{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:13:26Z","timestamp":1791252806875,"version":"4.1.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Gastroenterol Hepatol"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1038\/nrgastro.2009.202","type":"journal-article","created":{"date-parts":[[2010,1,6]],"date-time":"2010-01-06T07:58:04Z","timestamp":1262764684000},"page":"41-49","source":"Crossref","is-referenced-by-count":52,"title":["Treatment of hepatocellular carcinoma with intra-arterial injection of radionuclides"],"prefix":"10.1038","volume":"7","author":[{"given":"Jean-Luc","family":"Raoul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline","family":"Boucher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Rolland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Garin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFnrgastro2009202_CR1","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.1053\/j.gastro.2004.09.011","volume":"127","author":"FX Bosch","year":"2004","unstructured":"Bosch, F. X., Ribes, J., Diaz, M. & Cleries, R. Primary liver cancer: worldwide incidence and trends. Gastroenterology 127, S5\u2013S16 (2004).","journal-title":"Gastroenterology"},{"key":"BFnrgastro2009202_CR2","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1200\/JCO.2008.20.7753","volume":"27","author":"SF Altekruse","year":"2009","unstructured":"Altekruse, S. F., McGlynn, K. A. & Reichman, M. E. Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. J. Clin. Oncol. 27, 1485\u20131491 (2009).","journal-title":"J. Clin. Oncol."},{"key":"BFnrgastro2009202_CR3","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1016\/S0168-8278(98)80262-6","volume":"29","author":"AM Benhamiche","year":"1998","unstructured":"Benhamiche, A. M. et al. Time trends and age-period-cohort effects on the incidence of primary liver cancer in a well-defined French population: 1976\u20131995. J. Hepatol. 29, 802\u2013806 (1998).","journal-title":"J. Hepatol."},{"key":"BFnrgastro2009202_CR4","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1002\/hep.22312","volume":"48","author":"C Bosetti","year":"2008","unstructured":"Bosetti, C., Levi, F., Boffetta, P., Lucchini, F., Negri, E. & La Vecchia, C. Trends in mortality from hepatocellular carcinoma in Europe, 1980\u20132004. Hepatology 48, 137\u2013145 (2008).","journal-title":"Hepatology"},{"key":"BFnrgastro2009202_CR5","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1093\/annonc\/mdn030","volume":"19","author":"S Collette","year":"2008","unstructured":"Collette, S. et al. Prognosis of advanced hepatocellular carcinoma: comparison of three staging systems in two French clinical trials. Ann. Oncol. 19, 1117\u20131126 (2008).","journal-title":"Ann. Oncol."},{"key":"BFnrgastro2009202_CR6","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1016\/S0140-6736(03)14964-1","volume":"362","author":"JM Llovet","year":"2003","unstructured":"Llovet, J. M., Burroughs, A. & Bruix, J. Hepatocellular carcinoma. Lancet 362, 1907\u20131917 (2003).","journal-title":"Lancet"},{"key":"BFnrgastro2009202_CR7","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/B978-0-12-035414-6.50013-4","volume":"14","author":"RL Jirtle","year":"1990","unstructured":"Jirtle, R. L., Anscher, M. S. & Alati, T. Radiation sensitivity of the liver. Adv. Radiat. Biol. 14, 269\u2013311 (1990).","journal-title":"Adv. Radiat. Biol."},{"key":"BFnrgastro2009202_CR8","doi-asserted-by":"publisher","first-page":"2210","DOI":"10.1200\/JCO.2000.18.11.2210","volume":"18","author":"LA Dawson","year":"2000","unstructured":"Dawson, L. A. et al. Escalated focal liver radiation and concurrent hepatic artery fluorodeoxyuridine for unresectable intrahepatic malignancies. J. Clin. Oncol. 18, 2210\u20132218 (2000).","journal-title":"J. Clin. Oncol."},{"key":"BFnrgastro2009202_CR9","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1093\/jnci\/djn134","volume":"100","author":"JM Llovet","year":"2008","unstructured":"Llovet, J. M. et al. Design and endpoints of clinical trials in hepatocellular carcinoma. J. Natl Cancer Inst. 100, 698\u2013711 (2008).","journal-title":"J. Natl Cancer Inst."},{"key":"BFnrgastro2009202_CR10","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1053\/jhep.2003.50047","volume":"37","author":"JM Llovet","year":"2003","unstructured":"Llovet, J. M. & Bruix, J. Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival. Hepatology 37, 429\u2013442 (2003).","journal-title":"Hepatology"},{"key":"BFnrgastro2009202_CR11","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1016\/S0140-6736(02)08649-X","volume":"359","author":"JM Llovet","year":"2002","unstructured":"Llovet, J. M. et al. Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial. Lancet 359, 1734\u20131739 (2002).","journal-title":"Lancet"},{"key":"BFnrgastro2009202_CR12","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1586\/14737140.8.10.1643","volume":"8","author":"K Malagari","year":"2008","unstructured":"Malagari, K. Drug-eluting particles in the treatment of HCC: chemoembolization with doxorubicin-loaded DC beads. Expert Rev. Anticancer Ther. 8, 1643\u20131650 (2008).","journal-title":"Expert Rev. Anticancer Ther."},{"key":"BFnrgastro2009202_CR13","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1586\/17474124.2.4.453","volume":"2","author":"CF Gonsalves","year":"2008","unstructured":"Gonsalves, C. F., Brown, D. B. & Barr, B. I. Regional radioactive treatments for hepatocellular carcinoma. Expert Rev. Gastroenterol. Hepatol. 2, 453\u2013456 (2008).","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"BFnrgastro2009202_CR14","first-page":"160","volume":"46","author":"B Lambert","year":"2005","unstructured":"Lambert, B. et al. 188Re-HDD\/lipiodol therapy for hepatocellular carcinoma: a phase I clinical trial. J. Nucl. Med. 46, 160\u2013166 (2005).","journal-title":"J. Nucl. Med."},{"key":"BFnrgastro2009202_CR15","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1097\/00006231-200410000-00004","volume":"25","author":"E Garin","year":"2005","unstructured":"Garin, E. et al. 188 Re8SSS lipiodol: radiolabelling and biodistribution following injection into the hepatic artery of rats bearing hepatoma. Nucl. Med. Comm. 25, 1007\u20131013 (2005).","journal-title":"Nucl. Med. Comm."},{"key":"BFnrgastro2009202_CR16","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1016\/j.jvir.2007.07.031","volume":"18","author":"R Salem","year":"2007","unstructured":"Salem, R. Radioembolization with 90Y microspheres: a state-of-the-art brachytherapy treatment for primary and secondary liver malignancies. Part 1: technical and methodologic considerations. J. Vasc. Interv. Radiol. 18, 1460\u20131461 (2007).","journal-title":"J. Vasc. Interv. Radiol."},{"key":"BFnrgastro2009202_CR17","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1148\/radiology.168.2.2839866","volume":"168","author":"JL Raoul","year":"1988","unstructured":"Raoul, J. L. et al. Hepatic artery injection of I131 labelled lipiodol. I. Biodistribution study results in patients with hepatocellular carcinoma. Radiology 168, 541\u2013545 (1988).","journal-title":"Radiology"},{"key":"BFnrgastro2009202_CR18","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1007\/s00259-005-1859-z","volume":"32","author":"B Lambert","year":"2005","unstructured":"Lambert, B. & Van de Wiele, C. Treatment of hepatocellular carcinoma by means of radiopharmaceuticals. Eur. J. Nucl. Med. Mol. Imaging 32, 980\u2013989 (2005).","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"BFnrgastro2009202_CR19","first-page":"1038","volume":"29","author":"MT Madsen","year":"1988","unstructured":"Madsen, M. T., Park, C. H. & Thakur, M. L. Dosimetry of iodine-131 ethiodol in the treatment of hepatoma. J. Nucl. Med. 29, 1038\u20131044 (1988).","journal-title":"J. Nucl. Med."},{"key":"BFnrgastro2009202_CR20","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1097\/MNM.0b013e32830439c6","volume":"29","author":"S Becker","year":"2008","unstructured":"Becker, S. et al. Dosimetric evaluation and therapeutic response to internal radiation therapy of hepatocellular carcinomas using iodine-131-labelled lipiodol. Nucl. Med. Commun. 29, 815\u2013825 (2008).","journal-title":"Nucl. Med. Commun."