{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:36:45Z","timestamp":1793068605635,"version":"4.5.0"},"reference-count":95,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T00:00:00Z","timestamp":1260230400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T00:00:00Z","timestamp":1260230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Rev Clin Oncol"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1038\/nrclinonc.2009.188","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T11:51:15Z","timestamp":1260273075000},"page":"44-54","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":329,"title":["Stereotactic body radiation therapy: a novel treatment modality"],"prefix":"10.1038","volume":"7","author":[{"given":"Simon S.","family":"Lo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achilles J.","family":"Fakiris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric L.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina A.","family":"Mayr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian Z.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lech","family":"Papiez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin S.","family":"Teh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald C.","family":"McGarry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Higinia R.","family":"Cardenes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Timmerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,12,8]]},"reference":[{"key":"BFnrclinonc2009188_CR1","doi-asserted-by":"crossref","first-page":"861","DOI":"10.3109\/02841869509127197","volume":"34","author":"H Blomgren","year":"1995","unstructured":"Blomgren, H., Lax, I., Naslund, I. & Svanstrom, R. Stereotactic high dose fraction radiation therapy of extracranial tumors using an accelerator. Clinical experience of the first thirty-one patients. Acta Oncol. 34, 861\u2013870 (1995).","journal-title":"Acta Oncol."},{"key":"BFnrclinonc2009188_CR2","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.currproblcancer.2005.05.001","volume":"29","author":"RD Timmerman","year":"2005","unstructured":"Timmerman, R. D. & Kavanagh, B. D. Stereotactic body radiation therapy. Curr. Probl. Cancer 29, 120\u2013157 (2005).","journal-title":"Curr. Probl. Cancer"},{"key":"BFnrclinonc2009188_CR3","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1002\/(SICI)1097-0142(19980315)82:6<1062::AID-CNCR8>3.0.CO;2-G","volume":"82","author":"M Uematsu","year":"1998","unstructured":"Uematsu, M. et al. Focal, high dose, and fractionated modified stereotactic radiation therapy for lung carcinoma patients: a preliminary experience. Cancer 82, 1062\u20131070 (1998).","journal-title":"Cancer"},{"key":"BFnrclinonc2009188_CR4","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1200\/JCO.2006.09.7469","volume":"25","author":"RD Timmerman","year":"2007","unstructured":"Timmerman, R. D., Kavanagh, B. D., Cho, L. C., Papiez, L. & Xing, L. Stereotactic body radiation therapy in multiple organ sites. J. Clin. Oncol. 25, 947\u2013952 (2007).","journal-title":"J. Clin. Oncol."},{"key":"BFnrclinonc2009188_CR5","first-page":"163","volume":"70","author":"L Norton","year":"1986","unstructured":"Norton, L. & Simon, R. The Norton\u2013Simon hypothesis revisited. Cancer Treat. Rep. 70, 163\u2013169 (1986).","journal-title":"Cancer Treat. Rep."},{"key":"BFnrclinonc2009188_CR6","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.ijrobp.2007.10.059","volume":"70","author":"C Park","year":"2008","unstructured":"Park, C., Papiez, L., Zhang, S., Story, M. & Timmerman, R. D. Universal survival curve and single fraction equivalent dose: useful tools in understanding potency of ablative radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 70, 847\u2013852 (2008).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR7","doi-asserted-by":"crossref","first-page":"S619","DOI":"10.1016\/j.ijrobp.2007.07.1943","volume":"69","author":"JZ Wang","year":"2007","unstructured":"Wang, J. Z., Mayr, N. A. & Yuh, W. T. C. A generalized linear-quadratic formula for high-dose-rate brachytherapy and radiosurgery. Int. J. Radiat. Oncol. Biol. Phys. 69, S619\u2013S620 (2007).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR8","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1378\/chest.124.5.1946","volume":"124","author":"R Timmerman","year":"2003","unstructured":"Timmerman, R. et al. Extracranial stereotactic radioablation: results of a phase I study in medically inoperable stage I non-small cell lung cancer. Chest 124, 1946\u20131955 (2003).","journal-title":"Chest"},{"key":"BFnrclinonc2009188_CR9","doi-asserted-by":"crossref","first-page":"4833","DOI":"10.1200\/JCO.2006.07.5937","volume":"24","author":"R Timmerman","year":"2006","unstructured":"Timmerman, R. et al. Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer. J. Clin. Oncol. 24, 4833\u20134839 (2006).","journal-title":"J. Clin. Oncol."