{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T06:04:42Z","timestamp":1792821882714,"version":"4.5.0"},"reference-count":105,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T00:00:00Z","timestamp":1472515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T00:00:00Z","timestamp":1472515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Rev Microbiol"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1038\/nrmicro.2016.125","type":"journal-article","created":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T05:01:19Z","timestamp":1472533279000},"page":"707-715","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":349,"title":["Zika virus \u2014 reigniting the TORCH"],"prefix":"10.1038","volume":"14","author":[{"given":"Carolyn B.","family":"Coyne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen M.","family":"Lazear","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,30]]},"reference":[{"key":"BFnrmicro2016125_CR1","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/0035-9203(52)90042-4","volume":"46","author":"GW Dick","year":"1952","unstructured":"Dick, G. W., Kitchen, S. F. & Haddow, A. J. Zika virus. I. Isolations and serological specificity. Trans. R. Soc. Trop. Med. Hyg. 46, 509\u2013520 (1952).","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"BFnrmicro2016125_CR2","doi-asserted-by":"publisher","first-page":"4864","DOI":"10.1128\/JVI.00252-16","volume":"90","author":"HM Lazear","year":"2016","unstructured":"Lazear, H. M. & Diamond, M. S. Zika virus: new clinical syndromes and its emergence in the Western hemisphere. J. Virol. 90, 4864\u20134875 (2016).","journal-title":"J. Virol."},{"key":"BFnrmicro2016125_CR3","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1056\/NEJMp1600297","volume":"374","author":"AS Fauci","year":"2016","unstructured":"Fauci, A. S. & Morens, D. M. Zika virus in the Americas \u2014 yet another arbovirus threat. N. Engl. J. Med. 374, 601\u2013604 (2016).","journal-title":"N. Engl. J. Med."},{"key":"BFnrmicro2016125_CR4","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/0035-9203(64)90201-9","volume":"58","author":"DI Simpson","year":"1964","unstructured":"Simpson, D. I. Zika virus infection in man. Trans. R. Soc. Trop. Med. Hyg. 58, 335\u2013338 (1964).","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"BFnrmicro2016125_CR5","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/0035-9203(56)90090-6","volume":"50","author":"WG Bearcroft","year":"1956","unstructured":"Bearcroft, W. G. Zika virus infection experimentally induced in a human volunteer. Trans. R. Soc. Trop. Med. Hyg. 50, 442\u2013448 (1956).","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"BFnrmicro2016125_CR6","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1590\/0074-02760150192","volume":"110","author":"C Zanluca","year":"2015","unstructured":"Zanluca, C. et al. First report of autochthonous transmission of Zika virus in Brazil. Mem. Inst. Oswaldo Cruz 110, 569\u2013572 (2015).","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"BFnrmicro2016125_CR7","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.3201\/eid2110.150847","volume":"21","author":"GS Campos","year":"2015","unstructured":"Campos, G. S., Bandeira, A. C. & Sardi, S. I. Zika virus outbreak, Bahia, Brazil. Emerg. Infect. Dis. 21, 1885\u20131886 (2015).","journal-title":"Emerg. Infect. Dis."},{"key":"BFnrmicro2016125_CR8","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1126\/science.aaf5036","volume":"352","author":"NR Faria","year":"2016","unstructured":"Faria, N. R. et al. Zika virus in the Americas: Early epidemiological and genetic findings. Science 352, 345\u2013349 (2016).","journal-title":"Science"},{"key":"BFnrmicro2016125_CR9","doi-asserted-by":"publisher","first-page":"59","DOI":"10.15585\/mmwr.mm6503e2","volume":"65","author":"L Schuler-Faccini","year":"2016","unstructured":"Schuler-Faccini, L. et al. Possible association between Zika virus infection and microcephaly \u2014 Brazil, 2015. MMWR. Morb. Mortal. Wkly Rep. 65, 59\u201362 (2016).","journal-title":"MMWR. Morb. Mortal. Wkly Rep."},{"key":"BFnrmicro2016125_CR10","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1016\/S0140-6736(16)00651-6","volume":"387","author":"S Cauchemez","year":"2016","unstructured":"Cauchemez, S. et al. Association between Zika virus and microcephaly in French Polynesia, 2013\u201315: a retrospective study. Lancet 387, 2125\u20132132 (2016).","journal-title":"Lancet"},{"key":"BFnrmicro2016125_CR11","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1002\/uog.15831","volume":"47","author":"AS Oliveira Melo","year":"2016","unstructured":"Oliveira Melo, A. S. et al. Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg? Ultrasound Obstet. Gynecol. 