{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:10:34Z","timestamp":1780528234186,"version":"3.54.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2010,5,18]],"date-time":"2010-05-18T00:00:00Z","timestamp":1274140800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Clin Oncol"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1038\/nrclinonc.2010.67","type":"journal-article","created":{"date-parts":[[2010,5,18]],"date-time":"2010-05-18T10:22:22Z","timestamp":1274178142000},"page":"476-480","source":"Crossref","is-referenced-by-count":25,"title":["A case of variant angina in a patient under chronic treatment with sorafenib"],"prefix":"10.1038","volume":"7","author":[{"given":"Italo","family":"Porto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Leo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Miele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Pompili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Landolfi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Crea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,5,18]]},"reference":[{"key":"BFnrclinonc201067_CR1","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/0002-9343(59)90003-8","volume":"27","author":"M Prinzmetal","year":"1959","unstructured":"Prinzmetal, M., Kennamer, R., Merliss, R., Wada, T. & Bor, N. Angina pectoris. I. A variant form of angina pectoris; preliminary report. Am. J. Med. 27, 375\u2013388 (1959).","journal-title":"Am. J. Med."},{"key":"BFnrclinonc201067_CR2","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.ijcard.2006.06.016","volume":"118","author":"GA Lanza","year":"2007","unstructured":"Lanza, G. A. et al. Current clinical features, diagnostic assessment and prognostic determinants of patients with variant angina. Int. J. Cardiol. 118, 41\u201347 (2007).","journal-title":"Int. J. Cardiol."},{"key":"BFnrclinonc201067_CR3","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1161\/CIRCULATIONAHA.108.843474","volume":"119","author":"S Stern","year":"2009","unstructured":"Stern, S. & Bayes de Luna, A. Coronary artery spasm: a 2009 update. Circulation 119, 2531\u20132534 (2009).","journal-title":"Circulation"},{"key":"BFnrclinonc201067_CR4","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1093\/oxfordjournals.eurheartj.a059919","volume":"12","author":"RJ Luwaert","year":"1991","unstructured":"Luwaert, R. J., Descamps, O., Majois, F., Chaudron, J. M. & Beauduin, M. Coronary artery spasm induced by 5-fluorouracil. Eur. Heart J. 12, 468\u2013470 (1991).","journal-title":"Eur. Heart J."},{"key":"BFnrclinonc201067_CR5","doi-asserted-by":"publisher","first-page":"505","DOI":"10.4070\/kcj.2009.39.12.505","volume":"39","author":"SY Yoo","year":"2009","unstructured":"Yoo, S. Y. & Kim, J. Y. Recent insights into the mechanisms of vasospastic angina. Korean Circ. J. 39, 505\u2013511 (2009).","journal-title":"Korean Circ. J."},{"issue":"Suppl. 5","key":"BFnrclinonc201067_CR6","first-page":"76","volume":"18","author":"JT Shepherd","year":"1991","unstructured":"Shepherd, J. T. & Katusic, Z. S. Endothelium-derived vasoactive factors: I. Endothelium-dependent relaxation. Hypertension 18 (Suppl. 5), 76\u201385 (1991).","journal-title":"Hypertension"},{"key":"BFnrclinonc201067_CR7","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1161\/01.CIR.94.3.266","volume":"94","author":"K Kugiyama","year":"1996","unstructured":"Kugiyama, K. et al. Nitric oxide activity is deficient in spasm arteries of patients with coronary spastic angina. Circulation 94, 266\u2013271 (1996).","journal-title":"Circulation"},{"key":"BFnrclinonc201067_CR8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","volume":"43","author":"S Moncada","year":"1991","unstructured":"Moncada, S., Palmer, R. M. & Higgs, E. A. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43, 109\u2013142 (1991).","journal-title":"Pharmacol. Rev."},{"key":"BFnrclinonc201067_CR9","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1161\/01.CIR.101.11.1319","volume":"101","author":"T Kandabashi","year":"2000","unstructured":"Kandabashi, T. et al. Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta. Circulation 101, 1319\u20131323 (2000).","journal-title":"Circulation"},{"key":"BFnrclinonc201067_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00380-004-0794-4","volume":"20","author":"K Miwa","year":"2005","unstructured":"Miwa, K., Fujita, M. & Sasayama, S. Recent insights into the mechanisms, predisposing factors, and racial differences of coronary vasospasm. Heart Vessels 20, 1\u20137 (2005).","journal-title":"Heart Vessels"},{"key":"BFnrclinonc201067_CR11","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1056\/NEJMsa063904","volume":"355","author":"F Murad","year":"2006","unstructured":"Murad, F. Nitric oxide and cyclic GMP in cell signaling and drug development. N. Engl. J. Med. 355, 2003\u20132011 (2006).","journal-title":"N. Engl. J. Med."},{"key":"BFnrclinonc201067_CR12","unstructured":"Norman, P. Kinase therapeutic pipelines: an assessment of targets and agents in development. Insight Pharma. Reports (2007)."},{"key":"BFnrclinonc201067_CR13","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/nrclinonc.2009.130","volume":"6","author":"SP Ivy","year":"2009","unstructured":"Ivy, S. P., Wick, J. Y. & Kaufman, B. M. An overview of small-molecule inhibitors of VEGFR signaling. Nat. Rev. Clin. Oncol. 