},{"key":"BFnrclinonc2009188_CR10","doi-asserted-by":"crossref","first-page":"S128","DOI":"10.1016\/j.ijrobp.2008.06.432","volume":"72","author":"HR Cardenes","year":"2008","unstructured":"Cardenes, H. R. et al. Phase I trial of steroetactic body radiation therapy for primary heptaocellular carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 72, S128 (2008).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR11","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1200\/JCO.2007.14.3529","volume":"26","author":"RV Tse","year":"2008","unstructured":"Tse, R. V. et al. Phase I study of individualized stereotactic body radiotherapy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma. J. Clin. Oncol. 26, 657\u2013664 (2008).","journal-title":"J. Clin. Oncol."},{"key":"BFnrclinonc2009188_CR12","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1200\/JCO.2008.19.6386","volume":"27","author":"KE Rusthoven","year":"2009","unstructured":"Rusthoven, K. E. et al. Multi-institutional phase I\/II trial of stereotactic body radiation therapy for lung metastases. J. Clin. Oncol. 27, 1579\u20131584 (2009).","journal-title":"J. Clin. Oncol."},{"key":"BFnrclinonc2009188_CR13","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1200\/JCO.2008.19.6329","volume":"27","author":"KE Rusthoven","year":"2009","unstructured":"Rusthoven, K. E. et al. Multi-institutional phase I\/II trial of stereotactic body radiation therapy for liver metastases. J. Clin. Oncol. 27, 1572\u20131578 (2009).","journal-title":"J. Clin. Oncol."},{"key":"BFnrclinonc2009188_CR14","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.ijrobp.2004.04.025","volume":"59","author":"EL Chang","year":"2004","unstructured":"Chang, E. L. et al. Phase I clinical evaluation of near-simultaneous computed tomographic image-guided stereotactic body radiotherapy for spinal metastases. Int. J. Radiat. Oncol. Biol. Phys. 59, 1288\u20131294 (2004).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3171\/SPI-07\/08\/151","volume":"7","author":"EL Chang","year":"2007","unstructured":"Chang, E. L. et al. Phase I\/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure. J. Neurosurg. Spine 7, 151\u2013160 (2007).","journal-title":"J. Neurosurg. Spine"},{"key":"BFnrclinonc2009188_CR16","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/0360-3016(82)90299-1","volume":"8","author":"AB Wolbarst","year":"1982","unstructured":"Wolbarst, A. B., Chin, L. M. & Svensson, G. K. Optimization of radiation therapy: integral-response of a model biological system. Int. J. Radiat. Oncol. Biol. Phys. 8, 1761\u20131769 (1982).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ccr.2005.07.014","volume":"8","author":"Z Fuks","year":"2005","unstructured":"Fuks, Z. & Kolesnick, R. Engaging the vascular component of the tumor response. Cancer Cell 8, 89\u201391 (2005).","journal-title":"Cancer Cell"},{"key":"BFnrclinonc2009188_CR18","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1126\/science.1082504","volume":"300","author":"M Garcia-Barros","year":"2003","unstructured":"Garcia-Barros, M. et al. Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science 300, 1155\u20131159 (2003).","journal-title":"Science"},{"key":"BFnrclinonc2009188_CR19","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1182\/blood-2009-02-206870","volume":"114","author":"Y Lee","year":"2009","unstructured":"Lee, Y. et al. Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment. Blood 114, 589\u2013595 (2009).","journal-title":"Blood"},{"key":"BFnrclinonc2009188_CR20","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.radonc.2008.08.010","volume":"91","author":"M Guckenberger","year":"2009","unstructured":"Guckenberger, M. et al. Potential of image-guidance, gating and real-time tracking to improve accuracy in pulmonary stereotactic body radiotherapy. Radiother. Oncol. 91, 288\u2013295 (2009).","journal-title":"Radiother. Oncol."},{"key":"BFnrclinonc2009188_CR21","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.ijrobp.2008.08.004","volume":"74","author":"JJ Sonke","year":"2009","unstructured":"Sonke, J. J. et al. Frameless stereotactic body radiotherapy for lung cancer using four-dimensional cone beam CT guidance. Int. J. Radiat. Oncol. Biol. Phys. 74, 567\u2013574 (2009).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR22","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1097\/COC.0b013e3180ca7cb1","volume":"30","author":"BK Chang","year":"2007","unstructured":"Chang, B. K. & Timmerman, R. D. Stereotactic body radiation therapy: a comprehensive review. Am. J. Clin. Oncol. 30, 637\u2013644 (2007).","journal-title":"Am. J. Clin. Oncol."},{"key":"BFnrclinonc2009188_CR23","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1586\/14737140.8.12.1939","volume":"8","author":"SS Lo","year":"2008","unstructured":"Lo, S. S. et al. Stereotactic body radiation therapy for nonpulmonary primary tumors. Expert Rev. Anticancer Ther. 8, 1939\u20131951 (2008).","journal-title":"Expert Rev. Anticancer Ther."