},{"key":"BFnrgastro2009202_CR21","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1148\/radiology.168.2.2839867","volume":"168","author":"JF Bretagne","year":"1988","unstructured":"Bretagne, J. F. et al. Hepatic artery injection of I131 labelled lipiodol. II. Preliminary results of therapeutic use in patients with hepatocellular carcinoma and liver metastases. Radiology 168, 547\u2013550 (1988).","journal-title":"Radiology"},{"key":"BFnrgastro2009202_CR22","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1002\/1097-0142(19920115)69:2<346::AID-CNCR2820690212>3.0.CO;2-E","volume":"69","author":"JL Raoul","year":"1992","unstructured":"Raoul, J. L. et al. Internal radiation therapy of hepatocellular carcinoma. Results of a French multicenter phase II trial of transarterial injection of I131 labeled Lipiodol. Cancer 69, 346\u2013352 (1992).","journal-title":"Cancer"},{"key":"BFnrgastro2009202_CR23","first-page":"1782","volume":"35","author":"JL Raoul","year":"1994","unstructured":"Raoul, J. L. et al. Randomized controlled trial for hepatocellular carcinoma with portal vein thrombosis: intra-arterial iodine-131-iodized oil versus medical support. J. Nucl. Med. 35, 1782\u20131787 (1994).","journal-title":"J. Nucl. Med."},{"key":"BFnrgastro2009202_CR24","doi-asserted-by":"publisher","first-page":"217","DOI":"10.3109\/00365529309096075","volume":"28","author":"JL Raoul","year":"1993","unstructured":"Raoul, J. L. et al. Usefulness of hepatic artery injection of I131 Lipiodol in the therapeutic decision in hepatocellular carcinoma. Scand. J. Gastroenterol. 28, 217\u2013223 (1993).","journal-title":"Scand. J. Gastroenterol."},{"key":"BFnrgastro2009202_CR25","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1148\/radiology.212.3.r99se03665","volume":"212","author":"T De Baere","year":"1999","unstructured":"De Baere, T. et al. Hepatic intraarterial 131I iodized oil for the treatment of hepatocellular carcinoma in patients with impeded portal venous flow. Radiology 212, 665\u2013668 (1999).","journal-title":"Radiology"},{"key":"BFnrgastro2009202_CR26","first-page":"1156","volume":"26","author":"JL Raoul","year":"1997","unstructured":"Raoul, J. L. et al. Prospective randomized trial of chemoembolization versus intra-arterial injection of 131-I-labeled-iodized oil in the treatment of hepatocellular carcinoma. Hepatology 26, 1156\u20131161 (1997).","journal-title":"Hepatology"},{"key":"BFnrgastro2009202_CR27","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/S0140-6736(98)06475-7","volume":"353","author":"WY Lau","year":"1999","unstructured":"Lau, W. Y. et al. Adjuvant intra-arterial lipiodol-iodine-131 for resectable hepatocellular carcinoma: a prospective randomised trial. Lancet 353, 797\u2013801 (1999).","journal-title":"Lancet"},{"key":"BFnrgastro2009202_CR28","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1097\/SLA.0b013e3181571047","volume":"247","author":"WY Lau","year":"2008","unstructured":"Lau, W. Y., Lai, E. C., Leung, T. W. & Yu, S. C. Adjuvant intra-arterial iodine-131-labeled lipiodol for resectable hepatocellular carcinoma: a prospective randomized trial-update on 5-year and 10-year survival. Ann. Surg. 247, 43\u201348 (2008).","journal-title":"Ann. Surg."},{"key":"BFnrgastro2009202_CR29","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1053\/jhep.2003.50473","volume":"38","author":"E Boucher","year":"2003","unstructured":"Boucher, E. et al. Adjuvant intra-arterial injection of iodine-131-labeled lipiodol after resection of hepatocellular carcinoma. Hepatology 38, 1237\u20131241 (2003).","journal-title":"Hepatology"},{"key":"BFnrgastro2009202_CR30","doi-asserted-by":"publisher","first-page":"362","DOI":"10.2967\/jnumed.107.044750","volume":"49","author":"E Boucher","year":"2008","unstructured":"Boucher, E., Bouguen, G., Garin, E., Guillygomac'h, A., Boudjema, K. & Raoul, J. L. Adjuvant intra-arterial injection of iodine 131-labeled lipiodol after resection of hepatocellular carcinoma: progress report of a case-control study with a 5 year minimal follow-up. J. Nucl. Med. 49, 362\u2013366 (2008).","journal-title":"J. Nucl. Med."