{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T05:30:06Z","timestamp":1761197406273,"version":"3.37.3"},"reference-count":83,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T00:00:00Z","timestamp":1467849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Rev Cardiol"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1038\/nrcardio.2016.104","type":"journal-article","created":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T11:30:56Z","timestamp":1467891056000},"page":"560-566","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Management of survivors of cardiac arrest \u2014 the importance of genetic investigation"],"prefix":"10.1038","volume":"13","author":[{"given":"Peter J.","family":"Schwartz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Dagradi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,7,7]]},"reference":[{"key":"BFnrcardio2016104_CR1","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.jacc.2013.04.044","volume":"62","author":"PJ Schwartz","year":"2013","unstructured":"Schwartz, P. J., Ackerman, M. J., George, A. L. & Wilde, A. A. Impact of genetics on the clinical management of channelopathies. J. Am. Coll. Cardiol. 62, 169\u2013180 (2013).","journal-title":"J. Am. Coll. Cardiol."},{"key":"BFnrcardio2016104_CR2","doi-asserted-by":"publisher","first-page":"3109","DOI":"10.1093\/eurheartj\/eht089","volume":"34","author":"PJ Schwartz","year":"2013","unstructured":"Schwartz, P. J. & Ackerman, M. J. The long QT syndrome: a transatlantic clinical approach to diagnosis and therapy. Eur. Heart J. 34, 3109\u20133116 (2013).","journal-title":"Eur. Heart J."},{"key":"BFnrcardio2016104_CR3","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.1016\/j.jacc.2012.07.046","volume":"60","author":"P Chockalingam","year":"2012","unstructured":"Chockalingam, P. et al. Not all beta-blockers are equal in the management of long QT syndrome types 1 and 2: higher recurrence of events under metoprolol. J. Am. Coll. Cardiol. 60, 2092\u20132099 (2012).","journal-title":"J. Am. Coll. Cardiol."},{"key":"BFnrcardio2016104_CR4","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.hrthm.2009.04.009","volume":"6","author":"PJ Schwartz","year":"2009","unstructured":"Schwartz, P. J. Cutting nerves and saving lives. Heart Rhythm 6, 760\u2013763 (2009).","journal-title":"Heart Rhythm"},{"key":"BFnrcardio2016104_CR5","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/nrcardio.2014.19","volume":"11","author":"PJ Schwartz","year":"2014","unstructured":"Schwartz, P. J. Cardiac sympathetic denervation to prevent life-threatening arrhythmias. Nat. Rev. Cardiol. 11, 346\u2013353 (2014).","journal-title":"Nat. Rev. Cardiol."},{"key":"BFnrcardio2016104_CR6","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1161\/01.CIR.0000125523.14403.1E","volume":"109","author":"PJ Schwartz","year":"2004","unstructured":"Schwartz, P. J. et al. Left cardiac sympathetic denervation in the management of high-risk patients affected by the long-QT syndrome. Circulation 109, 1826\u20131833 (2004).","journal-title":"Circulation"},{"key":"BFnrcardio2016104_CR7","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1161\/CIRCULATIONAHA.110.950147","volume":"122","author":"PJ Schwartz","year":"2010","unstructured":"Schwartz, P. J. et al. Who are the long-QT syndrome patients who receive an implantable cardioverter-defibrillator and what happens to them?: data from the European Long-QT Syndrome Implantable Cardioverter-Defibrillator (LQTS ICD) Registry. Circulation 122, 1272\u20131282 (2010).","journal-title":"Circulation"},{"key":"BFnrcardio2016104_CR8","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1161\/01.CIR.99.4.529","volume":"99","author":"SG Priori","year":"1999","unstructured":"Priori, S. G., Napolitano, C. & Schwartz, P. J. Low penetrance in the long-QT syndrome: clinical impact. Circulation 99, 529\u2013533 (1999).","journal-title":"Circulation"},{"key":"BFnrcardio2016104_CR9","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1056\/NEJMoa022147","volume":"348","author":"SG Priori","year":"2003","unstructured":"Priori, S. G. et al. Risk stratification in the long-QT syndrome. N. Engl. J. Med. 348, 1866\u20131874 (2003).","journal-title":"N. Engl. J. Med."