{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:05:24Z","timestamp":1791396324609,"version":"4.3.3"},"reference-count":80,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Immunol"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1038\/nri2726","type":"journal-article","created":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T10:32:07Z","timestamp":1267093927000},"page":"201-209","source":"Crossref","is-referenced-by-count":393,"title":["Awakening dormant haematopoietic stem cells"],"prefix":"10.1038","volume":"10","author":[{"given":"Andreas","family":"Trumpp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke","family":"Essers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFnri2726_CR1","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/ni1560","volume":"9","author":"E Dzierzak","year":"2008","unstructured":"Dzierzak, E. & Speck, N. A. Of lineage and legacy: the development of mammalian hematopoietic stem cells. Nature Immunol. 9, 129\u2013136 (2008).","journal-title":"Nature Immunol."},{"key":"BFnri2726_CR2","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1038\/457801a","volume":"457","author":"M Yoshimoto","year":"2009","unstructured":"Yoshimoto, M. & Yoder, M. C. Developmental biology: birth of the blood cell. Nature 457, 801\u2013803 (2009).","journal-title":"Nature"},{"key":"BFnri2726_CR3","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nri1779","volume":"6","author":"A Wilson","year":"2006","unstructured":"Wilson, A. & Trumpp, A. Bone-marrow haematopoietic-stem-cell niches. Nature Rev. Immunol. 6, 93\u2013106 (2006).","journal-title":"Nature Rev. Immunol."},{"key":"BFnri2726_CR4","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/j.1749-6632.2009.04561.x","volume":"1176","author":"F Arai","year":"2009","unstructured":"Arai, F. et al. Niche regulation of hematopoietic stem cells in the endosteum. Ann. NY Acad. Sci. 1176, 36\u201346 (2009).","journal-title":"Ann. NY Acad. Sci."},{"key":"BFnri2726_CR5","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/nri2279","volume":"8","author":"MJ Kiel","year":"2008","unstructured":"Kiel, M. J. & Morrison, S. J. Uncertainty in the niches that maintain haematopoietic stem cells. Nature Rev. Immunol. 8, 290\u2013301 (2008).","journal-title":"Nature Rev. Immunol."},{"key":"BFnri2726_CR6","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1038\/nature07815","volume":"458","author":"MA Essers","year":"2009","unstructured":"Essers, M. A. et al. IFN\u03b1 activates dormant haematopoietic stem cells in vivo. Nature 458, 904\u2013908 (2009).","journal-title":"Nature"},{"key":"BFnri2726_CR7","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1016\/j.cell.2008.10.048","volume":"135","author":"A Wilson","year":"2008","unstructured":"Wilson, A. et al. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell 135, 1118\u20131129 (2008).","journal-title":"Cell"},{"key":"BFnri2726_CR8","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1158\/1078-0432.CCR-05-0429","volume":"12","author":"HG Jorgensen","year":"2006","unstructured":"Jorgensen, H. G. et al. Intermittent exposure of primitive quiescent chronic myeloid leukemia cells to granulocyte-colony stimulating factor in vitro promotes their elimination by imatinib mesylate. Clin. Cancer Res. 12, 626\u2013633 (2006).","journal-title":"Clin. Cancer Res."},{"key":"BFnri2726_CR9","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1126\/science.273.5272.242","volume":"273","author":"M Osawa","year":"1996","unstructured":"Osawa, M., Hanada, K., Hamada, H. & Nakauchi, H. Long-term lymphohematopoietic reconstitution by a single CD34-low\/negative hematopoietic stem cell. Science 273, 242\u2013245 (1996).","journal-title":"Science"},{"key":"BFnri2726_CR10","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.stem.2007.05.015","volume":"1","author":"B Dykstra","year":"2007","unstructured":"Dykstra, B. et al. Long-term propagation of distinct hematopoietic differentiation programs in vivo. Cell Stem Cell 1, 218\u2013229 (2007).","journal-title":"Cell Stem Cell"},{"key":"BFnri2726_CR11","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1182\/blood-2005-02-0655","volume":"107","author":"FD Camargo","year":"2006","unstructured":"Camargo, F. D., Chambers, S. M., Drew, E., McNagny, K. M. & Goodell, M. A. Hematopoietic stem cells do not engraft with absolute efficiencies. Blood 107, 501\u2013507 (2006).","journal-title":"Blood"},{"key":"BFnri2726_CR12","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.devcel.2005.03.019","volume":"8","author":"H Ema","year":"2005","unstructured":"Ema, H. et al. Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice. Dev. Cell 8, 907\u2013914 (2005).","journal-title":"Dev. Cell"},{"key":"BFnri2726_CR13","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.cell.2005.05.026","volume":"121","author":"MJ Kiel","year":"2005","unstructured":"Kiel, M. J., Yilmaz, O. H., Iwashita, T., Terhorst, C. & Morrison, S. J. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 121, 1109\u20131121 (2005).","journal-title":"Cell"},{"key":"BFnri2726_CR14","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/1074-7613(94)90037-X","volume":"1","author":"SJ Morrison","year":"1994","unstructured":"Morrison, S. J. & Weissman, I. L. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity 1, 661\u2013673 (1994).","journal-title":"Immunity"},{"key":"BFnri2726_CR15","doi-asserted-by":"publisher","first-page":"3120","DOI":"10.1073\/pnas.96.6.3120","volume":"96","author":"SH Cheshier","year":"1999","unstructured":"Cheshier, S. H., Morrison, S. J., Liao, X. & Weissman, I. L. In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells. Proc. Natl Acad. Sci. USA 96, 3120\u20133125 (1999).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnri2726_CR16","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1182\/blood-2008-04-146480","volume":"113","author":"S Yamazaki","year":"2009","unstructured":"Yamazaki, S. et al. TGF-\u03b2 as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation. Blood 113, 1250\u20131256 (2009).","journal-title":"Blood"},{"key":"BFnri2726_CR17","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1084\/jem.20050967","volume":"202","author":"E Passegue","year":"2005","unstructured":"Passegue, E., Wagers, A. J., Giuriato, S., Anderson, W. C. & Weissman, I. L. Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J. Exp. Med. 202, 1599\u20131611 (2005).","journal-title":"J. Exp. Med."},{"key":"BFnri2726_CR18","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.stem.2007.10.020","volume":"1","author":"H Yoshihara","year":"2007","unstructured":"Yoshihara, H. et al. Thrombopoietin\/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell 1, 685\u2013697 (2007).","journal-title":"Cell Stem Cell"},{"key":"BFnri2726_CR19","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/nbt.1517","volume":"27","author":"A Foudi","year":"2009","unstructured":"Foudi, A. et al. Analysis of histone 2B\u2013GFP retention reveals slowly cycling hematopoietic stem cells. Nature Biotechnol. 27, 84\u201390 (2009).","journal-title":"Nature Biotechnol."},{"key":"BFnri2726_CR20","doi-asserted-by":"publisher","first-page":"e6972","DOI":"10.1371\/journal.pone.0006972","volume":"4","author":"RC van der Wath","year":"2009","unstructured":"van der Wath, R. C., Wilson, A., Laurenti, E., Trumpp, A. & Lio, P. Estimating dormant and active hematopoietic stem cell kinetics through extensive modeling of bromodeoxyuridine label-retaining cell dynamics. PLoS ONE 4, e6972 (2009).","journal-title":"PLoS ONE"},{"key":"BFnri2726_CR21","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1089\/scd.2007.0017","volume":"16","author":"SH Cheshier","year":"2007","unstructured":"Cheshier, S. H., Prohaska, S. S. & Weissman, I. L. The effect of bleeding on hematopoietic stem cell cycling and self-renewal. Stem Cells Dev. 16, 707\u2013717 (2007).","journal-title":"Stem Cells Dev."},{"key":"BFnri2726_CR22","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1038\/nature02041","volume":"425","author":"J Zhang","year":"2003","unstructured":"Zhang, J. et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425, 836\u2013841 (2003).","journal-title":"Nature"},{"key":"BFnri2726_CR23","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1101\/gad.313104","volume":"18","author":"A Wilson","year":"2004","unstructured":"Wilson, A. et al. c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. Genes Dev. 18, 2747\u20132763 (2004).","journal-title":"Genes Dev."