{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:15:43Z","timestamp":1790363743091,"version":"4.1.0"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T00:00:00Z","timestamp":1470960000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Rev Drug Discov"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1038\/nrd.2016.154","type":"journal-article","created":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T01:14:24Z","timestamp":1470964464000},"page":"661-662","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Open data in drug discovery and development: lessons from malaria"],"prefix":"10.1038","volume":"15","author":[{"given":"Timothy N. C.","family":"Wells","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Willis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy N.","family":"Burrows","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob Hooft","family":"van Huijsduijnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,12]]},"reference":[{"key":"BFnrd2016154_CR1","doi-asserted-by":"publisher","first-page":"e1002165","DOI":"10.1371\/journal.pbio.1002165","volume":"13","author":"LP Freedman","year":"2015","unstructured":"Freedman, L. P., Cockburn, I. M. & Simcoe, T. S. The economics of reproducibility in preclinical research. PLoS Biol. 13, e1002165 (2015).","journal-title":"PLoS Biol."},{"key":"BFnrd2016154_CR2","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1517\/17460441.2014.905539","volume":"9","author":"M Allarakhia","year":"2014","unstructured":"Allarakhia, M. The successes and challenges of open-source biopharmaceutical innovation. Expert Opin. Drug Discov. 9, 459\u2013465 (2014).","journal-title":"Expert Opin. Drug Discov."},{"key":"BFnrd2016154_CR3","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1038\/nature09107","volume":"465","author":"FJ Gamo","year":"2010","unstructured":"Gamo, F. J. et al. Thousands of chemical starting points for antimalarial lead identification. Nature 465, 305\u2013310 (2010).","journal-title":"Nature"},{"key":"BFnrd2016154_CR4","doi-asserted-by":"publisher","unstructured":"Van Voorhis, W. C. et al. Open source drug discovery with the Malaria Box compound collection for neglected diseases and beyond. PLoS Pathogens \n                    http:\/\/dx.doi.org\/10.1371\/journal.ppat.1005763\n                    \n                   (2016).","DOI":"10.1371\/journal.ppat.1005763"},{"key":"BFnrd2016154_CR5","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/488148a","volume":"488","author":"A Maxmen","year":"2012","unstructured":"Maxmen, A. Cancer research: open ambition. Nature 488, 148\u2013150 (2012).","journal-title":"Nature"}],"container-title":["Nature Reviews Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrd.2016.154.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrd.2016.154","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrd.2016.154.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T23:35:07Z","timestamp":1684452907000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrd.2016.154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,12]]},"references-count":5,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["BFnrd2016154"],"URL":"https:\/\/doi.org\/10.1038\/nrd.2016.154","relation":{},"ISSN":["1474-1776","1474-1784"],"issn-type":[{"value":"1474-1776","type":"print"},{"value":"1474-1784","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,12]]},"assertion":[{"value":"12 August 2016","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2016","order":2,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":3,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"In the Acknowledgements, ESAC was incorrectly defined as European Surveillance of Antimicrobial Consumption. This has now been changed to Expert Scientific Advisory Committee.","order":4,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}