},{"key":"BFnrgastro2009202_CR31","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1002\/hep.20692","volume":"41","author":"M Tabone","year":"2005","unstructured":"Tabone, M., Vigano, L., Laudi, C., Ferrero, A., Pellerito, R. & Capussotti, L. Adjuvant iodine-131-labeled lipiodol for prevention of intrahepatic recurrence of hepatocellular carcinoma: which is the best treatment schedule? Hepatology 41, 1433\u20131434 (2005).","journal-title":"Hepatology"},{"key":"BFnrgastro2009202_CR32","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1080\/13651820802074449","volume":"10","author":"KM Ng","year":"2008","unstructured":"Ng, K. M. et al. Adjuvant lipiodol I-131 after curative resection\/ablation of hepatocellular carcinoma. HPB (Oxford) 10, 388\u2013395 (2008).","journal-title":"(Oxford)"},{"key":"BFnrgastro2009202_CR33","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.jamcollsurg.2005.06.265","volume":"201","author":"E Dupont-Bierre","year":"2005","unstructured":"Dupont-Bierre, E. et al. Resection of hepatocellular carcinoma in noncirrhotic liver: analysis of risk factors for survival. J. Am. Coll. Surg. 201, 663\u2013670 (2005).","journal-title":"J. Am. Coll. Surg."},{"key":"BFnrgastro2009202_CR34","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1002\/bjs.4271","volume":"90","author":"JL Raoul","year":"2003","unstructured":"Raoul, J. L., Messner, M., Boucher, E., Bretagne, J. F., Campion, J. P. & Boudjema, K. Preoperative treatment of hepatocellular carcinoma with intra-arterial injection of 131I-labelled lipiodol. Br. J. Surg. 90, 1379\u20131383 (2003).","journal-title":"Br. J. Surg."},{"key":"BFnrgastro2009202_CR35","first-page":"76","volume":"82","author":"E Boucher","year":"2007","unstructured":"Boucher, E., Garin, E., Guillygomac'h, A., Olivie, D., Boudjema, K. & Raoul, J. L. Intraarterial injection of iodine-131-labeled lipiodol for treatment of hepatocellular carcinoma. Radiother. Oncol. 82, 76\u201382 (2007).","journal-title":"Oncol."},{"key":"BFnrgastro2009202_CR36","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1097\/00004424-199410000-00004","volume":"29","author":"K Kishi","year":"1994","unstructured":"Kishi, K. et al. Acute toxicity of lipiodol infusion into the hepatic arteries of dogs. Invest. Radiol. 29, 882\u2013889 (1994).","journal-title":"Invest. Radiol."},{"key":"BFnrgastro2009202_CR37","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s00270-006-0062-3","volume":"30","author":"L Marelli","year":"2007","unstructured":"Marelli, L. et al. Transarterial therapy for hepatocellular carcinoma: which technique is more effective? A systematic review of cohort and randomized studies. Cardiovasc. Intervent. Radiol. 30, 6\u201325 (2007).","journal-title":"Cardiovasc. Intervent. Radiol."},{"key":"BFnrgastro2009202_CR38","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1097\/00006231-200306000-00009","volume":"24","author":"E Garin","year":"2003","unstructured":"Garin, E. et al. Safe radiation exposure of medical personnel by using simple methods of radioprotection while administering 131I-lipiodol therapy for hepatocellular carcinoma. Nucl. Med. Comm. 24, 671\u2013678 (2003).","journal-title":"Nucl. Med. Comm."},{"key":"BFnrgastro2009202_CR39","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1016\/j.ijrobp.2007.05.009","volume":"69","author":"P Bernal","year":"2007","unstructured":"Bernal, P. et al. Intra-arterial rhenium-188 lipiodol in the treatment of inoperable hepatocellular carcinoma: results of an IAEA-sponsored multination study. Int. J. Radiat. Oncol. Biol. Phys. 69, 1448\u20131455 (2007).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrgastro2009202_CR40","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1148\/radiol.2432051246","volume":"243","author":"A Kumar","year":"2007","unstructured":"Kumar, A. et al. Inoperable hepatocellular carcinoma: transarterial 188Re-HDD-labeled iodized oil for treatment; prospective multicenter clinical trial. Radiology 243, 509\u2013519 (2007).","journal-title":"Radiology"},{"key":"BFnrgastro2009202_CR41","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.5858\/132.11.1734","volume":"132","author":"F Ogawa","year":"2008","unstructured":"Ogawa, F. et al. Gastroduodenitis associated with Yttrium90-microsphere selective internal radiation. An iatrogenic complication in need of recognition. Arch. Pathol. Lab. Med. 132, 1734\u20131738 (2008).","journal-title":"Arch. Pathol. Lab. Med."},{"key":"BFnrgastro2009202_CR42","doi-asserted-by":"publisher","first-page":"2250","DOI":"10.1002\/1097-0142(19921101)70:9<2250::AID-CNCR2820700906>3.0.CO;2-4","volume":"70","author":"FA Shepherd","year":"1992","unstructured":"Shepherd, F. A. et al. A phase I dose escalation trial of yttrium-90 microspheres in the treatment of primary hepatocellular carcinoma. Cancer 70, 2250\u20132254 (1992).","journal-title":"Cancer"},{"key":"BFnrgastro2009202_CR43","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1097\/01.RVI.0000184594.01661.81","volume":"16","author":"R Salem","year":"2005","unstructured":"Salem, R. et al. Treatment of unresectable hepatocellular carcinoma with use of 90Y microspheres (TheraSpheres): safety, tumor response, and survival. J. Vasc. Interv. Radiol. 