{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:16:53Z","timestamp":1788545813856,"version":"build-2803163510"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2013,2,12]],"date-time":"2013-02-12T00:00:00Z","timestamp":1360627200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Gastroenterol Hepatol"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1038\/nrgastro.2013.14","type":"journal-article","created":{"date-parts":[[2013,2,12]],"date-time":"2013-02-12T07:13:46Z","timestamp":1360653226000},"page":"134-141","source":"Crossref","is-referenced-by-count":238,"title":["Functional dyspepsia\u2014symptoms, definitions and validity of the Rome III criteria"],"prefix":"10.1038","volume":"10","author":[{"given":"Jan","family":"Tack","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Talley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,2,12]]},"reference":[{"key":"BFnrgastro201314_CR1","first-page":"183","volume-title":"Sleisenger and Fordtran, Handbook of Gastroenterology","author":"J Tack","year":"2010","unstructured":"Tack, J. in Sleisenger and Fordtran, Handbook of Gastroenterology 9th edn, Vol. 1, Ch. 13 (eds Feldman, M., Friedman, L. S. & Brandt, L. J.) 183\u2013196 (Saunders, Philadelphia, 2010)."},{"key":"BFnrgastro201314_CR2","first-page":"159","volume":"3","author":"DA Drossman","year":"1990","unstructured":"Drossman, D. A.  et al. Identification of subgroups of functional gastrointestinal disorders. Gastroenterol. Int. 3, 159\u2013172 (1990).","journal-title":"Gastroenterol. Int."},{"issue":"Suppl. 2","key":"BFnrgastro201314_CR3","first-page":"37","volume":"45","author":"NJ Talley","year":"1999","unstructured":"Talley, N. J.  et al. Functional gastroduodenal disorders. Gut 45 (Suppl. 2), 37\u201342 (1999).","journal-title":"Gut"},{"key":"BFnrgastro201314_CR4","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1053\/j.gastro.2005.11.059","volume":"130","author":"J Tack","year":"2006","unstructured":"Tack, J.  et al. Functional gastroduodenal disorders. Gastroenterology 130, 1466\u20131479 (2006).","journal-title":"Gastroenterology"},{"key":"BFnrgastro201314_CR5","doi-asserted-by":"publisher","first-page":"222","DOI":"10.3109\/00365528509089661","volume":"20","author":"A Nesland","year":"1985","unstructured":"Nesland, A. & Berstad, A. Erosive prepyloric changes in persons with and without dyspepsia. Scand. J. Gastroenterol. 20, 222\u2013228 (1985).","journal-title":"Scand. J. Gastroenterol."},{"key":"BFnrgastro201314_CR6","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1016\/j.cgh.2007.05.015","volume":"5","author":"NJ Talley","year":"2007","unstructured":"Talley, N. J.  et al. Non-ulcer dyspepsia and duodenal eosinophilia: an adult endoscopic population-based case-control study. Clin. Gastroenterol. Hepatol. 5, 1175\u20131183 (2007).","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"BFnrgastro201314_CR7","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1001\/archinternmed.2011.533","volume":"171","author":"LE Mazzoleni","year":"2011","unstructured":"Mazzoleni, L. E.  et al. Helicobacter pylori eradication in functional dyspepsia: HEROES trial. Arch. Intern. Med. 171, 1929\u20131936 (2011).","journal-title":"Arch. Intern. Med."},{"key":"BFnrgastro201314_CR8","doi-asserted-by":"publisher","unstructured":"Vanheel, H. & Farr\u00e9, R. Changes in gastrointestinal tract function and structure in functional dyspepsia. Nat. Rev. Gastroenterol. Hepatol. \n                    http:\/\/dx.doi.org\/10.1038\/nrgastro.2012.255\n                    \n                  .","DOI":"10.1038\/nrgastro.2012.255"},{"key":"BFnrgastro201314_CR9","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1111\/j.1365-2036.2004.01897.x","volume":"19","author":"HB El-Serag","year":"2004","unstructured":"El-Serag, H. B. & Talley, N. J. Systematic review: the prevalence and clinical course of functional dyspepsia. Aliment. Pharmacol. Ther. 19, 643\u2013654 (2004).","journal-title":"Aliment. Pharmacol. Ther."