{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T21:36:22Z","timestamp":1776893782120,"version":"3.51.2"},"reference-count":111,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,1,24]],"date-time":"2012-01-24T00:00:00Z","timestamp":1327363200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Gastroenterol Hepatol"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1038\/nrgastro.2011.274","type":"journal-article","created":{"date-parts":[[2012,1,24]],"date-time":"2012-01-24T07:29:56Z","timestamp":1327390196000},"page":"140-151","source":"Crossref","is-referenced-by-count":94,"title":["Unraveling the mystery of pain in chronic pancreatitis"],"prefix":"10.1038","volume":"9","author":[{"given":"Pankaj Jay","family":"Pasricha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,1,24]]},"reference":[{"key":"BFnrgastro2011274_CR1","unstructured":"American Gastroenterological Association. The Burden of Gastrointestinal Diseases. AGA Publications. http:\/\/www.lewin.com\/content\/publications\/2695.pdf (2001)."},{"key":"BFnrgastro2011274_CR2","volume-title":"The Burden of Digestive Diseases in the United States","author":"JE Everhart","year":"2008","unstructured":"Everhart, J. E. The Burden of Digestive Diseases in the United States. (US Department of Health and Human Services, NIH Publication No. 09\u20136443) (US Government Printing Office, Washington D.C. 2008)."},{"key":"BFnrgastro2011274_CR3","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1136\/gut.2010.213835","volume":"60","author":"DK Mullady","year":"2011","unstructured":"Mullady, D. K. et al. Type of pain, pain-associated complications, quality of life, disability and resource utilisation in chronic pancreatitis: a prospective cohort study. Gut 60, 77\u201384 (2011).","journal-title":"Gut"},{"issue":"Suppl. 1","key":"BFnrgastro2011274_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/gut.2006.117598","volume":"56","author":"JG Williams","year":"2007","unstructured":"Williams, J. G. et al. Gastroenterology services in the UK. The burden of disease, and the organisation and delivery of services for gastrointestinal and liver disorders: a review of the evidence. Gut 56 (Suppl. 1), 1\u2013113 (2007).","journal-title":"Gut"},{"issue":"Suppl. 2","key":"BFnrgastro2011274_CR5","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/j.1440-1746.2010.06599.x","volume":"26","author":"R Rerknimitr","year":"2011","unstructured":"Rerknimitr, R. Asian chronic pancreatitis: the common and the unique. J. Gastroenterol. Hepatol. 26 (Suppl. 2), 6\u201311 (2011).","journal-title":"J. Gastroenterol. Hepatol."},{"key":"BFnrgastro2011274_CR6","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/S0016-5085(24)05129-1","volume":"86","author":"RW Ammann","year":"1984","unstructured":"Ammann, R. W., Akovbiantz, A., Largiader, F. & Schueler, G. Course and outcome of chronic pancreatitis. Longitudinal study of a mixed medical-surgical series of 245 patients. Gastroenterology 86, 820\u2013828 (1984).","journal-title":"Gastroenterology"},{"key":"BFnrgastro2011274_CR7","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1097\/00004836-200302000-00014","volume":"36","author":"PJ Thuluvath","year":"2003","unstructured":"Thuluvath, P. J., Imperio, D., Nair, S. & Cameron, J. L. Chronic pancreatitis. Long-term pain relief with or without surgery, cancer risk, and mortality. J. Clin. Gastroenterol. 36, 159\u2013165 (2003).","journal-title":"J. Clin. Gastroenterol."},{"key":"BFnrgastro2011274_CR8","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.bpg.2010.03.005","volume":"24","author":"J Jupp","year":"2010","unstructured":"Jupp, J., Fine, D. & Johnson, C. D. The epidemiology and socioeconomic impact of chronic pancreatitis. Best Pract. Res. Clin. Gastroenterol. 24, 219\u2013231 (2010).","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"BFnrgastro2011274_CR9","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1016\/S0016-5085(99)70031-4","volume":"116","author":"EP DiMagno","year":"1999","unstructured":"DiMagno, E. P. Toward understanding (and management) of painful chronic pancreatitis. Gastroenterology 116, 1252\u20131257 (1999).","journal-title":"Gastroenterology"},{"key":"BFnrgastro2011274_CR10","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/S0016-5085(98)70157-X","volume":"115","author":"AL Warshaw","year":"1998","unstructured":"Warshaw, A. L., Banks, P. A. & Fernandez-Del Castillo, C. AGA technical review: treatment of pain in chronic pancreatitis. Gastroenterology 115, 765\u2013776 (1998).","journal-title":"Gastroenterology"},{"key":"BFnrgastro2011274_CR11","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1053\/j.gastro.2008.02.056","volume":"134","author":"T Strate","year":"2008","unstructured":"Strate, T. et al. Resection vs drainage in treatment of chronic pancreatitis: long-term results of a randomized trial. Gastroenterology 134, 1406\u20131411 (2008).","journal-title":"Gastroenterology"},{"key":"BFnrgastro2011274_CR12","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1055\/s-2003-40237","volume":"35","author":"P Dite","year":"2003","unstructured":"Dite, P., Ruzicka, M., Zboril, V. & Novotny, I. A prospective, randomized trial comparing endoscopic and surgical therapy for chronic pancreatitis. Endoscopy 35, 553\u2013558 (2003).","journal-title":"Endoscopy"},{"key":"BFnrgastro2011274_CR13","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1097\/MPA.0b013e3181bab623","volume":"39","author":"B