},{"key":"BFnrclinonc2009188_CR24","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1586\/era.09.15","volume":"9","author":"SS Lo","year":"2009","unstructured":"Lo, S. S. et al. Stereotactic body radiation therapy for oligometastases. Expert Rev. Anticancer Ther. 9, 621\u2013635 (2009).","journal-title":"Expert Rev. Anticancer Ther."},{"key":"BFnrclinonc2009188_CR25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1586\/14737140.8.1.87","volume":"8","author":"SS Lo","year":"2008","unstructured":"Lo, S. S. et al. Stereotactic body radiation therapy for early-stage non-small-cell lung cancer. Expert Rev. Anticancer Ther. 8, 87\u201398 (2008).","journal-title":"Expert Rev. Anticancer Ther."},{"key":"BFnrclinonc2009188_CR26","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.ijrobp.2004.07.665","volume":"60","author":"RW Underberg","year":"2004","unstructured":"Underberg, R. W. et al. Four-dimensional CT scans for treatment planning in stereotactic radiotherapy for stage I lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 60, 1283\u20131290 (2004).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR27","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.ijrobp.2005.03.073","volume":"63","author":"RC McGarry","year":"2005","unstructured":"McGarry, R. C., Papiez, L., Williams, M., Whitford, T. & Timmerman, R. D. Stereotactic body radiation therapy of early-stage non-small-cell lung carcinoma: phase I study. Int. J. Radiat. Oncol. Biol. Phys. 63, 1010\u20131015 (2005).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR28","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.ijrobp.2008.11.042","volume":"75","author":"AJ Fakiris","year":"2009","unstructured":"Fakiris, A. J. et al. Stereotactic body radiation therapy for early-stage non-small-cell lung carcinoma: four-year results of a prospective phase II study. Int. J. Radiat. Oncol. Biol. Phys. 75, 677\u2013682 (2009).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR29","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.ijrobp.2008.08.001","volume":"72","author":"JY Chang","year":"2008","unstructured":"Chang, J. Y. et al. Stereotactic body radiation therapy in centrally and superiorly located stage I or isolated recurrent non-small-cell lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 72, 967\u2013971 (2008).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR30","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.ijrobp.2005.05.034","volume":"63","author":"Y Nagata","year":"2005","unstructured":"Nagata, Y. et al. Clinical outcomes of a phase I II study of 48 Gy of stereotactic body radiotherapy in 4 fractions for primary lung cancer using a stereotactic body frame. Int. J. Radiat. Oncol. Biol. Phys. 63, 1427\u20131431 (2005).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR31","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1200\/JCO.2008.21.5681","volume":"27","author":"P Baumann","year":"2009","unstructured":"Baumann, P. et al. Outcome in a prospective phase II trial of medically inoperable stage I non-small-cell lung cancer patients treated with stereotactic body radiotherapy. J. Clin. Oncol. 27, 3290\u20133296 (2009).","journal-title":"J. Clin. Oncol."},{"key":"BFnrclinonc2009188_CR32","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0360-3016(99)00118-2","volume":"45","author":"DA Jaffray","year":"1999","unstructured":"Jaffray, D. A., Drake, D. G., Moreau, M., Martinez, A. A. & Wong, J. W. A radiographic and tomographic imaging system integrated into a medical linear accelerator for localization of bone and soft-tissue targets. Int. J. Radiat. Oncol. Biol. Phys. 45, 773\u2013789 (1999).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR33","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/cncr.22763","volume":"110","author":"H Hof","year":"2007","unstructured":"Hof, H. et al. Stereotactic single-dose radiotherapy (radiosurgery) of early stage non-small-cell lung cancer (NSCLC). Cancer 110, 148\u2013155 (2007).","journal-title":"Cancer"},{"key":"BFnrclinonc2009188_CR34","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.lungcan.2005.08.011","volume":"51","author":"J Nyman","year":"2006","unstructured":"Nyman, J., Johansson, K. A. & Hulten, U. Stereotactic hypofractionated radiotherapy for stage I non-small cell lung cancer\u2014mature results for medically inoperable patients. Lung Cancer 51, 97\u2013103 (2006).","journal-title":"Lung Cancer"},{"key":"BFnrclinonc2009188_CR35","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1002\/cncr.20539","volume":"101","author":"H Onishi","year":"2004","unstructured":"Onishi, H. et al. Stereotactic hypofractionated high-dose irradiation for stage I nonsmall cell lung carcinoma: clinical outcomes in 245 subjects in a Japanese multiinstitutional study. Cancer 101, 1623\u20131631 (2004).","journal-title":"Cancer"},{"key":"BFnrclinonc2009188_CR36","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1080\/02841860600913210","volume":"45","author":"FB Zimmermann","year":"2006","unstructured":"Zimmermann, F. B. et al. Stereotactic hypofractionated radiotherapy in stage I (T1\u20132 N0 M0) non-small-cell lung cancer (NSCLC). Acta Oncol. 