},{"key":"BFnrcardio2016104_CR10","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.jacc.2010.07.038","volume":"57","author":"I Goldenberg","year":"2011","unstructured":"Goldenberg, I. et al. Risk for life-threatening cardiac events in patients with genotype-confirmed long-QT syndrome and normal-range corrected QT intervals. J. Am. Coll. Cardiol. 57, 51\u201359 (2011).","journal-title":"J. Am. Coll. Cardiol."},{"key":"BFnrcardio2016104_CR11","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1093\/eurheartj\/ehv695","volume":"37","author":"H Itoh","year":"2016","unstructured":"Itoh, H. et al. The genetics underlying acquired Long QT Syndrome. Impact on management. Eur. Heart J. 37, 1456\u20131464 (2016).","journal-title":"Eur. Heart J."},{"key":"BFnrcardio2016104_CR12","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1016\/j.jacc.2015.12.063","volume":"67","author":"PJ Schwartz","year":"2016","unstructured":"Schwartz, P. J. & Woosley, R. L. Predicting the unpredictable: drug-induced QT prolongation and torsades de pointes. J. Am. Coll. Cardiol. 67, 1639\u20131650 (2016).","journal-title":"J. Am. Coll. Cardiol."},{"key":"BFnrcardio2016104_CR13","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.1016\/j.jacc.2009.12.063","volume":"55","author":"N Hofman","year":"2010","unstructured":"Hofman, N., Tan, H. L., Alders, M., van Langen, I. M. & Wilde, A. A. Active cascade screening in primary inherited arrhythmia syndromes: does it lead to prophylactic treatment? J. Am. Coll. Cardiol. 55, 2570\u20132576 (2010).","journal-title":"J. Am. Coll. Cardiol."},{"key":"BFnrcardio2016104_CR14","doi-asserted-by":"publisher","first-page":"2577","DOI":"10.1016\/j.jacc.2009.12.064","volume":"55","author":"PJ Schwartz","year":"2010","unstructured":"Schwartz, P. J. Cascades or waterfalls, the cataracts of genetic screening are being opened on clinical cardiology. J. Am. Coll. Cardiol. 55, 2577\u20132579 (2010).","journal-title":"J. Am. Coll. Cardiol."},{"key":"BFnrcardio2016104_CR15","doi-asserted-by":"publisher","first-page":"3381","DOI":"10.1161\/01.CIR.92.12.3381","volume":"92","author":"PJ Schwartz","year":"1995","unstructured":"Schwartz, P. J. et al. Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate. Implications for gene-specific therapy. Circulation 92, 3381\u20133386 (1995).","journal-title":"Circulation"},{"key":"BFnrcardio2016104_CR16","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1161\/01.CIR.103.1.89","volume":"103","author":"PJ Schwartz","year":"2001","unstructured":"Schwartz, P. J. et al. Genotype\u2013phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias. Circulation 103, 89\u201395 (2001).","journal-title":"Circulation"},{"key":"BFnrcardio2016104_CR17","volume-title":"Cardiac Electrophysiology: From Cell to Bedside","author":"PJ Schwartz","year":"2016","unstructured":"Schwartz, P. J. & Crotti, L. Cardiac Electrophysiology: From Cell to Bedside 7th edn Ch. 93 (eds Zipes, D. P. & Jalife, J.) (Elsevier\/Saunders, 2016)."},{"key":"BFnrcardio2016104_CR18","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1161\/CIRCULATIONAHA.106.676551","volume":"116","author":"O Anttonen","year":"2007","unstructured":"Anttonen, O. et al. Prevalence and prognostic significance of short QT interval in a middle-aged Finnish population. Circulation 116, 714\u2013720 (2007).","journal-title":"Circulation"},{"key":"BFnrcardio2016104_CR19","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1016\/j.jacc.2010.09.048","volume":"57","author":"MH Gollob","year":"2011","unstructured":"Gollob, M. H., Redpath, C. J. & Roberts, J. D. The short QT syndrome. Proposed diagnostic criteria. J. Am. Coll. Cardiol. 57, 802\u2013814 (2011).","journal-title":"J. Am. Coll. Cardiol."},{"key":"BFnrcardio2016104_CR20","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.1161\/CIRCULATIONAHA.108.829267","volume":"119","author":"M Hayashi","year":"2009","unstructured":"Hayashi, M. et al. Incidence and risk factors of arrhythmic events in catecholaminergic polymorphic ventricular tachycardia. Circulation 119, 2426\u20132434 (2009).","journal-title":"Circulation"},{"key":"BFnrcardio2016104_CR21","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1086\/324565","volume":"69","author":"H Lahat","year":"2001","unstructured":"Lahat, H. et al. A missense mutation in highly conserved region of CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in Bedouin families from Israel. Am. J. Hum. Genet. 