},{"key":"BFnrgastro201314_CR10","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1111\/j.1365-2982.2009.01262.x","volume":"21","author":"H Piessevaux","year":"2009","unstructured":"Piessevaux, H.  et al. Dyspeptic symptoms in the general population: a factor and cluster analysis of symptom groupings. Neurogastroenterol. Motil. 21, 378\u2013388 (2009).","journal-title":"Neurogastroenterol. Motil."},{"issue":"Suppl. 4","key":"BFnrgastro201314_CR11","first-page":"iv2","volume":"50","author":"L Agreus","year":"2002","unstructured":"Agreus, L. Natural history of dyspepsia. Gut 50 (Suppl. 4), iv2\u2013iv9 (2002).","journal-title":"Gut"},{"key":"BFnrgastro201314_CR12","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/S1542-3565(05)00153-9","volume":"3","author":"M Camilleri","year":"2005","unstructured":"Camilleri, M.  et al. Prevalence and socioeconomic impact of upper gastrointestinal disorders in the United States: results of the US Upper Gastrointestinal Study. Clin. Gastroenterol. Hepatol. 3, 543\u2013552 (2005).","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"BFnrgastro201314_CR13","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1080\/003655299750025264","volume":"231","author":"P Enck","year":"1999","unstructured":"Enck, P., Dubois, D. & Marquis, P. Quality of life in patients with upper gastrointestinal symptoms: results from the Domestic\/International Gastroenterology Surveillance Study (DIGEST). Scand. J. Gastroenterol. Suppl. 231, 48\u201354 (1999).","journal-title":"Scand. J. Gastroenterol. Suppl."},{"issue":"Suppl. 4","key":"BFnrgastro201314_CR14","first-page":"iv10","volume":"50","author":"P Moayyedi","year":"2002","unstructured":"Moayyedi, P. & Mason, J. Clinical and economic consequences of dyspepsia in the community. Gut 50 (Suppl. 4), iv10\u2013iv12 (2002).","journal-title":"Gut"},{"key":"BFnrgastro201314_CR15","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1111\/j.1572-0241.2001.03789.x","volume":"96","author":"NA Koloski","year":"2001","unstructured":"Koloski, N. A., Talley, N. J. & Boyce, P. M. Predictors of health care seeking for irritable bowel syndrome and nonulcer dyspepsia: a critical review of the literature on symptom and psychosocial factors. Am. J. Gastroenterol. 96, 1340\u20131349 (2001).","journal-title":"Am. J. Gastroenterol."},{"key":"BFnrgastro201314_CR16","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1053\/j.gastro.2004.05.030","volume":"127","author":"J Tack","year":"2004","unstructured":"Tack, J., Bisschops, R. & Sarnelli, G. Pathophysiology and treatment of functional dyspepsia. Gastroenterology 127, 1239\u20131255 (2004).","journal-title":"Gastroenterology"},{"key":"BFnrgastro201314_CR17","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1111\/j.1572-0241.2008.01935.x","volume":"103","author":"MP Jones","year":"2008","unstructured":"Jones, M. P., Talley, N. J., Eslick, G. D., Dubois, D. & Tack, J. Community subgroups in dyspepsia and their association with weight loss. Am. J. Gastroenterol. 103, 2051\u20132060 (2008).","journal-title":"Am. J. Gastroenterol."},{"key":"BFnrgastro201314_CR18","first-page":"576","volume":"1","author":"DG Colin-Jones","year":"1988","unstructured":"Colin-Jones, D. G.  et al. Management of dyspepsia. Report of a working party. Lancet 1, 576\u2013579 (1988).","journal-title":"Lancet"},{"key":"BFnrgastro201314_CR19","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/j.1365-2982.2004.00581.x","volume":"17","author":"GR Locke 3rd","year":"2005","unstructured":"Locke, G. R. 3rd, Zinsmeister, A. R., Fett, S. L., Melton, L. J. 3rd & Talley, N. J. Overlap of gastrointestinal symptom complexes in a US community. Neurogastroenterol. Motil. 