{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:31:03Z","timestamp":1791851463348,"version":"4.3.4"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Gastroenterol Hepatol"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1038\/nrgastro.2009.198","type":"journal-article","created":{"date-parts":[[2009,11,30]],"date-time":"2009-11-30T08:46:25Z","timestamp":1259570785000},"page":"692-694","source":"Crossref","is-referenced-by-count":16,"title":["Carvedilol\u2014the best \u03b2-blocker for primary prophylaxis?"],"prefix":"10.1038","volume":"6","author":[{"given":"Emmanuel A.","family":"Tsochatzis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos K.","family":"Triantos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew K.","family":"Burroughs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFnrgastro2009198_CR1","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1136\/gut.49.5.682","volume":"49","author":"PA McCormick","year":"2001","unstructured":"McCormick, P. A. & O'Keefe, C. Improving prognosis following a first variceal haemorrhage over four decades. Gut 49, 682\u2013685 (2001).","journal-title":"Gut"},{"key":"BFnrgastro2009198_CR2","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1053\/j.gastro.2006.09.013","volume":"131","author":"G D'Amico","year":"2006","unstructured":"D'Amico, G., Garcia-Pagan, J. C., Luca, A. & Bosch, J. Hepatic vein pressure gradient reduction and prevention of variceal bleeding in cirrhosis: a systematic review. Gastroenterology 131, 1611\u20131624 (2006).","journal-title":"Gastroenterology"},{"key":"BFnrgastro2009198_CR3","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1002\/hep.23045","volume":"50","author":"D Tripathi","year":"2009","unstructured":"Tripathi, D.  et al. Randomized controlled trial of carvedilol versus variceal band ligation for the prevention of the first variceal bleed. Hepatology 50, 825\u2013833 (2009).","journal-title":"Hepatology"},{"key":"BFnrgastro2009198_CR4","doi-asserted-by":"publisher","first-page":"2842","DOI":"10.1111\/j.1572-0241.2007.01564.x","volume":"102","author":"LL Gluud","year":"2007","unstructured":"Gluud, L. L., Klingenberg, S., Nikolova, D. & Gluud, C. Banding ligation versus beta-blockers as primary prophylaxis in esophageal varices: systematic review of randomized trials. Am. J. Gastroenterol. 102, 2842\u20132848 (2007).","journal-title":"Am. J. Gastroenterol."},{"key":"BFnrgastro2009198_CR5","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1002\/hep.1840360612","volume":"36","author":"R Banares","year":"2002","unstructured":"Banares, R.  et al. Randomized comparison of long-term carvedilol and propranolol administration in the treatment of portal hypertension in cirrhosis. Hepatology 36, 1367\u20131373 (2002).","journal-title":"Hepatology"},{"key":"BFnrgastro2009198_CR6","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1080\/00365520600780403","volume":"41","author":"R Bruha","year":"2006","unstructured":"Bruha, R.  et al. Effect of carvedilol on portal hypertension depends on the degree of endothelial activation and inflammatory changes. Scand. J. Gastroenterol. 41, 1454\u20131463 (2006).","journal-title":"Scand. J. Gastroenterol."},{"key":"BFnrgastro2009198_CR7","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/S0168-8278(99)80108-1","volume":"30","author":"AJ Stanley","year":"1999","unstructured":"Stanley, A. J., Therapondos, G., Helmy, A. & Hayes, P. C. Acute and chronic haemodynamic and renal effects of carvedilol in patients with cirrhosis. J. Hepatol. 30, 479\u2013484 (1999).","journal-title":"J. Hepatol."},{"key":"BFnrgastro2009198_CR8","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1046\/j.1365-2036.2002.01190.x","volume":"16","author":"D Tripathi","year":"2002","unstructured":"Tripathi, D., Therapondos, G., Lui, H. F., Stanley, A. J. & Hayes, P. C. Haemodynamic effects of acute and chronic administration of low-dose carvedilol, a vasodilating beta-blocker, in patients with cirrhosis and portal hypertension. Aliment. Pharmacol. Ther. 16, 373\u2013380 (2002).","journal-title":"Aliment. Pharmacol. Ther."},{"key":"BFnrgastro2009198_CR9","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1111\/j.1478-3231.2009.02038.x","volume":"29","author":"M Senzolo","year":"2009","unstructured":"Senzolo, M.  et al. Beta-blockers protect against spontaneous bacterial peritonitis in cirrhotic patients: a meta-analysis. Liver Int. 29, 1189\u20131193 (2009).","journal-title":"Liver Int."}],"container-title":["Nature Reviews Gastroenterology & Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrgastro.2009.198","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrgastro.2009.198.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrgastro.2009.198.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T03:39:19Z","timestamp":1684467559000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrgastro.2009.198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":9,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["BFnrgastro2009198"],"URL":"https:\/\/doi.org\/10.1038\/nrgastro.2009.198","relation":{},"ISSN":["1759-5045","1759-5053"],"issn-type":[{"value":"1759-5045","type":"print"},{"value":"1759-5053","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}