45, 796\u2013801 (2006).","journal-title":"Acta Oncol."},{"key":"BFnrclinonc2009188_CR37","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S0360-3016(01)02731-6","volume":"52","author":"Y Nagata","year":"2002","unstructured":"Nagata, Y. et al. Clinical outcomes of 3D conformal hypofractionated single high-dose radiotherapy for one or two lung tumors using a stereotactic body frame. Int. J. Radiat. Oncol. Biol. Phys. 52, 1041\u20131046 (2002).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR38","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/S0360-3016(01)01703-5","volume":"51","author":"M Uematsu","year":"2001","unstructured":"Uematsu, M. et al. Computed tomography-guided frameless stereotactic radiotherapy for stage I non-small cell lung cancer: a 5-year experience. Int. J. Radiat. Oncol. Biol. Phys. 51, 666\u2013670 (2001).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR39","first-page":"178","volume":"4","author":"RA Abrams","year":"1998","unstructured":"Abrams, R. A., Pajak, T. F., Haulk, T. L., Flam, M. & Asbell, S. O. Survival results among patients with \u03b1-fetoprotein-positive, unresectable hepatocellular carcinoma: analysis of three sequential treatments of the RTOG and Johns Hopkins Oncology Center. Cancer J. Sci. Am. 4, 178\u2013184 (1998).","journal-title":"Cancer J. Sci. Am."},{"key":"BFnrclinonc2009188_CR40","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1200\/JCO.2000.18.11.2210","volume":"18","author":"LA Dawson","year":"2000","unstructured":"Dawson, L. A. et al. Escalated focal liver radiation and concurrent hepatic artery fluorodeoxyuridine for unresectable intrahepatic malignancies. J. Clin. Oncol. 18, 2210\u20132218 (2000).","journal-title":"J. Clin. Oncol."},{"key":"BFnrclinonc2009188_CR41","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1023\/B:JORA.0000010880.40483.c4","volume":"1","author":"H Blomgren","year":"1998","unstructured":"Blomgren, H. et al. Radiosurgery for tumors in the body: clinical experience using a new method. J. Radiosurg. 1, 63\u201374 (1998).","journal-title":"J. Radiosurg."},{"key":"BFnrclinonc2009188_CR42","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1080\/02841860600904821","volume":"45","author":"J Wulf","year":"2006","unstructured":"Wulf, J. et al. Stereotactic radiotherapy of primary liver cancer and hepatic metastases. Acta Oncol. 45, 838\u2013847 (2006).","journal-title":"Acta Oncol."},{"key":"BFnrclinonc2009188_CR43","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/jjco\/hyi236","volume":"36","author":"BO Choi","year":"2006","unstructured":"Choi, B. O. et al. Fractionated stereotactic radiotherapy in patients with primary hepatocellular carcinoma. Jpn J. Clin. Oncol. 36, 154\u2013158 (2006).","journal-title":"Jpn J. Clin. Oncol."},{"key":"BFnrclinonc2009188_CR44","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1080\/02841860600897934","volume":"45","author":"A Mendez Romero","year":"2006","unstructured":"Mendez Romero, A. et al. Stereotactic body radiation therapy for primary and metastatic liver tumors: a single institution phase I\u2013II study. Acta Oncol. 45, 831\u2013837 (2006).","journal-title":"Acta Oncol."},{"key":"BFnrclinonc2009188_CR45","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.semradonc.2005.12.003","volume":"16","author":"BD Kavanagh","year":"2006","unstructured":"Kavanagh, B. D., McGarry, R. C. & Timmerman, R. D. Extracranial radiosurgery (stereotactic body radiation therapy) for oligometastases. Semin. Radiat. Oncol. 16, 77\u201384 (2006).","journal-title":"Semin. Radiat. Oncol."},{"key":"BFnrclinonc2009188_CR46","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0360-3016(00)00617-9","volume":"48","author":"K Nakagawa","year":"2000","unstructured":"Nakagawa, K., Aoki, Y., Tago, M., Terahara, A. & Ohtomo, K. Megavoltage CT-assisted stereotactic radiosurgery for thoracic tumors: original research in the treatment of thoracic neoplasms. Int. J. Radiat. Oncol. Biol. Phys. 48, 449\u2013457 (2000).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR47","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/PL00002379","volume":"177","author":"J Wulf","year":"2001","unstructured":"Wulf, J. et al. Stereotactic radiotherapy of targets in the lung and liver. Strahlenther Onkol. 177, 645\u2013655 (2001).","journal-title":"Strahlenther Onkol."},{"key":"BFnrclinonc2009188_CR48","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ijrobp.2004.02.060","volume":"60","author":"J Wulf","year":"2004","unstructured":"Wulf, J. et al. Stereotactic radiotherapy for primary lung cancer and pulmonary metastases: a noninvasive treatment approach in medically inoperable patients. Int. J. Radiat. Oncol. Biol. Phys. 60, 186\u2013196 (2004).