Mullhaupt","year":"2010","unstructured":"Mullhaupt, B. & Ammann, R. W. Total pancreatectomy for intractable pain in chronic pancreatitis? Pancreas 39, 111\u2013112 (2010).","journal-title":"Pancreas"},{"key":"BFnrgastro2011274_CR14","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1097\/00006676-198611000-00015","volume":"1","author":"N Ebbehoj","year":"1986","unstructured":"Ebbehoj, N., Borly, L., Madsen, P. & Svendsen, L. B. Pancreatic tissue pressure and pain in chronic pancreatitis. Pancreas 1, 556\u2013558 (1986).","journal-title":"Pancreas"},{"key":"BFnrgastro2011274_CR15","doi-asserted-by":"publisher","first-page":"337","DOI":"10.3109\/00365528709078601","volume":"22","author":"N Ebbehoj","year":"1987","unstructured":"Ebbehoj, N., Christensen, E. & Madsen, P. Prediction of outcome of pancreaticogastrostomy for pain in chronic pancreatitis. Scand. J. Gastroenterol. 22, 337\u2013342 (1987).","journal-title":"Scand. J. Gastroenterol."},{"key":"BFnrgastro2011274_CR16","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/0002-9610(89)90560-6","volume":"157","author":"N Ebbehoj","year":"1989","unstructured":"Ebbehoj, N., Klaaborg, K. E., Kronborg, O. & Madsen, P. Pancreaticogastrostomy for chronic pancreatitis. Am. J. Surg. 157, 315\u2013317 (1989).","journal-title":"Am. J. Surg."},{"key":"BFnrgastro2011274_CR17","doi-asserted-by":"publisher","first-page":"462","DOI":"10.3109\/00365529009095516","volume":"25","author":"N Ebbehoj","year":"1990","unstructured":"Ebbehoj, N., Borly, L., Bulow, J., Rasmussen, S. G. & Madsen, P. Evaluation of pancreatic tissue fluid pressure and pain in chronic pancreatitis. A longitudinal study. Scand. J. Gastroenterol. 25, 462\u2013466 (1990).","journal-title":"Scand. J. Gastroenterol."},{"key":"BFnrgastro2011274_CR18","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.3109\/00365529008997633","volume":"25","author":"N Ebbehoj","year":"1990","unstructured":"Ebbehoj, N. et al. Pancreatic tissue fluid pressure in chronic pancreatitis. Relation to pain, morphology, and function. Scand. J. Gastroenterol. 25, 1046\u20131051 (1990).","journal-title":"Scand. J. Gastroenterol."},{"key":"BFnrgastro2011274_CR19","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.3109\/00365529008997632","volume":"25","author":"N Ebbehoj","year":"1990","unstructured":"Ebbehoj, N., Borly, L., Madsen, P. & Matzen, P. Pancreatic tissue fluid pressure during drainage operations for chronic pancreatitis. Scand. J. Gastroenterol. 25, 1041\u20131045 (1990).","journal-title":"Scand. J. Gastroenterol."},{"key":"BFnrgastro2011274_CR20","first-page":"128","volume":"39","author":"N Ebbehoj","year":"1992","unstructured":"Ebbehoj, N. Pancreatic tissue fluid pressure and pain in chronic pancreatitis. Dan. Med. Bull. 39, 128\u2013133 (1992).","journal-title":"Dan. Med. Bull."},{"key":"BFnrgastro2011274_CR21","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0889-8553(21)00520-3","volume":"19","author":"ND Karanjia","year":"1990","unstructured":"Karanjia, N. D. & Reber, H. A. The cause and management of the pain of chronic pancreatitis. Gastroenterol. Clin. North Am. 19, 895\u2013904 (1990).","journal-title":"Gastroenterol. Clin. North Am."},{"key":"BFnrgastro2011274_CR22","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1002\/bjs.1800810236","volume":"81","author":"ND Karanjia","year":"1994","unstructured":"Karanjia, N. D. et al. Compartment syndrome in experimental chronic obstructive pancreatitis: effect of decompressing the main pancreatic duct. Br. J. Surg. 81, 259\u2013264 (1994).","journal-title":"Br. J. Surg."},{"key":"BFnrgastro2011274_CR23","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF02924661","volume":"15","author":"G Manes","year":"1994","unstructured":"Manes, G., Buchler, M., Pieramico, O., Di Sebastiano, P. & Malfertheiner, P. Is increased pancreatic pressure related to pain in chronic pancreatitis? Int. J. Pancreatol. 15, 113\u2013117 (1994).","journal-title":"Int. J. Pancreatol."},{"key":"BFnrgastro2011274_CR24","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1385\/IJGC:27:2:143","volume":"27","author":"C Renou","year":"2000","unstructured":"Renou, C., Grandval, P., Ville, E. & Laugier, R. Endoscopic treatment of the main pancreatic duct: correlations among morphology, manometry, and clinical follow-up. Int. J. Pancreatol. 27, 143\u2013149 (2000).","journal-title":"Int. J. Pancreatol."},{"key":"BFnrgastro2011274_CR25","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1007\/s00268-003-7235-x","volume":"27","author":"PC Bornman","year":"2003","unstructured":"Bornman, P. C. et al. Pathogenesis of pain in chronic pancreatitis: ongoing enigma. World J. Surg. 27, 1175\u20131182 (2003).","journal-title":"World J. Surg."},{"key":"BFnrgastro2011274_CR26","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s11894-008-0029-4","volume":"10","author":"R Anaparthy","year":"2008","unstructured":"Anaparthy, R. & Pasricha, P. J. Pain and chronic pancreatitis: is it the plumbing or the wiring? Curr. Gastroenterol. Rep. 10, 101\u2013106 (2008).","journal-title":"Curr. Gastroenterol. Rep."},{"key":"BFnrgastro2011274_CR27","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","volume":"139","author":"AI Basbaum","year":"2009","unstructured":"Basbaum, A. I., Bautista, D. M., Scherrer, G. & Julius, D. Cellular and molecular mechanisms of pain. Cell 139, 267\u2013284 (2009).","journal-title":"Cell"},{"key":"BFnrgastro2011274_CR28","doi-asserted-by":"publisher","first-page":"3760","DOI":"10.1172\/JCI42843","volume":"120","author":"AE Dubin","year":"2010","unstructured":"Dubin, A. E. & Patapoutian, A. Nociceptors: the sensors of the pain pathway. J. Clin. Invest. 