},{"key":"BFnri2726_CR24","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.cell.2004.07.004","volume":"118","author":"F Arai","year":"2004","unstructured":"Arai, F. et al. Tie2\/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118, 149\u2013161 (2004).","journal-title":"Cell"},{"key":"BFnri2726_CR25","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/nature07434","volume":"457","author":"C Lo Celso","year":"2009","unstructured":"Lo Celso, C. et al. Live-animal tracking of individual haematopoietic stem\/progenitor cells in their niche. Nature 457, 92\u201396 (2009).","journal-title":"Nature"},{"key":"BFnri2726_CR26","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/nature07639","volume":"457","author":"Y Xie","year":"2009","unstructured":"Xie, Y. et al. Detection of functional haematopoietic stem cell niche using real-time imaging. Nature 457, 97\u2013101 (2009).","journal-title":"Nature"},{"key":"BFnri2726_CR27","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1196\/annals.1392.005","volume":"1106","author":"F Arai","year":"2007","unstructured":"Arai, F. & Suda, T. Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche. Ann. NY Acad. Sci. 1106, 41\u201353 (2007).","journal-title":"Ann. NY Acad. Sci."},{"key":"BFnri2726_CR28","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1182\/blood-2009-01-202606","volume":"114","author":"SW Lane","year":"2009","unstructured":"Lane, S. W., Scadden, D. T. & Gilliland, D. G. The leukemic stem cell niche: current concepts and therapeutic opportunities. Blood 114, 1150\u20131157 (2009).","journal-title":"Blood"},{"key":"BFnri2726_CR29","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.stem.2009.01.006","volume":"4","author":"AT Hooper","year":"2009","unstructured":"Hooper, A. T. et al. Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells. Cell Stem Cell 4, 263\u2013274 (2009).","journal-title":"Cell Stem Cell"},{"key":"BFnri2726_CR30","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/S0092-8674(02)00754-7","volume":"109","author":"B Heissig","year":"2002","unstructured":"Heissig, B. et al. Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell 109, 625\u2013637 (2002).","journal-title":"Cell"},{"key":"BFnri2726_CR31","doi-asserted-by":"publisher","first-page":"2837","DOI":"10.1084\/jem.20090778","volume":"206","author":"D Bhattacharya","year":"2009","unstructured":"Bhattacharya, D. et al. Niche recycling through division-independent egress of hematopoietic stem cells. J. Exp. Med. 206, 2837\u20132850 (2009).","journal-title":"J. Exp. Med."},{"key":"BFnri2726_CR32","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/nm1388","volume":"12","author":"K Ito","year":"2006","unstructured":"Ito, K. et al. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nature Med. 12, 446\u2013451 (2006).","journal-title":"Nature Med."},{"key":"BFnri2726_CR33","doi-asserted-by":"publisher","first-page":"3056","DOI":"10.1182\/blood-2007-05-087759","volume":"110","author":"YY Jang","year":"2007","unstructured":"Jang, Y. Y. & Sharkis, S. J. A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche. Blood 110, 3056\u20133063 (2007).","journal-title":"Blood"},{"key":"BFnri2726_CR34","doi-asserted-by":"publisher","first-page":"3339","DOI":"10.1172\/JCI26674","volume":"115","author":"K Kaushansky","year":"2005","unstructured":"Kaushansky, K. The molecular mechanisms that control thrombopoiesis. J. Clin. Invest. 115, 3339\u20133347 (2005).","journal-title":"J. Clin. Invest."},{"key":"BFnri2726_CR35","doi-asserted-by":"publisher","first-page":"2808","DOI":"10.1172\/JCI28310","volume":"116","author":"MB Bowie","year":"2006","unstructured":"Bowie, M. B. et al. Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect. J. Clin. Invest. 116, 2808\u20132816 (2006).","journal-title":"J. Clin. Invest."