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR49","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0167-8140(02)00063-4","volume":"63","author":"R Hara","year":"2002","unstructured":"Hara, R. et al. Stereotactic single high dose irradiation of lung tumors under respiratory gating. Radiother. Oncol. 63, 159\u2013163 (2002).","journal-title":"Radiother. Oncol."},{"key":"BFnrclinonc2009188_CR50","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0169-5002(03)00040-0","volume":"40","author":"SW Lee","year":"2003","unstructured":"Lee, S. W. et al. Stereotactic body frame based fractionated radiosurgery on consecutive days for primary or metastatic tumors in the lung. Lung Cancer 40, 309\u2013315 (2003).","journal-title":"Lung Cancer"},{"key":"BFnrclinonc2009188_CR51","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00066-007-1724-z","volume":"183","author":"H Hof","year":"2007","unstructured":"Hof, H., Hoess, A., Oetzel, D., Debus, J. & Herfarth, K. Stereotactic single-dose radiotherapy of lung metastases. Strahlenther Onkol. 183, 673\u2013678 (2007).","journal-title":"Strahlenther Onkol."},{"key":"BFnrclinonc2009188_CR52","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1080\/02841860600908954","volume":"45","author":"P Okunieff","year":"2006","unstructured":"Okunieff, P. et al. Stereotactic body radiation therapy (SBRT) for lung metastases. Acta Oncol. 45, 808\u2013817 (2006).","journal-title":"Acta Oncol."},{"key":"BFnrclinonc2009188_CR53","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.ijrobp.2008.01.002","volume":"72","author":"Y Norihisa","year":"2008","unstructured":"Norihisa, Y. et al. Stereotactic body radiotherapy for oligometastatic lung tumors. Int. J. Radiat. Oncol. Biol. Phys. 72, 398\u2013403 (2008).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR54","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ijrobp.2008.06.1939","volume":"74","author":"M Guckenberger","year":"2009","unstructured":"Guckenberger, M. et al. Dose\u2013response relationship for image-guided stereotactic body radiotherapy of pulmonary tumors: relevance of 4D dose calculation. Int. J. Radiat. Oncol. Biol. Phys. 74, 47\u201354 (2009).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR55","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1007\/s00066-006-1577-x","volume":"182","author":"A Ernst-Stecken","year":"2006","unstructured":"Ernst-Stecken, A., Lambrecht, U., Mueller, R., Sauer, R. & Grabenbauer, G. Hypofractionated stereotactic radiotherapy for primary and secondary intrapulmonary tumors: first results of a phase I\/II study. Strahlenther Onkol. 182, 696\u2013702 (2006).","journal-title":"Strahlenther Onkol."},{"key":"BFnrclinonc2009188_CR56","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1097\/01243894-200610000-00008","volume":"1","author":"QT Le","year":"2006","unstructured":"Le, Q. T. et al. Results of a phase I dose-escalation study using single-fraction stereotactic radiotherapy for lung tumors. J. Thorac. Oncol. 1, 802\u2013809 (2006).","journal-title":"J. Thorac. Oncol."},{"key":"BFnrclinonc2009188_CR57","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1023\/B:JORA.0000015199.41948.7c","volume":"1","author":"M Sato","year":"1998","unstructured":"Sato, M., Uematsu, M. & Yamamoto, F. Feasibility of frameless stereotactic high-dose radiation therapy for primary and metastatic liver cancer. J. Radiosurg. 1, 233\u2013238 (1998).","journal-title":"J. Radiosurg."},{"key":"BFnrclinonc2009188_CR58","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.ijrobp.2006.10.025","volume":"67","author":"AW Katz","year":"2007","unstructured":"Katz, A. W. et al. Hypofractionated stereotactic body radiation therapy (SBRT) for limited hepatic metastases. Int. J. Radiat. Oncol. Biol. Phys. 67, 793\u2013798 (2007).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR59","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.ijrobp.2003.08.012","volume":"58","author":"H Wada","year":"2004","unstructured":"Wada, H., Takai, Y., Nemoto, K. & Yamada, S. Univariate analysis of factors correlated with tumor control probability of three-dimensional conformal hypofractionated high-dose radiotherapy for small pulmonary or hepatic tumors. Int. J. Radiat. Oncol. Biol. Phys. 58, 1114\u20131120 (2004).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR60","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s12032-008-9125-4","volume":"26","author":"P Gunv\u00e9n","year":"2008","unstructured":"Gunv\u00e9n, P., Blomgren, H., Lax, I. & Levitt, S. H. Curative stereotactic body radiotherapy for liver malignancy. Med. Oncol. 26, 327\u2013334 (2008).","journal-title":"Med. Oncol."},{"key":"BFnrclinonc2009188_CR61","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1200\/JCO.2001.19.1.164","volume":"19","author":"KK Herfarth","year":"2001","unstructured":"Herfarth, K. K. et al. Stereotactic single-dose radiation therapy of liver tumors: results of a phase I\/II trial. J. Clin. Oncol. 