16, 1627\u20131639 (2005).","journal-title":"J. Vasc. Interv. Radiol."},{"key":"BFnrgastro2009202_CR44","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1002\/hep.21980","volume":"47","author":"LM Kulik","year":"2008","unstructured":"Kulik, L. M. et al. Safety and efficacy of 90Y radiotherapy for hepatocellular carcinoma with and without portal vein thrombosis. Hepatology 47, 71\u201381 (2008).","journal-title":"Hepatology"},{"key":"BFnrgastro2009202_CR45","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/hep.22152","volume":"47","author":"A Forner","year":"2008","unstructured":"Forner, A. & Bruix, J. Locoregional treatment for hepatocellular carcinoma: from clinical explorations to robust clinical data, changing standards of care. Hepatology 47, 5\u20137 (2008).","journal-title":"Hepatology"},{"key":"BFnrgastro2009202_CR46","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1002\/jso.20609","volume":"94","author":"LM Kulik","year":"2006","unstructured":"Kulik, L. M. et al. Yttrium-90 microspheres (TheraSphere\u00ae) treatment of unresectable hepatocellular carcinoma: downstaging to resection, RFA and bridge to transplantation. J. Surg. Oncol. 94, 572\u2013586 (2006).","journal-title":"J. Surg. Oncol."},{"key":"BFnrgastro2009202_CR47","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1002\/hep.22747","volume":"49","author":"A Riaz","year":"2009","unstructured":"Riaz, A. et al. Radiologic-pathologic correlation of hepatocellular carcinoma treated with internal radiation using yttrium-90 microspheres. Hepatology 49, 1185\u20131193 (2009).","journal-title":"Hepatology"},{"key":"BFnrgastro2009202_CR48","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1111\/j.1600-6143.2009.02695.x","volume":"9","author":"RJ Lewandowski","year":"2009","unstructured":"Lewandowski, R. J. et al. A comparative analysis of transarterial downstaging for hepatocellular carcinoma: chemoembolization versus radioembolization. Am. J. Transplant. 9, 1920\u20131928 (2009).","journal-title":"Am. J. Transplant."},{"key":"BFnrgastro2009202_CR49","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1016\/j.ijrobp.2004.09.004","volume":"60","author":"AS Kennedy","year":"2004","unstructured":"Kennedy, A. S. et al. Pathologic response and microdosimetry of 90Y microspheres in man: review of four explanted whole livers. Int. J. Radiat. Oncol. Biol. Phys. 60, 1552\u20131563 (2004).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrgastro2009202_CR50","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1002\/jso.20141","volume":"88","author":"G Van Hazel","year":"2004","unstructured":"Van Hazel, G. et al. Randomized phase 2 trial of SIR-Spheres plus fluorouracil\/leucovorin chemotherapy versus fluorouracil\/leucovorin chemotherapy alone in advanced colorectal cancer. J. Surg. Oncol. 88, 78\u201385 (2004).","journal-title":"J. Surg. Oncol."},{"key":"BFnrgastro2009202_CR51","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1023\/A:1013569329846","volume":"12","author":"B Gray","year":"2001","unstructured":"Gray, B. et al. Randomised trial of SIR-Spheres plus chemotherapy vs. chemotherapy alone for treating patients with liver metastases from primary large bowel cancer. Ann. Oncol. 12, 1711\u20131720 (2001).","journal-title":"Ann. Oncol."},{"key":"BFnrgastro2009202_CR52","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1200\/JCO.2006.08.7916","volume":"25","author":"RA Sharma","year":"2007","unstructured":"Sharma, R. A. et al. Radioembolization of liver metastases from colorectal cancer using yttrium-90 microspheres with concomitant systemic oxaliplatin, fluorouracil, and leucovorin chemotherapy. J. Clin. Oncol. 25, 1099\u20131106 (2007).","journal-title":"J. Clin. Oncol."