47, 6\u20137 (2016).","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"BFnrmicro2016125_CR12","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/S0140-6736(16)00006-4","volume":"387","author":"CV Ventura","year":"2016","unstructured":"Ventura, C. V., Maia, M., Bravo-Filho, V., Gois, A. L. & Belfort, R. Zika virus in Brazil and macular atrophy in a child with microcephaly. Lancet 387, 228 (2016).","journal-title":"Lancet"},{"key":"BFnrmicro2016125_CR13","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1056\/NEJMsr1604338","volume":"374","author":"SA Rasmussen","year":"2016","unstructured":"Rasmussen, S. A., Jamieson, D. J., Honein, M. A. & Petersen, L. R. Zika virus and birth defects \u2014 reviewing the evidence for causality. N. Engl. J. Med. 374, 1981\u20131987 (2016).","journal-title":"N. Engl. J. Med."},{"key":"BFnrmicro2016125_CR14","doi-asserted-by":"publisher","first-page":"e0004517","DOI":"10.1371\/journal.pntd.0004517","volume":"10","author":"M Sarno","year":"2016","unstructured":"Sarno, M. et al. Zika virus infection and stillbirths: a case of hydrops fetalis, hydranencephaly and fetal demise. PLoS Negl. Trop. Dis. 10, e0004517 (2016).","journal-title":"PLoS Negl. Trop. Dis."},{"key":"BFnrmicro2016125_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1056\/NEJMp1605367","volume":"375","author":"MA Johansson","year":"2016","unstructured":"Johansson, M. A., Mier-y- Teran-Romero, L., Reefhuis, J., Gilboa, S. M. & Hills, S. L. Zika and the risk of microcephaly. N. Engl. J. Med. 375, 1\u20134 (2016).","journal-title":"N. Engl. J. Med."},{"key":"BFnrmicro2016125_CR16","doi-asserted-by":"publisher","unstructured":"Franca, G. V. et al. Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation. Lancet http:\/\/dx.doi.org\/10.1016\/S0140-6736(16)30902-3 (2016).","DOI":"10.1016\/S0140-6736(16)30902-3"},{"key":"BFnrmicro2016125_CR17","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1007\/s004310100813","volume":"160","author":"JR Corona-Rivera","year":"2001","unstructured":"Corona-Rivera, J. R. et al. Report and review of the fetal brain disruption sequence. Eur. J. Pediatr. 160, 664\u2013667 (2001).","journal-title":"Eur. J. Pediatr."},{"key":"BFnrmicro2016125_CR18","doi-asserted-by":"publisher","first-page":"315","DOI":"10.15585\/mmwr.mm6512e2","volume":"65","author":"EE Petersen","year":"2016","unstructured":"Petersen, E. E. et al. Update: interim guidance for health care providers caring for women of reproductive age with possible Zika virus exposure \u2014 United States, 2016. MMWR. Morb. Mortal. Wkly Rep. 65, 315\u2013322 (2016).","journal-title":"MMWR. Morb. Mortal. Wkly Rep."},{"key":"BFnrmicro2016125_CR19","doi-asserted-by":"publisher","unstructured":"Brasil, P. et al. Zika virus infection in pregnant women in Rio de Janeiro \u2014 preliminary report. N. Engl. J. Med. http:\/\/dx.doi.org\/10.1056\/NEJMoa1602412 (2016).","DOI":"10.1056\/NEJMoa1602412"},{"key":"BFnrmicro2016125_CR20","first-page":"1","volume":"79","author":"CV Ventura","year":"2016","unstructured":"Ventura, C. V. et al. Ophthalmological findings in infants with microcephaly and presumable intra-uterus Zika virus infection. Arq. Bras. Oftalmol. 79, 1\u20133 (2016).","journal-title":"Arq. Bras. Oftalmol."},{"key":"BFnrmicro2016125_CR21","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.jinf.2016.02.011","volume":"72","author":"JF Chan","year":"2016","unstructured":"Chan, J. F., Choi, G. K., Yip, C. C., Cheng, V. C. & Yuen, K. Y. Zika fever and congenital Zika syndrome: An unexpected emerging arboviral disease. J. Infect. 72, 507\u2013524 (2016).","journal-title":"J. Infect."},{"key":"BFnrmicro2016125_CR22","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/S0002-9378(87)80371-X","volume":"157","author":"J Hustin","year":"1987","unstructured":"Hustin, J. & Schaaps, J. P. Echographic [corrected] and anatomic studies of the maternotrophoblastic border during the first trimester of pregnancy. Am. J. Obstet. Gynecol. 157, 162\u2013168 (1987).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"BFnrmicro2016125_CR23","first-page":"451","volume":"36","author":"JM Foidart","year":"1992","unstructured":"Foidart, J. M., Hustin, J., Dubois, M. & Schaaps, J. P. The human placenta becomes haemochorial at the 13th week of pregnancy. Int. J. Dev. Biol. 36, 451\u2013453 (1992).","journal-title":"Int. J. Dev. Biol."},{"key":"BFnrmicro2016125_CR24","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/S0002-9378(99)70518-1","volume":"181","author":"GJ Burton","year":"1999","unstructured":"Burton, G. J., Jauniaux, E. & Watson, A. L. Maternal arterial connections to the placental intervillous space during the first trimester of human pregnancy: the Boyd collection revisited. Am. J. Obstet. Gynecol. 181, 718\u2013724 (1999).