69, 1378\u20131384 (2001).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnrcardio2016104_CR22","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.ajhg.2012.08.015","volume":"91","author":"M Nyegaard","year":"2012","unstructured":"Nyegaard, M. et al. Mutations in calmodulin cause ventricular tachycardia and sudden cardiac death. Am. J. Hum. Genet. 91, 703\u2013712 (2012).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnrcardio2016104_CR23","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.1093\/hmg\/dds104","volume":"21","author":"N Roux-Buisson","year":"2012","unstructured":"Roux-Buisson, N. et al. Absence of triadin, a protein of the calcium release complex, is responsible for cardiac arrhythmia with sudden death in human. Hum. Mol. Genet. 21, 2759\u20132767 (2012).","journal-title":"Hum. Mol. Genet."},{"key":"BFnrcardio2016104_CR24","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1016\/j.jacc.2011.01.026","volume":"57","author":"C van der Werf","year":"2011","unstructured":"van der Werf, C. et al. Flecainide therapy reduces exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia. J. Am. Coll. Cardiol. 57, 2244\u20132254 (2011).","journal-title":"J. Am. Coll. Cardiol."},{"key":"BFnrcardio2016104_CR25","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1161\/CIRCEP.113.000170","volume":"6","author":"CY Miyake","year":"2013","unstructured":"Miyake, C. Y. et al. Efficacy of implantable cardioverter defibrillators in young patients with catecholaminergic polymorphic ventricular tachycardia: success depends on substrate. Circ. Arrhythm. Electrophysiol. 6, 579\u2013587 (2013).","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"BFnrcardio2016104_CR26","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.hrthm.2013.10.027","volume":"11","author":"F Roses-Noguer","year":"2014","unstructured":"Roses-Noguer, F., Jarman, J. W., Clague, J. R. & Till, J. Outcomes of defibrillator therapy in catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm 11, 58\u201366 (2014).","journal-title":"Heart Rhythm"},{"key":"BFnrcardio2016104_CR27","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1161\/CIRCEP.114.002217","volume":"8","author":"TM Roston","year":"2015","unstructured":"Roston, T. M. et al. Catecholaminergic polymorphic ventricular tachycardia in children: analysis of therapeutic strategies and outcomes from an international multicenter registry. Circ. Arrhythm. Electrophysiol. 8, 633\u2013642 (2015).","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"BFnrcardio2016104_CR28","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1161\/CIRCULATIONAHA.115.015731","volume":"131","author":"GM De Ferrari","year":"2015","unstructured":"De Ferrari, G. M. et al. Clinical management of catecholaminergic polymorphic ventricular tachycardia: the role of left cardiac sympathetic denervation. Circulation 131, 2185\u20132193 (2015).","journal-title":"Circulation"},{"key":"BFnrcardio2016104_CR29","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1016\/j.hrthm.2006.08.018","volume":"3","author":"U Mohamed","year":"2006","unstructured":"Mohamed, U., Gollob, M. H., Gow, R. M. & Krahn, A. D. Sudden cardiac death despite an implantable cardioverter-defibrillator in a young female with catecholaminergic ventricular tachycardia. Heart Rhythm 3, 1486\u20131489 (2006).","journal-title":"Heart Rhythm"},{"key":"BFnrcardio2016104_CR30","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1111\/j.1540-8167.2008.01211.x","volume":"19","author":"S Pizzale","year":"2008","unstructured":"Pizzale, S., Gollob, M. H., Gow, R. & Birnie, D. H. Sudden death in a young man with catecholaminergic polymorphic ventricular tachycardia and paroxysmal atrial fibrillation. J. Cardiovasc. Electrophysiol. 