},{"key":"BFnrgastro2009202_CR53","first-page":"317","volume":"53","author":"C Van de Wiele","year":"2009","unstructured":"Van de Wiele, C. et al. Yttrium-90 labelled resin microspheres for treatment of primary and secondary malignant liver tumors. Q. J. Nucl. Med. Mol. Imaging 53, 317\u2013324 (2009).","journal-title":"Q. J. Nucl. Med. Mol. Imaging"},{"key":"BFnrgastro2009202_CR54","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/S0360-3016(97)00818-3","volume":"40","author":"WY Lau","year":"1998","unstructured":"Lau, W. Y. et al. Selective internal radiation therapy for nonresectable hepatocellular carcinoma with intraarterial infusion of 90Yttrium microspheres. Int. J. Radiat. Oncol. Biol. Phys. 40, 583\u2013592 (1998).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrgastro2009202_CR55","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1097\/01.sla.0000133123.11932.19","volume":"240","author":"WY Lau","year":"2004","unstructured":"Lau, W. Y. et al. Salvage surgery following downstaging of unresectable hepatocellular carcinoma. Ann. Surg. 240, 299\u2013305 (2004).","journal-title":"Ann. Surg."},{"key":"BFnrgastro2009202_CR56","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.ijrobp.2006.05.065","volume":"66","author":"B Sangro","year":"2006","unstructured":"Sangro, B. et al. Radioembolization using 90Y-resin microspheres for patients with advanced hepatocellular carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 66, 792\u2013800 (2006).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrgastro2009202_CR57","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1016\/j.ijrobp.2008.10.005","volume":"74","author":"AS Kennedy","year":"2009","unstructured":"Kennedy, A. S. et al. Treatment parameters and outcome of 680 treatments of internal radiation with resin (90)Y-microspheres for unresectable hepatic tumors. Int. J. Radiat. Oncol. Biol. Phys. 74, 1494\u20131500 (2009).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrgastro2009202_CR58","first-page":"900","volume":"39","author":"N Chenoufi","year":"1998","unstructured":"Chenoufi, N. et al. In vitro demonstration of synergy between radionuclide and chemotherapy. J. Nucl. Med. 39, 900\u2013903 (1998).","journal-title":"J. Nucl. Med."},{"key":"BFnrgastro2009202_CR59","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.ijrobp.2005.09.007","volume":"64","author":"JL Raoul","year":"2006","unstructured":"Raoul, J. L. et al. Association of cisplatin and intra-arterial injection of 131I-lipiodol in treatment of hepatocellular carcinoma: results of phase II trial. Int. J. Radiat. Oncol. Biol. Phys. 64, 745\u2013750 (2006).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"BFnrgastro2009202_CR60","doi-asserted-by":"publisher","first-page":"4089","DOI":"10.1200\/JCO.2008.20.8116","volume":"27","author":"G Van Hazel","year":"2009","unstructured":"Van Hazel, G. et al. Treatment of fluorouracil-refractory patients with liver metastases from colorectal cancer by using Yttrium-90 resin microspheres plus concomitant systemic irinotecan chemotherapy. J. Clin. Oncol. 27, 4089\u20134095 (2009).","journal-title":"J. Clin. Oncol."},{"key":"BFnrgastro2009202_CR61","first-page":"378","volume":"359","author":"JM Llovet","year":"2008","unstructured":"Llovet, J. M. et al. Sorafenib in advanced hepatocellular carcinoma. N. Engl. J. Med. 359, 378\u2013390 (2008).","journal-title":"Med."},{"key":"BFnrgastro2009202_CR62","doi-asserted-by":"publisher","first-page":"340","DOI":"10.2967\/jnumed.107.047639","volume":"49","author":"C Divgi","year":"2008","unstructured":"Divgi, C. The promise of locoregional radiopharmaceutical therapy: will it ever be realized? J. Nucl. Med. 49, 340 (2008).","journal-title":"J. Nucl. Med."}],"container-title":["Nature Reviews Gastroenterology &amp; Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrgastro.2009.202","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrgastro.2009.202.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrgastro.2009.202.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T03:39:21Z","timestamp":1684467561000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrgastro.2009.202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":62,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["BFnrgastro2009202"],"URL":"https:\/\/doi.org\/10.1038\/nrgastro.2009.202","relation":{},"ISSN":["1759-5045","1759-5053"],"issn-type":[{"value":"1759-5045","type":"print"},{"value":"1759-5053","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}