},{"key":"BFnri2726_CR36","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1182\/blood-2005-10-4135","volume":"108","author":"I Kim","year":"2006","unstructured":"Kim, I., He, S., Yilmaz, O. H., Kiel, M. J. & Morrison, S. J. Enhanced purification of fetal liver hematopoietic stem cells using SLAM family receptors. Blood 108, 737\u2013744 (2006).","journal-title":"Blood"},{"key":"BFnri2726_CR37","doi-asserted-by":"publisher","first-page":"5878","DOI":"10.1073\/pnas.0700460104","volume":"104","author":"MB Bowie","year":"2007","unstructured":"Bowie, M. B. et al. Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties. Proc. Natl Acad. Sci. USA 104, 5878\u20135882 (2007).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnri2726_CR38","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.cell.2007.06.011","volume":"130","author":"I Kim","year":"2007","unstructured":"Kim, I., Saunders, T. L. & Morrison, S. J. Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell 130, 470\u2013483 (2007).","journal-title":"Cell"},{"key":"BFnri2726_CR39","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.1073\/pnas.94.5.1908","volume":"94","author":"SJ Morrison","year":"1997","unstructured":"Morrison, S. J., Wright, D. E. & Weissman, I. L. Cyclophosphamide\/granulocyte colony-stimulating factor induces hematopoietic stem cells to proliferate prior to mobilization. Proc. Natl Acad. Sci. USA 94, 1908\u20131913 (1997).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnri2726_CR40","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/MOH.0b013e3282f29012","volume":"15","author":"HE Broxmeyer","year":"2008","unstructured":"Broxmeyer, H. E. Chemokines in hematopoiesis. Curr. Opin. Hematol. 15, 49\u201358 (2008).","journal-title":"Curr. Opin. Hematol."},{"key":"BFnri2726_CR41","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1038\/ni813","volume":"3","author":"I Petit","year":"2002","unstructured":"Petit, I. et al. G.-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nature Immunol. 3, 687\u2013694 (2002).","journal-title":"Nature Immunol."},{"key":"BFnri2726_CR42","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1038\/nrd2422","volume":"6","author":"EC Borden","year":"2007","unstructured":"Borden, E. C. et al. Interferons at age 50: past, current and future impact on biomedicine. Nature Rev. Drug Discov. 6, 975\u2013990 (2007).","journal-title":"Nature Rev. Drug Discov."},{"key":"BFnri2726_CR43","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1634\/theoncologist.6-1-34","volume":"6","author":"E Jonasch","year":"2001","unstructured":"Jonasch, E. & Haluska, F. G. Interferon in oncological practice: review of interferon biology, clinical applications, and toxicities. Oncologist 6, 34\u201355 (2001).","journal-title":"Oncologist"},{"key":"BFnri2726_CR44","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1189\/jlb.69.6.912","volume":"69","author":"MJ de Veer","year":"2001","unstructured":"de Veer, M. J. et al. Functional classification of interferon-stimulated genes identified using microarrays. J. Leukoc. Biol. 69, 912\u2013920 (2001).","journal-title":"J. Leukoc. Biol."},{"key":"BFnri2726_CR45","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1634\/stemcells.2006-0644","volume":"25","author":"C Holmes","year":"2007","unstructured":"Holmes, C. & Stanford, W. L. Concise review: stem cell antigen-1: expression, function, and enigma. Stem Cells 25, 1339\u20131347 (2007).","journal-title":"Stem Cells"},{"key":"BFnri2726_CR46","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1182\/blood-2002-06-1918","volume":"101","author":"CY Ito","year":"2003","unstructured":"Ito, C. Y., Li, C. Y., Bernstein, A., Dick, J. E. & Stanford, W. L. Hematopoietic stem cell and progenitor defects in Sca-1\/Ly-6A-null mice. Blood 101, 517\u201323 (2003).","journal-title":"Blood"},{"key":"BFnri2726_CR47","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1126\/science.7660125","volume":"269","author":"R Kuhn","year":"1995","unstructured":"Kuhn, R., Schwenk, F., Aguet, M. & Rajewsky, K. Inducible gene targeting in mice. Science 269, 1427\u20131429 (1995).","journal-title":"Science"},{"key":"BFnri2726_CR48","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/S1074-7613(00)80054-0","volume":"10","author":"F Radtke","year":"1999","unstructured":"Radtke, F. et al. Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity 10, 547\u2013558 (1999).","journal-title":"Immunity"},{"key":"BFnri2726_CR49","doi-asserted-by":"publisher","first-page":"2724","DOI":"10.1182\/blood-2004-08-3037","volume":"105","author":"JR Gothert","year":"2005","unstructured":"Gothert, J. R. et al. In vivo fate-tracing studies using the Scl stem cell enhancer: embryonic hematopoietic stem cells significantly contribute to adult hematopoiesis. Blood 105, 2724\u20132732 (2005).","journal-title":"Blood"},{"key":"BFnri2726_CR50","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/nm.1973","volume":"15","author":"T Sato","year":"2009","unstructured":"Sato, T. et al. Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion. Nature Med. 15, 696\u2013700 (2009).","journal-title":"Nature Med."},{"key":"BFnri2726_CR51","doi-asserted-by":"publisher","first-page":"e301","DOI":"10.1371\/journal.pbio.0020301","volume":"2","author":"TA Venezia","year":"2004","unstructured":"Venezia, T. A. et al. Molecular signatures of proliferation and quiescence in hematopoietic stem cells. PLoS Biol. 2, e301 (2004).","journal-title":"PLoS Biol."},{"key":"BFnri2726_CR52","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.stem.2007.10.007","volume":"2","author":"CG Feng","year":"2008","unstructured":"Feng, C. G., Weksberg, D. C., Taylor, G. A., Sher, A. & Goodell, M. A. The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation. Cell Stem Cell 2, 83\u201389 (2008).","journal-title":"Cell Stem Cell"},{"key":"BFnri2726_CR53","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.virol.2008.07.029","volume":"380","author":"CX George","year":"2008","unstructured":"George, C. X., Das, S. & Samuel, C. E. Organization of the mouse RNA-specific adenosine deaminase Adar1 gene 5\u2032-region and demonstration of STAT1-independent, STAT2-dependent transcriptional activation by interferon. Virology 380, 338\u2013343 (2008).","journal-title":"Virology"},{"key":"BFnri2726_CR54","doi-asserted-by":"publisher","first-page":"4621","DOI":"10.1073\/pnas.96.8.4621","volume":"96","author":"CX George","year":"1999","unstructured":"George, C. X. & Samuel, C. E. Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible. Proc. Natl Acad. Sci. USA 96, 4621\u20134626 (1999).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnri2726_CR55","doi-asserted-by":"publisher","first-page":"15020","DOI":"10.1074\/jbc.M500476200","volume":"280","author":"CX George","year":"2005","unstructured":"George, C. X., Wagner, M. V. & Samuel, C. E. Expression of interferon-inducible RNA adenosine deaminase ADAR1 during pathogen infection and mouse embryo development involves tissue-selective promoter utilization and alternative splicing. J. Biol. Chem. 280, 15020\u201315028 (2005).","journal-title":"J. Biol. Chem."},{"key":"BFnri2726_CR56","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/ni.1680","volume":"10","author":"JC Hartner","year":"2009","unstructured":"Hartner, J. C., Walkley, C. R., Lu, J. & Orkin, S. H. ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling. Nature Immunol. 10, 109\u2013115 (2009).","journal-title":"Nature Immunol."},{"key":"BFnri2726_CR57","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.gde.2009.08.005","volume":"19","author":"A Wilson","year":"2009","unstructured":"Wilson, A., Laurenti, E. & Trumpp, A. Balancing dormant and self-renewing hematopoietic stem cells. Curr. Opin. Genet. Dev. 19, 461\u2013468 (2009).","journal-title":"Curr. Opin. Genet. Dev."},{"key":"BFnri2726_CR58","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/nrg2269","volume":"9","author":"KW Orford","year":"2008","unstructured":"Orford, K. W. & Scadden, D. T. Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation. Nature Rev. Genet. 9, 115\u2013128 (2008).","journal-title":"Nature Rev. Genet."