19, 1319\u20131321 (2008).","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"BFnrcardio2016104_CR31","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1056\/NEJMoa0708006","volume":"358","author":"AA Wilde","year":"2008","unstructured":"Wilde, A. A. et al. Left cardiac sympathetic denervation for catecholaminergic polymorphic ventricular tachycardia. N. Engl. J. Med. 358, 2024\u20132029 (2008).","journal-title":"N. Engl. J. Med."},{"key":"BFnrcardio2016104_CR32","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.hrthm.2015.09.020","volume":"13","author":"PJ Schwartz","year":"2016","unstructured":"Schwartz, P. J. When the risk is sudden death, does quality of life matter? Heart Rhythm 13, 70\u201371 (2016).","journal-title":"Heart Rhythm"},{"key":"BFnrcardio2016104_CR33","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1016\/j.hrthm.2013.05.014","volume":"10","author":"SG Priori","year":"2013","unstructured":"Priori, S. G. et al. HRS\/EHRA\/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes: document endorsed by HRS, EHRA, and APHRS in May 2013 and by ACCF, AHA, PACES, and AEPC in June 2013. Heart Rhythm 10, 1932\u20131963 (2013).","journal-title":"Heart Rhythm"},{"key":"BFnrcardio2016104_CR34","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1093\/europace\/eur245","volume":"13","author":"MJ Ackerman","year":"2011","unstructured":"Ackerman, M. J. et al. HRS\/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies: this document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA). Europace 13, 1077\u20131109 (2011).","journal-title":"Europace"},{"key":"BFnrcardio2016104_CR35","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1016\/j.hrthm.2009.07.002","volume":"6","author":"PG Postema","year":"2009","unstructured":"Postema, P. G. et al. Drugs and Brugada syndrome patients: review of the literature, recommendations and an up-to-date website ( www.brugadadrugs.org ). Heart Rhythm 6, 1335\u20131341 (2009).","journal-title":"Heart Rhythm"},{"key":"BFnrcardio2016104_CR36","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.cjca.2010.12.078","volume":"27","author":"MH Gollob","year":"2011","unstructured":"Gollob, M. H. et al. Recommendations for the use of genetic testing in the clinical evaluation of inherited cardiac arrhythmias associated with sudden cardiac death: Canadian Cardiovascular Society\/Canadian Heart Rhythm Society joint position paper. Can. J. Cardiol. 27, 232\u2013245 (2011).","journal-title":"Can. J. Cardiol."},{"key":"BFnrcardio2016104_CR37","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1097\/00045415-199905000-00009","volume":"7","author":"C Basso","year":"1999","unstructured":"Basso, C., Corrado, D. & Thiene, G. Cardiovascular causes of sudden death in young individuals including athletes. Cardiol. Rev. 7, 127\u2013135 (1999).","journal-title":"Cardiol. Rev."},{"key":"BFnrcardio2016104_CR38","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1016\/j.jacc.2008.09.019","volume":"52","author":"S Sen-Chowdhry","year":"2008","unstructured":"Sen-Chowdhry, S. et al. Left-dominant arrhythmogenic cardiomyopathy: an under-recognized clinical entity. J. Am. Coll. Cardiol. 52, 2175\u20132187 (2008).","journal-title":"J. Am. Coll. Cardiol."},{"key":"BFnrcardio2016104_CR39","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1093\/eurheartj\/ehq025","volume":"31","author":"FI Marcus","year":"2010","unstructured":"Marcus, F. I. et al. Diagnosis of arrhythmogenic right ventricular cardiomyopathy\/dysplasia: proposed modification of the Task Force Criteria. Eur. Heart J. 31, 806\u2013814 (2010).","journal-title":"Eur. Heart J."},{"key":"BFnrcardio2016104_CR40","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1016\/j.jacc.2007.08.008","volume":"50","author":"S Sen-Chowdhry","year":"2007","unstructured":"Sen-Chowdhry, S., Syrris, P. & McKenna, W. J. Role of genetic analysis in the management of patients with arrhythmogenic right ventricular dysplasia\/cardiomyopathy. J. Am. Coll. Cardiol. 50, 1813\u20131821 (2007).","journal-title":"J. Am. Coll. Cardiol."},{"key":"BFnrcardio2016104_CR41","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1016\/S0140-6736(00)02379-5","volume":"355","author":"G McKoy","year":"2000","unstructured":"McKoy, G. et al. Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease). Lancet 355, 2119\u20132124 (2000).","journal-title":"Lancet"},{"key":"BFnrcardio2016104_CR42","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.carpath.2004.03.609","volume":"13","author":"N Protonotarios","year":"2004","unstructured":"Protonotarios, N. & Tsatsopoulou, A. Naxos disease and Carvajal syndrome: cardiocutaneous disorders that highlight the pathogenesis and broaden the spectrum of arrhythmogenic right ventricular cardiomyopathy. Cardiovasc. Pathol. 13, 185\u2013194 (2004).","journal-title":"Cardiovasc. Pathol."},{"key":"BFnrcardio2016104_CR43","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.ajhg.2008.01.010","volume":"82","author":"ND Merner","year":"2008","unstructured":"Merner, N. D. et al. Arrhythmogenic right ventricular cardiomyopathy type 5 is a fully penetrant, lethal arrhythmic disorder caused by a missense mutation in the TMEM43 gene. Am. J. Hum. Genet. 82, 809\u2013821 (2008).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnrcardio2016104_CR44","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1136\/hrt.2005.068577","volume":"92","author":"PM Elliott","year":"2006","unstructured":"Elliott, P. M. et al. Historical trends in reported survival rates in patients with hypertrophic cardiomyopathy. Heart 92, 785\u2013791 (2006).","journal-title":"Heart"},{"key":"BFnrcardio2016104_CR45","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1093\/eurheartj\/ehm342","volume":"29","author":"P Elliott","year":"2008","unstructured":"Elliott, P. et al. Classification of the cardiomyopathies: a position statement from the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur. Heart J. 29, 270\u2013276 (2008).","journal-title":"Eur. Heart J."},{"key":"BFnrcardio2016104_CR46","doi-asserted-by":"publisher","unstructured":"Pinto, Y. M. et al. Proposal for a revised definition of dilated cardiomyopathy, hypokinetic non-dilated cardiomyopathy, and its implications for clinical practice: a position statement of the ESC working group on myocardial and pericardial diseases. Eur. Heart J. http:\/\/dx.doi.org\/10.1093\/eurheartj\/ehv727 (2016).","DOI":"10.1093\/eurheartj\/ehv727"},{"key":"BFnrcardio2016104_CR47","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1093\/eurheartj\/ehs397","volume":"34","author":"C Rapezzi","year":"2013","unstructured":"Rapezzi, C. et al. Diagnostic work-up in cardiomyopathies: bridging the gap between clinical phenotypes and final diagnosis. A position statement from the ESC Working Group on Myocardial and Pericardial Diseases. Eur. Heart J. 34, 1448\u20131458 (2013).","journal-title":"Eur. Heart J."},{"key":"BFnrcardio2016104_CR48","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1093\/eurjhf\/hft013","volume":"15","author":"KY van Spaendonck-Zwarts","year":"2013","unstructured":"van Spaendonck-Zwarts, K. Y. et al. Genetic analysis in 418 index patients with idiopathic dilated cardiomyopathy: overview of 10 years' experience. Eur. J. Heart Fail. 15, 628\u2013636 (2013).","journal-title":"Eur. J. Heart Fail."},{"key":"BFnrcardio2016104_CR49","doi-asserted-by":"publisher","first-page":"2793","DOI":"10.1093\/eurheartj\/ehv316","volume":"36","author":"SG Priori","year":"2015","unstructured":"Priori, S. G. et al. 2015 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: the Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC). Eur. Heart J. 36, 2793\u20132867 (2015).","journal-title":"Eur. Heart J."},{"key":"BFnrcardio2016104_CR50","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1161\/CIRCULATIONAHA.115.015431","volume":"132","author":"KG Harmon","year":"2015","unstructured":"Harmon, K. G. et al. Incidence, cause, and comparative frequency of sudden cardiac death in national collegiate athletic association athletes: a decade in review. Circulation 132, 10\u201319 (2015).","journal-title":"Circulation"},{"key":"BFnrcardio2016104_CR51","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1016\/j.jacc.2003.03.002","volume":"42","author":"D Corrado","year":"2003","unstructured":"Corrado, D., Basso, C., Rizzoli, G., Schiavon, M. & Thiene, G. Does sports activity enhance the risk of sudden death in adolescents and young adults? J. Am. Coll. Cardiol. 