120, 3760\u20133772 (2010).","journal-title":"J. Clin. Invest."},{"key":"BFnrgastro2011274_CR29","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1002\/9781444300758.ch14","volume-title":"Principles of Clinical Gastroenterology","author":"PJ Pasricha","year":"2008","unstructured":"Pasricha, P. J. Approach to the patient with abdominal pain in Principles of Clinical Gastroenterology (eds Yamada, T. et al.) 228\u2013254 (Wiley Blackwell, Chichester, 2008)."},{"key":"BFnrgastro2011274_CR30","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1152\/physrev.00025.2008","volume":"89","author":"J Sandkuhler","year":"2009","unstructured":"Sandkuhler, J. Models and mechanisms of hyperalgesia and allodynia. Physiol. Rev. 89, 707\u2013758 (2009).","journal-title":"Physiol. Rev."},{"key":"BFnrgastro2011274_CR31","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1016\/j.pain.2010.09.030","volume":"152","author":"CJ Woolf","year":"2010","unstructured":"Woolf, C. J. Central sensitization: implications for the diagnosis and treatment of pain. Pain 152, S2\u2013S15 (2010).","journal-title":"Pain"},{"key":"BFnrgastro2011274_CR32","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.jpain.2009.06.012","volume":"10","author":"A Latremoliere","year":"2009","unstructured":"Latremoliere, A. & Woolf, C. J. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J. Pain 10, 895\u2013926 (2009).","journal-title":"J. Pain"},{"key":"BFnrgastro2011274_CR33","doi-asserted-by":"publisher","first-page":"7723","DOI":"10.1073\/pnas.96.14.7723","volume":"96","author":"CJ Woolf","year":"1999","unstructured":"Woolf, C. J. & Costigan, M. Transcriptional and posttranslational plasticity and the generation of inflammatory pain. Proc. Natl Acad. Sci. USA 96, 7723\u20137730 (1999).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrgastro2011274_CR34","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/S1526-5900(03)00636-9","volume":"4","author":"JH Winston","year":"2003","unstructured":"Winston, J. H. et al. Acute pancreatitis results in referred mechanical hypersensitivity and neuropeptide up-regulation that can be suppressed by the protein kinase inhibitor k252a. J. Pain 4, 329\u2013337 (2003).","journal-title":"J. Pain"},{"key":"BFnrgastro2011274_CR35","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1097\/00000542-200409000-00026","volume":"101","author":"MM Smiley","year":"2004","unstructured":"Smiley, M. M., Lu, Y., Vera-Portocarrero, L. P., Zidan, A. & Westlund, K. N. Intrathecal gabapentin enhances the analgesic effects of subtherapeutic dose morphine in a rat experimental pancreatitis model. Anesthesiology 101, 759\u2013765 (2004).","journal-title":"Anesthesiology"},{"key":"BFnrgastro2011274_CR36","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1097\/00000542-200303000-00024","volume":"98","author":"Y Lu","year":"2003","unstructured":"Lu, Y., Vera-Portocarrero, L. P. & Westlund, K. N. Intrathecal coadministration of D-APV and morphine is maximally effective in a rat experimental pancreatitis model. Anesthesiology 98, 734\u2013740 (2003).","journal-title":"Anesthesiology"},{"key":"BFnrgastro2011274_CR37","doi-asserted-by":"publisher","first-page":"3795","DOI":"10.1097\/00001756-199712010-00028","volume":"8","author":"AK Houghton","year":"1997","unstructured":"Houghton, A. K., Kadura, S. & Westlund, K. N. Dorsal column lesions reverse the reduction of homecage activity in rats with pancreatitis. Neuroreport 8, 3795\u20133800 (1997).","journal-title":"Neuroreport"},{"key":"BFnrgastro2011274_CR38","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/S0022-4804(03)00123-9","volume":"117","author":"EH Kim","year":"2004","unstructured":"Kim, E. H. et al. Activation of nociceptive neurons in T9 and T10 in cerulein pancreatitis. J. Surg. Res. 117, 195\u2013201 (2004).","journal-title":"J. Surg. Res."},{"key":"BFnrgastro2011274_CR39","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.pbb.2004.01.004","volume":"77","author":"LP Vera-Portocarrero","year":"2004","unstructured":"Vera-Portocarrero, L. P. & Westlund, K. N. Attenuation of nociception in a model of acute pancreatitis by an NK-1 antagonist. Pharmacol. Biochem. Behav. 77, 631\u2013640 (2004).","journal-title":"Pharmacol. Biochem. Behav."},{"key":"BFnrgastro2011274_CR40","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.pbb.2003.10.004","volume":"77","author":"L Zhang","year":"2004","unstructured":"Zhang, L., Zhang, X. & Westlund, K. N. Restoration of spontaneous exploratory behaviors with an intrathecal NMDA receptor antagonist or a PKC inhibitor in rats with acute pancreatitis. Pharmacol. Biochem. Behav. 77, 145\u2013153 (2004).","journal-title":"Pharmacol. Biochem. Behav."