging and targeted therapeutics. Ann. Biomed. Eng. 37, 1922\u20131933 (2009).","journal-title":"Ann. Biomed. Eng."},{"key":"BFnprot2014178_CR33","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s10456-012-9310-0","volume":"16","author":"C Giraudeau","year":"2013","unstructured":"Giraudeau, C. et al. 19F molecular MR imaging for detection of brain tumor angiogenesis: in vivo validation using targeted PFOB nanoparticles. Angiogenesis 16, 171\u2013179 (2013).","journal-title":"Angiogenesis"},{"key":"BFnprot2014178_CR34","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.ultras.2012.06.014","volume":"53","author":"AH Liao","year":"2013","unstructured":"Liao, A.H. et al. Evaluation of 18F-labeled targeted perfluorocarbon-filled albumin microbubbles as a probe for micro-US and micro-PET in tumor-bearing mice. Ultrasonics 53, 320\u2013327 (2013).","journal-title":"Ultrasonics"},{"key":"BFnprot2014178_CR35","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1148\/radiol.10100667","volume":"258","author":"B Turkbey","year":"2011","unstructured":"Turkbey, B. et al. Is apparent diffusion coefficient associated with clinical risk scores for prostate cancers that are visible on 3-T MR images? Radiology 258, 488\u2013495 (2011).","journal-title":"Radiology"},{"key":"BFnprot2014178_CR36","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1102\/1470-7330.2011.0007","volume":"11","author":"B Turkbey","year":"2011","unstructured":"Turkbey, B. et al. Documenting the location of systematic transrectal ultrasound-guided prostate biopsies: correlation with multi-parametric MRI. Cancer Imaging 11, 31\u201336 (2011).","journal-title":"Cancer Imaging"}],"container-title":["Nature Protocols"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nprot.2014.178.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nprot.2014.178","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nprot.2014.178.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:17:44Z","timestamp":1684455464000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nprot.2014.178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,23]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["BFnprot2014178"],"URL":"https:\/\/doi.org\/10.1038\/nprot.2014.178","relation":{},"ISSN":["1754-2189","1750-2799"],"issn-type":[{"value":"1754-2189","type":"print"},{"value":"1750-2799","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,23]]},"assertion":[{"value":"23 October 2014","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}