42, 1959\u20131963 (2003).","journal-title":"J. Am. Coll. Cardiol."},{"key":"BFnrcardio2016104_CR52","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1161\/CIRCULATIONAHA.108.804617","volume":"119","author":"BJ Maron","year":"2009","unstructured":"Maron, B. J., Doerer, J. J., Haas, T. S., Tierney, D. M. & Mueller, F. O. Sudden deaths in young competitive athletes: analysis of 1866 deaths in the United States, 1980\u20132006. Circulation 119, 1085\u20131092 (2009).","journal-title":"Circulation"},{"key":"BFnrcardio2016104_CR53","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1001\/jama.296.13.1593","volume":"296","author":"D Corrado","year":"2006","unstructured":"Corrado, D. et al. Trends in sudden cardiovascular death in young competitive athletes after implementation of a preparticipation screening program. JAMA 296, 1593\u20131601 (2006).","journal-title":"JAMA"},{"key":"BFnrcardio2016104_CR54","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1016\/j.jacc.2016.03.527","volume":"67","author":"B Hainline","year":"2016","unstructured":"Hainline, B. et al. Interassociation consensus statement on cardiovascular care of college student-athletes. J. Am. Coll. Cardiol. 67, 2981\u20132995 (2016).","journal-title":"J. Am. Coll. Cardiol."},{"key":"BFnrcardio2016104_CR55","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1007\/978-1-84628-854-8_68","volume-title":"Electrical Diseases of the Heart. Genetics, Mechanisms, Treatment, Prevention","author":"PJ Schwartz","year":"2008","unstructured":"Schwartz, P. J., Stramba-Badiale, M., Crotti, L. & Ackerman, M. J. in Electrical Diseases of the Heart. Genetics, Mechanisms, Treatment, Prevention (eds Gussak, I. et al.) 924\u2013933 (Springer, 2008)."},{"key":"BFnrcardio2016104_CR56","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/0002-9343(76)90425-3","volume":"60","author":"PJ Schwartz","year":"1976","unstructured":"Schwartz, P. J. Cardiac sympathetic innervation and the sudden infant death syndrome. A possible pathogenetic link. Am. J. Med. 60, 167\u2013172 (1976).","journal-title":"Am. J. Med."},{"key":"BFnrcardio2016104_CR57","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1161\/CIRCULATIONAHA.106.658021","volume":"115","author":"M Arnestad","year":"2007","unstructured":"Arnestad, M. et al. Prevalence of long QT syndrome gene variants in sudden infant death syndrome. Circulation 115, 361\u2013367 (2007).","journal-title":"Circulation"},{"key":"BFnrcardio2016104_CR58","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.hrthm.2007.02.026","volume":"4","author":"DJ Tester","year":"2007","unstructured":"Tester, D. J. et al. A mechanism for sudden infant death syndrome (SIDS): stress induced leak via ryanodine receptors. Heart Rhythm 4, 733\u2013739 (2007).","journal-title":"Heart Rhythm"},{"key":"BFnrcardio2016104_CR59","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.forsciint.2012.01.018","volume":"219","author":"M Brion","year":"2012","unstructured":"Brion, M. et al. Sarcomeric gene mutations in sudden infant death syndrome (SIDS). Forensic Sci. Int. 219, 278\u2013281 (2012).","journal-title":"Forensic Sci. Int."},{"key":"BFnrcardio2016104_CR60","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1016\/j.hrthm.2006.07.016","volume":"3","author":"PJ Schwartz","year":"2006","unstructured":"Schwartz, P. J. Newborn ECG screening to prevent sudden cardiac death. Heart Rhythm 3, 1353\u20131355 (2006).","journal-title":"Heart Rhythm"},{"key":"BFnrcardio2016104_CR61","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1016\/j.hrthm.2006.07.015","volume":"3","author":"IM van Langen","year":"2006","unstructured":"van Langen, I. M. & Wilde, A. A. Newborn screening to prevent sudden cardiac death? Heart Rhythm 3, 1356\u20131359 (2006).","journal-title":"Heart Rhythm"},{"key":"BFnrcardio2016104_CR62","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.1016\/j.hrthm.2014.09.047","volume":"11","author":"JP Saul","year":"2014","unstructured":"Saul, J. P., Schwartz, P. J., Ackerman, M. J. & Triedman, J. K. Rationale and objectives for ECG screening in infancy. Heart Rhythm 11, 2316\u20132321 (2014).","journal-title":"Heart