},{"key":"BFnrgastro2011274_CR41","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.pain.2005.06.013","volume":"117","author":"JH Winston","year":"2005","unstructured":"Winston, J. H., He, Z. J., Shenoy, M., Xiao, S. Y. & Pasricha, P. J. Molecular and behavioral changes in nociception in a novel rat model of chronic pancreatitis for the study of pain. Pain 117, 214\u2013222 (2005).","journal-title":"Pain"},{"key":"BFnrgastro2011274_CR42","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1097\/00000542-200302000-00029","volume":"98","author":"LP Vera-Portocarrero","year":"2003","unstructured":"Vera-Portocarrero, L. P., Lu, Y. & Westlund, K. N. Nociception in persistent pancreatitis in rats: effects of morphine and neuropeptide alterations. Anesthesiology 98, 474\u2013484 (2003).","journal-title":"Anesthesiology"},{"key":"BFnrgastro2011274_CR43","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0887-2333(01)00114-X","volume":"16","author":"T Unno","year":"2002","unstructured":"Unno, T., Inaba, Y., Ohashi, H. & Komori, S. Inhibitory effects of organotin compounds on voltage-dependent, tetrodotoxin-resistant Na+ channel current in guinea pig dorsal root ganglion cells. Toxicol. In Vitro 16, 141\u2013150 (2002).","journal-title":"Toxicol. In Vitro"},{"key":"BFnrgastro2011274_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.devbrainres.2004.03.015","volume":"151","author":"SM Jenkins","year":"2004","unstructured":"Jenkins, S. M., Ehman, K. & Barone, S. Jr. Structure-activity comparison of organotin species: dibutyltin is a developmental neurotoxicant in vitro and in vivo. Brain Res. Dev. Brain Res. 151, 1\u201312 (2004).","journal-title":"Brain Res. Dev. Brain Res."},{"key":"BFnrgastro2011274_CR45","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/0378-4274(91)90132-P","volume":"55","author":"MA Khaliq","year":"1991","unstructured":"Khaliq, M. A., Husain, R., Seth, P. K. & Srivastava, S. P. Effect of dibutyltin dilaurate on regional brain polyamines in rats. Toxicol. Lett. 55, 179\u2013183 (1991).","journal-title":"Toxicol. Lett."},{"key":"BFnrgastro2011274_CR46","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1254\/jjp.72.317","volume":"72","author":"H Kobayashi","year":"1996","unstructured":"Kobayashi, H. et al. Effects of tri-, di- and monobutyltin on synaptic parameters of the cholinergic system in the cerebral cortex of mice. Jpn J. Pharmacol. 72, 317\u2013324 (1996).","journal-title":"Jpn J. Pharmacol."},{"key":"BFnrgastro2011274_CR47","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.bbadis.2007.02.012","volume":"1772","author":"RA Liddle","year":"2007","unstructured":"Liddle, R. A. The role of Transient Receptor Potential Vanilloid 1 (TRPV1) channels in pancreatitis. Biochim. Biophys. Acta 1772, 869\u2013878 (2007).","journal-title":"Biochim. Biophys. Acta"},{"key":"BFnrgastro2011274_CR48","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1136\/gut.2008.151910","volume":"58","author":"S Nishimura","year":"2009","unstructured":"Nishimura, S. et al. Hydrogen sulfide as a novel mediator for pancreatic pain in rodents. Gut 58, 762\u2013770 (2009).","journal-title":"Gut"},{"key":"BFnrgastro2011274_CR49","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1053\/j.gastro.2007.06.015","volume":"133","author":"GY Xu","year":"2007","unstructured":"Xu, G. Y. et al. Transient receptor potential vanilloid 1 mediates hyperalgesia and is up-regulated in rats with chronic pancreatitis. Gastroenterology 133, 1282\u20131292 (2007).","journal-title":"Gastroenterology"},{"key":"BFnrgastro2011274_CR50","doi-asserted-by":"publisher","first-page":"G556","DOI":"10.1152\/ajpgi.00433.2009","volume":"299","author":"E Ceppa","year":"2010","unstructured":"Ceppa, E. et al. Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 299, G556\u2013G571 (2010).","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"BFnrgastro2011274_CR51","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1053\/j.gastro.2010.12.033","volume":"140","author":"ES Schwartz","year":"2011","unstructured":"Schwartz, E. S. et al. Synergistic role of TRPV1 and TRPA1 in pancreatic pain and inflammation. Gastroenterology 140, 1283\u20131291.e1\u20132 (2011).","journal-title":"Gastroenterology"},{"key":"BFnrgastro2011274_CR52","doi-asserted-by":"publisher","first-page":"9036","DOI":"10.1523\/JNEUROSCI.21-22-09036.2001","volume":"21","author":"WA Hoogerwerf","year":"2001","unstructured":"Hoogerwerf, W. A. et al. The proteinase-activated receptor 2 is involved in nociception. J. Neurosci. 21, 9036\u20139042 (2001).","journal-title":"J. Neurosci."},{"key":"BFnrgastro2011274_CR53","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1113\/jphysiol.2006.111534","volume":"575","author":"S Amadesi","year":"2006","unstructured":"Amadesi, S. et al. Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice. J. Physiol. 575, 555\u2013571 (2006).","journal-title":"J. Physiol."},{"key":"BFnrgastro2011274_CR54","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1053\/j.gastro.2004.07.002","volume":"127","author":"WA Hoogerwerf","year":"2004","unstructured":"Hoogerwerf, W. A. et al. Trypsin mediates nociception via the proteinase-activated receptor 2: a potentially novel role in pancreatic pain. Gastroenterology 127, 883\u2013891 (2004).","journal-title":"Gastroenterology"},{"key":"BFnrgastro2011274_CR55","doi-asserted-by":"publisher","first-page":"G424","DOI":"10.1152\/ajpgi.00560.2005","volume":"291","author":"GY Xu","year":"2006","unstructured":"Xu, G. Y., Winston, J. H., Shenoy, M., Yin, H. & Pasricha, P. J. Enhanced excitability and suppression of A-type K+ current of pancreas-specific afferent neurons in a rat model of chronic pancreatitis. Am. J. Physiol. Gastrointest. Liver Physiol. 