19, 164\u2013170 (2001).","journal-title":"J. Clin. Oncol."},{"key":"BFnrclinonc2009188_CR62","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1200\/JCO.2008.20.0600","volume":"27","author":"MT Lee","year":"2009","unstructured":"Lee, M. T. et al. Phase I study of individualized stereotactic body radiotherapy of liver metastases. J. Clin. Oncol. 27, 1585\u20131591 (2009).","journal-title":"J. Clin. Oncol."},{"key":"BFnrclinonc2009188_CR63","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1586\/14737175.7.1.85","volume":"7","author":"SS Lo","year":"2007","unstructured":"Lo, S. S. et al. Stereotactic radiosurgery and radiation therapy for spinal tumors. Expert Rev. Neurother. 7, 85\u201393 (2007).","journal-title":"Expert Rev. Neurother."},{"key":"BFnrclinonc2009188_CR64","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.ijrobp.2008.02.060","volume":"71","author":"A Sahgal","year":"2008","unstructured":"Sahgal, A., Larson, D. A. & Chang, E. L. Stereotactic body radiosurgery for spinal metastases: a critical review. Int. J. Radiat. Oncol. Biol. Phys. 71, 652\u2013665 (2008).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR65","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1002\/cncr.11296","volume":"97","author":"S Ryu","year":"2003","unstructured":"Ryu, S. et al. Image-guided and intensity-modulated radiosurgery for patients with spinal metastasis. Cancer 97, 2013\u20132018 (2003).","journal-title":"Cancer"},{"issue":"Suppl. 3","key":"BFnrclinonc2009188_CR66","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3171\/sup.2004.101.supplement3.0402","volume":"101","author":"S Ryu","year":"2004","unstructured":"Ryu, S., Rock, J., Rosenblum, M. & Kim, J. H. Patterns of failure after single-dose radiosurgery for spinal metastasis. J. Neurosurg. 101 (Suppl. 3), 402\u2013405 (2004).","journal-title":"J. Neurosurg."},{"key":"BFnrclinonc2009188_CR67","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1227\/01.NEU.0000209913.72761.4F","volume":"58","author":"JP Rock","year":"2006","unstructured":"Rock, J. P. et al. Postoperative radiosurgery for malignant spinal tumors. Neurosurgery 58, 891\u2013898 (2006).","journal-title":"Neurosurgery"},{"key":"BFnrclinonc2009188_CR68","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3171\/spi.2005.3.4.0288","volume":"3","author":"PC Gerszten","year":"2005","unstructured":"Gerszten, P. C. et al. Stereotactic radiosurgery for spinal metastases from renal cell carcinoma. J. Neurosurg. Spine 3, 288\u2013295 (2005).","journal-title":"J. Neurosurg. Spine"},{"key":"BFnrclinonc2009188_CR69","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/01.brs.0000251863.76595.a2","volume":"32","author":"PC Gerszten","year":"2007","unstructured":"Gerszten, P. C., Burton, S. A., Ozhasoglu, C. & Welch, W. C. Radiosurgery for spinal metastases: clinical experience in 500 cases from a single institution. Spine 32, 193\u2013199 (2007).","journal-title":"Spine"},{"key":"BFnrclinonc2009188_CR70","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000091952","volume":"83","author":"PC Gerszten","year":"2005","unstructured":"Gerszten, P. C., Burton, S. A., Quinn, A. E., Agarwala, S. S. & Kirkwood, J. M. Radiosurgery for the treatment of spinal melanoma metastases. Stereotact. Funct. Neurosurg. 83, 213\u2013221 (2005).","journal-title":"Stereotact. Funct. Neurosurg."},{"key":"BFnrclinonc2009188_CR71","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1002\/cncr.21467","volume":"104","author":"PC Gerszten","year":"2005","unstructured":"Gerszten, P. C. et al. Single-fraction radiosurgery for the treatment of spinal breast metastases. Cancer 104, 2244\u20132254 (2005).","journal-title":"Cancer"},{"key":"BFnrclinonc2009188_CR72","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3171\/spi.2005.3.4.0296","volume":"3","author":"PC Gerszten","year":"2005","unstructured":"Gerszten, P. C. et al. Combination kyphoplasty and spinal radiosurgery: a new treatment paradigm for pathological fractures. J. Neurosurg. Spine 3, 296\u2013301 (2005).","journal-title":"J. Neurosurg. Spine"},{"key":"BFnrclinonc2009188_CR73","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.radonc.2006.11.023","volume":"82","author":"IC Gibbs","year":"2007","unstructured":"Gibbs, I. C. et al. Image-guided robotic radiosurgery for spinal metastases. Radiother. Oncol. 82, 185\u2013190 (2007).","journal-title":"Radiother. Oncol."},{"key":"BFnrclinonc2009188_CR74","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ijrobp.2004.09.006","volume":"62","author":"Y Yamada","year":"2005","unstructured":"Yamada, Y. et al. Multifractionated image-guided and stereotactic intensity-modulated radiotherapy of paraspinal tumors: a preliminary report. Int. J. Radiat. Oncol. Biol. Phys. 62, 53\u201361 (2005).