17, 29\u201334 (2005).","journal-title":"Neurogastroenterol. Motil."},{"key":"BFnrgastro201314_CR20","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1080\/003655298750026697","volume":"33","author":"R Carlsson","year":"1998","unstructured":"Carlsson, R.  et al. The usefulness of a structured questionnaire in the assessment of symptomatic gastroesophageal reflux disease. Scand. J. Gastroenterol. 33, 1023\u20131029 (1998).","journal-title":"Scand. J. Gastroenterol."},{"key":"BFnrgastro201314_CR21","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/j.1365-2036.1993.tb00073.x","volume":"7","author":"F Johnsson","year":"1993","unstructured":"Johnsson, F., Roth, Y., Damgaard Pedersen, N. E. & Joelsson, B. Cimetidine improves GERD symptoms in patients selected by a validated GERD questionnaire. Aliment. Pharmacol. Ther. 7, 81\u201386 (1993).","journal-title":"Aliment. Pharmacol. Ther."},{"key":"BFnrgastro201314_CR22","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1136\/gut.2004.053355","volume":"54","author":"J Tack","year":"2005","unstructured":"Tack, J.  et al. Prevalence of acid reflux in functional dyspepsia and its association with symptom profile. Gut 54, 1370\u20131376 (2005).","journal-title":"Gut"},{"key":"BFnrgastro201314_CR23","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1111\/j.1572-0241.2004.30040.x","volume":"99","author":"M Corsetti","year":"2004","unstructured":"Corsetti, M., Caenepeel, P., Fischler, B., Janssens, J. & Tack, J. Impact of coexisting irritable bowel syndrome on symptoms and pathophysiological mechanisms in functional dyspepsia. Am. J. Gastroenterol. 99, 1152\u20131159 (2004).","journal-title":"Am. J. Gastroenterol."},{"key":"BFnrgastro201314_CR24","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1097\/01.mcg.0000123164.86324.24","volume":"38","author":"RJ Laheij","year":"2004","unstructured":"Laheij, R. J.  et al. Predominant symptom behavior in patients with persistent dyspepsia during treatment. J. Clin. Gastroenterol. 38, 490\u2013495 (2004).","journal-title":"J. Clin. Gastroenterol."},{"key":"BFnrgastro201314_CR25","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1111\/j.1365-2036.2006.02845.x","volume":"23","author":"NJ Talley","year":"2006","unstructured":"Talley, N. J.  et al. Predictors of the placebo response in functional dyspepsia. Aliment. Pharmacol. Ther. 23, 923\u2013936 (2006).","journal-title":"Aliment. Pharmacol. Ther."},{"key":"BFnrgastro201314_CR26","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1053\/j.gastro.2005.10.019","volume":"130","author":"G Karamanolis","year":"2006","unstructured":"Karamanolis, G., Caenepeel, P., Arts, J. & Tack, J. Association of the predominant symptom with clinical characteristics and pathophysiological mechanisms in functional dyspepsia. Gastroenterology 130, 296\u2013303 (2006).","journal-title":"Gastroenterology"},{"key":"BFnrgastro201314_CR27","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/S1542-3565(04)00454-9","volume":"2","author":"EJ Castillo","year":"2004","unstructured":"Castillo, E. J.  et al. A community-based, controlled study of the epidemiology and pathophysiology of dyspepsia. Clin. Gastroenterol. Hepatol. 2, 985\u2013996 (2004).","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"BFnrgastro201314_CR28","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1136\/gut.2007.137125","volume":"57","author":"R Bisschops","year":"2008","unstructured":"Bisschops, R.  et al. Relationship between symptoms and ingestion of a meal in functional dyspepsia. Gut 57, 1495\u20131503 (2008).","journal-title":"Gut"},{"key":"BFnrgastro201314_CR29","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1111\/j.1572-0241.2007.01381.x","volume":"102","author":"RS Choung","year":"2007","unstructured":"Choung, R. S., Locke, G. R., Schleck, C. D., Zinsmeister, A. R. & Talley, N. J. Do distinct dyspepsia subgroups exist in the community? A population-based study. Am. J. Gastroenterol. 