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"BFnrmicro2016125_CR25","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/0002-9378(71)90580-1","volume":"110","author":"AJ Nahmias","year":"1971","unstructured":"Nahmias, A. J. et al. Perinatal risk associated with maternal genital herpes simplex virus infection. Am. J. Obstet. Gynecol. 110, 825\u2013837 (1971).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"BFnrmicro2016125_CR26","doi-asserted-by":"publisher","first-page":"3311","DOI":"10.1016\/S0264-410X(01)00073-1","volume":"19","author":"SA Plotkin","year":"2001","unstructured":"Plotkin, S. A. Rubella eradication. Vaccine 19, 3311\u20133319 (2001).","journal-title":"Vaccine"},{"key":"BFnrmicro2016125_CR27","first-page":"186","volume":"2","author":"J Schantz-Dunn","year":"2009","unstructured":"Schantz-Dunn, J. & Nour, N. M. Malaria and pregnancy: a global health perspective. Rev. Obstet. Gynecol. 2, 186\u2013192 (2009).","journal-title":"Rev. Obstet. Gynecol."},{"key":"BFnrmicro2016125_CR28","doi-asserted-by":"publisher","unstructured":"Martines, R. B. et al. Pathology of congenital Zika syndrome in Brazil: a case series. Lancet http:\/\/dx.doi.org\/10.1016\/S0140-6736(16)30883-2 (2016).","DOI":"10.1016\/S0140-6736(16)30883-2"},{"key":"BFnrmicro2016125_CR29","doi-asserted-by":"publisher","unstructured":"Pacheco, O. et al. Zika virus disease in Colombia \u2014 preliminary report. N. Engl. J. Med. http:\/\/dx.doi.org\/10.1056\/NEJMoa1604037 (2016).","DOI":"10.1056\/NEJMoa1604037"},{"key":"BFnrmicro2016125_CR30","doi-asserted-by":"publisher","first-page":"2502","DOI":"10.1016\/S0140-6736(16)30776-0","volume":"387","author":"CV Ventura","year":"2016","unstructured":"Ventura, C. V., Maia, M., Dias, N., Ventura, L. O. & Belfort, R. Zika: neurological and ocular findings in infant without microcephaly. Lancet 387, 2502 (2016).","journal-title":"Lancet"},{"key":"BFnrmicro2016125_CR31","unstructured":"US National Institutes of Health. NIH launches large study of pregnant women in areas affected by Zika virus. NIH https:\/\/www.nih.gov\/news-events\/news-releases\/nih-launches-large-study-pregnant-women-areas-affected-zika-virus (2016)."},{"key":"BFnrmicro2016125_CR32","doi-asserted-by":"publisher","first-page":"e1000732","DOI":"10.1371\/journal.ppat.1000732","volume":"6","author":"JR Robbins","year":"2010","unstructured":"Robbins, J. R., Skrzypczynska, K. M., Zeldovich, V. B., Kapidzic, M. & Bakardjiev, A. I. Placental syncytiotrophoblast constitutes a major barrier to vertical transmission of Listeria monocytogenes. PLoS Pathog. 6, e1000732 (2010).","journal-title":"PLoS Pathog."},{"key":"BFnrmicro2016125_CR33","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1128\/IAI.05899-11","volume":"80","author":"JR Robbins","year":"2012","unstructured":"Robbins, J. R., Zeldovich, V. B., Poukchanski, A., Boothroyd, J. C. & Bakardjiev, A. I. Tissue barriers of the human placenta to infection with Toxoplasma gondii. Infect. Immun. 80, 418\u2013428 (2012).","journal-title":"Infect. Immun."},{"key":"BFnrmicro2016125_CR34","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.ajog.2014.07.060","volume":"212","author":"A Bayer","year":"2015","unstructured":"Bayer, A. et al. Human trophoblasts confer resistance to viruses implicated in perinatal infection. Am. J. Obstet. Gynecol. 212, 71 (2015).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"BFnrmicro2016125_CR35","doi-asserted-by":"publisher","first-page":"12048","DOI":"10.1073\/pnas.1304718110","volume":"110","author":"E Delorme-Axford","year":"2013","unstructured":"Delorme-Axford, E. et al. Human placental trophoblasts confer viral resistance to recipient cells. Proc. Natl Acad. Sci. USA 110, 12048\u201312053 (2013).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrmicro2016125_CR36","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/j.chom.2016.03.008","volume":"19","author":"A Bayer","year":"2016","unstructured":"Bayer, A. et al. Type III interferons produced by human placental trophoblasts confer protection against Zika virus infection. Cell Host Microbe 19, 705\u2013712 (2016).","journal-title":"Cell Host Microbe"},{"key":"BFnrmicro2016125_CR37","doi-asserted-by":"publisher","first-page":"e1003821","DOI":"10.1371\/journal.ppat.1003821","volume":"9","author":"VB Zeldovich","year":"2013","unstructured":"Zeldovich, V. B. et al. Placental syncytium forms a biophysical barrier against pathogen invasion. PLoS Pathog. 9, e1003821 (2013).","journal-title":"PLoS Pathog."},{"key":"BFnrmicro2016125_CR38","doi-asserted-by":"publisher","unstructured":"Tabata, T. et al. Zika virus targets different primary human placental cells, suggesting two routes for vertical transmission. Cell Host Microbe http:\/\/dx.doi.org\/10.1016\/j.chom.2016.07.002 (2016).","DOI":"10.1016\/j.chom.2016.07.002"},{"key":"BFnrmicro2016125_CR39","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1056\/NEJMoa1601824","volume":"374","author":"RW Driggers","year":"2016","unstructured":"Driggers, R. W. et al. Zika virus infection with prolonged maternal viremia and fetal brain abnormalities. N. Engl. J. Med. 374, 2142\u20132151 (2016).","journal-title":"N. Engl. J. Med."