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR75","doi-asserted-by":"crossref","first-page":"S243","DOI":"10.1016\/j.ijrobp.2007.07.1240","volume":"69","author":"A Sahgal","year":"2007","unstructured":"Sahgal, A., Chuang, C. & Larson, D. Proximity of spinous\/paraspinous radiosurgery metastatic targets to the spinal cord versus risk of local failure. Int. J. Radiat. Oncol. Biol. Phys. 69, S243 (2007).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR76","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.ijrobp.2007.11.046","volume":"71","author":"Y Yamada","year":"2008","unstructured":"Yamada, Y. et al. High-dose, single-fraction image-guided intensity-modulated radiotherapy for metastatic spinal lesions. Int. J. Radiat. Oncol. Biol. Phys. 71, 484\u2013490 (2008).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR77","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1227\/01.neu.0000318174.28461.fc","volume":"62","author":"PC Gerszten","year":"2008","unstructured":"Gerszten, P. C., Burton, S. A., Ozhasoglu, C., McCue, K. J. & Quinn, A. E. Radiosurgery for benign intradural spinal tumors. Neurosurgery 62, 887\u2013896 (2008).","journal-title":"Neurosurgery"},{"key":"BFnrclinonc2009188_CR78","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1227\/01.NEU.0000204128.84742.8F","volume":"58","author":"RL Dodd","year":"2006","unstructured":"Dodd, R. L. et al. CyberKnife radiosurgery for benign intradural extramedullary spinal tumors. Neurosurgery 58, 674\u2013685 (2006).","journal-title":"Neurosurgery"},{"key":"BFnrclinonc2009188_CR79","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1177\/153303460700600602","volume":"6","author":"A Sahgal","year":"2007","unstructured":"Sahgal, A. et al. Image-guided robotic stereotactic body radiotherapy for benign spinal tumors: the University of California San Francisco preliminary experience. Technol. Cancer Res. Treat. 6, 595\u2013604 (2007).","journal-title":"Technol. Cancer Res. Treat."},{"key":"BFnrclinonc2009188_CR80","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.ijrobp.2006.10.050","volume":"67","author":"BL Madsen","year":"2007","unstructured":"Madsen, B. L. et al. Stereotactic hypofractionated accurate radiotherapy of the prostate (SHARP), 33.5 Gy in five fractions for localized disease: first clinical trial results. Int. J. Radiat. Oncol. Biol. Phys. 67, 1099\u20131105 (2007).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR81","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.ijrobp.2008.05.059","volume":"73","author":"CR King","year":"2009","unstructured":"King, C. R. et al. Stereotactic body radiotherapy for localized prostate cancer: interim results of a prospective phase II clinical trial. Int. J. Radiat. Oncol. Biol. Phys. 73, 1043\u20131048 (2009).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR82","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1177\/1553350607310546","volume":"14","author":"LE Ponsky","year":"2007","unstructured":"Ponsky, L. E., Mahadevan, A., Gill, I. S., Djemil, T. & Novick, A. C. Renal radiosurgery: initial clinical experience with histological evaluation. Surg. Innov. 14, 265\u2013269 (2007).","journal-title":"Surg. Innov."},{"key":"BFnrclinonc2009188_CR83","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1097\/01.coc.0000145289.57705.07","volume":"27","author":"JJ Beitler","year":"2004","unstructured":"Beitler, J. J., Makara, D., Silverman, P. & Lederman, G. Definitive, high-dose-per-fraction, conformal, stereotactic external radiation for renal cell carcinoma. Am. J. Clin. Oncol. 27, 646\u2013648 (2004).","journal-title":"Am. J. Clin. Oncol."},{"key":"BFnrclinonc2009188_CR84","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.radonc.2005.03.022","volume":"77","author":"PJ Wersall","year":"2005","unstructured":"Wersall, P. J. et al. Extracranial stereotactic radiotherapy for primary and metastatic renal cell carcinoma. Radiother. Oncol. 77, 88\u201395 (2005).","journal-title":"Radiother. Oncol."},{"key":"BFnrclinonc2009188_CR85","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1080\/02841860600954875","volume":"45","author":"C Svedman","year":"2006","unstructured":"Svedman, C. et al. A prospective phase II trial of using extracranial stereotactic radiotherapy in primary and metastatic renal cell carcinoma. Acta Oncol. 45, 870\u2013875 (2006).","journal-title":"Acta Oncol."},{"key":"BFnrclinonc2009188_CR86","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.ijrobp.2003.11.004","volume":"58","author":"AC Koong","year":"2004","unstructured":"Koong, A. C. et al. Phase I study of stereotactic radiosurgery in patients with locally advanced pancreatic cancer. Int. J. Radiat. Oncol. Biol. Phys. 58, 1017\u20131021 (2004).