102, 1983\u20131989 (2007).","journal-title":"Am. J. Gastroenterol."},{"key":"BFnrgastro201314_CR30","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1053\/j.gastro.2009.03.039","volume":"137","author":"P Aro","year":"2009","unstructured":"Aro, P.  et al. Anxiety is associated with uninvestigated and functional dyspepsia (ROME III criteria) in a Swedish population based study. Gastroenterology 137, 94\u2013100 (2009).","journal-title":"Gastroenterology"},{"key":"BFnrgastro201314_CR31","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1053\/j.gastro.2009.12.057","volume":"138","author":"RM Zagari","year":"2010","unstructured":"Zagari, R. M.  et al. Epidemiology of functional dyspepsia and subgroups in the Italian general population: an endoscopic study. Gastroenterology 138, 1302\u20131311 (2010).","journal-title":"Gastroenterology"},{"key":"BFnrgastro201314_CR32","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/j.1365-2982.2011.01859.x","volume":"24","author":"J Matsuzaki","year":"2012","unstructured":"Matsuzaki, J.  et al. Classification of functional dyspepsia based on concomitant bowel symptoms. Neurogastroenterol. Motil. 24, 325\u2013e164 (2012).","journal-title":"Neurogastroenterol. Motil."},{"key":"BFnrgastro201314_CR33","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1111\/j.1365-2982.2012.01939.x","volume":"24","author":"J Matsuzaki","year":"2012","unstructured":"Matsuzaki, J.  et al. High frequency of overlap between functional dyspepsia and overactive bladder. Neurogastroenterol. Motil. 24, 821\u2013827 (2012).","journal-title":"Neurogastroenterol. Motil."},{"key":"BFnrgastro201314_CR34","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1097\/MCG.0b013e31815591f7","volume":"43","author":"LA van Kerkhoven","year":"2009","unstructured":"van Kerkhoven, L. A.  et al. Functional dyspepsia: not all roads seem to lead to Rome. J. Clin. Gastroenterol. 43, 118\u2013122 (2009).","journal-title":"J. Clin. Gastroenterol."},{"key":"BFnrgastro201314_CR35","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/1471-230X-8-43","volume":"8","author":"AJ Wang","year":"2008","unstructured":"Wang, A. J.  et al. The clinical overlap between functional dyspepsia and irritable bowel syndrome based on Rome III criteria. BMC Gastroenterol. 8, 43 (2008).","journal-title":"BMC Gastroenterol."},{"issue":"Suppl. 1","key":"BFnrgastro201314_CR36","first-page":"A-627","volume":"134","author":"J Arts","year":"2008","unstructured":"Arts, J.  et al. Discriminant value of dyspepsia subgroups according to the Rome III consensus in dyspeptic patients referred for upper gastrointestinal endoscopy [abstract]. Gastroenterology 134 (Suppl. 1), A-627 (2008).","journal-title":"Gastroenterology"},{"key":"BFnrgastro201314_CR37","doi-asserted-by":"publisher","first-page":"129","DOI":"10.4103\/1319-3767.77244","volume":"17","author":"S Abid","year":"2011","unstructured":"Abid, S., Siddiqui, S. & Jafri, W. Discriminant value of Rome III questionnaire in dyspeptic patients. Saudi J. Gastroenterol. 17, 129\u2013133 (2011).","journal-title":"Saudi J. Gastroenterol."},{"key":"BFnrgastro201314_CR38","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1111\/j.1365-2982.2009.01415.x","volume":"22","author":"S Haag","year":"2010","unstructured":"Haag, S.  et al. Is there any association between disturbed gastrointestinal visceromotor and sensory function and impaired quality of life in functional dyspepsia? Neurogastroenterol. Motil. 