291, G424\u2013G431 (2006).","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"BFnrgastro2011274_CR56","doi-asserted-by":"publisher","first-page":"4644","DOI":"10.1523\/JNEUROSCI.19-11-04644.1999","volume":"19","author":"N Yoshimura","year":"1999","unstructured":"Yoshimura, N. & de Groat, W. C. Increased excitability of afferent neurons innervating rat urinary bladder after chronic bladder inflammation. J. Neurosci. 19, 4644\u20134653 (1999).","journal-title":"J. Neurosci."},{"key":"BFnrgastro2011274_CR57","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1113\/jphysiol.2003.046409","volume":"552","author":"T Stewart","year":"2003","unstructured":"Stewart, T., Beyak, M. J. & Vanner, S. Ileitis modulates potassium and sodium currents in guinea pig dorsal root ganglia sensory neurons. J. Physiol. 552, 797\u2013807 (2003).","journal-title":"J. Physiol."},{"key":"BFnrgastro2011274_CR58","doi-asserted-by":"publisher","first-page":"G573","DOI":"10.1152\/ajpgi.00258.2003","volume":"286","author":"K Dang","year":"2004","unstructured":"Dang, K., Bielefeldt, K. & Gebhart, G. F. Gastric ulcers reduce A-type potassium currents in rat gastric sensory ganglion neurons. Am. J. Physiol. Gastrointest. Liver Physiol. 286, G573\u2013G579 (2004).","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"BFnrgastro2011274_CR59","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.1038\/ajg.2009.227","volume":"104","author":"AH Qian","year":"2009","unstructured":"Qian, A. H. et al. Voltage-gated potassium channels in IB4-positive colonic sensory neurons mediate visceral hypersensitivity in the rat. Am. J. Gastroenterol. 104, 2014\u20132027 (2009).","journal-title":"Am. J. Gastroenterol."},{"key":"BFnrgastro2011274_CR60","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.pain.2003.12.035","volume":"108","author":"JA Black","year":"2004","unstructured":"Black, J. A., Liu, S., Tanaka, M., Cummins, T. R. & Waxman, S. G. Changes in the expression of tetrodotoxin-sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain. Pain 108, 237\u2013247 (2004).","journal-title":"Pain"},{"key":"BFnrgastro2011274_CR61","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1097\/MPA.0b013e318214fb77","volume":"40","author":"MS Hughes","year":"2011","unstructured":"Hughes, M. S. et al. Brain-derived neurotrophic factor is upregulated in rats with chronic pancreatitis and mediates pain behavior. Pancreas 40, 551\u2013556 (2011).","journal-title":"Pancreas"},{"key":"BFnrgastro2011274_CR62","first-page":"389","volume":"12","author":"L Liu","year":"2011","unstructured":"Liu, L., Shenoy, M. & Pasricha, P. J. Substance P and calcitonin gene related peptide mediate pain in chronic pancreatitis and their expression is driven by nerve growth factor. JOP 12, 389\u2013394 (2011).","journal-title":"JOP"},{"key":"BFnrgastro2011274_CR63","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/0306-4522(94)90366-2","volume":"62","author":"CJ Woolf","year":"1994","unstructured":"Woolf, C. J., Safieh-Garabedian, B., Ma, Q. P., Crilly, P. & Winter, J. Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity. Neuroscience 62, 327\u2013331 (1994).","journal-title":"Neuroscience"},{"key":"BFnrgastro2011274_CR64","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1053\/gast.2000.19264","volume":"119","author":"H Toma","year":"2000","unstructured":"Toma, H., Winston, J., Micci, M. A., Shenoy, M. & Pasricha, P. J. Nerve growth factor expression is up-regulated in the rat model of L-arginine-induced acute pancreatitis. Gastroenterology 119, 1373\u20131381 (2000).","journal-title":"Gastroenterology"},{"key":"BFnrgastro2011274_CR65","doi-asserted-by":"publisher","unstructured":"Zhu, Y. et al. Systemic administration of anti-NGF increases A-type potassium currents and decreases pancreatic nociceptor excitability in a rat model of chronic pancreatitis. Am. J. Physiol. Gastrointest. Liver Physiol. http:\/\/dx.doi.org\/10.1152\/ajpgi.00053.2011 .","DOI":"10.1152\/ajpgi.00053.2011"},{"key":"BFnrgastro2011274_CR66","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1053\/j.gastro.2011.03.046","volume":"141","author":"Y Zhu","year":"2011","unstructured":"Zhu, Y. et al. Nerve growth factor modulates TRPV1 expression and function and mediates pain in chronic pancreatitis. Gastroenterology 141, 370\u2013377 (2011).","journal-title":"Gastroenterology"},{"key":"BFnrgastro2011274_CR67","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1471-230X-5-8","volume":"5","author":"WA Hoogerwerf","year":"2005","unstructured":"Hoogerwerf, W. A. et al. The role of mast cells in the pathogenesis of pain in chronic pancreatitis. BMC Gastroenterol. 5, 8 (2005).","journal-title":"BMC Gastroenterol."},{"key":"BFnrgastro2011274_CR68","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.pain.2010.05.022","volume":"151","author":"M Vardanyan","year":"2010","unstructured":"Vardanyan, M. et al. Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist. Pain 151, 257\u2013265 (2010).","journal-title":"Pain"},{"key":"BFnrgastro2011274_CR69","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.neuroscience.2010.02.005","volume":"167","author":"QX Feng","year":"2010","unstructured":"Feng, Q. X. et al. Astrocytic activation in thoracic spinal cord contributes to persistent pain in rat model of chronic pancreatitis. Neuroscience 167, 501\u2013509 (2010).","journal-title":"Neuroscience"},{"key":"BFnrgastro2011274_CR70","doi-asserted-by":"publisher","unstructured":"Liu, P. Y. et al. Spinal microglia initiate and maintain hyperalgesia in a rat model of chronic pancreatitis. Gastroenterology http:\/\/dx.doi.org\/10.1053\/j.gastro.2011.09.041 .","DOI":"10.1053\/j.gastro.2011.09.041"},{"key":"BFnrgastro2011274_CR71","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.1053\/j.gastro.2006.03.025","volume":"130","author":"LP Vera-Portocarrero","year":"2006","unstructured":"Vera-Portocarrero, L. P. et al. Descending facilitation from the rostral ventromedial medulla maintains visceral pain in rats with experimental pancreatitis. Gastroenterology 130, 2155\u20132164 (2006).","journal-title":"Gastroenterology"},{"key":"BFnrgastro2011274_CR72","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1053\/j.gastro.2008.09.029","volume":"136","author":"GO Ceyhan","year":"2009","unstructured":"Ceyhan, G. O. et al. Pancreatic neuropathy and neuropathic pain\u2014a comprehensive pathomorphological study of 546 cases. Gastroenterology 136, 177\u2013186 e1 (2009).","journal-title":"Gastroenterology"},{"key":"BFnrgastro2011274_CR73","doi-asserted-by":"publisher","first-page":"3742","DOI":"10.1172\/JCI45178","volume":"120","author":"CJ Woolf","year":"2010","unstructured":"Woolf, C. J. What is this thing called pain? J. Clin. Invest. 120, 3742\u20133744 (2010).","journal-title":"J. Clin. Invest."},{"key":"BFnrgastro2011274_CR74","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.bpg.2007.10.016","volume":"22","author":"GO Ceyhan","year":"2008","unstructured":"Ceyhan, G. O., Michalski, C. W., Demir, I. E., Muller, M. W. & Friess, H. Pancreatic pain. Best Pract. Res. Clin. Gastroenterol. 22, 31\u201344 (2008).","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"BFnrgastro2011274_CR75","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1097\/00000658-199911000-00002","volume":"230","author":"H Friess","year":"1999","unstructured":"Friess, H. et al. Nerve growth factor and its high-affinity receptor in chronic pancreatitis. Ann. Surg. 230, 615\u2013624 (1999).","journal-title":"Ann. Surg."},{"key":"BFnrgastro2011274_CR76","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1136\/gut.47.3.423","volume":"47","author":"P Di Sebastiano","year":"2000","unstructured":"Di Sebastiano, P. et al. Expression of interleukin 8 (IL-8) and substance P in human chronic pancreatitis. Gut 47, 423\u2013428 (2000).","journal-title":"Gut"},{"key":"BFnrgastro2011274_CR77","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1136\/gut.2005.073205","volume":"55","author":"M Hartel","year":"2006","unstructured":"Hartel, M. et al. Vanilloids in pancreatic cancer: potential for chemotherapy and pain management. Gut 55, 519\u2013528 (2006).","journal-title":"Gut"},{"key":"BFnrgastro2011274_CR78","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1097\/00006676-199203000-00009","volume":"7","author":"M Buchler","year":"1992","unstructured":"Buchler, M. Changes in peptidergic innervation in chronic pancreatitis. Pancreas 7, 183\u2013192 (1992).","journal-title":"Pancreas"},{"key":"BFnrgastro2011274_CR79","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/S0304-3959(00)00436-X","volume":"91","author":"SV Shrikhande","year":"2001","unstructured":"Shrikhande, S. V. et al. NK-1 receptor gene expression is related to pain in chronic pancreatitis. Pain 91, 209\u2013217 (2001).","journal-title":"Pain"},{"key":"BFnrgastro2011274_CR80","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1023\/A:1010684916863","volume":"46","author":"ZW Zhu","year":"2001","unstructured":"Zhu, Z. W., Friess, H., Wang, L., Zimmermann, A. & Buchler, M. W. Brain-derived neurotrophic factor (BDNF) is upregulated and associated with pain in chronic pancreatitis. Dig. Dis. Sci. 46, 1633\u20131639 (2001).","journal-title":"Dig. Dis. Sci."},{"key":"BFnrgastro2011274_CR81","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1136\/gut.2006.105528","volume":"56","author":"GO Ceyhan","year":"2007","unstructured":"Ceyhan, G. O. et al. The neurotrophic factor artemin influences the extent of neural damage and growth in chronic pancreatitis. Gut 56, 534\u2013544 (2007).","journal-title":"Gut"},{"key":"BFnrgastro2011274_CR82","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1016\/S0016-5085(97)70047-7","volume":"112","author":"P Di Sebastiano","year":"1997","unstructured":"Di Sebastiano, P. et al. Immune cell infiltration and growth-associated protein 43 expression correlate with pain in chronic pancreatitis. Gastroenterology 112, 1648\u20131655 (1997).","journal-title":"Gastroenterology"},{"key":"BFnrgastro2011274_CR83","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/labinvest.2008.170","volume":"89","author":"GO Ceyhan","year":"2009","unstructured":"Ceyhan, G. O. et al. Neural fractalkine expression is closely linked to pain and pancreatic neuritis in human chronic pancreatitis. Lab. Invest. 89, 347\u2013361 (2009).","journal-title":"Lab. Invest."},{"key":"BFnrgastro2011274_CR84","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1159\/000051875","volume":"63","author":"JM Braganza","year":"2001","unstructured":"Braganza, J. M. Towards a novel treatment strategy for acute pancreatitis. 1. Reappraisal of the evidence on aetiogenesis. Digestion 63, 69\u201391 (2001).","journal-title":"Digestion"},{"key":"BFnrgastro2011274_CR85","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1053\/hupa.2001.28947","volume":"32","author":"I Esposito","year":"2001","unstructured":"Esposito, I. Mast cell distribution and activation in chronic pancreatitis. Hum. Pathol. 32, 1174\u20131183 (2001).","journal-title":"Hum. Pathol."