Rhythm"},{"key":"BFnrcardio2016104_CR63","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.1016\/j.hrthm.2014.09.046","volume":"11","author":"JR Skinner","year":"2014","unstructured":"Skinner, J. R. & Van Hare, G. F. Routine ECG screening in infancy and early childhood should not be performed. Heart Rhythm 11, 2322\u20132327 (2014).","journal-title":"Heart Rhythm"},{"key":"BFnrcardio2016104_CR64","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.hrthm.2014.11.032","volume":"12","author":"JP Saul","year":"2015","unstructured":"Saul, J. P., Schwartz, P. J., Ackerman, M. J. & Triedman, J. K. Neonatal ECG screening: opinions and facts. Heart Rhythm 12, 610\u2013611 (2015).","journal-title":"Heart Rhythm"},{"key":"BFnrcardio2016104_CR65","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1001\/jama.279.22.1817","volume":"279","author":"DW Glover","year":"1998","unstructured":"Glover, D. W. & Maron, B. J. Profile of preparticipation cardiovascular screening for high school athletes. JAMA 279, 1817\u20131819 (1998).","journal-title":"JAMA"},{"key":"BFnrcardio2016104_CR66","unstructured":"Myerburg, R. J. We can prevent sudden death in teenagers. Miami Herald (17 March 1999)."},{"key":"BFnrcardio2016104_CR67","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1093\/eurheartj\/ehu176","volume":"35","author":"HJ Wellens","year":"2014","unstructured":"Wellens, H. J. et al. Risk stratification for sudden cardiac death: current status and challenges for the future Eur. Heart J. 35, 1642\u20131651 (2014).","journal-title":"Eur. Heart J."},{"key":"BFnrcardio2016104_CR68","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.cca.2015.10.033","volume":"454","author":"I Ramasamy","year":"2016","unstructured":"Ramasamy, I. Update on the molecular biology of dyslipidemias. Clin. Chim. Acta 454, 143\u2013185 (2016).","journal-title":"Clin. Chim. Acta"},{"key":"BFnrcardio2016104_CR69","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.jacl.2015.07.005","volume":"9","author":"J Pang","year":"2015","unstructured":"Pang, J. et al. Frequency of familial hypercholesterolemia in patients with early-onset coronary artery disease admitted to a coronary care unit. J. Clin. Lipidol. 9, 703\u2013708 (2015).","journal-title":"J. Clin. Lipidol."},{"key":"BFnrcardio2016104_CR70","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1093\/eurheartj\/ehs289","volume":"33","author":"PG Steg","year":"2012","unstructured":"Steg, P. G. et al. ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur. Heart J. 33, 2569\u20132619 (2012).","journal-title":"Eur. Heart J."},{"key":"BFnrcardio2016104_CR71","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1161\/01.CIR.99.15.1978","volume":"99","author":"X Jouven","year":"1999","unstructured":"Jouven, X., Desnos, M., Guerot, C. & Ducimeti\u00e8re, P. Predicting sudden death in the population. Circulation 99, 1978\u20131983 (1999).","journal-title":"Circulation"},{"key":"BFnrcardio2016104_CR72","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1161\/CIRCULATIONAHA.105.606145","volume":"114","author":"LR Dekker","year":"2006","unstructured":"Dekker, L. R. et al. Familial sudden death is an important risk factor for primary ventricular fibrillation: a case\u2013control study in acute myocardial infarction patients. Circulation 114, 1140\u20131145 (2006).","journal-title":"Circulation"},{"key":"BFnrcardio2016104_CR73","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1161\/CIRCULATIONAHA.106.624593","volume":"114","author":"KS Kaikkonen","year":"2006","unstructured":"Kaikkonen, K. S., Kortelainen, M. L., Linna, E. & Huikuri, H. V. Family history and the risk of sudden cardiac death as a manifestation of an acute coronary event. Circulation 114, 1462\u20131467 (2006).","journal-title":"Circulation"},{"key":"BFnrcardio2016104_CR74","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1093\/eurheartj\/ehp160","volume":"30","author":"X Jouven","year":"2009","unstructured":"Jouven, X. et al. Excessive heart rate increase during mild mental stress in preparation for exercise predicts sudden death in the general population. Eur. Heart J. 30, 1703\u20131710 (2009).","journal-title":"Eur. Heart J."