22, 262\u2013e79 (2010).","journal-title":"Neurogastroenterol. Motil."},{"key":"BFnrgastro201314_CR39","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1159\/000205740","volume":"79","author":"T Shindo","year":"2009","unstructured":"Shindo, T.  et al. Comparison of gastric emptying and plasma ghrelin levels in patients with functional dyspepsia and non-erosive reflux disease. Digestion 79, 65\u201372 (2009).","journal-title":"Digestion"},{"issue":"Suppl. 1","key":"BFnrgastro201314_CR40","first-page":"A-140","volume":"136","author":"S Kindt","year":"2009","unstructured":"Kindt, S.  et al. Impaired accommodation is a feature of functional dyspepsia patients with postprandial distress syndrome, not with epigastric pain syndrome [abstract]. Gastroenterology 136 (Suppl. 1), A-140\u2013A-141 (2009).","journal-title":"Gastroenterology"},{"issue":"Suppl. 1","key":"BFnrgastro201314_CR41","first-page":"A-531","volume":"134","author":"AB Ahmed","year":"2008","unstructured":"Ahmed, A. B., Matre, K., Hausken, T., Gregersen, H. & Gilja, O. H. ROME III Subgroups of functional dyspepsia exhibit different characteristics of antral strain measured by strain rate imaging [abstract]. Gastroenterology 134 (Suppl. 1), A-531 (2008).","journal-title":"Gastroenterology"},{"issue":"Suppl. 3","key":"BFnrgastro201314_CR42","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/j.1440-1746.2011.06627.x","volume":"26","author":"M Kusano","year":"2011","unstructured":"Kusano, M.  et al. Rapid gastric emptying, rather than delayed gastric emptying, might provoke functional dyspepsia. J. Gastroenterol. Hepatol. 26 (Suppl. 3), 75\u201378 (2011).","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"Suppl. 3","key":"BFnrgastro201314_CR43","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1111\/j.1440-1746.2011.06652.x","volume":"26","author":"RK Vilaichone","year":"2011","unstructured":"Vilaichone, R. K., Mahacahai, V., Tumwasorn, S. & Kachintorn, U. CagA genotype and metronidazole resistant strain of Helicobacter pylori in functional dyspepsia in Thailand. J. Gastroenterol. Hepatol. 26 (Suppl. 3), 46\u201348 (2011).","journal-title":"J. Gastroenterol. Hepatol."},{"key":"BFnrgastro201314_CR44","doi-asserted-by":"publisher","first-page":"148","DOI":"10.5056\/jnm.2010.16.2.148","volume":"16","author":"YW Noh","year":"2010","unstructured":"Noh, Y. W., Jung, H. K., Kim, S. E. & Jung, S. A. Overlap of erosive and non-erosive reflux diseases with functional gastrointestinal disorders according to Rome III criteria. J. Neurogastroenterol. Motil. 16, 148\u2013156 (2010).","journal-title":"J. Neurogastroenterol. Motil."},{"key":"BFnrgastro201314_CR45","doi-asserted-by":"publisher","first-page":"4379","DOI":"10.3748\/wjg.v18.i32.4379","volume":"18","author":"A Santonicola","year":"2012","unstructured":"Santonicola, A.  et al. Prevalence of functional dyspepsia and its subgroups in patients with eating disorders. World J. Gastroenterol. 18, 4379\u20134385 (2012).","journal-title":"World J. Gastroenterol."},{"key":"BFnrgastro201314_CR46","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1038\/ajg.2010.151","volume":"105","author":"S Futagami","year":"2010","unstructured":"Futagami, S.  et al. Migration of eosinophils and CCR2-\/CD68-double positive cells into the duodenal mucosa of patients with postinfectious functional dyspepsia. Am. J. Gastroenterol. 105, 1835\u20131842 (2010).","journal-title":"Am. J. Gastroenterol."},{"key":"BFnrgastro201314_CR47","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1016\/j.cgh.2007.05.015","volume":"5","author":"NJ Talley","year":"2007","unstructured":"Talley, N. J.  et al. Non-ulcer dyspepsia and duodenal eosinophilia: an adult endoscopic population-based case-control study. Clin. Gastroenterol. Hepatol. 