},{"key":"BFnrgastro2011274_CR86","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1097\/00000658-200112000-00008","volume":"234","author":"H Friess","year":"2001","unstructured":"Friess, H. et al. Identification of disease-specific genes in chronic pancreatitis using DNA array technology. Ann. Surg. 234, 769\u2013778 (2001).","journal-title":"Ann. Surg."},{"key":"BFnrgastro2011274_CR87","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.ejpain.2005.06.006","volume":"10","author":"HC Buscher","year":"2006","unstructured":"Buscher, H. C., Wilder-Smith, O. H. & van Goor, H. Chronic pancreatitis patients show hyperalgesia of central origin: a pilot study. Eur. J. Pain 10, 363\u2013370 (2006).","journal-title":"Eur. J. Pain"},{"key":"BFnrgastro2011274_CR88","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1053\/j.gastro.2007.01.037","volume":"132","author":"G Dimcevski","year":"2007","unstructured":"Dimcevski, G. et al. Pain in chronic pancreatitis: the role of reorganization in the central nervous system. Gastroenterology 132, 1546\u20131556 (2007).","journal-title":"Gastroenterology"},{"key":"BFnrgastro2011274_CR89","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1159\/000321644","volume":"10","author":"SS Olesen","year":"2011","unstructured":"Olesen, S. S., Frokjaer, J. B., Lelic, D., Valeriani, M. & Drewes, A. M. Pain-associated adaptive cortical reorganisation in chronic pancreatitis. Pancreatology 10, 742\u2013751 (2011).","journal-title":"Pancreatology"},{"key":"BFnrgastro2011274_CR90","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1097\/MEG.0b013e3283457b09","volume":"23","author":"SS Olesen","year":"2011","unstructured":"Olesen, S. S. et al. Slowed EEG rhythmicity in patients with chronic pancreatitis: evidence of abnormal cerebral pain processing? Eur. J. Gastroenterol. Hepatol. 23, 418\u2013424 (2011).","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"BFnrgastro2011274_CR91","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1136\/gut.2010.236620","volume":"60","author":"JB Frokjaer","year":"2011","unstructured":"Frokjaer, J. B. et al. Altered brain microstructure assessed by diffusion tensor imaging in patients with chronic pancreatitis. Gut 60, 1554\u20131562 (2011).","journal-title":"Gut"},{"key":"BFnrgastro2011274_CR92","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1097\/01.meg.0000223903.70492.c5","volume":"18","author":"G Dimcevski","year":"2006","unstructured":"Dimcevski, G. et al. Hypoalgesia to experimental visceral and somatic stimulation in painful chronic pancreatitis. Eur. J. Gastroenterol. Hepatol. 18, 755\u2013764 (2006).","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"BFnrgastro2011274_CR93","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1097\/mpa.0b013e31805c1762","volume":"35","author":"G Dimcevski","year":"2007","unstructured":"Dimcevski, G. et al. Assessment of experimental pain from skin, muscle, and esophagus in patients with chronic pancreatitis. Pancreas 35, 22\u201329 (2007).","journal-title":"Pancreas"},{"key":"BFnrgastro2011274_CR94","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.cgh.2010.03.005","volume":"8","author":"SS Olesen","year":"2010","unstructured":"Olesen, S. S. et al. Descending inhibitory pain modulation is impaired in patients with chronic pancreatitis. Clin. Gastroenterol. Hepatol. 8, 724\u2013730 (2010).","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"BFnrgastro2011274_CR95","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1053\/j.gastro.2007.02.060","volume":"132","author":"GF Gebhart","year":"2007","unstructured":"Gebhart, G. F. It's chickens and eggs all over again: is central reorganization the result or cause of persistent visceral pain? Gastroenterology 132, 1618\u20131620 (2007).","journal-title":"Gastroenterology"},{"key":"BFnrgastro2011274_CR96","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1097\/AAP.0b013e31822e0d4a","volume":"36","author":"SA Bouwense","year":"2011","unstructured":"Bouwense, S. A., Buscher, H. C., van Goor, H. & Wilder-Smith, O. H. Has central sensitization become independent of nociceptive input in chronic pancreatitis patients who fail thoracoscopic splanchnicectomy? Reg. Anesth. Pain Med. 36, 531\u2013536 (2011).","journal-title":"Reg. Anesth. Pain Med."},{"key":"BFnrgastro2011274_CR97","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.ejpain.2006.06.001","volume":"11","author":"HC Buscher","year":"2007","unstructured":"Buscher, H. C., van Goor, H. & Wilder-Smith, O. H. Effect of thoracoscopic splanchnic denervation on pain processing in chronic pancreatitis patients. Eur. J. Pain 11, 437\u2013443 (2007).","journal-title":"Eur. J. Pain"},{"key":"BFnrgastro2011274_CR98","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S0304-3959(02)00259-2","volume":"101","author":"JC Eisenach","year":"2003","unstructured":"Eisenach, J. C., Carpenter, R. & Curry, R. Analgesia from a peripherally active kappa-opioid receptor agonist in patients with chronic pancreatitis. Pain 101, 89\u201395 (2003).","journal-title":"Pain"},{"key":"BFnrgastro2011274_CR99","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/S0165-6147(00)01536-4","volume":"21","author":"EJ Bradbury","year":"2000","unstructured":"Bradbury, E. J., McMahon, S. B. & Ramer, M. S. Keeping in touch: sensory neurone regeneration in the CNS. Trends Pharmacol. Sci. 21, 389\u2013394 (2000).","journal-title":"Trends Pharmacol. Sci."