},{"key":"BFnrmicro2016125_CR40","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/j.cell.2016.05.008","volume":"165","author":"JJ Miner","year":"2016","unstructured":"Miner, J. J. et al. Zika virus infection during pregnancy in mice causes placental damage and fetal demise. Cell 165, 1081\u20131091 (2016).","journal-title":"Cell"},{"key":"BFnrmicro2016125_CR41","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1172\/JCI41211","volume":"120","author":"E Maltepe","year":"2010","unstructured":"Maltepe, E., Bakardjiev, A. I. & Fisher, S. J. The placenta: transcriptional, epigenetic, and physiological integration during development. J. Clin. Invest. 120, 1016\u20131025 (2010).","journal-title":"J. Clin. Invest."},{"key":"BFnrmicro2016125_CR42","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.tim.2016.06.002","volume":"24","author":"K Kim","year":"2016","unstructured":"Kim, K. & Shresta, S. Neuroteratogenic viruses and lessons for Zika virus models. Trends Microbiol. 24, 622\u2013636 (2016).","journal-title":"Trends Microbiol."},{"key":"BFnrmicro2016125_CR43","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.chom.2016.05.015","volume":"20","author":"KM Quicke","year":"2016","unstructured":"Quicke, K. M. et al. Zika virus infects human placental macrophages. Cell Host Microbe 20, 83\u201390 (2016).","journal-title":"Cell Host Microbe"},{"key":"BFnrmicro2016125_CR44","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1001\/jama.291.9.1127","volume":"291","author":"KM Adams","year":"2004","unstructured":"Adams, K. M. & Nelson, J. L. Microchimerism: an investigative frontier in autoimmunity and transplantation. JAMA 291, 1127\u20131131 (2004).","journal-title":"JAMA"},{"key":"BFnrmicro2016125_CR45","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.2353\/ajpath.2006.050482","volume":"168","author":"E Maidji","year":"2006","unstructured":"Maidji, E., McDonagh, S., Genbacev, O., Tabata, T. & Pereira, L. Maternal antibodies enhance or prevent cytomegalovirus infection in the placenta by neonatal Fc receptor-mediated transcytosis. Am. J. Pathol. 168, 1210\u20131226 (2006).","journal-title":"Am. J. Pathol."},{"key":"BFnrmicro2016125_CR46","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1007\/s00705-013-1645-3","volume":"158","author":"MG Guzman","year":"2013","unstructured":"Guzman, M. G., Alvarez, M. & Halstead, S. B. Secondary infection as a risk factor for dengue hemorrhagic fever\/dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of infection. Arch. Virol. 158, 1445\u20131459 (2013).","journal-title":"Arch. Virol."},{"key":"BFnrmicro2016125_CR47","doi-asserted-by":"publisher","first-page":"e1004386","DOI":"10.1371\/journal.ppat.1004386","volume":"10","author":"R de Alwis","year":"2014","unstructured":"de Alwis, R. et al. Dengue viruses are enhanced by distinct populations of serotype cross-reactive antibodies in human immune sera. PLoS Pathog. 10, e1004386 (2014).","journal-title":"PLoS Pathog."},{"key":"BFnrmicro2016125_CR48","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1093\/infdis\/jiw143","volume":"214","author":"PM Castanha","year":"2016","unstructured":"Castanha, P. M. et al. Placental transfer of dengue virus (DENV)-specific antibodies and kinetics of DENV infection-enhancing activity in Brazilian infants. J. Infect. Dis. 214, 265\u2013272 (2016).","journal-title":"J. Infect. Dis."},{"key":"BFnrmicro2016125_CR49","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.3201\/eid1408.080287","volume":"14","author":"RS Lanciotti","year":"2008","unstructured":"Lanciotti, R. S. et al. Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg. Infect. Dis. 14, 1232\u20131239 (2008).","journal-title":"Emerg. Infect. Dis."},{"key":"BFnrmicro2016125_CR50","doi-asserted-by":"publisher","unstructured":"Dejnirattisai, W. et al. Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with Zika virus. Nat. Immunol. http:\/\/dx.doi.org\/10.1038\/ni.3515 (2016).","DOI":"10.1038\/ni.3515"},{"key":"BFnrmicro2016125_CR51","doi-asserted-by":"publisher","first-page":"7852","DOI":"10.1073\/pnas.1607931113","volume":"113","author":"L Priyamvada","year":"2016","unstructured":"Priyamvada, L. et al. Human antibody responses after Dengue virus infection are highly cross-reactive to Zika virus. Proc. Natl Acad. Sci. USA 113, 7852\u20137857 (2016).