5, 1175\u20131183 (2007).","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"BFnrgastro201314_CR48","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1365-2036.2009.03937.x","volume":"29","author":"MM Walker","year":"2009","unstructured":"Walker, M. M.  et al. Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia. Aliment. Pharmacol. Ther. 29, 765\u2013773 (2009).","journal-title":"Aliment. Pharmacol. Ther."},{"key":"BFnrgastro201314_CR49","doi-asserted-by":"publisher","first-page":"S170","DOI":"10.1016\/S0016-5085(12)60641-6","volume":"142","author":"KR Aggarwal","year":"2012","unstructured":"Aggarwal, K. R.  et al. Duodenal eosinophilia and early satiety in functional dyspepsia (FD): confirmation of a positive biomarker association for FD in an Australian cohort [abstract]. Gastroenterology 142, S170\u2013S171 (2012).","journal-title":"Gastroenterology"},{"key":"BFnrgastro201314_CR50","doi-asserted-by":"publisher","first-page":"S171","DOI":"10.1016\/S0016-5085(12)60643-X","volume":"142","author":"M Bafutto","year":"2012","unstructured":"Bafutto, M.  et al. Duodenal eosinophilia: a link between functional dyspepsia and post-infective functional dyspepsia [abstract]? Gastroenterology 142, S171 (2012).","journal-title":"Gastroenterology"},{"key":"BFnrgastro201314_CR51","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1471-2350-11-13","volume":"11","author":"T Oshima","year":"2010","unstructured":"Oshima, T.  et al. The G-protein \u03b23 subunit 825 TT genotype is associated with epigastric pain syndrome-like dyspepsia. BMC Med. Genet. 11, 13 (2010).","journal-title":"BMC Med. Genet."},{"key":"BFnrgastro201314_CR52","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1111\/j.1365-2982.2011.01781.x","volume":"23","author":"M Shimpuku","year":"2011","unstructured":"Shimpuku, M.  et al. G-protein \u03b23 subunit 825CC genotype is associated with postprandial distress syndrome with impaired gastric emptying and with the feeling of hunger in Japanese. Neurogastroenterol. Motil. 23, 1073\u20131080 (2011).","journal-title":"Neurogastroenterol. Motil."},{"key":"BFnrgastro201314_CR53","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/1471-2350-12-88","volume":"12","author":"F Toyoshima","year":"2011","unstructured":"Toyoshima, F.  et al. Serotonin transporter gene polymorphism may be associated with functional dyspepsia in a Japanese population. BMC Med. Genet. 12, 88 (2011).","journal-title":"BMC Med. Genet."},{"key":"BFnrgastro201314_CR54","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s00535-012-0602-3","volume":"48","author":"T Arisawa","year":"2013","unstructured":"Arisawa, T.  et al. Genetic polymorphisms of SCN10A are associated with functional dyspepsia in Japanese subjects. J. Gastroenterol. 48, 73\u201380 (2013).","journal-title":"J. Gastroenterol."},{"key":"BFnrgastro201314_CR55","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s00535-010-0334-1","volume":"46","author":"YC Hsu","year":"2011","unstructured":"Hsu, Y. C.  et al. Proton pump inhibitor versus prokinetic therapy in patients with functional dyspepsia: is therapeutic response predicted by Rome III subgroups? J. Gastroenterol. 46, 183\u2013190 (2011).","journal-title":"J. Gastroenterol."},{"key":"BFnrgastro201314_CR56","doi-asserted-by":"publisher","first-page":"2626","DOI":"10.1038\/ajg.2010.351","volume":"105","author":"YL Xiao","year":"2010","unstructured":"Xiao, Y. L.  et al. Prevalence and symptom pattern of pathologic esophageal acid reflux in patients with functional dyspepsia based on the Rome III criteria. Am. J. Gastroenterol. 105, 2626\u20132631 (2010).","journal-title":"Am. J. Gastroenterol."