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR87","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.ijrobp.2005.07.002","volume":"63","author":"AC Koong","year":"2005","unstructured":"Koong, A. C. et al. Phase II study to assess the efficacy of conventionally fractionated radiotherapy followed by a stereotactic radiosurgery boost in patients with locally advanced pancreatic cancer. Int. J. Radiat. Oncol. Biol. Phys. 63, 320\u2013323 (2005).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR88","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.ijrobp.2008.01.051","volume":"72","author":"D Schellenberg","year":"2008","unstructured":"Schellenberg, D. et al. Gemcitabine chemotherapy and single-fraction stereotactic body radiotherapy for locally advanced pancreatic cancer. Int. J. Radiat. Oncol. Biol. Phys. 72, 678\u2013686 (2008).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrclinonc2009188_CR89","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.radonc.2004.12.022","volume":"76","author":"M Hoyer","year":"2005","unstructured":"Hoyer, M. et al. Phase II study on stereotactic radiotherapy of locally advanced pancreatic carcinoma. Radiother. Oncol. 76, 48\u201353 (2005).","journal-title":"Radiother. Oncol."},{"key":"BFnrclinonc2009188_CR90","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.radonc.2009.02.003","volume":"91","author":"GR Borst","year":"2009","unstructured":"Borst, G. R. et al. Radiation pneumonitis in patients treated for malignant pulmonary lesions with hypofractionated radiation therapy. Radiother. Oncol. 91, 307\u2013313 (2009).","journal-title":"Radiother. Oncol."},{"issue":"3","key":"BFnrclinonc2009188_CR91","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.ijrobp.2009.02.027","volume":"76","author":"Neal E. Dunlap","year":"2010","unstructured":"Dunlap, N. E. et al. Chest wall volume receiving &gt;30 Gy predicts risk of severe pain and\/or rib fracture after lung stereotactic body radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. doi:10.1016\/j.ijrobp.2009.02.027.","journal-title":"International Journal of Radiation Oncology*Biology*Physics"},{"key":"BFnrclinonc2009188_CR92","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.radonc.2009.03.022","volume":"91","author":"N Pettersson","year":"2009","unstructured":"Pettersson, N., Nyman, J. & Johansson, K. A. Radiation-induced rib fractures after hypofractionated stereotactic body radiation therapy of non-small cell lung cancer: a dose- and volume-response analysis. Radiother. Oncol. 91, 360\u2013368 (2009).","journal-title":"Radiother. Oncol."},{"key":"BFnrclinonc2009188_CR93","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.ijrobp.2008.08.036","volume":"72","author":"BS Hoppe","year":"2008","unstructured":"Hoppe, B. S. et al. Acute skin toxicity following stereotactic body radiation therapy for stage I non-small-cell lung cancer: who's at risk? Int. J. Radiat. Oncol. Biol. Phys. 72, 1283\u20131286 (2008).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"3","key":"BFnrclinonc2009188_CR94","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.radonc.2009.04.018","volume":"93","author":"Jeffrey A. Forquer","year":"2009","unstructured":"Forquer, J. A. et al. Brachial plexopathy from stereotactic body radiotherapy in early-stage NSCLC: dose-limiting toxicity in apical tumor sites. Radiother. Oncol. doi:10.1016\/j.radonc.2009.04.018.","journal-title":"Radiotherapy and Oncology"},{"key":"BFnrclinonc2009188_CR95","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1016\/j.ijrobp.2008.06.884","volume":"72","author":"I Laufer","year":"2008","unstructured":"Laufer, I., Rose, P., Lis, E., Bilsky, M. H. & Yamada, Y. An analysis of risk factors for vertebral body fracture following high-dose single-fraction image-guided intensity modulated radiotherapy (IG IMRT) of spinal metastases. Int. J. Radiat. Oncol. Biol. Phys. 72, S52 (2008).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."}],"updated-by":[{"DOI":"10.1038\/nrclinonc.2010.117","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000}}],"container-title":["Nature Reviews Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrclinonc.2009.188.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrclinonc.2009.188","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrclinonc.2009.188.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:02:52Z","timestamp":1684454572000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrclinonc.2009.188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,8]]},"references-count":95,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["BFnrclinonc2009188"],"URL":"https:\/\/doi.org\/10.1038\/nrclinonc.2009.188","relation":{},"ISSN":["1759-4774","1759-4782"],"issn-type":[{"value":"1759-4774","type":"print"},{"value":"1759-4782","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,8]]},"assertion":[{"value":"8 December 2009","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"R. Timmerman receives grant\/research support from Elekta Oncology and Varian Medical Systems. The other authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}