},{"key":"BFnrcardio2016104_CR75","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/ng.623","volume":"42","author":"CR Bezzina","year":"2010","unstructured":"Bezzina, C. R. et al. Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction. Nat. Genet. 42, 688\u2013691 (2010).","journal-title":"Nat. Genet."},{"key":"BFnrcardio2016104_CR76","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/978-88-470-5379-3_6","volume-title":"New Diagnostic, Therapeutic and Organizational Strategies for Acute Coronary Syndromes Patients","author":"GM De Ferrari","year":"2013","unstructured":"De Ferrari, G. M. et al. in New Diagnostic, Therapeutic and Organizational Strategies for Acute Coronary Syndromes Patients (eds Grieco, N. et al.) 85\u201396 (Springer-Verlag, 2013)."},{"key":"BFnrcardio2016104_CR77","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1161\/01.CIR.57.6.1074","volume":"57","author":"PJ Schwartz","year":"1978","unstructured":"Schwartz, P. J. & Wolf, S. QT interval prolongation as predictor of sudden death in patients with myocardial infarction. Circulation 57, 1074\u20131077 (1978).","journal-title":"Circulation"},{"key":"BFnrcardio2016104_CR78","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1016\/j.hrthm.2012.02.014","volume":"9","author":"L Crotti","year":"2012","unstructured":"Crotti, L. et al. Torsades de pointes following acute myocardial infarction: evidence for a deadly link with a common genetic variant. Heart Rhythm 9, 1104\u20131112 (2012).","journal-title":"Heart Rhythm"},{"key":"BFnrcardio2016104_CR79","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.hrthm.2010.12.035","volume":"8","author":"PJ Schwartz","year":"2011","unstructured":"Schwartz, P. J. Sudden cardiac death, founder populations and mushrooms. What is the link with gold mines and modifier genes? Heart Rhythm 8, 548\u2013550 (2011).","journal-title":"Heart Rhythm"},{"key":"BFnrcardio2016104_CR80","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1097\/HCO.0b013e32835b0a9e","volume":"28","author":"H Raju","year":"2013","unstructured":"Raju, H. & Behr, E. R. Unexplained sudden death, focussing on genetics and family phenotyping. Curr. Opin. Cardiol. 28, 19\u201325 (2013).","journal-title":"Curr. Opin. Cardiol."},{"key":"BFnrcardio2016104_CR81","doi-asserted-by":"publisher","first-page":"e003440","DOI":"10.1161\/CIRCEP.115.003440","volume":"9","author":"A Adler","year":"2016","unstructured":"Adler, A. et al. Patient outcomes from a specialized inherited arrhythmia clinic. Circ. Arrhythm. Electrophysiol. 9, e003440 (2016).","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"BFnrcardio2016104_CR82","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.hrthm.2015.11.013","volume":"13","author":"KG Spoonamore","year":"2016","unstructured":"Spoonamore, K. G. & Ware, S. M. Genetic testing and genetic counseling in patients with sudden death risk due to heritable arrhythmias. Heart Rhythm 13, 789\u2013797 (2016).","journal-title":"Heart Rhythm"},{"key":"BFnrcardio2016104_CR83","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.tcm.2015.03.007","volume":"25","author":"M Vatta","year":"2015","unstructured":"Vatta, M. & Spoonamore, K. G. Use of genetic testing to identify sudden cardiac death syndromes. Trends Cardiovasc. Med. 25, 738\u2013748 (2015).","journal-title":"Trends Cardiovasc. Med."}],"container-title":["Nature Reviews Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrcardio.2016.104.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrcardio.2016.104","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrcardio.2016.104.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T04:31:39Z","timestamp":1692419499000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrcardio.2016.104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,7]]},"references-count":83,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["BFnrcardio2016104"],"URL":"https:\/\/doi.org\/10.1038\/nrcardio.2016.104","relation":{},"ISSN":["1759-5002","1759-5010"],"issn-type":[{"type":"print","value":"1759-5002"},{"type":"electronic","value":"1759-5010"}],"subject":[],"published":{"date-parts":[[2016,7,7]]},"assertion":[{"value":"7 July 2016","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}