},{"key":"BFnrgastro201314_CR57","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1159\/000339111","volume":"86","author":"S Futagami","year":"2012","unstructured":"Futagami, S.  et al. Nizatidine improves clinical symptoms and gastric emptying in patients with functional dyspepsia accompanied by impaired gastric emptying. Digestion 86, 114\u2013121 (2012).","journal-title":"Digestion"},{"key":"BFnrgastro201314_CR58","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1517\/13543784.2011.562890","volume":"20","author":"J Tack","year":"2011","unstructured":"Tack, J. & Janssen, P. Acotiamide (Z-338, YM-443), a new drug for the treatment of functional dyspepsia. Expert Opin. Investig. Drugs 20, 701\u2013712 (2011).","journal-title":"Expert Opin. Investig. Drugs"},{"key":"BFnrgastro201314_CR59","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1111\/j.1365-2982.2009.01261.x","volume":"21","author":"J Tack","year":"2009","unstructured":"Tack, J.  et al. A dose-ranging, placebo-controlled, pilot trial of acotiamide in patients with functional dyspepsia. Neurogastroenterol. Motil. 21, 272\u2013280 (2009).","journal-title":"Neurogastroenterol. Motil."},{"key":"BFnrgastro201314_CR60","first-page":"A467","volume":"128","author":"K Matsueda","year":"2005","unstructured":"Matsueda, K.  et al. Therapeutic efficacy of novel agent (Z-338) in functional dyspepsia. Gastroenterology 128, A467 (2005).","journal-title":"Gastroenterology"},{"key":"BFnrgastro201314_CR61","doi-asserted-by":"publisher","first-page":"S805","DOI":"10.1016\/S0016-5085(11)63337-4","volume":"140","author":"JF Tack","year":"2011","unstructured":"Tack, J. F.  et al. Efficacy and safety study of acotiamide (Z-338) in European patients with functional dyspepsia. Gastroenterology 140, S805\u2013S805 (2011).","journal-title":"Gastroenterology"},{"key":"BFnrgastro201314_CR62","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1111\/j.1365-2982.2009.01449.x","volume":"22","author":"K Matsueda","year":"2010","unstructured":"Matsueda, K.  et al. Clinical trial: dose-dependent therapeutic efficacy of acotiamide hydrochloride (Z-338) in patients with functional dyspepsia\u2014100 mg t.i.d. is an optimal dosage. Neurogastroenterol. Motil. 22, 618\u2013e173 (2010).","journal-title":"Neurogastroenterol. Motil."},{"key":"BFnrgastro201314_CR63","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1136\/gutjnl-2011-301454","volume":"61","author":"K Matsueda","year":"2012","unstructured":"Matsueda, K., Hongo, M., Tack, J., Saito Y. & Kato, H. A placebo-controlled trial of acotiamide for meal-related symptoms of functional dyspepsia. Gut 61, 821\u2013828 (2012).","journal-title":"Gut"},{"key":"BFnrgastro201314_CR64","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1136\/gut.2008.158162","volume":"57","author":"L Van Oudenhove","year":"2008","unstructured":"Van Oudenhove, L.  et al. Determinants of symptoms in functional dyspepsia: gastric sensorimotor function, psychosocial factors or somatisation? Gut 57, 1666\u20131673 (2008).","journal-title":"Gut"}],"container-title":["Nature Reviews Gastroenterology & Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrgastro.2013.14.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrgastro.2013.14","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrgastro.2013.14.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T03:47:58Z","timestamp":1684468078000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrgastro.2013.14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,12]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["BFnrgastro201314"],"URL":"https:\/\/doi.org\/10.1038\/nrgastro.2013.14","relation":{},"ISSN":["1759-5045","1759-5053"],"issn-type":[{"value":"1759-5045","type":"print"},{"value":"1759-5053","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,12]]}}}