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrmicro2016125_CR52","doi-asserted-by":"publisher","first-page":"e01123-16","DOI":"10.1128\/mBio.01123-16","volume":"7","author":"JA Swanstrom","year":"2016","unstructured":"Swanstrom, J. A. et al. Dengue virus envelope dimer epitope monoclonal antibodies isolated from dengue patients are protective against Zika virus. mBio 7, e01123-16 (2016).","journal-title":"mBio"},{"key":"BFnrmicro2016125_CR53","doi-asserted-by":"publisher","unstructured":"Stettler, K. et al. Specificity, cross-reactivity and function of antibodies elicited by Zika virus infection. Science http:\/\/dx.doi.org\/10.1126\/science.aaf8505 (2016).","DOI":"10.1126\/science.aaf8505"},{"key":"BFnrmicro2016125_CR54","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S0002-9378(16)36111-7","volume":"82","author":"J Dancis","year":"1961","unstructured":"Dancis, J., Lind, J., Oratz, M., Smolens, J. & Vara, P. Placental transfer of proteins in human gestation. Am. J. Obstet. Gynecol. 82, 167\u2013171 (1961).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"BFnrmicro2016125_CR55","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1177\/43.9.7642966","volume":"43","author":"NA Bright","year":"1995","unstructured":"Bright, N. A. & Ockleford, C. D. Cytotrophoblast cells: a barrier to maternofetal transmission of passive immunity. J. Histochem. Cytochem. 43, 933\u2013944 (1995).","journal-title":"J. Histochem. Cytochem."},{"key":"BFnrmicro2016125_CR56","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/S0002-9378(16)34434-9","volume":"103","author":"JP Gusdon","year":"1969","unstructured":"Gusdon, J. P. Fetal and maternal immunoglobulin levels during pregnancy. Am. J. Obstet. Gynecol. 103, 895\u2013900 (1969).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"BFnrmicro2016125_CR57","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1128\/cdli.1.6.667-669.1994","volume":"1","author":"BZ Garty","year":"1994","unstructured":"Garty, B. Z., Ludomirsky, A., Danon, Y. L., Peter, J. B. & Douglas, S. D. Placental transfer of immunoglobulin G subclasses. Clin. Diagn. Lab Immunol. 1, 667\u2013669 (1994).","journal-title":"Clin. Diagn. Lab Immunol."},{"key":"BFnrmicro2016125_CR58","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1111\/j.1600-0897.1996.tb00172.x","volume":"36","author":"A Malek","year":"1996","unstructured":"Malek, A., Sager, R., Kuhn, P., Nicolaides, K. H. & Schneider, H. Evolution of maternofetal transport of immunoglobulins during human pregnancy. Am. J. Reprod. Immunol. 36, 248\u2013255 (1996).","journal-title":"Am. J. Reprod. Immunol."},{"key":"BFnrmicro2016125_CR59","doi-asserted-by":"publisher","first-page":"12204","DOI":"10.1038\/ncomms12204","volume":"7","author":"DM Dudley","year":"2016","unstructured":"Dudley, D. M. et al. A rhesus macaque model of Asian-lineage Zika virus infection. Nat. Commun. 7, 12204 (2016).","journal-title":"Nat. Commun."},{"key":"BFnrmicro2016125_CR60","doi-asserted-by":"publisher","unstructured":"Prisant, N. et al. Zika virus in the female genital tract. Lancet Infect. Dis. http:\/\/dx.doi.org\/10.1016\/S1473-3099(16)30193-1 (2016).","DOI":"10.1016\/S1473-3099(16)30193-1"},{"key":"BFnrmicro2016125_CR61","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1056\/NEJMoa1600651","volume":"374","author":"J Mlakar","year":"2016","unstructured":"Mlakar, J. et al. Zika virus associated with microcephaly. N. Engl. J. Med. 374, 951\u2013958 (2016).","journal-title":"N. Engl. J. Med."},{"key":"BFnrmicro2016125_CR62","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1016\/j.cell.2016.04.032","volume":"165","author":"X Qian","year":"2016","unstructured":"Qian, X. et al. Brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure. Cell 165, 1238\u20131254 (2016).","journal-title":"Cell"},{"key":"BFnrmicro2016125_CR63","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1016\/j.celrep.2016.05.075","volume":"15","author":"NW Hanners","year":"2016","unstructured":"Hanners, N. W. et al. Western Zika virus in human fetal neural progenitors persists long term with partial cytopathic and limited immunogenic effects. Cell Rep. 15, 2315\u20132322 (2016).","journal-title":"Cell Rep."},{"key":"BFnrmicro2016125_CR64","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.stem.2016.02.016","volume":"18","author":"H Tang","year":"2016","unstructured":"Tang, H. et al. Zika virus infects human cortical neural progenitors and attenuates their growth. Cell Stem Cell 18, 587\u2013590 (2016).","journal-title":"Cell Stem Cell"},{"key":"BFnrmicro2016125_CR65","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1126\/science.aaf6116","volume":"352","author":"PP Garcez","year":"2016","unstructured":"Garcez, P. P. et al. Zika virus impairs growth in human neurospheres and brain organoids. Science 352, 816\u2013818 (2016).","journal-title":"Science"},{"key":"BFnrmicro2016125_CR66","doi-asserted-by":"publisher","unstructured":"Dang, J. et al. Zika virus depletes neural progenitors in human cerebral organoids through activation of the innate immune receptor TLR3. Cell Stem Cell http:\/\/dx.doi.org\/10.1016\/j.stem.2016.04.014 (2016).","DOI":"10.1016\/j.stem.2016.04.014"},{"key":"BFnrmicro2016125_CR67","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/nature18296","volume":"534","author":"FR Cugola","year":"2016","unstructured":"Cugola, F. R. et al. The Brazilian Zika virus strain causes birth defects in experimental models. Nature 534, 267\u2013271 (2016).","journal-title":"Nature"},{"key":"BFnrmicro2016125_CR68","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.chom.2016.03.010","volume":"19","author":"HM Lazear","year":"2016","unstructured":"Lazear, H. M. et al. A mouse model of Zika virus pathogenesis. Cell Host Microbe 19, 720\u2013730 (2016).","journal-title":"Cell Host Microbe"},{"key":"BFnrmicro2016125_CR69","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.4269\/ajtmh.16-0111","volume":"94","author":"SL Rossi","year":"2016","unstructured":"Rossi, S. L. et al. Characterization of a novel murine model to study Zika virus. Am. J. Trop. Med. Hyg. 94, 1362\u20131369 (2016).","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"BFnrmicro2016125_CR70","doi-asserted-by":"publisher","first-page":"e0004682","DOI":"10.1371\/journal.pntd.0004682","volume":"10","author":"MT Aliota","year":"2016","unstructured":"Aliota, M. T. et al. Characterization of lethal Zika virus infection in AG129 mice. PLoS Negl. Trop. Dis. 10, e0004682 (2016).","journal-title":"PLoS Negl. Trop. Dis."},{"key":"BFnrmicro2016125_CR71","doi-asserted-by":"publisher","first-page":"e0004658","DOI":"10.1371\/journal.pntd.0004658","volume":"10","author":"SD Dowall","year":"2016","unstructured":"Dowall, S. D. et al. A susceptible mouse model for Zika virus infection. PLoS Negl. Trop. Dis. 10, e0004658 (2016).","journal-title":"PLoS Negl. Trop. Dis."},{"key":"BFnrmicro2016125_CR72","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/cr.2016.58","volume":"26","author":"KY Wu","year":"2016","unstructured":"Wu, K. Y. et al. Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice. Cell Res. 26, 645\u2013654 (2016).","journal-title":"Cell Res."},{"key":"BFnrmicro2016125_CR73","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.jri.2015.03.001","volume":"108","author":"A Schmidt","year":"2015","unstructured":"Schmidt, A., Morales-Prieto, D. M., Pastuschek, J., Frohlich, K. & Markert, U. R. Only humans have human placentas: molecular differences between mice and humans. J. Reprod. Immunol. 108, 65\u201371 (2015).","journal-title":"J. Reprod. Immunol."},{"key":"BFnrmicro2016125_CR74","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1038\/ni.3212","volume":"16","author":"A Wack","year":"2015","unstructured":"Wack, A., Terczynska-Dyla, E. & Hartmann, R. Guarding the frontiers: the biology of type III interferons. Nat. Immunol. 16, 802\u2013809 (2015).","journal-title":"Nat. Immunol."},{"key":"BFnrmicro2016125_CR75","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.stem.2016.04.017","volume":"19","author":"C Li","year":"2016","unstructured":"Li, C. et al. Zika virus disrupts neural progenitor development and leads to microcephaly in mice. Cell Stem Cell 19, 120\u2013126 (2016).","journal-title":"Cell Stem Cell"},{"key":"BFnrmicro2016125_CR76","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/0035-9203(52)90043-6","volume":"46","author":"GW Dick","year":"1952","unstructured":"Dick, G. W. Zika virus. II. Pathogenicity and physical properties. Trans. R. Soc. Trop. Med. Hyg. 46, 521\u2013534 (1952).","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"BFnrmicro2016125_CR77","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/S1473-3099(16)00088-8","volume":"16","author":"ES Paixao","year":"2016","unstructured":"Paixao, E. S., Teixeira, M. G., Costa, M. D. & Rodrigues, L. C. Dengue during pregnancy and adverse fetal outcomes: a systematic review and meta-analysis. Lancet Infect. Dis. 16, 857\u2013865 (2016).","journal-title":"Lancet Infect. Dis."},{"key":"BFnrmicro2016125_CR78","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/S1473-3099(16)00146-8","volume":"16","author":"DS Shepard","year":"2016","unstructured":"Shepard, D. S., Undurraga, E. A., Halasa, Y. A. & Stanaway, J. D. The global economic burden of dengue: a systematic analysis. Lancet Infect. Dis. 16, 935\u2013941 (2016).","journal-title":"Lancet Infect. Dis."},{"key":"BFnrmicro2016125_CR79","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/nature12060","volume":"496","author":"S Bhatt","year":"2013","unstructured":"Bhatt, S. et al. The global distribution and burden of dengue. Nature 496, 504\u2013507 (2013).","journal-title":"Nature"},{"key":"BFnrmicro2016125_CR80","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/S0095-5108(18)30670-5","volume":"15","author":"JS Kinney","year":"1988","unstructured":"Kinney, J. S. & Kumar, M. L. Should we expand the TORCH complex? A description of clinical and diagnostic aspects of selected old and new agents. Clin. Perinatol. 15, 727\u2013744 (1988).","journal-title":"Clin. Perinatol."