},{"key":"BFnri2726_CR59","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1038\/leu.2009.142","volume":"23","author":"JM Goldman","year":"2009","unstructured":"Goldman, J. M. et al. Chronic myeloproliferative diseases with and without the Ph chromosome: some unresolved issues. Leukemia 23, 1708\u20131715 (2009).","journal-title":"Leukemia"},{"key":"BFnri2726_CR60","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1182\/blood-2004-04-1335","volume":"104","author":"J Cortes","year":"2004","unstructured":"Cortes, J., O'Brien, S. & Kantarjian, H. Discontinuation of imatinib therapy after achieving a molecular response. Blood 104, 2204\u20132205 (2004).","journal-title":"Blood"},{"key":"BFnri2726_CR61","doi-asserted-by":"publisher","first-page":"6041","DOI":"10.1200\/JCO.2009.25.0779","volume":"27","author":"M Baccarani","year":"2009","unstructured":"Baccarani, M. et al. Chronic myeloid leukemia: an update of concepts and management recommendations of European LeukemiaNet. J. Clin. Oncol. 27, 6041\u20136051 (2009).","journal-title":"J. Clin. Oncol."},{"key":"BFnri2726_CR62","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1038\/nm1487","volume":"12","author":"I Roeder","year":"2006","unstructured":"Roeder, I. et al. Dynamic modeling of imatinib-treated chronic myeloid leukemia: functional insights and clinical implications. Nature Med. 12, 1181\u20131184 (2006).","journal-title":"Nature Med."},{"key":"BFnri2726_CR63","doi-asserted-by":"publisher","first-page":"e1000503","DOI":"10.1371\/journal.pcbi.1000503","volume":"5","author":"J Foo","year":"2009","unstructured":"Foo, J., Drummond, M. W., Clarkson, B., Holyoake, T. & Michor, F. Eradication of chronic myeloid leukemia stem cells: a novel mathematical model predicts no therapeutic benefit of adding G-CSF to imatinib. PLoS Comput. Biol. 5, e1000503 (2009).","journal-title":"PLoS Comput. Biol."},{"key":"BFnri2726_CR64","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1038\/nature07016","volume":"453","author":"K Ito","year":"2008","unstructured":"Ito, K. et al. PML targeting eradicates quiescent leukaemia-initiating cells. Nature 453, 1072\u20131078 (2008).","journal-title":"Nature"},{"key":"BFnri2726_CR65","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1038\/nm.1891","volume":"14","author":"R Nasr","year":"2008","unstructured":"Nasr, R. et al. Eradication of acute promyelocytic leukemia-initiating cells through PML\u2013RARA degradation. Nature Med. 14, 1333\u20131342 (2008).","journal-title":"Nature Med."},{"key":"BFnri2726_CR66","doi-asserted-by":"publisher","first-page":"6321","DOI":"10.1158\/1078-0432.CCR-09-0209","volume":"15","author":"R Nasr","year":"2009","unstructured":"Nasr, R., Lallemand-Breitenbach, V., Zhu, J., Guillemin, M. C. & de The, H. Therapy-induced PML\/RARA proteolysis and acute promyelocytic leukemia cure. Clin. Cancer Res. 15, 6321\u20136326 (2009).","journal-title":"Clin. Cancer Res."},{"key":"BFnri2726_CR67","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1038\/leu.2009.43","volume":"23","author":"MW Drummond","year":"2009","unstructured":"Drummond, M. W. et al. A pilot study of continuous imatinib vs pulsed imatinib with or without G-CSF in CML patients who have achieved a complete cytogenetic response. Leukemia 23, 1199\u20131201 (2009).","journal-title":"Leukemia"},{"key":"BFnri2726_CR68","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.cytogfr.2007.06.015","volume":"18","author":"LA Kujawski","year":"2007","unstructured":"Kujawski, L. A. & Talpaz, M. The role of interferon-\u03b1 in the treatment of chronic myeloid leukemia. Cytokine Growth Factor Rev. 18, 459\u2013471 (2007).","journal-title":"Cytokine Growth Factor Rev."},{"key":"BFnri2726_CR69","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.6004\/jnccn.2008.0001","volume":"6","author":"A Hochhaus","year":"2008","unstructured":"Hochhaus, A. First-line management of CML: a state of the art review. J. Natl Compr. Canc. Netw. 6, S1\u2013S10 (2008).","journal-title":"J. Natl Compr. Canc. Netw."},{"key":"BFnri2726_CR70","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/j.1600-065X.2008.00600.x","volume":"222","author":"M Johansson","year":"2008","unstructured":"Johansson, M., Denardo, D. G. & Coussens, L. M. Polarized immune responses differentially regulate cancer development. Immunol. Rev. 222, 145\u2013154 (2008).","journal-title":"Immunol. Rev."},{"key":"BFnri2726_CR71","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/nature04247","volume":"439","author":"GB Adams","year":"2006","unstructured":"Adams, G. B. et al. Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor. Nature 439, 599\u2013603 (2006).","journal-title":"Nature"},{"key":"BFnri2726_CR72","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/j.1749-6632.2001.tb03583.x","volume":"938","author":"M Ogawa","year":"2001","unstructured":"Ogawa, M. et al. CD34 expression by murine hematopoietic stem cells. Developmental changes and kinetic alterations. Ann. NY Acad. Sci. 938, 139\u2013145 (2001).","journal-title":"Ann. NY Acad. Sci."},{"key":"BFnri2726_CR73","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1182\/blood.V87.10.4057.bloodjournal87104057","volume":"87","author":"TD Randall","year":"1996","unstructured":"Randall, T. D., Lund, F. E., Howard, M. C. & Weissman, I. L. Expression of murine CD38 defines a population of long-term reconstituting hematopoietic stem cells. Blood 87, 4057\u20134067 (1996).","journal-title":"Blood"},{"key":"BFnri2726_CR74","doi-asserted-by":"publisher","first-page":"15468","DOI":"10.1073\/pnas.202614899","volume":"99","author":"CZ Chen","year":"2002","unstructured":"Chen, C. Z. et al. Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells. Proc. Natl Acad. Sci. USA 99, 15468\u201315473 (2002).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnri2726_CR75","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/S1074-7613(03)00265-6","volume":"19","author":"CZ Chen","year":"2003","unstructured":"Chen, C. Z., Li, L., Li, M. & Lodish, H. F. The endoglinpositive sca-1positive rhodaminelow phenotype defines a near-homogeneous population of long-term repopulating hematopoietic stem cells. Immunity 19, 525\u2013533 (2003).","journal-title":"Immunity"},{"key":"BFnri2726_CR76","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.1182\/blood.V80.12.3044.3044","volume":"80","author":"S Okada","year":"1992","unstructured":"Okada, S. et al. In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells. Blood 80, 3044\u20133050 (1992).","journal-title":"Blood"},{"key":"BFnri2726_CR77","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.1182\/blood-2005-06-2249","volume":"107","author":"AB Balazs","year":"2006","unstructured":"Balazs, A. B., Fabian, A. J., Esmon, C. T. & Mulligan, R. C. Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow. Blood 107, 2317\u20132321 (2006).","journal-title":"Blood"},{"key":"BFnri2726_CR78","doi-asserted-by":"publisher","first-page":"6342","DOI":"10.1182\/blood-2008-12-192054","volume":"113","author":"DG Kent","year":"2009","unstructured":"Kent, D. G. et al. Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential. Blood 113, 6342\u20136350 (2009).","journal-title":"Blood"},{"key":"BFnri2726_CR79","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/j.immuni.2006.10.016","volume":"25","author":"T Sugiyama","year":"2006","unstructured":"Sugiyama, T., Kohara, H., Noda, M. & Nagasawa, T. Maintenance of the hematopoietic stem cell pool by CXCL12\u2013CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 25, 977\u2013988 (2006).","journal-title":"Immunity"},{"key":"BFnri2726_CR80","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1126\/science.2898810","volume":"241","author":"GJ Spangrude","year":"1988","unstructured":"Spangrude, G. J., Heimfeld, S. & Weissman, I. L. Purification and characterization of mouse hematopoietic stem cells. Science 241, 58\u201362 (1988).","journal-title":"Science"}],"container-title":["Nature Reviews Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nri2726.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nri2726","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nri2726.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T12:55:32Z","timestamp":1711284932000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nri2726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":80,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["BFnri2726"],"URL":"https:\/\/doi.org\/10.1038\/nri2726","relation":{},"ISSN":["1474-1733","1474-1741"],"issn-type":[{"value":"1474-1733","type":"print"},{"value":"1474-1741","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}