},{"key":"BFnrgastro2011274_CR100","doi-asserted-by":"crossref","first-page":"145","DOI":"10.36076\/ppj.2011\/14\/145","volume":"14","author":"M Lee","year":"2011","unstructured":"Lee, M., Silverman, S. M., Hansen, H., Patel, V. B. & Manchikanti, L. A comprehensive review of opioid-induced hyperalgesia. Pain Physician 14, 145\u2013161 (2011).","journal-title":"Pain Physician"},{"key":"BFnrgastro2011274_CR101","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1111\/j.1365-2036.2011.04802.x","volume":"34","author":"SS Olesen","year":"2011","unstructured":"Olesen, S. S. et al. Randomised clinical trial: pregabalin attenuates experimental visceral pain through sub-cortical mechanisms in patients with painful chronic pancreatitis. Aliment. Pharmacol. Ther. 34, 878\u2013887 (2011).","journal-title":"Aliment. Pharmacol. Ther."},{"key":"BFnrgastro2011274_CR102","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1053\/j.gastro.2011.04.003","volume":"141","author":"SS Olesen","year":"2011","unstructured":"Olesen, S. S., Bouwense, S. A., Wilder-Smith, O. H., van Goor, H. & Drewes, A. M. Pregabalin reduces pain in patients with chronic pancreatitis in a randomized, controlled trial. Gastroenterology 141, 536\u2013543 (2011).","journal-title":"Gastroenterology"},{"key":"BFnrgastro2011274_CR103","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.1016\/j.pain.2011.05.003","volume":"152","author":"N Katz","year":"2011","unstructured":"Katz, N. et al. Efficacy and safety of tanezumab in the treatment of chronic low back pain. Pain 152, 2248\u20132258 (2011).","journal-title":"Pain"},{"key":"BFnrgastro2011274_CR104","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s11934-011-0194-0","volume":"12","author":"AE Te","year":"2011","unstructured":"Te, A. E. A study to investigate tanezumab in patients with interstitial cystitis\/painful bladder syndrome. Curr. Urol. Rep. 12, 245\u2013246 (2011).","journal-title":"Curr. Urol. Rep."},{"key":"BFnrgastro2011274_CR105","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1016\/j.juro.2010.12.088","volume":"185","author":"RJ Evans","year":"2010","unstructured":"Evans, R. J. et al. Proof of concept trial of tanezumab for the treatment of symptoms associated with interstitial cystitis. J. Urol. 185, 1716\u20131721 (2010).","journal-title":"J. Urol."},{"key":"BFnrgastro2011274_CR106","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.joca.2011.01.009","volume":"19","author":"TJ Schnitzer","year":"2011","unstructured":"Schnitzer, T. J. et al. Long-term open-label study of tanezumab for moderate to severe osteoarthritic knee pain. Osteoarthritis Cartilage 19, 639\u2013646 (2011).","journal-title":"Osteoarthritis Cartilage"},{"key":"BFnrgastro2011274_CR107","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1056\/NEJMoa0901510","volume":"363","author":"NE Lane","year":"2010","unstructured":"Lane, N. E. et al. Tanezumab for the treatment of pain from osteoarthritis of the knee. N. Engl. J. Med. 363, 1521\u20131531 (2010).","journal-title":"N. Engl. J. Med."},{"key":"BFnrgastro2011274_CR108","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.brainresrev.2008.12.006","volume":"60","author":"GY Wong","year":"2009","unstructured":"Wong, G. Y. & Gavva, N. R. Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: recent advances and setbacks. Brain Res. Rev. 60, 267\u2013277 (2009).","journal-title":"Brain Res. Rev."},{"key":"BFnrgastro2011274_CR109","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1213\/01.ane.0000231635.14872.40","volume":"103","author":"T Sprenger","year":"2006","unstructured":"Sprenger, T. et al. Imaging pain modulation by subanesthetic S-(+)-ketamine. Anesth. Analg. 103, 729\u2013737 (2006).","journal-title":"Anesth. Analg."},{"key":"BFnrgastro2011274_CR110","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1093\/bja\/79.5.600","volume":"79","author":"S Ilkjaer","year":"1997","unstructured":"Ilkjaer, S., Dirks, J., Brennum, J., Wernberg, M. & Dahl, J. B. Effect of systemic N-methyl-D-aspartate receptor antagonist (dextromethorphan) on primary and secondary hyperalgesia in humans. Br. J. Anaesth. 79, 600\u2013605 (1997).","journal-title":"Br. J. Anaesth."},{"key":"BFnrgastro2011274_CR111","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1097\/AAP.0b013e3182177022","volume":"36","author":"SA Bouwense","year":"2011","unstructured":"Bouwense, S. A., Buscher, H. C., van Goor, H. & Wilder-Smith, O. H. S-ketamine modulates hyperalgesia in patients with chronic pancreatitis pain. Reg. Anesth. Pain Med. 36, 303\u2013307 (2011).","journal-title":"Reg. Anesth. Pain Med."}],"container-title":["Nature Reviews Gastroenterology & Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrgastro.2011.274.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrgastro.2011.274","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrgastro.2011.274.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T05:34:43Z","timestamp":1742362483000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrgastro.2011.274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,24]]},"references-count":111,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["BFnrgastro2011274"],"URL":"https:\/\/doi.org\/10.1038\/nrgastro.2011.274","relation":{},"ISSN":["1759-5045","1759-5053"],"issn-type":[{"value":"1759-5045","type":"print"},{"value":"1759-5053","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,24]]}}}