},{"key":"BFnrmicro2016125_CR81","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3201\/eid2102.141363","volume":"21","author":"D Musso","year":"2015","unstructured":"Musso, D. et al. Potential sexual transmission of Zika virus. Emerg. Infect. Dis. 21, 359\u2013361 (2015).","journal-title":"Emerg. Infect. Dis."},{"key":"BFnrmicro2016125_CR82","doi-asserted-by":"publisher","first-page":"215","DOI":"10.15585\/mmwr.mm6508e2","volume":"65","author":"SL Hills","year":"2016","unstructured":"Hills, S. L. et al. Transmission of Zika virus through sexual contact with travelers to areas of ongoing transmission \u2014 continental United States, 2016. MMWR. Morb. Mortal. Wkly Rep. 65, 215\u2013216 (2016).","journal-title":"MMWR. Morb. Mortal. Wkly Rep."},{"key":"BFnrmicro2016125_CR83","doi-asserted-by":"publisher","first-page":"372","DOI":"10.15585\/mmwr.mm6514a3","volume":"65","author":"DT Deckard","year":"2016","unstructured":"Deckard, D. T. et al. Male-to-male sexual transmission of Zika virus \u2014 Texas, January 2016. MMWR. Morb. Mortal. Wkly Rep. 65, 372\u2013374 (2016).","journal-title":"MMWR. Morb. Mortal. Wkly Rep."},{"key":"BFnrmicro2016125_CR84","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1056\/NEJMc1604449","volume":"374","author":"E D'Ortenzio","year":"2016","unstructured":"D'Ortenzio, E. et al. Evidence of sexual transmission of Zika virus. N. Engl. J. Med. 374, 2195\u20132198 (2016).","journal-title":"N. Engl. J. Med."},{"key":"BFnrmicro2016125_CR85","doi-asserted-by":"publisher","first-page":"880","DOI":"10.3201\/eid1705.101939","volume":"17","author":"BD Foy","year":"2011","unstructured":"Foy, B. D. et al. Probable non-vector-borne transmission of Zika virus, Colorado, USA. Emerg. Infect. Dis. 17, 880\u2013882 (2011).","journal-title":"Emerg. Infect. Dis."},{"key":"BFnrmicro2016125_CR86","doi-asserted-by":"publisher","first-page":"716","DOI":"10.15585\/mmwr.mm6528e2","volume":"65","author":"A Davidson","year":"2016","unstructured":"Davidson, A., Slavinski, S., Komoto, K., Rakeman, J. & Weiss, D. Suspected female-to-male sexual transmission of Zika virus \u2014 New York City, 2016. MMWR. Morb. Mortal. Wkly Rep. 65, 716\u2013717 (2016).","journal-title":"MMWR. Morb. Mortal. Wkly Rep."},{"key":"BFnrmicro2016125_CR87","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/S1473-3099(16)00138-9","volume":"16","author":"JM Mansuy","year":"2016","unstructured":"Mansuy, J. M. et al. Zika virus: high infectious viral load in semen, a new sexually transmitted pathogen? Lancet Infect. Dis. 16, 405 (2016).","journal-title":"Lancet Infect. Dis."},{"key":"BFnrmicro2016125_CR88","doi-asserted-by":"publisher","first-page":"2536","DOI":"10.1056\/NEJMoa0805715","volume":"360","author":"MR Duffy","year":"2009","unstructured":"Duffy, M. R. et al. Zika virus outbreak on Yap Island, Federated States of Micronesia. N. Engl. J. Med. 360, 2536\u20132543 (2009).","journal-title":"N. Engl. J. Med."},{"key":"BFnrmicro2016125_CR89","doi-asserted-by":"publisher","unstructured":"Besnard, M. et al. Congenital cerebral malformations and dysfunction in fetuses and newborns following the 2013 to 2014 Zika virus epidemic in French Polynesia. Euro Surveill. http:\/\/dx.doi.org\/10.2807\/1560-7917.ES.2016.21.13.30181 (2016).","DOI":"10.2807\/1560-7917.ES.2016.21.13.30181"},{"key":"BFnrmicro2016125_CR90","doi-asserted-by":"publisher","first-page":"13224","DOI":"10.3390\/ijerph121013224","volume":"12","author":"G Liotta","year":"2015","unstructured":"Liotta, G. et al. Elimination of mother-to-child transmission of HIV infection: the drug resource enhancement against AIDS and malnutrition model. Int. J. Environ. Res. Public Health 12, 13224\u201313239 (2015).","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"Suppl. 1","key":"BFnrmicro2016125_CR91","doi-asserted-by":"publisher","first-page":"S56","DOI":"10.1016\/j.jinf.2014.07.018","volume":"69","author":"J Stevens","year":"2014","unstructured":"Stevens, J. & Lyall, H. Mother to child transmission of HIV: what works and how much is enough? J. Infect. 69 (Suppl. 1), S56\u2013S62 (2014).","journal-title":"J. Infect."},{"key":"BFnrmicro2016125_CR92","doi-asserted-by":"publisher","first-page":"16126","DOI":"10.1038\/nmicrobiol.2016.126","volume":"1","author":"TA Perkins","year":"2016","unstructured":"Perkins, T. A., Siraj, A. S., Ruktanonchai, C. W., Kraemer, M. U. G. & Tatem, A. J. Model-based projections of Zika virus infections in childbearing women in the Americas. Nat. Microbiol. 1, 16126 (2016).","journal-title":"Nat. Microbiol."