6, 569\u2013579 (2009).","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"BFnrclinonc201067_CR14","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1161\/CIRCULATIONAHA.108.776831","volume":"118","author":"MH Chen","year":"2008","unstructured":"Chen, M. H., Kerkel\u00e4, R. & Force, T. Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics. Circulation 118, 84\u201395 (2008).","journal-title":"Circulation"},{"key":"BFnrclinonc201067_CR15","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/nrc2106","volume":"7","author":"T Force","year":"2007","unstructured":"Force, T., Krause, D. S. & Van Etten, R. A. Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition. Nat. Rev. Cancer 7, 332\u2013344 (2007).","journal-title":"Nat. Rev. Cancer"},{"key":"BFnrclinonc201067_CR16","doi-asserted-by":"publisher","first-page":"7099","DOI":"10.1158\/0008-5472.CAN-04-1443","volume":"64","author":"SM Wilhelm","year":"2004","unstructured":"Wilhelm, S. M. et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF\/MEK\/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 64, 7099\u20137109 (2004).","journal-title":"Cancer Res."},{"key":"BFnrclinonc201067_CR17","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/ncponc1225","volume":"5","author":"AY Khakoo","year":"2008","unstructured":"Khakoo, A. Y. & Yeh, E. T. Therapy Insight: management of cardiovascular disease in patients with cancer and cardiac complications of cancer therapy. Nat. Clin. Pract. Oncol. 5, 655\u2013667 (2008).","journal-title":"Nat. Clin. Pract. Oncol."},{"key":"BFnrclinonc201067_CR18","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1056\/NEJMoa060655","volume":"356","author":"B Escudier","year":"2007","unstructured":"Escudier, B. et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N. Engl. J. Med. 356, 125\u2013134 (2007).","journal-title":"N. Engl. J. Med."},{"key":"BFnrclinonc201067_CR19","doi-asserted-by":"publisher","first-page":"5204","DOI":"10.1200\/JCO.2007.15.6331","volume":"26","author":"M Schmidinger","year":"2008","unstructured":"Schmidinger, M. et al. Cardiac toxicity of sunitinib and sorafenib in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 26, 5204\u20135212 (2008).","journal-title":"J. Clin. Oncol."},{"key":"BFnrclinonc201067_CR20","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/S1388-9842(01)00129-5","volume":"3","author":"RA de Boer","year":"2001","unstructured":"de Boer, R. A., Siebelink, H. J., Tio, R. A., Boomsma, F. & van Veldhuisen, D. J. Carvedilol increases plasma vascular endothelial growth factor (VEGF) in patients with chronic heart failure. Eur. J. Heart Fail. 3, 331\u2013333 (2001).","journal-title":"Eur. J. Heart Fail."},{"key":"BFnrclinonc201067_CR21","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.jjcc.2009.03.009","volume":"54","author":"Y Arima","year":"2009","unstructured":"Arima, Y. et al. Sorafenib-induced acute myocardial infarction due to coronary artery spasm. J. Cardiol. 54, 512\u2013515 (2009).","journal-title":"J. Cardiol."},{"key":"BFnrclinonc201067_CR22","doi-asserted-by":"publisher","first-page":"3662","DOI":"10.1182\/blood-2006-06-030577","volume":"108","author":"RM Shepherd","year":"2006","unstructured":"Shepherd, R. M. et al. Angiogenic cells can be rapidly mobilized and efficiently harvested from the blood following treatment with AMD3100. Blood 108, 3662\u20133667 (2006).","journal-title":"Blood"},{"key":"BFnrclinonc201067_CR23","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1016\/S0140-6736(07)61865-0","volume":"370","author":"TF Chu","year":"2007","unstructured":"Chu, T. F. et al. Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet 370, 2011\u20132019 (2007).","journal-title":"Lancet"},{"key":"BFnrclinonc201067_CR24","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1091\/mbc.01-02-0302","volume":"13","author":"G Pawlak","year":"2002","unstructured":"Pawlak, G. & Helfman, D. M. Post-transcriptional down-regulation of ROCKI\/Rho-kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts. Mol. Biol. Cell 13, 336\u2013347 (2002).","journal-title":"Mol. Biol. Cell"},{"key":"BFnrclinonc201067_CR25","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1111\/j.1476-5381.2009.00158.x","volume":"157","author":"M Hennenberg","year":"2009","unstructured":"Hennenberg, M. et al. Sorafenib targets dysregulated Rho kinase expression and portal hypertension in rats with secondary biliary cirrhosis. Br. J. Pharmacol. 157, 258\u2013270 (2009).","journal-title":"Br. J. Pharmacol."},{"key":"BFnrclinonc201067_CR26","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.ccr.2005.12.021","volume":"9","author":"G Mavria","year":"2006","unstructured":"Mavria, G. et al. ERK-MAPK signaling opposes Rho-kinase to promote endothelial cell survival and sprouting during angiogenesis. Cancer Cell 9, 33\u201344 (2006).","journal-title":"Cancer Cell"}],"container-title":["Nature Reviews Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrclinonc.2010.67.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrclinonc.2010.67","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrclinonc.2010.67.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T22:51:57Z","timestamp":1740091917000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrclinonc.2010.67"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,18]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["BFnrclinonc201067"],"URL":"https:\/\/doi.org\/10.1038\/nrclinonc.2010.67","relation":{},"ISSN":["1759-4774","1759-4782"],"issn-type":[{"value":"1759-4774","type":"print"},{"value":"1759-4782","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,18]]}}}