},{"key":"BFnrmicro2016125_CR93","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1016\/S0140-6736(14)60539-0","volume":"385","author":"N Lambert","year":"2015","unstructured":"Lambert, N., Strebel, P., Orenstein, W., Icenogle, J. & Poland, G. A. Rubella. Lancet 385, 2297\u20132307 (2015).","journal-title":"Lancet"},{"key":"BFnrmicro2016125_CR94","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1128\/CMR.00062-12","volume":"26","author":"S Manicklal","year":"2013","unstructured":"Manicklal, S., Emery, V. C., Lazzarotto, T., Boppana, S. B. & Gupta, R. K. The \u201csilent\u201d global burden of congenital cytomegalovirus. Clin. Microbiol. Rev. 26, 86\u2013102 (2013).","journal-title":"Clin. Microbiol. Rev."},{"key":"BFnrmicro2016125_CR95","doi-asserted-by":"publisher","first-page":"501","DOI":"10.2471\/BLT.12.111732","volume":"91","author":"PR Torgerson","year":"2013","unstructured":"Torgerson, P. R. & Mastroiacovo, P. The global burden of congenital toxoplasmosis: a systematic review. Bull. World Health Organ. 91, 501\u2013508 (2013).","journal-title":"Bull. World Health Organ."},{"key":"BFnrmicro2016125_CR96","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1038\/35080570","volume":"2","author":"J Rossant","year":"2001","unstructured":"Rossant, J. & Cross, J. C. Placental development: lessons from mouse mutants. Nat. Rev. Genet. 2, 538\u2013548 (2001).","journal-title":"Nat. Rev. Genet."},{"key":"BFnrmicro2016125_CR97","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.2217\/fvl.13.106","volume":"8","author":"MR Schleiss","year":"2013","unstructured":"Schleiss, M. R. Developing a vaccine against congenital cytomegalovirus (CMV) infection: what have we learned from animal models? where should we go next? Future Virol. 8, 1161\u20131182 (2013).","journal-title":"Future Virol."},{"issue":"Suppl. A","key":"BFnrmicro2016125_CR98","doi-asserted-by":"publisher","first-page":"S41","DOI":"10.1016\/j.placenta.2006.11.002","volume":"28","author":"AM Carter","year":"2007","unstructured":"Carter, A. M. Animal models of human placentation \u2014 a review. Placenta 28 (Suppl. A), S41\u2013S47 (2007).","journal-title":"Placenta"},{"key":"BFnrmicro2016125_CR99","unstructured":"World Health Organization. Zika situation report. WHO http:\/\/www.who.int\/emergencies\/zika-virus\/situation-report\/14-july-2016\/en\/ (2016)."},{"key":"BFnrmicro2016125_CR100","doi-asserted-by":"publisher","unstructured":"Perez, S. et al. Confirmed case of Zika virus congenital infection, Spain, March 2016. Euro Surveill. http:\/\/dx.doi.org\/10.2807\/1560-7917.ES.2016.21.24.30261 (2016).","DOI":"10.2807\/1560-7917.ES.2016.21.24.30261"},{"key":"BFnrmicro2016125_CR101","doi-asserted-by":"publisher","unstructured":"Culjat, M. et al. Clinical and imaging findings in an infant with Zika embryopathy. Clin. Infect. Dis. http:\/\/dx.doi.org\/10.1093\/cid\/ciw324 (2016).","DOI":"10.1093\/cid\/ciw324"},{"key":"BFnrmicro2016125_CR102","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1056\/NEJMc1605389","volume":"375","author":"AR Aiken","year":"2016","unstructured":"Aiken, A. R. et al. Requests for abortion in Latin America related to concern about Zika virus exposure. N. Engl. J. Med. 375, 396\u2013398 (2016).","journal-title":"N. Engl. J. Med."},{"key":"BFnrmicro2016125_CR103","doi-asserted-by":"publisher","first-page":"323","DOI":"10.15585\/mmwr.mm6512e3","volume":"65","author":"AM Oster","year":"2016","unstructured":"Oster, A. M. et al. Update: interim guidance for prevention of sexual transmission of Zika virus \u2014 United States, 2016. MMWR. Morb. Mortal. Wkly Rep. 65, 323\u2013325 (2016).","journal-title":"MMWR. Morb. Mortal. Wkly Rep."},{"key":"BFnrmicro2016125_CR104","unstructured":"Guttmacher Institute. Facts on abortion in Latin America and the Caribbean. Guttmacher Institute https:\/\/www.guttmacher.org\/fact-sheet\/facts-abortion-latin-america-and-caribbean (2015)."},{"key":"BFnrmicro2016125_CR105","doi-asserted-by":"publisher","first-page":"e1501462","DOI":"10.1126\/sciadv.1501462","volume":"2","author":"CA McConkey","year":"2016","unstructured":"McConkey, C. A. et al. A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistance. Sci. Adv. 2, e1501462 (2016).","journal-title":"Sci. Adv."}],"container-title":["Nature Reviews Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/nrmicro.2016.125.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nrmicro.2016.125","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nrmicro.2016.125.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T09:39:07Z","timestamp":1659173947000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrmicro.2016.125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,30]]},"references-count":105,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["BFnrmicro2016125"],"URL":"https:\/\/doi.org\/10.1038\/nrmicro.2016.125","relation":{},"ISSN":["1740-1526","1740-1534"],"issn-type":[{"value":"1740-1526","type":"print"},{"value":"1740-1534","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,30]]},"assertion":[{"value":"30 August 2016","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}